Channel:  The Howard Hughes Medical Institute (HHMI)

2,708 Articles

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Rapid neocortical network modifications via dendritic plateau potential induced plasticity
Xiao, K., Li, Y., Sullivan, B. J., Li, G., Magee, J. C.
10.1101/2025.11.19.689338 — Posted: 2025-11-19
De novo Design of All-atom Biomolecular Interactions with RFdiffusion3
Butcher, J., Krishna, R., Mitra, R., Brent, R. I., Li, Y., Corley, N., Kim, P. T., Funk, J., Mathis, S. V., Salike, S., Muraishi, A., Eisenach, H., Thompson, T. R., Chen, J., Politanska, Y., Sehgal, E., Coventry, B., Zhang, O., Qiang, B., Didi, K., Kazman, M., DiMaio, F., Baker, D.
10.1101/2025.09.18.676967 — Posted: 2025-11-19
Imp1 acts as a dosage- and stage-dependent temporal rheostat orchestrating radial glial fate transitions and cortical morphogenesis
Azur, R. A. G., Feliciano, D., Espinosa-Medina, I., Adhikari, R., Lilao-Garzon, J., Jansen, E., Yang, C.-P., Lee, T.
10.1101/2025.11.18.688993 — Posted: 2025-11-18
Structural Basis for Iterative Methylation by a Cobalamin-dependent Radical S-Adenosylmethionine Enzyme in Cystobactamids Biosynthesis
Cui, J., Wang, B., Maurya, R., Booker, S. J.
10.1101/2025.11.17.688841 — Posted: 2025-11-17
ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment
Qiao, K., Yang, Q.-L., Li, T., Chen, X., Yazgan, Z., Kim, Y. J., Gilbreath, C., Lim, J. Y. S., Xie, Y., Sun, X., Liu, Y., Jia, Y., Chen, Z. J., Huang, H., Wu, S.
10.1101/2025.11.15.688565 — Posted: 2025-11-16
Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression
Coley, A., Batra, K., Delahanty, J., Keyes, L., Pamintuan, R., Ramot, A., Hagemann, J., Lee, C., Liu, V., Adivikolanu, H., Cressy, J., Jia, C., Massa, F., LeDuke, D., Gabir, M., Durubeh, B., linderhof, L., Patel, R., Wichmann, R., Li, H., Fischer, K., Pereira, T., Tye, K.
10.1101/2024.12.18.629202 — Posted: 2025-11-15
Massively parallel reporter assay for mapping gene-specific regulatory regions at single nucleotide resolution
Tulloch, A. J., Delgado, R. N., Catta-Preta, R., Cepko, C. L.
10.1101/2025.05.13.653746 — Posted: 2025-11-14
Evolutionary basis of intermale sexual behavior by multiple pheromone switches in Drosophila
Ouadah, Y., Naragon, T. H., Smihula, H., Behrman, E. L., Khallaf, M. A., Ding, Y., Stern, D. L., Parker, J., Anderson, D. J.
10.1101/2025.10.14.682417 — Posted: 2025-11-14
FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity
Ladewig, E., Nazir, A., Park, T., Fan, V. B., Cao, Z., Hawk, J., Kelly, L., Tjian, R., Leslie, C. S., Sawyers, C.
10.1101/2025.11.13.688263 — Posted: 2025-11-14
The G3BP stress-granule proteins reinforce the integrated-stress-response translation program
Smith, J., Bartel, D. P.
10.1101/2024.10.04.616305 — Posted: 2025-11-13

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