Channel:  Aligning Science Across Parkinson's (ASAP)

456 Articles

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TDP-43 loss of function drives aberrant splicing in Parkinson's disease
Brenton, J. W., Follett, J., Nirujogi, R., Toomey, C. E., Lopez-Garcia, P., Evans, J. R., Lee, Y. J., Syed, K. M., Rocamora Perez, G., Fairbrother-Browne, A., D'Sa, K., Grant-Peters, M., Lachica, J., Hicks, A. R., Wagen, A. Z., O'Callaghan, B., Macpherson, H., Montgomery, K.-a., Busquets, O., Reynolds, R. H., Garcia Ruiz, S., Cao, T., Chen, Z., Plun-Favreau, H., Wong, P. C., Farrer, M., Lashley, T., Soldner, F., Hockemeyer, D., Alessi, D., Wood, N. W., Hardy, J., Rio, D. C., Jaunmuktane, Z., Gustavsson, E. K., Gandhi, S., Ryten, M.
10.1101/2025.09.04.673943 — Posted: 2025-09-09
Proteome-wide impact of LRRK1 and 2 inhibitors on protein interactions and phosphorylation
Jansen, J., Wendel, M., Raig, N. D., Kraus, T. V., Surridge, K. J., Mahesula, S., Richter-Muller, N., Mathea, S., Reck-Peterson, S. L., Knapp, S., Stengel, F.
10.1101/2025.09.03.674114 — Posted: 2025-09-07
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Garza, R., Adami, A., Thiruvalluvan, A., Wijesinghe, S., Curle, A. J., Tam, O., Forcier, T., Lagka, D. A., Kazakou, N. L., Atacho, D. A. M., Sharma, Y., Jonsson, M. E., Horvath, V., Bermudez, S., Johansson, J. G., Rainbow, D. B., Castilla-Vallmanya, L., Jones, J. L., Quaegebeur, A., Gale Hammell, M., Kirkeby, A., Barker, R. A., Jakobsson, J.
10.1101/2025.09.03.673956 — Posted: 2025-09-07
Comparison of Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson's Disease Mutations
Lee, Y. J., Syed, K., Busquets, O., Li, H., Dunnack, J., Bateup, H., Soldner, F., Hockemeyer, D., Rio, D.
10.1101/2024.02.28.582420 — Posted: 2025-09-04
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons
Chen, C., He, Q., Tombesi, G., Napier, E., Jaconelli, M., Moreno-Ramos, O., Serio, H., Naaldijk, Y., Promes, V., Schneeweis, A., Quinn, K., Nasios, C., Greggio, E., Kozorovitskiy, Y., Arango, D., Khan, A. R., Alessi, D. R., Dombeck, D. A., Hilfiker, S., Awatramani, R., Parisiadou, L.
10.1101/2025.08.28.672006 — Posted: 2025-09-03
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Evans, J. R., Grant-Peters, M., Beckwith, J. S., Toomey, C. E., Popovic, R., Breiter, J. C., Brenton, J. W., Fairbrother-Browne, A., Strohbuecker, S., Lachica, J., Rodriguez-Lopez, M., Brock, E. E., Fu, B., Nahidiazar, L., Lopez-Garcia, P., Ferguson, R., Saleeb, R. S., Lucas-Clarke, H., Penverne, A., D'Sa, K., Pang, C. W., Horrocks, M. H., Vendruscolo, M., Wood, N., Lee, S. F., Ryten, M., Gandhi, S.
10.1101/2025.08.25.671921 — Posted: 2025-08-28
LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload
Goldman, A., Nguyen, M., Lanoix, J., Fahmy, A., Zhong Xu, Y., Schurr, E., Thibault, P., Desjardins, M., McBride, H.
10.1101/2025.08.25.672135 — Posted: 2025-08-25
TMEM175, SCARB2 and CTSB associations with Parkinson's disease risk across populations.
Sun, W., Schulte, C., Gasser, T., Tan, M., The Global Parkinson's Genetics Program (GP2)
10.1101/2025.08.17.25333823 — Posted: 2025-08-25
Integrated Representations of Threat and Controllability in the Lateral Frontal Pole
Stasiak, J. E., Wang, J., Dundon, N. M., Rizor, E. J., Villanueva, C. M., Barandon, P. L., Grafton, S. T., Lapate, R. C.
10.1101/2025.08.24.671754 — Posted: 2025-08-24
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved TBM motif
Waschbuesch, D., Pal, P., Nirujogi, R. S., Cavin, M., Singh, J., Alessi, D. R., Khan, A. R.
10.1101/2025.08.19.670962 — Posted: 2025-08-24

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