Channel:  The Howard Hughes Medical Institute (HHMI)

2,398 Articles

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NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Wu, Z., Nguyen, P. T., Sondhi, V., Yao, R.-W., Dai, T., Chiang, J.-C., Shang, Z., Cai, F., Zhang, J., Moore, M. D., Alshamleh, I., Li, X., Ogu, T., Zacharias, L. G., Winston, R., Patricio, J. S., Johnson, X., Chen, W.-M., Cong, Q., Mathews, T. P., Zhang, Y., DeBerardinis, R. J.
10.1101/2025.03.29.646096 — Posted: 2025-04-01
Glutamate indicators with increased sensitivity and tailored deactivation rates
Aggarwal, A., Negrean, A., Chen, Y., Iyer, R., Reep, D., Liu, A., Palutla, A., Xie, M. E., MacLennan, B., Hagihara, K. M., Kinsey, L. W., Sun, J. L., Yao, P., Zheng, J., Tsang, A., Tsegaye, G., Zhang, Y., Patel, R. H., Arthur, B. J., Hiblot, J., Leippe, P., Tarnawski, M., Marvin, J. S., Vevea, J. D., Turaga, S. C., Tebo, A. G., Carandini, M., Rossi, L. F., Kleinfeld, D., Konnerth, A., Svoboda, K., Turner, G. C., Hasseman, J., Podgorski, K.
10.1101/2025.03.20.643984 — Posted: 2025-03-31
Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulation
Song, J. H., Carter, A. C., Bushinsky, E. M., Beck, S. G., Petrocelli, J. E., Koreman, G. T., Babu, J., Kingsley, D. M., Greenberg, M. E., Walsh, C. A.
10.1101/2025.03.31.646367 — Posted: 2025-03-31
In-Situ High-Resolution Cryo-EM Reconstructions from CEMOVIS
Elferich, J., Kaminek, M., Kong, L., Odriozola, A., Kukulski, W., Zuber, B., Grigorieff, N.
10.1101/2025.03.29.646093 — Posted: 2025-03-31
Interleukin-1 receptor antagonist is a conserved early factor for exacerbating tuberculosis susceptibility
Lee, O. V., Ji, D. X., Rosa, B. A., Jaye, D. L., Suliman, S., Mitreva, M., Gabay, C., Vance, R. E., Kotov, D. I.
10.1101/2023.10.27.564420 — Posted: 2025-03-29
IL-25-induced memory ILC2s mediate long-term small intestinal adaptation
Cortez, V. S., Viragova, S., Koga, S., Liu, M., O'Leary, C., Ricardo-Gonzalez, R. R., Schroeder, A. W., Kochhar, N., Klein, O., Diamond, M., Liang, H.-E., Locksley, R. M.
10.1101/2025.03.25.645270 — Posted: 2025-03-29
Synaptic editing of frontostriatal circuitry prevents excessive grooming in SAPAP3-deficient mice
Walder-Christensen, K. K., Soliman, H. A., Calakos, N., Dzirasa, K.
10.1101/2025.03.27.645613 — Posted: 2025-03-29
Delphy: scalable, near-real-time Bayesian phylogenetics for outbreaks
Varilly, P., Schifferli, M., Yang, K., Burcham, T., Cronan, P., Glennon, O., Jacks, O., Laning, E., Marrs, L., Oba, K., Yeung, S., Parker, E., Omah, I., Pekar, J. E., Luebbert, L., Andersen, K. G., Park, D. J., Schaffner, S. F., MacInnis, B. L., Happi, C., Lemieux, J. E., Ozonoff, A., Mitzenmacher, M. D., Fry, B., Sabeti, P. C.
10.1101/2025.03.25.645253 — Posted: 2025-03-26
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Agarwal, G., Antoszewski, M., Xie, X., Pershad, Y., Arora, U. P., Poon, C.-L., Lyu, P., Lee, A. J., Guo, C.-J., Ye, T., Norford, L. B., Neehus, A.-L., della Volpe, L., Wahlster, L., Ranasinghe, D., Ho, T.-C., Barlowe, T. S., Chow, A., Schurer, A., Taggart, J., Durham, B. H., Abdel-Wahab, O., McGraw, K. L., Allan, J. M., Soldatov, R., Bick, A. G., Kharas, M. G., Sankaran, V. G.
10.1101/2025.03.24.645017 — Posted: 2025-03-26
Long-term editing of brain circuits in mice using an engineered electrical synapse
Ransey, E., Thomas, G., Wisdom, E., Almoril-Porras, A., Bowman, R., Adamson, E., Walder-Christensen, K. K., White, J. A., Hughes, D. N., Schwennesen, H., Ferguson, C., Tye, K., Mague, S. D., Niu, L.-G., Wang, Z.-W., Colon-Ramos, D., Hultman, R., Bursac, N., Dzirasa, K.
10.1101/2025.03.25.645291 — Posted: 2025-03-26

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