Channel:  The Howard Hughes Medical Institute (HHMI)

2,708 Articles

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Drosophila maintain a consistent navigational goal angle for days to weeks
Weisman, J. L., Mohren, T. L., Ryu, J. D., Wyse, M. Z., Dias-Ferreira, E., Maimon, G.
10.64898/2025.12.09.693277 — Posted: 2025-12-11
A shared DNA-repeat toxicity threshold, reached somatically at cell-type-specific rates, unites cortical and striatal neurodegeneration in Huntingtons disease
Kashin, S., Lee, W.-S., McDonald, T. M., Morris, K., Handsaker, R. E., Mello, C., Spina, L., Reed, N. M., de Rivera, H., Jana, S. H., Hogan, M., Berretta, S., McCarroll, S. A.
10.64898/2025.12.09.688862 — Posted: 2025-12-11
The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages
Barr, H. J., Caldwell, S. K., Reimertz, J. M., Depp, C., Walker, A. J., Marsh, S. E., Gupte, A. S., Hingerl, M., Patel, J., Park, S.-O., Ferraro, S., Lipton, J., Stevens, B.
10.64898/2025.12.08.693074 — Posted: 2025-12-11
Multimodal cell lineage reconstruction in the hindbrain reveals a link between progenitor origin and activity patterning
Blanc, M., Meister, L., Lemon, W. C., Fiuza, U.-M., Keller, P. J., Espinosa-Medina, I., Pujades, C.
10.1101/2025.11.14.688499 — Posted: 2025-12-09
Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels
Moon, S. J., Hu, Y., Dzieciatkowska, M., Kim, A.-R., Asara, J. M., D'Alessandro, A., Perrimon, N.
10.1101/2024.04.24.591006 — Posted: 2025-12-09
High-efficiency, transgene-free plant genome editing by viral delivery of an engineered TnpB
Nagalakshmi, U., Rodriguez, J. E., Nguyen, T., Weissman, R. F., Thornton, B. W., Savage, D. F., Dinesh-Kumar, S. P.
10.64898/2025.12.05.692691 — Posted: 2025-12-09
Inhibition of FicD-mediated AMPylation and deAMPylation by Isoprenoid Diphosphates
Blevins, A. M., Peng, W., Kinch, L., Monshad, Z., Paredes, A. G., Volz, C., Rutter, J., Casey, A., Hicks, K., Orth, K.
10.64898/2025.12.08.693056 — Posted: 2025-12-08
Structure and evolution-guided design of minimal RNA-guided nucleases
Skopintsev, P., Esain-Garcia, I., DeTurk, E. C., Yoon, P. H., Zhou, Z., Weiss, T., Kamalu, M., Chamraj, A., Loi, K. J., Langeberg, C. J., Boger, R., Nisonoff, H., Karp, H. M., Chen, L., Shi, H., Vohra, K., Banfield, J. F., Cate, J. H. D., Jacobsen, S. E., Doudna, J. A.
10.64898/2025.12.08.692503 — Posted: 2025-12-08
Brain-immune interactions generate pathogen-specific sickness states
Sullivan, Z. A., Wong, B. J., Kapoor, V., Vincze, P. K., Kaplan, H. S., Giraudet, P., Watson, B. R., Misherghi, A., Lourido, S., Moffitt, J. R., Dulac, C.
10.64898/2025.12.06.692770 — Posted: 2025-12-08
Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling
Hevler, J. F., Sojitra, M., Caval, T., Schoof, M. L., Mateus, A., Bertozzi, C.
10.64898/2025.12.06.692499 — Posted: 2025-12-07

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