Channel:  The Howard Hughes Medical Institute (HHMI)

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A genome-scale drug discovery pipeline uncovers new therapeutic targets and a unique p97 allosteric binding site in Schistosoma mansoni
Stephens, D. R., Fung, H. Y. J., Han, Y., Liang, J., Chen, Z., Ready, J., Collins, J.
10.1101/2025.03.14.643303 — Posted: 2025-03-15
Nonequilibrium polysome dynamics promote chromosome segregation and its coupling to cell growth in Escherichia coli
Papagiannakis, A., Yu, Q., Govers, S. K., Lin, W.-H., Wingreen, N. S., Jacobs-Wagner, C.
10.1101/2024.10.08.617237 — Posted: 2025-03-15
Design of solubly expressed miniaturized SMART MHCs
White, W. L., Bai, H., Kim, C. J., Jude, K. M., Sun, R., Guerrero, L., Han, X., Chen, X. T., Chaudhuri, A., Bonzanini, J. E., Sun, Y., Onwuka, A. E., Wang, N., Wang, C., Li, X., Goreshnik, I., Allen, A., Levine, P. M., Kueh, H. Y., Jewett, M. C., Sgourakis, N., Achour, A., Garcia, K. C., Baker, D.
10.1101/2025.03.14.643101 — Posted: 2025-03-14
HortaCloud: An Open and Collaborative Platform for Whole Brain Neuronal Reconstructions
Rokicki, K., Schauder, D., Olbris, D. J., Goina, C., Clements, J., Edson, P., Kawase, T., Svirskas, R., Arshadi, C., Feng, D., Chandrashekar, J., Ferreira, T. A., MouseLight Project Team
10.1101/2025.03.13.642887 — Posted: 2025-03-14
Canonical Wnt Signaling Suppresses Brain Endothelial Cell Transcytosis to Maintain Blood-Brain Barrier Integrity
du Maine, X., Gu, C.
10.1101/2025.03.10.642437 — Posted: 2025-03-13
Engineering Multiplexed Synthetic Breath Biomarkers as Diagnostic Probes
Wang, S.-T., Anahtar, M., Kim, D. M., Samad, T. S., Zhang, C. M., Patel, S., Ko, H., Ngambenjawong, C., Wang, C. S., Kirkpatrick, J. D., Kumar, V., Fleming, H. E., Bhatia, S. N.
10.1101/2024.12.30.630769 — Posted: 2025-03-13
Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1
Xue, J., Zeng, W., John, S., Attiq, N., Ottolia, M., Jiang, Y.
10.1101/2024.12.05.627058 — Posted: 2025-03-13
Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis
Lee, Y., Biasini, A., Tipping, C., Hong, S. H., Zamore, P.
10.1101/2025.03.05.641556 — Posted: 2025-03-11
Functional microRNA targeting without seed pairing
Hall, M. H., Wang, P. Y., Pham, T. M., Bartel, D. P.
10.1101/2025.03.03.641270 — Posted: 2025-03-11
Gradients of Recognition Molecules Wire Visuomotor Transformation
Dombrovski, M., Zang, Y., Frighetto, G., Vaccari, A., Jang, H., Mirshahidi, P. S., Xie, F., Sanfilippo, P., Hina, B. W., Rehan, A., Hussein, R. H., Mirshahidi, P. S., Lee, C., Morris, A., Frye, M. A., von Reyn, C. R., Kurmangaliyev, Y. Z., Card, G. M., Zipursky, S. L.
10.1101/2024.09.04.610846 — Posted: 2025-03-10

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