Channel:  Aligning Science Across Parkinson's (ASAP)

467 Articles

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Programmable self-assembling system to model intracellular protein aggregation and decode neurodegenerative diseases
Fan, Y., Hoang, J., Steele, C., Benchetrit, Y., Dutta, S., Coughlin, G., Appling, N., Ding, X., Lin, C., Qu, Z., Mackey, E. D., Gradinaru, V.
10.1101/2025.03.06.641009 — Posted: 2025-10-06
Alternate Splicing Directs PMCA2 to Lysosomes and is Linked to Neurodegeneration
Fernandez-Suarez, M. E., Bush, R., Brenton, J. W., Pereira, G., Grant-Peters, M., Reynolds, R. H., te Vruchte, D., Shepherd, D., Weng, Y., Artaza-Fernandez, E., Lis, P., Sanchez-Pulido, L., Morgan, A., Davis, L., Gomez-Coronado, D., Eden, E. R., Alessi, D. R., Ponting, C., Galione, A., Newstead, S., Hardy, J., Patel, S., Ryten, M., Platt, F. M.
10.1101/2025.10.01.679724 — Posted: 2025-10-02
Fall frequency, Risk Factors, and Outcomes in Parkinson's disease: A Cross-Sectional Analysis
Vizcarra, J. A., Hefter, K., Lafontant, D.-E., Duong, M. T., Ertefaie, A., Litt, B., Bassett, D. S., Siderowf, A., The Parkinson's Progression Markers Initiative
10.1101/2025.08.05.25332959 — Posted: 2025-09-25
Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice
Moiseyenko, A., Antonello, G., Schonhoff, A. M., Boktor, J. C., Long, K., Dirks, B., Oguienko, A. D., Winnett, A. V., Simpson, P., Daeizadeh, D., Ismagilov, R. F., Krajmalnik-Brown, R., Segata, N., Waldron, L. D., Mazmanian, S. K.
10.1101/2025.09.18.677192 — Posted: 2025-09-21
A molecular atlas of cell-type specific signatures in the parkinsonian striatum.
Graziano, M., Mantas, I., Masarapu, Y., Frapard, S., Garza, R., Adami, A., Fazal, S., Quaegebeur, A., Barker, R., Jakobsson, J., Giacomello, S., Meletis, K.
10.1101/2025.09.09.675138 — Posted: 2025-09-10
TDP-43 loss of function drives aberrant splicing in Parkinson's disease
Brenton, J. W., Follett, J., Nirujogi, R., Toomey, C. E., Lopez-Garcia, P., Evans, J. R., Lee, Y. J., Syed, K. M., Rocamora Perez, G., Fairbrother-Browne, A., D'Sa, K., Grant-Peters, M., Lachica, J., Hicks, A. R., Wagen, A. Z., O'Callaghan, B., Macpherson, H., Montgomery, K.-a., Busquets, O., Reynolds, R. H., Garcia Ruiz, S., Cao, T., Chen, Z., Plun-Favreau, H., Wong, P. C., Farrer, M., Lashley, T., Soldner, F., Hockemeyer, D., Alessi, D., Wood, N. W., Hardy, J., Rio, D. C., Jaunmuktane, Z., Gustavsson, E. K., Gandhi, S., Ryten, M.
10.1101/2025.09.04.673943 — Posted: 2025-09-09
Proteome-wide impact of LRRK1 and 2 inhibitors on protein interactions and phosphorylation
Jansen, J., Wendel, M., Raig, N. D., Kraus, T. V., Surridge, K. J., Mahesula, S., Richter-Muller, N., Mathea, S., Reck-Peterson, S. L., Knapp, S., Stengel, F.
10.1101/2025.09.03.674114 — Posted: 2025-09-07
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Garza, R., Adami, A., Thiruvalluvan, A., Wijesinghe, S., Curle, A. J., Tam, O., Forcier, T., Lagka, D. A., Kazakou, N. L., Atacho, D. A. M., Sharma, Y., Jonsson, M. E., Horvath, V., Bermudez, S., Johansson, J. G., Rainbow, D. B., Castilla-Vallmanya, L., Jones, J. L., Quaegebeur, A., Gale Hammell, M., Kirkeby, A., Barker, R. A., Jakobsson, J.
10.1101/2025.09.03.673956 — Posted: 2025-09-07
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons
Chen, C., He, Q., Tombesi, G., Napier, E., Jaconelli, M., Moreno-Ramos, O., Serio, H., Naaldijk, Y., Promes, V., Schneeweis, A., Quinn, K., Nasios, C., Greggio, E., Kozorovitskiy, Y., Arango, D., Khan, A. R., Alessi, D. R., Dombeck, D. A., Hilfiker, S., Awatramani, R., Parisiadou, L.
10.1101/2025.08.28.672006 — Posted: 2025-09-03
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Evans, J. R., Grant-Peters, M., Beckwith, J. S., Toomey, C. E., Popovic, R., Breiter, J. C., Brenton, J. W., Fairbrother-Browne, A., Strohbuecker, S., Lachica, J., Rodriguez-Lopez, M., Brock, E. E., Fu, B., Nahidiazar, L., Lopez-Garcia, P., Ferguson, R., Saleeb, R. S., Lucas-Clarke, H., Penverne, A., D'Sa, K., Pang, C. W., Horrocks, M. H., Vendruscolo, M., Wood, N., Lee, S. F., Ryten, M., Gandhi, S.
10.1101/2025.08.25.671921 — Posted: 2025-08-28

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