Channel:  The Howard Hughes Medical Institute (HHMI)

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Deep learning guided design of protease substrates
Martin Alonso, M. C., Alamdari, S., Samad, T. S., Yang, K. K., Bhatia, S. N., Amini, A. P.
10.1101/2025.02.27.640681 — Posted: 2025-03-02
DNA origami vaccines program antigen-focused germinal centers
Romanov, A., Knappe, G. A., Ronsard, L., Suh, H., Omer, M., Chapman, A. P., Lewis, V., Spivakovsky, K., Canales, J., Reizis, B., Tingle, R., Cottrell, C., Schiffner, T., Lingwood, D., Bathe, M., Irvine, D. J.
10.1101/2025.02.21.639354 — Posted: 2025-03-01
Atomically accurate de novo design of antibodies with RFdiffusion
Bennett, N. R., Watson, J. L., Ragotte, R. J., Borst, A. J., See, D. L., Weidle, C., Biswas, R., Yu, Y., Shrock, E. L., Ault, R., Leung, P. J. Y., Huang, B., Goreshnik, I., Tam, J., Carr, K. D., Singer, B., Criswell, C., Wicky, B. I. M., Vafeados, D., Garcia Sanchez, M., Kim, H. M., Vazquez Torres, S., Chan, S., Sun, S. M., Spear, T., Sun, Y., OReilly, K., Maris, J. M., Sgourakis, N. G., Melnyk, R. A., Liu, C. C., Baker, D.
10.1101/2024.03.14.585103 — Posted: 2025-02-28
Molecular grammars of intrinsically disordered regions that span the human proteome
Ruff, K. M., King, M. R., Ying, A. W., Liu, V., Pant, A., Lieberman, W. E., Shinn, M. K., su, x., Kadoch, C., Pappu, R. V.
10.1101/2025.02.27.640591 — Posted: 2025-02-28
Massively parallel assessment of designed protein solution properties using mass spectrometry and peptide barcoding
Feldman, D., Sims, J. N., Li, X., Johnson, R., Gerben, S., Kim, D. E., Richardson, C., Koepnik, B., Eisenach, H., Hicks, D. R., Yang, E., Wicky, B. I. M., Milles, L. F., Bera, A., Brackenbrough, E., Joyce, E., Sankaran, B., Lubner, J. M., Goreshnik, I., Vafeados, D., Allen, A., Stewart, L., MacCoss, M. J., Baker, D.
10.1101/2025.02.24.639402 — Posted: 2025-02-28
Pseudomonads coordinate innate defense against viruses and bacteria with a single regulatory system
Brinkley, D. M., Bertolli, S. K., Gallagher, L. A., Tan, Y., Motha de Silva, M., Brockman, A., Zhang, D., Peterson, S. B., Mougous, J. D.
10.1101/2025.02.26.640152 — Posted: 2025-02-27
Characterization of energy filtering slit widths for MicroED data collection
Clabbers, M. T. B., Hattne, J., Martynowycz, M. W., Gonen, T.
10.1101/2025.02.24.639939 — Posted: 2025-02-27
Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C
Wang, X., Xu, P., Bentley-DeSousa, A., Hancock-Cerutti, W., Cai, S., Johnson, B. T., Tonelli, F., Shao, L., Talaia, G., Alessi, D. R., Ferguson, S. M., De Camilli, P.
10.1101/2024.06.08.598070 — Posted: 2025-02-26
Combining Sampling Methods with Attractor Dynamics in Spiking Models of Head-Direction Systems
Pjanovic, V., Zavatone-Veth, J. A., Masset, P., Keemink, S. W., Nardin, M.
10.1101/2025.02.25.640158 — Posted: 2025-02-26
Stress drives plasticity in leaf maturation transcriptional dynamics
Swift, J., Wu, X., Xu, J., Jain, T., Illouz-Eliaz, N., Nery, J. R., Chory, J., Ecker, J. R.
10.1101/2025.02.24.639183 — Posted: 2025-02-25

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