Channel:  The Howard Hughes Medical Institute (HHMI)

2,708 Articles

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B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes
Zhou, P., Hartweger, H., MacLean, A. J., Ramos, V., Yao, K.-h., Hernandez, B., Wang, Z., Gazumyan, A., Nussenzweig, M. C.
10.1101/2025.10.30.685663 — Posted: 2025-11-01
Specialized parallel pathways for adaptive control of visual object pursuit
Collie, M. F., Jin, C., Rockwell, V., Kellogg, E., Vanerbeck, Q. X., Hartman, A. K., Holtz, S. L., Wilson, R. I.
10.1101/2025.04.23.650240 — Posted: 2025-11-01
Adapting CRISPR-associated transposons for rapid and high-throughput reverse genetics
Basta, D. W., Zingl, F. G., Yang, Y., Nguyen, K. T., Liu, Y.-Y., Waldor, M. K.
10.1101/2025.10.31.685825 — Posted: 2025-11-01
De novo design of metal-oxide templating proteins
Saragovi, A., Pyles, H., Huddy, T. F., Li, X., Borst, A. J., Hanikel, N., Courbet, A., Kwon, P., Davila-Hernandez, F. A., Kibler, R. D., Vafeados, D. K., Allen, A., Carr, K. D., Bera, A., Kang, A., Brackenbrough, E., Schmid, S., Bae, Y., Stewart, L., Zhang, S., De Yoreo, J., Baker, D.
10.1101/2024.06.24.600095 — Posted: 2025-11-01
HaloTrace: A spatiotemporally precise fluorescent readout of blood-brain barrier permeability in mice
Zucker, H. L., Konshina, E., Mitchell, P., Gu, C.
10.1101/2025.10.30.685531 — Posted: 2025-10-31
Trimodal brain-wide ultrasound imaging of brain-tumor interaction
Rabut, C., Shivaei, S., Heiles, B., Shapiro, M. G.
10.1101/2025.10.29.685462 — Posted: 2025-10-31
Sleep-dependent clearance of brain lipids by peripheral blood cells
Cho, B., Youngstrom, D. E., Killiany, S., Guevara, C., Randolph, C. E., Beveridge, C. H., Saklani, P., Chopra, G., Sehgal, A.
10.1101/2025.10.30.685668 — Posted: 2025-10-31
larch: mapping the parsimony-optimal landscape of trees for directed exploration
Barker, M., Milanov, O., Dumm, W., Rich, D., Turakhia, Y., Matsen, F. A.
10.1101/2025.10.29.685337 — Posted: 2025-10-31
Sexual dimorphism in the complete connectome of the Drosophila male central nervous system
Berg, S., Beckett, I. R., Costa, M., Schlegel, P., Januszewski, M., Marin, E. C., Nern, A., Preibisch, S., Qiu, W., Takemura, S.-y., Fragniere, A. M. C., Champion, A. S., Adjavon, D.-Y., Cook, M., Gkantia, M., Hayworth, K. J., Huang, G. B., Kampf, F., Katz, W. T., Lu, Z., Ordish, C., Paterson, T., Stuerner, T., Trautman, E. T., Whittle, C. R., Burnett, L. E., Hoeller, J., Li, F., Loesche, F., Morris, B. J., Pietzsch, T., Pleijzier, M. W., Silva, V., Yin, Y., Ali, I., Bates, A. S., Beresford, R. J., Bogovic, J., Brooks, P., Cachero, S., Canino, B. S., Chaisrisawatsuk, B., Clements, J., Crowe, A
10.1101/2025.10.09.680999 — Posted: 2025-10-30
Mutational scanning of TnpB reveals latent activity for genome editing
Thornton, B. W.-L., Weissman, R. F., Rodriguez, J. E., Tran, R. V., Duong, B. T., Terrace, C. I., Nagalakshmi, U., Austin, G., Groover, E. D., Wang, F. Z., Park, J.-U., Georgieva, V., Tartaglia, J., Cho, M.-J., Dinesh-Kumar, S., Doudna, J. A., Savage, D.
10.1101/2025.02.11.637750 — Posted: 2025-10-30

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