Channel:  The Howard Hughes Medical Institute (HHMI)

1,286 Articles

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PD-linked LRRK2 G2019S mutation impairs astrocyte morphology and synapse maintenance via ERM hyperphosphorylation
Wang, S., Baumert, R., Sejourne, G., Sivadasan Bindu, D., Dimond, K., Sakers, K., Vazquez, L., Moore, J. L., Tan, C. X., Takano, T., Rodriguez, M. P., Brose, N., Bradley, L., Lessing, R., Soderling, S. H., La Spada, A. R., Eroglu, C.
10.1101/2023.04.09.536178 — Posted: 2025-04-29
The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut
Zhang, Y., Noya, S. B., Li, Y., chao, F. J., Sehgal, A.
10.1101/2024.02.29.582770 — Posted: 2025-04-28
Tanycyte Bmal1 sex-specifically regulates weight gain and hypothalamic neurogenesis in female mice
Iascone, D. M., Pivarshev, P., Yang, J., Lopez Valencia, M., Noya, S. B., Lin, H., Anafi, R. C., Bedont, J. L., Sehgal, A.
10.1101/2025.04.21.649851 — Posted: 2025-04-28
DNA Methylation Dynamics of Dose-dependent Acute Exercise, Training Adaptation, and Detraining
Hariharan, M., Patel, S., Song, H., Rehman, A., Barragan, C., Bartlett, A., Castanon, R., Nery, J., Rothenberg, V., Chen, H., Tian, W., Ding, W., Wang, W., McAdam, J., Graham, Z., Lavin, K., Bamman, M., Broderick, T., Ecker, J.
10.1101/2025.04.22.650067 — Posted: 2025-04-25
Benchmarking cellular segmentation methods against Cellpose
Stringer, C., Pachitariu, M.
10.1101/2024.04.06.587952 — Posted: 2025-04-24
BRCA2 reversion mutation-independent resistance to PARP inhibition in prostate cancer through loss of function perturbations in the DNA pre-replication complex
Pappas, K. J., Ferrari, M., Smith, P., Nandakumar, S., Khan, Z., Young, S. B., LaClair, J., Russo, M. V., Huang-Hobbs, E., Schultz, N., Abida, W., Karthaus, W., Jasin, M., Sawyers, C.
10.1101/2025.04.20.649668 — Posted: 2025-04-24
Structures of human organellar SPFH protein complexes
Gao, J., Sherpa, D., Kupko, N., Shao, S.
10.1101/2025.04.21.649849 — Posted: 2025-04-22
Nuclear 2'-O-methylation regulates RNA splicing through its binding protein FUBP1
Gao, B., Jiang, B., Zou, Z., Liu, B., Liu, W., Chen, L., Zhang, L., He, C.
10.1101/2025.04.20.649728 — Posted: 2025-04-21
Nuclear envelope budding is a non-canonical mechanism to export large transcripts in muscle cells
Zaganelli, S., Meehl, J., Abrisch, R. G., Voeltz, G. K.
10.1101/2025.04.18.649598 — Posted: 2025-04-21
Cell-type-specific transposable element demethylation and TAD remodeling in the aging mouse brain
Zeng, Q., Tian, W., Klein, A., Bartlett, A., Liu, H., Nery, J. R., Castanon, R. G., Osteen, J., Johnson, N., Wang, W., Ding, W., Chen, H., Altshul, J., Kenworthy, M., Valadon, C., Owens, W., Wu, Z., Amaral, M. L., Song, Y., Baez-Becerra, C. T., Cho, S., Chen, C., Willier, J., Cao, S., Rink, J., Lee, J., Barcoma, A., Arzavala, J., Emerson, N., Lu, Y. R., Ren, B., Behrens, M. M., Ecker, J. R.
10.1101/2025.04.21.648266 — Posted: 2025-04-21

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