Channel:  The Howard Hughes Medical Institute (HHMI)

1,285 Articles

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Modular regulation of the stem cell transcriptome defines self-renewal, differentiation, and dedifferentiation
Raz, A. A., Hassan, H., Yamashita, Y. M.
10.1101/2025.04.10.648217 — Posted: 2025-04-14
De novo design and structure of a peptide-centric TCR mimic binding module
Householder, K. D., Xiang, X., Jude, K. M., Deng, A., Obenaus, M., Wilson, S. C., Chen, X., Wang, N., Garcia, K. C.
10.1101/2024.12.16.628822 — Posted: 2025-04-14
Designed NGF mimetics with reduced nociceptive signatures in neurons
Schlichthaerle, T., Yang, A., Detraux, D., Johnson, D. E., Peach, C. J., Edman, N. I., Sniezek, C., Williams, C. A., Arora, S., Katiyar, N., Chen, I., Etemadi, A., Favor, A., Lee, D., Kubo, C., Coventry, B., Huang, B., Gerben, S., Ennist, N. M., Milles, L., Sankaran, B., Kang, A., Nguyen, H., Bera, A. K., Negahdari, B., Hamazaki, N., Schweppe, D. K., Stewart, L., Young, J. E., Bunnett, N. W., Ruohola-Baker, H., Mathieu, J., Pattwell, S., Garcia, K. C., Baker, D.
10.1101/2025.04.14.648806 — Posted: 2025-04-14
Computational Design of Metallohydrolases
Kim, D., Woodbury, S. M., Ahern, W., Tischer, D., Hanikel, N., Salike, S., Yim, J., Pellock, S. J., Lauko, A., Kalvet, I., Hilvert, D., Baker, D.
10.1101/2024.11.13.623507 — Posted: 2025-04-11
Atom level enzyme active site scaffolding using RFdiffusion2
Ahern, W., Yim, J., Tischer, D., Salike, S., Woodbury, S., Kim, D., Kalvet, I., Kipnis, Y., Coventry, B., Altae-Tran, H., Bauer, M., Barzilay, R., Jaakkola, T., Krishna, R., Baker, D. A.
10.1101/2025.04.09.648075 — Posted: 2025-04-10
OmniSplice: a framework-free splicing event reporter
Lannes, R., Fingerhut, J. M., Yamashita, Y. M. M.
10.1101/2025.04.06.647416 — Posted: 2025-04-08
Transcription factor hubs exhibit gene-specific properties that tune expression
Fallacaro, S., Mukherjee, A., Turner, M. A., Garcia, H. G., Mir, M.
10.1101/2025.04.07.647578 — Posted: 2025-04-08
Biosynthesis of Macrocyclic Peptides by Formation and Crosslinking of ortho-Tyrosines
Padhi, C., Zhu, L., Chen, J. Y., Moreira, R., van der Donk, W. A.
10.1101/2025.04.04.647296 — Posted: 2025-04-08
Small-molecule modulation of Beta-arrestins
Kahsai, A. W., Pakharukova, N., Kwon, H. Y., Shah, K. S., Liang-Lin, J. G., del Real, C. T., Shim, P. J., Lee, M. A., Ngo, V. A., Shreiber, B. N., Liu, S., Schwalb, A. M., Espinoza, E. F., Thomas, B. N., Kunzle, C. A., Smith, J. S., Wang, J., Kim, J., Zhang, X., Rockman, H. A., Thomsen, A. R. B., Rein, L. A. M., Shi, L., Ahn, S., Masoudi, A., Lefkowitz, R. J.
10.1101/2024.12.27.630464 — Posted: 2025-04-08
Geospatial and demographic patterns of SARS-CoV-2 spread in Massachusetts from over 130,000 genomes
Moreno, G. K., Brock-Fisher, T., Krasilnikova, L. A., Schaffner, S., Burns, M., Casiello, C. E., Messer, K. S., Petros, B. A., Specht, I., DeRuff, K. C., Siddle, K. J., Loreth, C., Fitzgerald, N. A., Rooke, H. M., Gabriel, S. B., Smole, S., Wohl, S., Park, D. J., Madoff, L. C., Brown, C. M., MacInnis, B. L., Sabeti, P. C.
10.1101/2025.04.04.25324273 — Posted: 2025-04-06

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