bioRxiv Channel: Aligning Science Across Parkinson's (ASAP)
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This feed contains articles for bioRxiv Channel "Aligning Science Across Parkinson's (ASAP)"
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Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy
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https://biorxiv.org/cgi/content/short/2021.01.08.425958v1?rss=1"
Chang, C.Shi, X.Jensen, L.Yokom, A. L.Fracchiolla, D.Martens, S.Hurley, J. H.2021-01-09doi:10.1101/2021.01.08.425958Cold Spring Harbor Laboratory Press2021-01-09
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In situ architecture of neuronal alpha-Synuclein inclusions
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https://biorxiv.org/cgi/content/short/2020.08.07.234138v1?rss=1"
Trinkaus, V. A.Riera-Tur, I.Martinez-Sanchez, A.Baeuerlein, F. J. B.Guo, Q.Arzberger, T.Baumeister, W.Dudanova, I.Hipp, M. S.Hartl, F. U.Fernandez-Busnadiego, R.2020-08-07doi:10.1101/2020.08.07.234138Cold Spring Harbor Laboratory Press2020-08-07
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Structural basis for the specificity of PPM1H phosphatase for Rab GTPases
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https://biorxiv.org/cgi/content/short/2021.02.17.431620v1?rss=1"
Waschbüsch, D.Berndsen, K.Knebel, A.Alessi, D. R.Khan, A. R.2021-02-17doi:10.1101/2021.02.17.431620Cold Spring Harbor Laboratory Press2021-02-17
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Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain
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https://biorxiv.org/cgi/content/short/2021.03.02.433576v1?rss=1"
Khan, S. S.Sobu, Y.Dhekne, H. S.Tonelli, F.Berndsen, K.Alessi, D. R.Pfeffer, S. R.2021-03-02doi:10.1101/2021.03.02.433576Cold Spring Harbor Laboratory Press2021-03-02
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Multi-Modality Machine Learning Predicting Parkinsons Disease
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https://biorxiv.org/cgi/content/short/2021.03.05.434104v1?rss=1"
Makarious, M. B.Leonard, H. L.Vitale, D.Iwaki, H.Sargent, L.Dadu, A.Violich, I.Hutchins, E.Saffo, D.Bandres-Ciga, S.Kim, J. J.Song, Y.Bookman, M.Nojopranoto, W.Campbell, R. H.Hashemi, S. H.Botia, J. A.Carter, J. F.Maleknia, M.Craig, D. W.Keuren-Jensen, K. V.Morris, H. R.Hardy, J. A.Blauwendraat, C.Singleton, A. B.Faghri, F.Nalls, M. A.Accelerating Medicines Program - Parkinsons Disease (AMP PD),Global Parkinsons Genetics Program (GP2),2021-03-07doi:10.1101/2021.03.05.434104Cold Spring Harbor Laboratory Press2021-03-07
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Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9
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https://biorxiv.org/cgi/content/short/2020.12.28.424508v1?rss=1"
Yang, S.Park, D.Manning, L.Hill, S. E.Cao, M.Xuan, Z.Gonzalez, I.Shao, L.Okeke, I.De Camilli, P.Colon-Ramos, D.2020-12-28doi:10.1101/2020.12.28.424508Cold Spring Harbor Laboratory Press2020-12-28
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Miro recruits VPS13D to mitochondria
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https://biorxiv.org/cgi/content/short/2020.10.07.328906v1?rss=1"
Guillen-Samander, A.Leonzino, M.De Camilli, P.2020-10-07doi:10.1101/2020.10.07.328906Cold Spring Harbor Laboratory Press2020-10-07
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powerEQTL: An R package and shiny application for sample size and power calculation of bulk tissue and single-cell eQTL analysis
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https://biorxiv.org/cgi/content/short/2020.12.15.422954v1?rss=1"
Dong, X.Li, X.Chang, T.-W.Weiss, S. T.Qiu, W.2020-12-16doi:10.1101/2020.12.15.422954Cold Spring Harbor Laboratory Press2020-12-16
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ALS and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy
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https://biorxiv.org/cgi/content/short/2021.04.12.439050v1?rss=1"
Harding, O.Evans, C. S.Ye, J.Cheung, J.Maniatis, T.Holzbaur, E. L. F.2021-04-12doi:10.1101/2021.04.12.439050Cold Spring Harbor Laboratory Press2021-04-12
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Structural Basis for Membrane Recruitment of ATG16L1 by WIPI2 in Autophagy
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https://biorxiv.org/cgi/content/short/2021.05.14.444175v1?rss=1"
Strong, L. M.Chang, C.Boecker, A.Flower, T. G.Buffalo, C. Z.Ren, X.Stavoe, A. K.Holzbaur, E. L. F.Hurley, J. H.2021-05-14doi:10.1101/2021.05.14.444175Cold Spring Harbor Laboratory Press2021-05-14
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Subcellular proteomics of dopamine neurons in the mouse brain reveals axonal enrichment of proteins encoded by Parkinson's disease-linked genes
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https://biorxiv.org/cgi/content/short/2021.06.01.446584v1?rss=1"
Hobson, B. D.Choi, S. J.Soni, R. K.Sulzer, D.Sims, P. A.2021-06-01doi:10.1101/2021.06.01.446584Cold Spring Harbor Laboratory Press2021-06-01
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Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias
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https://biorxiv.org/cgi/content/short/2021.01.14.425874v1?rss=1"
Vavouraki, N.Tomkins, J. E.Kara, E.Houlden, H.Hardy, J.Tindall, M. J.Lewis, P. A.Manzoni, C.2021-01-16doi:10.1101/2021.01.14.425874Cold Spring Harbor Laboratory Press2021-01-16
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Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures
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https://biorxiv.org/cgi/content/short/2021.05.28.446215v1?rss=1"
Dhanwani, R.Rodrigues Lima-Junior, J.Sethi, A.Pham, J.Williams, G.Frazier, A.Xu, Y.Amara, A. W.Standaert, D. G.Goldman, J. G.Litvan, I.Alcalay, R. N.Peters, B.Sulzer, D.Lindestam Arlehamn, C. S.Sette, A.2021-05-29doi:10.1101/2021.05.28.446215Cold Spring Harbor Laboratory Press2021-05-29
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ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
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https://biorxiv.org/cgi/content/short/2021.06.08.447593v1?rss=1"
Hancock-Cerutti, W. F.Wu, Z.Tharkeshwar, A. K.Ferguson, S. M.Shadel, G. S.De Camilli, P.2021-06-08doi:10.1101/2021.06.08.447593Cold Spring Harbor Laboratory Press2021-06-08
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Targeted Neuronal Activation of the Gastrointestinal Tract Shapes the Environment of the Gut in Mice
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https://biorxiv.org/cgi/content/short/2021.04.12.439539v1?rss=1"
Yoo, B. B.Griffiths, J. A.Thuy-Boun, P.Cantu, V.Weldon, K.Challis, C.Sweredoski, M. J.Chan, K. Y.Thron, T. M.Sharon, G.Moradian, A.Humphrey, G.Zhu, Q.Shaffer, J.Wolan, D. W.Dorrestein, P.Knight, R.Gradinaru, V.Mazmanian, S.2021-04-13doi:10.1101/2021.04.12.439539Cold Spring Harbor Laboratory Press2021-04-13
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HyDrop: droplet-based scATAC-seq and scRNA-seq using dissolvable hydrogel beads
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https://biorxiv.org/cgi/content/short/2021.06.04.447104v1?rss=1"
De Rop, F. V.Ismail, J. N.Bravo Gonzalez-Blas, C.Hulselmans, G. J.Flerin, C. C.Janssens, J.Theunis, K.Christiaens, V. M.Wouters, J.Marcassa, G.de Wit, J.Poovathingal, S.Aerts, S.2021-06-06doi:10.1101/2021.06.04.447104Cold Spring Harbor Laboratory Press2021-06-06
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The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model
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https://biorxiv.org/cgi/content/short/2021.07.16.452659v1?rss=1"
Yuste-Checa, P.Trinkaus, V. A.Riera-Tur, I.Imamoglu, R.Schaller, T.Wang, H.Dudanova, I.Hipp, M. S.Bracher, A.Hartl, F. U.2021-07-16doi:10.1101/2021.07.16.452659Cold Spring Harbor Laboratory Press2021-07-16
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Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy
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https://biorxiv.org/cgi/content/short/2021.07.19.452535v1?rss=1"
Eapen, V.Swarup, S.Hoyer, M. J.Paulo, J. A.Harper, J. W.2021-07-19doi:10.1101/2021.07.19.452535Cold Spring Harbor Laboratory Press2021-07-19
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Global ubiquitylation analysis of mitochondria in primary neurons identifies physiological Parkin targets following activation of PINK1
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https://biorxiv.org/cgi/content/short/2021.04.01.438131v1?rss=1"
Antico, O.Ordureau, A.Stevens, M.Singh, F.Gierlinski, M.Barini, E.Rickwood, M.Prescott, A. R.Toth, R.Ganley, I.Harper, W.Muqit, M.2021-04-01doi:10.1101/2021.04.01.438131Cold Spring Harbor Laboratory Press2021-04-01
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Subcellular and regional localization of mRNA translation in midbrain dopamine neurons
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https://biorxiv.org/cgi/content/short/2021.07.30.454065v1?rss=1"
Hobson, B. D.Kong, L.Angelo, M. F.Lieberman, O. J.Mosharov, E. V.Herzog, E.Sulzer, D.Sims, P. A.2021-08-01doi:10.1101/2021.07.30.454065Cold Spring Harbor Laboratory Press2021-08-01
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SHIP164 is a Chorein Motif Containing Lipid Transport Protein that Controls Membrane Dynamics and Traffic at the Endosome-Golgi Interface.
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https://biorxiv.org/cgi/content/short/2021.11.04.467353v1?rss=1"
Hanna, M. G.Suen, P.Wu, Y.Reinisch, K. M.De Camilli, P.2021-11-04doi:10.1101/2021.11.04.467353Cold Spring Harbor Laboratory Press2021-11-04
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The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimental models of Parkinson's disease
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https://biorxiv.org/cgi/content/short/2021.09.27.461935v1?rss=1"
Kedariti, M.Frattini, E.Baden, P.Cogo, S.Civiero, L.Ziviani, E.Aureli, M.Kaganovich, A.Cookson, M. R.Stefanis, L. R.Surface, M.Deleidi, M.Di Fonzo, A.Alcalay, R. N.Rideout, H.Greggio, E.Plotegher, N.2021-09-28doi:10.1101/2021.09.27.461935Cold Spring Harbor Laboratory Press2021-09-28
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Intravenous gene transfer throughout the brain of infant Old World primates using AAV
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https://biorxiv.org/cgi/content/short/2022.01.08.475342v1?rss=1"
Chuapoco, M. R.Flytzanis, N.Goeden, N.Octeau, J. C.Roxas, K. M.Chan, K. Y.Scherrer, J.Winchester, J.Blackburn, R. J.Campos, L. J.Arokiaraj, C. M.Miles, T. F.Jang, M. J.Vendemiatti, J.Deverman, B. E.Pickel, J.Fox, A. S.Gradinaru, V.2022-01-09doi:10.1101/2022.01.08.475342Cold Spring Harbor Laboratory Press2022-01-09
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Mutations in Auxilin cause parkinsonism via impaired clathrin-mediated trafficking at the Golgi apparatus and synapse
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https://biorxiv.org/cgi/content/short/830802v1?rss=1"
Roosen, D. A.Landeck, N.Conti, M.Smith, N.Saez-Atienzar, S.Ding, J.Beilina, A.Kumaran, R.Kaganovich, A.du Hoffmann, J.Williamson, C.Gershlick, D. C.Bonet-Ponce, L.Sampieri, L.Bleck, C. K. E.Liu, C.Bonifacino, J. S.Li, Y.Lewis, P. A.Cookson, M. R.2019-11-05doi:10.1101/830802Cold Spring Harbor Laboratory Press2019-11-05
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Single-cell transcriptomic and proteomic analysis of Parkinson's disease Brains
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https://biorxiv.org/cgi/content/short/2022.02.14.480397v1?rss=1"
Zhu, B.Park, J.-M.Coffey, S.Hsu, I.-U.Lam, T. T.Gopal, P. P.Ginsberg, S. D.Wang, J.Su, C.Zhao, H.Hafler, D. A.Chandra, S.Zhang, L.2022-02-14doi:10.1101/2022.02.14.480397Cold Spring Harbor Laboratory Press2022-02-14
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Synergistic effect of mutations in the Parkinson's disease-linked proteins synaptojanin 1 and auxilin
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https://biorxiv.org/cgi/content/short/2022.02.28.482419v1?rss=1"
Ng, X. Y.Wu, Y.Lin, Y.Yaqoob, S. M.Greene, L. E.De Camilli, P.Cao, M.2022-03-02doi:10.1101/2022.02.28.482419Cold Spring Harbor Laboratory Press2022-03-02
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Structural basis for Parkinson's Disease-linked LRRK2's binding to microtubules
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https://biorxiv.org/cgi/content/short/2022.01.21.477284v1?rss=1"
Snead, D. M.Matyszewski, M.Dickey, A. M.Lin, Y. X.Leschziner, A. E.Reck-Peterson, S. L.2022-01-22doi:10.1101/2022.01.21.477284Cold Spring Harbor Laboratory Press2022-01-22
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Impact of 98 LRRK2 variants linked to Parkinson's Disease on kinase activity and microtubule binding
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https://biorxiv.org/cgi/content/short/2022.04.01.486724v1?rss=1"
Kalogeropulou, A. F.Purlyte, E.Tonelli, F.Lange, S. M.Wightman, M.Prescott, A. R.Padmanabhan, S.Sammler, E.Alessi, D. R.2022-04-01doi:10.1101/2022.04.01.486724Cold Spring Harbor Laboratory Press2022-04-01
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Structural and biochemical insights into lipid transport by VPS13 proteins.
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https://biorxiv.org/cgi/content/short/2022.03.11.484024v1?rss=1"
Adlakha, J.Hong, Z.Li, P.Reinisch, k. M.2022-03-12doi:10.1101/2022.03.11.484024Cold Spring Harbor Laboratory Press2022-03-12
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ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2
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https://biorxiv.org/cgi/content/short/2022.03.28.486050v1?rss=1"
Gustavsson, E. K.Zhang, D.Reynolds, R. H.Garcia-Ruiz, S.Ryten, M.2022-03-29doi:10.1101/2022.03.28.486050Cold Spring Harbor Laboratory Press2022-03-29
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Highly efficient generation of isogenic pluripotent stem cell models using prime editing
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https://biorxiv.org/cgi/content/short/2022.02.15.480601v1?rss=1"
Li, H.Busquets, O.Verma, Y.Syed, K. M.Kutnowski, N.Pangilinan, G. R.Gilbert, L.Bateup, H.Rio, D. C.Hockemeyer, D.Soldner, F.2022-02-15doi:10.1101/2022.02.15.480601Cold Spring Harbor Laboratory Press2022-02-15
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Multiscale model of primary motor cortex circuits reproduces in vivo cell type-specific dynamics associated with behavior
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https://biorxiv.org/cgi/content/short/2022.02.03.479040v1?rss=1"
Dura-Bernal, S.Neymotin, S. A.Suter, B. A.Dacre, J.Schiemann, J.Duguid, I.Shepherd, G. M. G.Lytton, W. W.2022-02-06doi:10.1101/2022.02.03.479040Cold Spring Harbor Laboratory Press2022-02-06
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Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE
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https://biorxiv.org/cgi/content/short/2022.02.03.479029v1?rss=1"
Borges, F. d. S.Moreira, J. V. S.Takarabe, L. M.Lytton, W. W.Dura-Bernal, S.2022-02-06doi:10.1101/2022.02.03.479029Cold Spring Harbor Laboratory Press2022-02-06
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Unaltered T cell responses to common antigens in individuals with Parkinson's disease
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https://biorxiv.org/cgi/content/short/2022.04.05.487195v1?rss=1"
Williams, G. P.Muskat, K.Frazier, A.Xu, Y.Mateus, J.Grifoni, A.Antunes, R. d. S.Weiskopf, D.Amara, A. W.Standaert, D. G.Goldman, J. G.Litvan, I.Alcalay, R. N.Sulzer, D.Arlehamn, C. S. L.Sette, A.2022-04-08doi:10.1101/2022.04.05.487195Cold Spring Harbor Laboratory Press2022-04-08
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A Feed-forward Pathway Drives LRRK2 kinaseMembrane Recruitment and Apparent Activation
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https://biorxiv.org/cgi/content/short/2022.04.25.489459v1?rss=1"
Vides, E. G.Adhikari, A.Lis, P.Purlyte, E.Shumate, J. L.Lasso, E. S.Dhekne, H. S.Alessi, D. R.Pfeffer, S. R.2022-04-25doi:10.1101/2022.04.25.489459Cold Spring Harbor Laboratory Press2022-04-25
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Structural basis of human LRRK2 membrane recruitment and activation
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https://biorxiv.org/cgi/content/short/2022.04.26.489605v1?rss=1"
Zhu, H.Tonelli, F.Alessi, D. R.Sun, J.2022-04-26doi:10.1101/2022.04.26.489605Cold Spring Harbor Laboratory Press2022-04-26
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Therapeutic Deep Brain Stimulation Disrupts Subthalamic Nucleus Activity Dynamics in Parkinsonian Mice
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https://biorxiv.org/cgi/content/short/2021.11.12.468404v1?rss=1"
Schor, J. S.Gonzalez Montalvo, I.Spratt, P. W. E.Brakaj, R. J.Stansil, J. A.Bender, K. J.Nelson, A. B.2021-11-13doi:10.1101/2021.11.12.468404Cold Spring Harbor Laboratory Press2021-11-13
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In situ structural analysis reveals membrane shape transitions during autophagosome formation
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https://biorxiv.org/cgi/content/short/2022.05.02.490291v1?rss=1"
Bieber, A.Capitanio, C.Erdmann, P. S.Fiedler, F.Beck, F.Lee, C.-W.Li, D.Hummer, G.Schulman, B.Baumeister, W.Wilfling, F.2022-05-02doi:10.1101/2022.05.02.490291Cold Spring Harbor Laboratory Press2022-05-02
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Early Endosome Capture Proteomics and its Application to Amyloid Precursor Protein Intramembrane Processing by β and γ-Secretases
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https://biorxiv.org/cgi/content/short/2022.03.31.486371v1?rss=1"
Park, H.Yu, Q.Hundley, F. V.Overmyer, K.Serrano, L.Paulo, J. A.Paoli, J. C.Swarup, S.Coon, J.Gygi, S.Harper, W.2022-03-31doi:10.1101/2022.03.31.486371Cold Spring Harbor Laboratory Press2022-03-31
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Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy
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https://biorxiv.org/cgi/content/short/2022.05.02.490309v1?rss=1"
Parmasad, J.-L. A.Ricke, K. M.Stykel, M. G.Buchner-Duby, B.Lian, E.Nguyen, B.Lengacher, N. A.Geertsma, H. M.Bruce, A.Callaghan, S. M.Joselin, A.Tomlinson, J. J.Schlossmacher, M. G.Stanford, W. L.Brundin, P.Ryan, S. D.Rousseaux, M. W. C.2022-05-02doi:10.1101/2022.05.02.490309Cold Spring Harbor Laboratory Press2022-05-02
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Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery
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https://biorxiv.org/cgi/content/short/2022.05.03.490522v1?rss=1"
Jensen, L. E.Rao, S.Schuschnig, M.Cada, A. K.Martens, S.Hummer, G.Hurley, J. H.2022-05-04doi:10.1101/2022.05.03.490522Cold Spring Harbor Laboratory Press2022-05-04
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Dopamine transporter and synaptic vesicle sorting defects initiate auxilin-linked Parkinson's disease
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https://biorxiv.org/cgi/content/short/2022.02.04.479203v1?rss=1"
Vidyadhara, D. J.Somayaji, M.Wade, N.Yücel, B.Zhao, H.Shashaank, N.Ribaudo, J.Gupta, J.Lam, T. T.Sames, D.Greene, L. E.Sulzer, D. L.Chandra, S. S.2022-02-06doi:10.1101/2022.02.04.479203Cold Spring Harbor Laboratory Press2022-02-06
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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds
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https://biorxiv.org/cgi/content/short/2022.02.18.481043v1?rss=1"
Saha, I.Yuste-Checa, P.da Silva Padilha, M.Guo, Q.Körner, R.Holthusen, H.Trinkaus, V. A.Dudanova, I.Fernandez-Busnadiego, R.Baumeister, W.Sanders, D. W.Gautam, S.Diamond, M. I.Hartl, F.-U.Hipp, M. S.2022-02-19doi:10.1101/2022.02.18.481043Cold Spring Harbor Laboratory Press2022-02-19
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The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson's disease data
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https://biorxiv.org/cgi/content/short/2022.05.04.490670v1?rss=1"
Leonard, H. L.Murtadha, R.Martinez-Carrasco, A.Muller-Nedebock, A.Gil-Martinez, A.-L.Illarionova, A.Moore, A.Bustos, B. I.Jadhav, B.Huxford, B.Storm, C.Towns, C.Vitale, D.Chetty, D.Yu, E.Jama, F.Grenn, F. P.Salazar, G.Rateau, G.Iwaki, H.Elsayed, I.Foote, I.van Rensburg, Z. J.Kim, J. J.Yuan, J.Lake, J.Brolin, K.Senkevich, K.Wu, L.Tan, M. M. X.Perinan, M. T.Makarious, M. B.Ta, M.Pillay, N. S.Betancor, O. L.Reyes-Perez, P. R.Jerez, P. A.Saini, P.al-Ouran, R.Sivakumar, R.Real, R.Reynolds, R. H.Hu, R.Abrahams, S.2022-05-10doi:10.1101/2022.05.04.490670Cold Spring Harbor Laboratory Press2022-05-10
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Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at Chr16q11.2 and on the MAPT H1 allele.
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https://biorxiv.org/cgi/content/short/2020.01.06.896241v1?rss=1"
Soutar, M.Melandri, D.Annuario, E.Monaghan, A.Welsh, N.D'Sa, K.Guelfi, S.Zhang, D.Pittman, A.Trabzuni, D.Pan, K.Kia, D. A.Bictash, M.Gandhi, S.Houlden, H.Cookson, M. R.Wood, N.Singleton, A.Hardy, J.Whiting, P.Blauwendraat, C.Whitworth, A.Manzoni, C.Ryten, M.Lewis, P.Plun-Favreau, H.2020-01-07doi:10.1101/2020.01.06.896241Cold Spring Harbor Laboratory Press2020-01-07
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PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
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https://biorxiv.org/cgi/content/short/2022.06.09.495448v1?rss=1"
Malik, A. U.Karapetsas, A.Nirujogi, R. S.Chatterjee, D.Phung, T. K.Wightman, M.Gourlay, R.Morrice, N.Mathea, S.Knapp, S.Alessi, D. R.2022-06-09doi:10.1101/2022.06.09.495448Cold Spring Harbor Laboratory Press2022-06-09
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Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
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https://biorxiv.org/cgi/content/short/2022.06.07.494932v1?rss=1"
Choi, M. L.Chappard, A.Singh, B. P.Maclachlan, C.Rodrigues, M.Fedotova, E.Berezhnov, A.De, S.Peddie, C.Athauda, D.Virdi, G. S.Zhang, W.Evans, J. R.Wernick, A.Zanjani, Z.Angelova, P. R.Esteras, N.Andrey, A.Morris, K.Jeacock, K.Tosatto, L.Little, D.Gissen, P.Collinson, L.Clarke, D. J.Kunath, T.Klenerman, D.Abramov, A. Y.Horrocks, M. H.Gandhi, S.2022-06-09doi:10.1101/2022.06.07.494932Cold Spring Harbor Laboratory Press2022-06-09
<![CDATA[
Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms
]]>
https://biorxiv.org/cgi/content/short/2022.06.08.495316v1?rss=1"
Wallen, Z. D.Demirkan, A.Twa, G.Cohen, G.Dean, M. N.Standaert, D. G.Sampson, T.Payami, H.2022-06-12doi:10.1101/2022.06.08.495316Cold Spring Harbor Laboratory Press2022-06-12
<![CDATA[
Basal Ganglia Neurons in Healthy and Parkinsonian Primates Generate Recurring Sequences of Spikes
]]>
https://biorxiv.org/cgi/content/short/2022.05.25.493476v1?rss=1"
Galvan, A.Wichmann, T.2022-05-26doi:10.1101/2022.05.25.493476Cold Spring Harbor Laboratory Press2022-05-26
<![CDATA[
Synaptic Location Is a Determinant of the Detrimental Effects of α-Synuclein Pathology to Glutamatergic Transmission in the Basolateral Amygdala
]]>
https://biorxiv.org/cgi/content/short/2022.02.20.481207v1?rss=1"
Nagaraja, C.Chen, L.Daniels, S.Meyerdirk, L.Steiner, J. A.Galvis, M. L. E.Henderson, M.Brundin, P.Chu, H.-y.2022-02-20doi:10.1101/2022.02.20.481207Cold Spring Harbor Laboratory Press2022-02-20
<![CDATA[
Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling
]]>
https://biorxiv.org/cgi/content/short/2022.06.21.496850v1?rss=1"
Harding, O.Holzbaur, E. L. F.2022-06-22doi:10.1101/2022.06.21.496850Cold Spring Harbor Laboratory Press2022-06-22
<![CDATA[
Dopaminergic axons track somatic signaling in behaving mice
]]>
https://biorxiv.org/cgi/content/short/2022.06.20.496872v1?rss=1"
Azcorra, M.Gaertner, Z.Davidson, C.Ramakrishnan, C.Fenno, L.Kim, Y. S.Deisseroth, K.Awatramani, R.Dombeck, D. A.2022-06-22doi:10.1101/2022.06.20.496872Cold Spring Harbor Laboratory Press2022-06-22
<![CDATA[
Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility.
]]>
https://biorxiv.org/cgi/content/short/2022.03.16.484460v1?rss=1"
Weglage, M.Aehrlund Richter, S.Skara, V.Lazaridis, I.Meletis, K.2022-03-18doi:10.1101/2022.03.16.484460Cold Spring Harbor Laboratory Press2022-03-18
<![CDATA[
Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation
]]>
https://biorxiv.org/cgi/content/short/2022.07.12.499634v1?rss=1"
Ren, X.Nguyen, T. N.Lam, W. K.Buffalo, C. Z.Lazarou, M.Yokom, A. L.Hurley, J. H.2022-07-13doi:10.1101/2022.07.12.499634Cold Spring Harbor Laboratory Press2022-07-13
<![CDATA[
Integrated multi-cohort analysis of the Parkinson's disease gut metagenome
]]>
https://biorxiv.org/cgi/content/short/2022.07.20.500694v1?rss=1"
Boktor, J. C.Sharon, G.Verhagen Metman, L. A.Hall, D. A.Engen, P. A.Zreloff, Z.Hakim, D. J.Bostick, J. W.Ousey, J.Lange, D.Humphrey, G.Ackermann, G.Carlin, M.Knight, R.Keshavarzian, A.Mazmanian, S. K.2022-07-21doi:10.1101/2022.07.20.500694Cold Spring Harbor Laboratory Press2022-07-21
<![CDATA[
A prebiotic diet modulates microglial states and motor deficits in α-synuclein overexpressing mice
]]>
https://biorxiv.org/cgi/content/short/2022.06.27.497828v1?rss=1"
Abdel-Haq, R.Schlachetzki, J. C. M.Boktor, J. C.Cantu-Jungles, T. M.Thron, T.Zhang, M.Bostick, J. W.Khazaei, T.Chilakala, S.Morais, L. H.Humphrey, G.Keshavarzian, A.Katz, J. E.Thomson, M.Knight, R.Gradinaru, V.Hamaker, B. R.Glass, C. K.Mazmanian, S. K.2022-06-30doi:10.1101/2022.06.27.497828Cold Spring Harbor Laboratory Press2022-06-30
<![CDATA[
Structural and functional landscape of α-synuclein fibril conformations amplified from cerebrospinal fluid
]]>
https://biorxiv.org/cgi/content/short/2022.07.13.499896v1?rss=1"
Sokratian, A.Zhou, Y.Xu, E.Viverette, E.Dillard, L.Yuan, Y.Li, J.Matarangas, A.Bouvette, J.Borgnia, M. J.Bartesaghi, A.West, A.2022-07-13doi:10.1101/2022.07.13.499896Cold Spring Harbor Laboratory Press2022-07-13
<![CDATA[
Nicotine-mediated rescue of α-synuclein toxicity requires synaptic vesicle glycoprotein 2
]]>
https://biorxiv.org/cgi/content/short/2022.07.26.501592v1?rss=1"
Olsen, A. L.Clemens, S. G.Feany, M. B.2022-07-28doi:10.1101/2022.07.26.501592Cold Spring Harbor Laboratory Press2022-07-28
<![CDATA[
In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2022.08.08.503142v1?rss=1"
Gonzalez-Sepulveda, M.Compte, J.Cuadros, T.Nicolau, A.Guillard-Sirieix, C.Penuelas, N.Lorente-Picon, M.Parent, A.Romero-Gimenez, J.Cladera-Sastre, J. M.Laguna, A.Vila, M.2022-08-11doi:10.1101/2022.08.08.503142Cold Spring Harbor Laboratory Press2022-08-11
<![CDATA[
Unconventional Initiation of PINK1/Parkin Mitophagy by Optineurin
]]>
https://biorxiv.org/cgi/content/short/2022.08.14.503930v1?rss=1"
Nguyen, T. N.Sawa-makarska, J.Khuu, G.Lam, W. K.Adriaenssens, E.Fracchiolla, D.Shoebridge, S.Padman, B. S.Skulsuppaisarn, M.Lindblom, R. S. J.Martens, S.Lazarou, M.2022-08-15doi:10.1101/2022.08.14.503930Cold Spring Harbor Laboratory Press2022-08-15
<![CDATA[
Is Tau the Initial Pathology in Dopaminergic Nigrostriatal Degeneration? Studies in Parkinsonism and Parkinson ' Disease
]]>
https://biorxiv.org/cgi/content/short/2022.08.04.502831v1?rss=1"
Chu, Y.Hirst, W. D.Federoff, H. J.Harms, A. S.Stoessl, A. J.Kordower, J. H.2022-08-06doi:10.1101/2022.08.04.502831Cold Spring Harbor Laboratory Press2022-08-06
<![CDATA[
Membrane remodeling properties of the Parkinson's disease protein LRRK2
]]>
https://biorxiv.org/cgi/content/short/2022.08.10.503505v1?rss=1"
Wang, X.Wu, Y.Cai, S.Ge, J.Shao, L.De Camilli, P.2022-08-10doi:10.1101/2022.08.10.503505Cold Spring Harbor Laboratory Press2022-08-10
<![CDATA[
Comprehensive Structural Variant Detection: From Mosaic to Population-Level
]]>
https://biorxiv.org/cgi/content/short/2022.04.04.487055v1?rss=1"
Smolka, M.Paulin, L. F.Grochowski, C. M.Mahmoud, M.Behera, S.Gandhi, M.Hong, K.Pehlivan, D.Scholz, S. W.Carvalho, C. M.Proukakis, C.Sedlazeck, F. J.2022-04-05doi:10.1101/2022.04.04.487055Cold Spring Harbor Laboratory Press2022-04-05
<![CDATA[
Pseudogenes limit the identification of novel common transcripts generated by their parent genes
]]>
https://biorxiv.org/cgi/content/short/2022.10.21.513169v1?rss=1"
Gustavsson, E. K.Sethi, S.Gao, Y.Brenton, J.Garcia Ruiz, S.Zhang, D.Garza, R.Reynolds, R. H.Evans, J. R.Chen, Z.Grant-Peters, M.MacPherson, H.Montgomery, K.Dore, R.Wernick, A. I.Arber, C.Wray, S.Gandhi, S.Esselborn, J.Blauwendraat, C.Douse, C. H.Adami, A.Atacho, D. A. M.Kouli, A.Quaegebeur, A.Barker, R. A.Englund, E.Platt, F. M.Jakobsson, J.Wood, N. W.Houlden, H.Saini, H.Bento, C. F.Hardy, J.Ryten, M.2022-10-21doi:10.1101/2022.10.21.513169Cold Spring Harbor Laboratory Press2022-10-21
<![CDATA[
Distinct adaptations revealed by unbiased proteomic analysis of autophagy cargos in the brain in PINK1 and LRRK2 models of Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2022.10.03.510717v1?rss=1"
Goldsmith, J.Ordureau, A.Stavoe, A. K.Boecker, C. A.Arany, M.Harper, J. W.Holzbaur, E. L.2022-10-04doi:10.1101/2022.10.03.510717Cold Spring Harbor Laboratory Press2022-10-04
<![CDATA[
PARK15/FBXO7 is dispensable for PINK1/Parkin-dependent mitophagy in iNeuron and HeLa cell systems
]]>
https://biorxiv.org/cgi/content/short/2022.11.02.514817v1?rss=1"
Kraus, F.Goodall, E. A.Smith, I. R.Jiang, Y.Paoli, J. C.Zhang, J.Paulo, J. A.Harper, J. W.2022-11-02doi:10.1101/2022.11.02.514817Cold Spring Harbor Laboratory Press2022-11-02
<![CDATA[
Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons
]]>
https://biorxiv.org/cgi/content/short/2022.10.28.514238v1?rss=1"
80%). We characterised their molecular identity using single-cell RNA sequencing and their functional identity through the synthesis and secretion of dopamine, the ability to generate action potentials, and form functional synapses and networks. RNA velocity analyses confirmed the developmental transcriptomic trajectory of midbrain neural precursors into mDA neurons using our approach, and identified key driver genes in mDA neuronal development. To characterise the synucleinopathy, we adopted super-resolution methods to determine the number, size and structure of aggregates in SNCA-mutant mDA neurons. At one week of differentiation, prior to maturation to mDA neurons of molecular and functional identity, we demonstrate the formation of small aggregates; specifically, {beta}-sheet rich oligomeric aggregates, in SNCA-mutant midbrain immature neurons. The aggregation progresses over time to accumulate phosphorylated aggregates, and later fibrillar aggregates. When the midbrain neurons were functional, we observed evidence of impaired physiological calcium signalling, with raised basal calcium, and impairments in cytosolic and mitochondrial calcium efflux. Once midbrain identity fully developed, SNCA-mutant neurons exhibited bioenergetic impairments, mitochondrial dysfunction and oxidative stress. During the maturation of mDA neurons, upregulation of mitophagy and autophagy occured, and ultimately these multiple cellular stresses lead to an increase in cell death by six weeks post-differentiation. Our differentiation paradigm generates an efficient model for studying disease mechanisms in PD, and highlights that protein misfolding to generate intraneuronal oligomers is one of the earliest critical events driving disease in human neurons, rather than a late-stage hallmark of the disease.
]]>Virdi, G. S.Choi, M. L.Evans, J. R.Yao, Z.Athauda, D.Strohbuecker, S.Wernick, A. I.Alrashidi, H.Melandri, D.Perez-lloret, J.Stroh, P. R.Sylantyev, S.Eaton, S.Heales, S.Kunath, T.Horrocks, M. H.Abramov, A. Y.Patani, R.Gandhi, S.2022-10-28doi:10.1101/2022.10.28.514238Cold Spring Harbor Laboratory Press2022-10-28
<![CDATA[
Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease
]]>
https://biorxiv.org/cgi/content/short/2022.10.12.511960v1?rss=1"
Schonhoff, A. M.Figge, D. A.Jurkuvenaite, A. J.Gallups, N. J.Childers, G. M.Webster, J. A.Standaert, D. G.Goldman, J. E.Harms, A. S.2022-10-16doi:10.1101/2022.10.12.511960Cold Spring Harbor Laboratory Press2022-10-16
<![CDATA[
Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
]]>
https://biorxiv.org/cgi/content/short/2022.11.14.516471v1?rss=1"
Dou, D.Smith, E. M.Evans, C. S.Boecker, C. A.Holzbaur, E. L. F.2022-11-14doi:10.1101/2022.11.14.516471Cold Spring Harbor Laboratory Press2022-11-14
<![CDATA[
Golgi-IP, a novel tool for multimodal analysis of Golgi molecular content
]]>
https://biorxiv.org/cgi/content/short/2022.11.22.517583v1?rss=1"
Fasimoye, R.Dong, W.Nirujogi, R. S.Rawat, E. S.Iguchi, M.Nyame, K.Phung, T. K.Bagnoli, E.Prescott, A. R.Alessi, D. R.Abu-remaileh, M.2022-11-23doi:10.1101/2022.11.22.517583Cold Spring Harbor Laboratory Press2022-11-23
<![CDATA[
Temporal landscape of mitochondrial proteostasis governed by the UPRmt
]]>
https://biorxiv.org/cgi/content/short/2022.11.30.518286v1?rss=1"
Uoselis, L.Lindblom, R.Skulsuppaisarn, M.Khuu, G.Nguyen, T. N.Rudler, D. L.Filipovska, A.Schittenhelm, R. B.Lazarou, M.2022-11-30doi:10.1101/2022.11.30.518286Cold Spring Harbor Laboratory Press2022-11-30
<![CDATA[
Sex-specific microglial responses to glucocerebrosidase inhibition: relevance to GBA1-linked Parkinson disease
]]>
https://biorxiv.org/cgi/content/short/2022.12.05.519143v1?rss=1"
Ciana, P.Brunialti, E.Villa, A.Toffoli, M.Lucas Del Pozo, S.Rizzi, N.Meda, C.Maggi, A. C.Schapira, A. H. V.2022-12-05doi:10.1101/2022.12.05.519143Cold Spring Harbor Laboratory Press2022-12-05
<![CDATA[
Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of alpha-synuclein inclusions
]]>
https://biorxiv.org/cgi/content/short/2022.11.08.515615v1?rss=1"
Lam, I.Ndayisaba, A.Lewis, A. J.Fu, Y.Sagredo, G. T.Zaccagnini, L.Sandoe, J.Sanz, R. L.Vahdatshoar, A.Martin, T. D.Morshed, N.Ichihashi, T.Tripathi, A.Ramalingam, N.Oettgen-Suazo, C.Bartels, T.Schabinger, M.Hallacli, E.Jiang, X.Verma, A.Tea, C.Wang, Z.Hakozaki, H.Yu, X.Hyles, K.Park, C.Theunissen, T. W.Wang, H.Jaenisch, R.Lindquist, S.Stevens, B.Stefanova, N.Wenning, G.Luk, K. C.Sanchez Pernaute, R.Gomez-Esteban, J. C.Felsky, D.Kiyota, Y.Sahni, N.Yi, S. S.Chung, C.-Y.Stahlberg, H.Ferrer, I.Schoneberg, J.Ell2022-11-09doi:10.1101/2022.11.08.515615Cold Spring Harbor Laboratory Press2022-11-09
<![CDATA[
Novel green fluorescent polyamines to analyze ATP13A2 and ATP13A3 activity in the mammalian polyamine transport system
]]>
https://biorxiv.org/cgi/content/short/2022.12.15.520427v1?rss=1"
Houdou, M. C.Jacobs, N.Coene, J.Azfar, M.Vanhoutte, R.Van den Haute, C.Eggermont, J.Daniels, V.Verhelst, S. H. L.Vangheluwe, P.2022-12-15doi:10.1101/2022.12.15.520427Cold Spring Harbor Laboratory Press2022-12-15
<![CDATA[
Quantitative mapping of autophagic cargo during nutrient stress reveals YIPF3-YIPF4 as membrane receptors for Golgiphagy
]]>
https://biorxiv.org/cgi/content/short/2022.12.06.519342v1?rss=1"
Hickey, K. L.Swarup, S.Smith, I. R.Paoli, J. C.Paulo, J. A.Harper, J. W.2022-12-07doi:10.1101/2022.12.06.519342Cold Spring Harbor Laboratory Press2022-12-07
<![CDATA[
Serine-129 phosphorylation of α-synuclein is a trigger for physiologic protein-protein interactions and synaptic function
]]>
https://biorxiv.org/cgi/content/short/2022.12.22.521485v1?rss=1"
Parra-Rivas, L. A.Madhivanan, K.Wang, L.Boyer, N. P.Prakashchand, D. D.Aulston, B. D.Pizzo, D. P.Branes-Guerrero, K.Tang, Y.Das, U.Scott, D. A.Rangamani, P.Roy, S.2022-12-23doi:10.1101/2022.12.22.521485Cold Spring Harbor Laboratory Press2022-12-23
<![CDATA[
From Policy to Practice: Tracking an Open Science Funding Initiative
]]>
https://biorxiv.org/cgi/content/short/2023.02.27.530238v1?rss=1"
Ratan, K.McIntosh, S.Shah, H. V.Lewis, M.Dumanis, S. B.Vines, T. H.Schekman, R.Riley, E. A. U.2023-02-28doi:10.1101/2023.02.27.530238Cold Spring Harbor Laboratory Press2023-02-28
<![CDATA[
Protein network analysis links the NSL complex to Parkinson's disease and mitochondrial biology
]]>
https://biorxiv.org/cgi/content/short/2023.01.27.524249v1?rss=1"
Kelly, K.Lewis, P.Plun-Favreau, H.Manzoni, C.2023-01-27doi:10.1101/2023.01.27.524249Cold Spring Harbor Laboratory Press2023-01-27
<![CDATA[
Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase
]]>
https://biorxiv.org/cgi/content/short/2023.02.17.529028v1?rss=1"
Dhekne, H. S.Tonelli, F.Yeshaw, W. M.Chiang, C. Y.Limouse, C.Jaimon, E.Purlyte, E.Alessi, D. R.Pfeffer, S. R.2023-02-18doi:10.1101/2023.02.17.529028Cold Spring Harbor Laboratory Press2023-02-18
<![CDATA[
L1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
]]>
https://biorxiv.org/cgi/content/short/2023.03.04.531072v1?rss=1"
Garza, R.Atacho, D.Adami, A.Gerdes, P.Vinod, M.Hsieh, P.Karlsson, O.Horvath, V.Johansson, P. A.Pandiloski, N.Matas, J.Quaegebeur, A.Kouli, A.Sharma, Y.Jonsson, M. E.Monni, E.Englund, E.Eichler, E. E.Gale Hammell, M.Barker, R. A.Kokaia, Z.Douse, C. H.Jakobsson, J.2023-03-06doi:10.1101/2023.03.04.531072Cold Spring Harbor Laboratory Press2023-03-06
<![CDATA[
Single cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, ageing and disease
]]>
https://biorxiv.org/cgi/content/short/2023.04.20.537553v1?rss=1"
Kilfeather, P.Khoo, J. H.Wagner, K.Liang, H.Caiazza, M.-C.An, Y.Zhang, X.Chen, X.Connor-Robson, N.Shang, Z.Wade-Martins, R.2023-04-20doi:10.1101/2023.04.20.537553Cold Spring Harbor Laboratory Press2023-04-20
<![CDATA[
Early striatal hyperexcitability in an in vitro human striatal microcircuit model carrying the Parkinson's GBA-N370S mutation
]]>
https://biorxiv.org/cgi/content/short/2023.03.01.530566v1?rss=1"
Do, Q. B.Ng, B.Marquez-Gomez, R.Beccano-Kelly, D.Ibarra-Aizpurua, N.Caiazza, M.-C.Lang, C.Baleriola, J.Bengoa-Vergniory, N.Wade-Martins, R.2023-03-02doi:10.1101/2023.03.01.530566Cold Spring Harbor Laboratory Press2023-03-02
<![CDATA[
Scalable, flexible carbon fiber electrode thread arrays for three-dimensional spatial profiling of neurochemical activity in deep brain structures of rodents
]]>
https://biorxiv.org/cgi/content/short/2023.04.15.537033v1?rss=1"
Xia, M.Agca, B. N.Yoshida, T.Choi, J.Amjad, U.Bose, K.Keren, N.Zukerman, S.Cima, M. J.Graybiel, A. M.Schwerdt, H. N.2023-04-17doi:10.1101/2023.04.15.537033Cold Spring Harbor Laboratory Press2023-04-17
<![CDATA[
Mitoguardin-2 is a lipid transporter and its lipid transfer ability is required for function
]]>
https://biorxiv.org/cgi/content/short/2022.07.08.499339v1?rss=1"
Hong, Z.Adlakha, J.Guinn, E.Giska, F.Gupta, K.Melia, T.Reinisch, K. M.2022-07-09doi:10.1101/2022.07.08.499339Cold Spring Harbor Laboratory Press2022-07-09
<![CDATA[
The chromatin modulating NSL complex regulates genes and pathways genetically linked to Parkinsons disease
]]>
https://biorxiv.org/cgi/content/short/2023.01.16.523926v1?rss=1"
Hicks, A. R.Reynolds, R. H.O'Callaghan, B.Garcia Ruiz, S.Gil Martinez, A. L.Botia, J. A.Plun-Favreau, H.Ryten, M.2023-01-18doi:10.1101/2023.01.16.523926Cold Spring Harbor Laboratory Press2023-01-18
<![CDATA[
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex
]]>
https://biorxiv.org/cgi/content/short/2023.06.01.543278v1?rss=1"
Chen, M. H.Ren, X.Cook, A. S. I.Hurley, J. H.2023-06-01doi:10.1101/2023.06.01.543278Cold Spring Harbor Laboratory Press2023-06-01
<![CDATA[
TNF-NFkB-p53 axis restricts in vivo survival of hPSC-derived dopamine neuron
]]>
https://biorxiv.org/cgi/content/short/2023.03.29.534819v1?rss=1"
Kim, T. W.Koo, S. Y.Riessland, M.Cho, H.Chaudhry, F.Kolisnyk, B.Russo, M. V.Saurat, N.Mehta, S.Garippa, R.Betel, D.Studer, L.2023-03-31doi:10.1101/2023.03.29.534819Cold Spring Harbor Laboratory Press2023-03-31
<![CDATA[
Reduced Thalamic Excitation to Motor Cortical Pyramidal Tract Neurons in a Mouse Model of Parkinsonism
]]>
https://biorxiv.org/cgi/content/short/2022.09.24.509340v1?rss=1"
Chen, L.Daniels, S.Dvorak, R.Chu, H.-y.2022-09-26doi:10.1101/2022.09.24.509340Cold Spring Harbor Laboratory Press2022-09-26
<![CDATA[
α-synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells
]]>
https://biorxiv.org/cgi/content/short/2023.04.02.535274v1?rss=1"
Hurley, M. J.Menozzi, E.Koletsi, S.Bates, R.Gegg, M. E.Chau, K.-Y.Blottiere, H. M.Macnaughtan, J.Schapira, A. H. V.2023-04-02doi:10.1101/2023.04.02.535274Cold Spring Harbor Laboratory Press2023-04-02
<![CDATA[
LRRK2-G2019S SYNERGIZES WITH AGEING AND LOW-GRADE INFLAMMATION TO PROMOTE GUT AND PERIPHERAL IMMUNE CELL ACTIVATION THAT PRECEDE NIGROSTRIATAL DEGENERATION
]]>
https://biorxiv.org/cgi/content/short/2022.09.01.505977v1?rss=1"
Giachino, C.Tirolo, C.Caniglia, S.Serapide, M. F.L'Episcopo, F.Bertoli, F.Giuliano, C.Mearelli, M.Jakobi, M.Schneiderhan-Marra, N.Deleidi, M.Marchetti, B.2022-09-03doi:10.1101/2022.09.01.505977Cold Spring Harbor Laboratory Press2022-09-03
<![CDATA[
Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo
]]>
https://biorxiv.org/cgi/content/short/2023.03.24.534149v1?rss=1"
Donzelli, S.OSullivan, S.Mahul-Mellier, A.-L.Ulusoy, A.Fusco, G.Kumar, S. T.Chiki, A.Burtscher, J.Boussouf, M. L. D.Rostami, I.De Simone, A. D. S.Di Monte, D. A.Lashuel, H. A.2023-03-25doi:10.1101/2023.03.24.534149Cold Spring Harbor Laboratory Press2023-03-25
<![CDATA[
Feed-forward metabotropic signaling by Cav1 Ca2+ channels supports pacemaking in pedunculopontine cholinergic neurons
]]>
https://biorxiv.org/cgi/content/short/2023.08.05.552108v1?rss=1"
Tubert, C.Zampese, E.Pancani, T.Tkatch, T.Surmeier, D. J.2023-08-07doi:10.1101/2023.08.05.552108Cold Spring Harbor Laboratory Press2023-08-07
<![CDATA[
Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates
]]>
https://biorxiv.org/cgi/content/short/2023.08.04.551615v1?rss=1"
Chocarro, J.Rico, A. J.Ariznabarreta, G.Roda, E.Honrubia, A.Collantes, M.Penuelas, I.Vazquez, A.Rodriguez-Perez, A. I.Labandeira-Garcia, J. L.Vila Bover, M.Lanciego, J. L.2023-08-06doi:10.1101/2023.08.04.551615Cold Spring Harbor Laboratory Press2023-08-06
<![CDATA[
Modelling human brain-wide pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits
]]>
https://biorxiv.org/cgi/content/short/2023.08.08.552400v1?rss=1"
Laguna, A.Penuelas, N.Gonzalez-Sepulveda, M.Nicolau, A.Arthaud, S.Guilliard.Sirieix, C.Lorente-Picon, M.Compte, J.Miquel-Rio, L.Xicoy, H.Liu, J.Parent, A.Cuadros, T.Romero-Gimenez, J.Pujol, G.Gimenez-Llort, L.Fort, P.Bortolozzi, A.Carballo-Carbajal, I.Vila, M.2023-08-08doi:10.1101/2023.08.08.552400Cold Spring Harbor Laboratory Press2023-08-08
<![CDATA[
The lipid flippase ATP10B enables cellular lipid uptake under stress conditions
]]>
https://biorxiv.org/cgi/content/short/2023.06.01.543059v1?rss=1"
Wouters, R.Beletchi, I.Van den Haute, C.Baekelandt, V.Martin, S.Eggermont, J.Vangheluwe, P.2023-06-01doi:10.1101/2023.06.01.543059Cold Spring Harbor Laboratory Press2023-06-01
<![CDATA[
Autophagy preferentially degrades non-fibrillar polyQ aggregates
]]>
https://biorxiv.org/cgi/content/short/2023.08.08.552291v1?rss=1"
Zhao, D. Y.Bauerlein, F. J.Saha, I.Hartl, F.-U.Baumeister, W.Wilfling, F.2023-08-09doi:10.1101/2023.08.08.552291Cold Spring Harbor Laboratory Press2023-08-09
<![CDATA[
Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells
]]>
https://biorxiv.org/cgi/content/short/2023.08.09.552634v1?rss=1"
Amos, C.Xu, P.De Camilli, P.2023-08-10doi:10.1101/2023.08.09.552634Cold Spring Harbor Laboratory Press2023-08-10
<![CDATA[
LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition
]]>
https://biorxiv.org/cgi/content/short/2022.12.17.520834v1?rss=1"
Yadavalli, N.Ferguson, S.2022-12-18doi:10.1101/2022.12.17.520834Cold Spring Harbor Laboratory Press2022-12-18
<![CDATA[
Non-ablative disease-modifying effects of magnetic resonance-guided focused ultrasound in neuromelanin-producing parkinsonian rodents
]]>
https://biorxiv.org/cgi/content/short/2023.08.08.552410v1?rss=1"
Compte, J.Tible, M.Cuadros, T.Romero-Jimenez, J.Laguna, A.Aubry, J.-F.Dumont, E.Constans, C.Tiennot, T.Santin, M. D.Lehericy, S.Vila, M.2023-08-11doi:10.1101/2023.08.08.552410Cold Spring Harbor Laboratory Press2023-08-11
<![CDATA[
Adaptor Protein-3 Produces Synaptic Vesicles that Release Phasic Dopamine
]]>
https://biorxiv.org/cgi/content/short/2023.08.07.552338v1?rss=1"
Jain, S.Yee, A. G.Maas, J.Gierok, S.Xu, H.Stansil, J.Eriksen, J.Nelson, A.Silm, K.Ford, C. P.Edwards, R. H.2023-08-08doi:10.1101/2023.08.07.552338Cold Spring Harbor Laboratory Press2023-08-08
<![CDATA[
L-type calcium channel contribution to striatal dopamine release is governed by calbindin-D28K, the dopamine transporter, D2-receptors, α2δ-subunits and sex differences
]]>
https://biorxiv.org/cgi/content/short/2020.07.03.186411v1?rss=1"
View larger version (21K):
org.highwire.dtl.DTLVardef@1ccc783org.highwire.dtl.DTLVardef@13e7296org.highwire.dtl.DTLVardef@d4e3d3org.highwire.dtl.DTLVardef@b9427b_HPS_FORMAT_FIGEXP M_FIG C_FIG
]]>Brimblecombe, K. R.Conor-Robson, N.Roberts, B. M.Gracie, C.te Water Naude, R.Karthik, G.Wade-Martins, R.Cragg, S. J.2020-07-04doi:10.1101/2020.07.03.186411Cold Spring Harbor Laboratory Press2020-07-04
<![CDATA[
M4-mediated cholinergic transmission is reduced in parkinsonian mice and its restoration alleviates motor deficits and levodopa-induced dyskinesia
]]>
https://biorxiv.org/cgi/content/short/2023.08.23.554510v1?rss=1"
Nielsen, B. E.Ford, C. P.2023-08-24doi:10.1101/2023.08.23.554510Cold Spring Harbor Laboratory Press2023-08-24
<![CDATA[
A RAB7A Phosphoswitch Coordinates Rubicon Homology Protein Regulation of PINK1/Parkin-Dependent Mitophagy
]]>
https://biorxiv.org/cgi/content/short/2023.08.28.555228v1?rss=1"
Tudorica, D. A.Basak, B. L. F.Cordova, A. P.Khuu, G.Rose, K.Lazarou, M.Holzbaur, E.Hurley, J. H.2023-08-29doi:10.1101/2023.08.28.555228Cold Spring Harbor Laboratory Press2023-08-29
<![CDATA[
State-dependent GABAergic regulation of striatal spiny projection neuron excitability
]]>
https://biorxiv.org/cgi/content/short/2023.03.14.532627v1?rss=1"
Day, M.Belal, M.Surmeier, C.Melendez-Zaidi, A.Tkatch, T.Clarke, V. R. J.Surmeier, D. J.2023-03-14doi:10.1101/2023.03.14.532627Cold Spring Harbor Laboratory Press2023-03-14
<![CDATA[
iATPSnFR2: a high dynamic range fluorescent sensor for monitoring intracellular ATP
]]>
https://biorxiv.org/cgi/content/short/2023.08.24.554624v1?rss=1"
Marvin, J. S.Kokotos, A. C.Kumar, M.Pulido, C.Tkachuk, A. N.Yao, J. S.Brown, T. A.Ryan, T. A.2023-08-24doi:10.1101/2023.08.24.554624Cold Spring Harbor Laboratory Press2023-08-24
<![CDATA[
Structural pathway for class III PI 3-kinase activation by the myristoylated GTP-binding pseudokinase VPS15
]]>
https://biorxiv.org/cgi/content/short/2023.09.28.559894v1?rss=1"
Cook, A. S. I.Chen, M. H.Ren, X.Rao, S.Garcia, S. N.Claveras Cabezudo, A.Iavarone, A. T.Hummer, G.Hurley, J. H.2023-09-28doi:10.1101/2023.09.28.559894Cold Spring Harbor Laboratory Press2023-09-28
<![CDATA[
Three-step docking by WIPI2, ATG16L1 and ATG3 delivers LC3 to the phagophore
]]>
https://biorxiv.org/cgi/content/short/2023.07.17.549391v1?rss=1"
Rao, S.Strong, L. M.Ren, X.Skulsuppaisarn, M.Lazarou, M.Hurley, J. H.Hummer, G.2023-07-17doi:10.1101/2023.07.17.549391Cold Spring Harbor Laboratory Press2023-07-17
<![CDATA[
Parkinson's genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes
]]>
https://biorxiv.org/cgi/content/short/2023.09.11.557213v1?rss=1"
Nguyen, M.Collier, J. J.Ignatenko, O.Morin, G.Huang, S.Desjardins, M.McBride, H. M.2023-09-12doi:10.1101/2023.09.11.557213Cold Spring Harbor Laboratory Press2023-09-12
<![CDATA[
LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology spread
]]>
https://biorxiv.org/cgi/content/short/2023.10.06.561190v1?rss=1"
Lubben, N.Brynildsen, J. K.Leyns, C. E. G.Webb, C. M.Li, H. L.Changolkar, L.Zhang, B.Meymand, E.O'Reilly, M.Madaj, Z.DeWeerd, D.Fell, M. J.Lee, V. M. Y.Bassett, D. S.Henderson, M. X.2023-10-06doi:10.1101/2023.10.06.561190Cold Spring Harbor Laboratory Press2023-10-06
<![CDATA[
A topographical atlas of alpha-Synuclein dosage and cell-type expression in the mouse brain and periphery
]]>
https://biorxiv.org/cgi/content/short/2023.10.05.559770v1?rss=1"
Geertsma, H. M.Fisk, Z. A.Sauline, L.Prigent, A.Kurgat, K.Callaghan, S. M.aSCENT PD Consortium,Henderson, M.Rousseaux, M. W. C.2023-10-07doi:10.1101/2023.10.05.559770Cold Spring Harbor Laboratory Press2023-10-07
<![CDATA[
Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging
]]>
https://biorxiv.org/cgi/content/short/2023.10.06.560646v1?rss=1"
Nithianandam, V.Bukhari, H.Leventhal, M. J.Battaglia, R. A.Dong, X.Fraenkel, E.Feany, M. B.2023-10-07doi:10.1101/2023.10.06.560646Cold Spring Harbor Laboratory Press2023-10-07
<![CDATA[
Localization of PPM1H phosphatase tunes Parkinsons disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis
]]>
https://biorxiv.org/cgi/content/short/2023.06.15.545139v1?rss=1"
Yeshaw, W. M.Adhikari, A.Chiang, C. Y.Dhekne, H. S.Wawro, P. S.Pfeffer, S. R.2023-06-15doi:10.1101/2023.06.15.545139Cold Spring Harbor Laboratory Press2023-06-15
<![CDATA[
CURTAIN - A Unique Web-based tool for exploration and sharing of MS-based proteomics data
]]>
https://biorxiv.org/cgi/content/short/2023.07.25.550405v1?rss=1"
Phung, T. K.Berndsen, K.Phan, T. L.Muqit, M. M.Alessi, D. R.Nirujogi, R. S.2023-07-25doi:10.1101/2023.07.25.550405Cold Spring Harbor Laboratory Press2023-07-25
<![CDATA[
Parkinson's VPS35 mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B
]]>
https://biorxiv.org/cgi/content/short/2023.06.07.544051v1?rss=1"
Pal, P.Taylor, M.Lam, P. Y.Tonelli, F.Hecht, C. A.Lis, P.Nirujogi, R. S.Phung, T. K.Dickie, E. A.Wightman, M.Macartney, T.Pfeffer, S. R.Alessi, D. R.2023-06-07doi:10.1101/2023.06.07.544051Cold Spring Harbor Laboratory Press2023-06-07
<![CDATA[
Unique functional responses differentially map onto genetic subtypes of dopamine neurons
]]>
https://biorxiv.org/cgi/content/short/2022.12.19.521076v1?rss=1"
Azcorra, M.Gaertner, Z.Davidson, C.Hayes, C. K.Ramakrishnan, C.Fenno, L.Kim, Y. S.Deisseroth, K.Longnecker, R.Awatramani, R.Dombeck, D. A.2022-12-19doi:10.1101/2022.12.19.521076Cold Spring Harbor Laboratory Press2022-12-19
<![CDATA[
Spatial transcriptomics reveals molecular dysfunction associated with Lewy pathology
]]>
https://biorxiv.org/cgi/content/short/2023.05.17.541144v1?rss=1"
Goralski, T.Meyerdirk, L.Breton, L.Brasseur, L.Kurgat, K.DeWeerd, D.Turner, L.Becker, K.Adams, M.Newhouse, D.Henderson, M. X.2023-05-17doi:10.1101/2023.05.17.541144Cold Spring Harbor Laboratory Press2023-05-17
<![CDATA[
Astrocytic LRRK2 Controls Synaptic Connectivity through ERM Phosphorylation
]]>
https://biorxiv.org/cgi/content/short/2023.04.09.536178v1?rss=1"
Wang, S.Sivadasan Bindu, D.Tan, C. X.Sakers, K.Takano, T.Rodriguez Salazar, M. P.Dimond, K.Soderling, S. H.La Spada, A. R.Eroglu, C.2023-04-10doi:10.1101/2023.04.09.536178Cold Spring Harbor Laboratory Press2023-04-10
<![CDATA[
Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers
]]>
https://biorxiv.org/cgi/content/short/2022.01.27.477991v1?rss=1"
Wu, S.Sirkis, D. W.Schekman, R.2022-01-27doi:10.1101/2022.01.27.477991Cold Spring Harbor Laboratory Press2022-01-27
<![CDATA[
A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy
]]>
https://biorxiv.org/cgi/content/short/2023.10.14.562004v1?rss=1"
Nebuloni, F.Do, Q.Cook, P. R.Walsh, E.Wade-Martins, R.2023-10-17doi:10.1101/2023.10.14.562004Cold Spring Harbor Laboratory Press2023-10-17
<![CDATA[
Phosphoglycerate kinase 1 is a central leverage point in Parkinson's disease driven neuronal metabolic deficits
]]>
https://biorxiv.org/cgi/content/short/2023.10.10.561760v1?rss=1"
Kokotos, A.Antoniazzi, A.Unda, S.Kokotos, M. S.Park, D.Eliezer, D.Kaplitt, M.De Camilli, P.Ryan, T.2023-10-10doi:10.1101/2023.10.10.561760Cold Spring Harbor Laboratory Press2023-10-10
<![CDATA[
The calcium sensor synaptotagmin-1 is critical for phasic axonal dopamine release in the striatum and mesencephalon, but is dispensable for basic motor behaviors in mice
]]>
https://biorxiv.org/cgi/content/short/2021.09.15.460511v1?rss=1"
Delignat-Lavaud, B.Kano, J.Ducrot, C.Masse, I.Mukherjee, S.Giguere, N.Moquin, L.Levesque, C.Nanni, S. B.Bourque, M.-J.Rosa-Neto, P.Levesque, D.De Beaumont, L.Trudeau, L.-E.2021-09-16doi:10.1101/2021.09.15.460511Cold Spring Harbor Laboratory Press2021-09-16
<![CDATA[
LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation
]]>
https://biorxiv.org/cgi/content/short/2023.06.14.545012v1?rss=1"
Fahmy, A. M.Cannon, T.Paredes, C. H.Ahmadi, A.Xu, Y. Z.Barette, B.Ibrahim, M.Lanoix, J.Arango-Duque, G.Schurr, E.Chevet, E.Thibault, P.Gruenheid, S.McBride, H.Desjardins, M.2023-06-15doi:10.1101/2023.06.14.545012Cold Spring Harbor Laboratory Press2023-06-15
<![CDATA[
Characterizing the diversity of enteric neurons using Dopamine Transporter (DAT)-Cre reporter mice
]]>
https://biorxiv.org/cgi/content/short/2023.06.16.545271v1?rss=1"
View larger version (24K):
org.highwire.dtl.DTLVardef@1e1830borg.highwire.dtl.DTLVardef@625579org.highwire.dtl.DTLVardef@1d9b59aorg.highwire.dtl.DTLVardef@219cab_HPS_FORMAT_FIGEXP M_FIG C_FIG Using a reporter mouse line, expressing a fluorescent protein under control of the dopamine transporter (DAT) promoter, discrete subtypes of dopaminergic neurons were unveiled across the ganglionated plexuses of the gut. A novel subpopulations of enteric DA neurons, expressing genes previously reported involved in dopamine signaling in the brain, exhibit a cholinergic phenotype.
]]>Recinto, S.Premachandran, S.Mukherjee, S.McDonald, A.Gruenheid, S.Trudeau, L. E.Stratton, J. A.2023-06-19doi:10.1101/2023.06.16.545271Cold Spring Harbor Laboratory Press2023-06-19
<![CDATA[
Comparative Analysis of Methods to Reduce Activation Signature Gene Expression in PBMCs
]]>
https://biorxiv.org/cgi/content/short/2023.07.31.549036v1?rss=1"
Andriamboavonjy, L.MacDonald, A.Hamilton, L. K.Labrecque, M.Boivin, M.-N.Karamchandani, J.Stratton, J. A.Tetreault, M.2023-08-02doi:10.1101/2023.07.31.549036Cold Spring Harbor Laboratory Press2023-08-02
<![CDATA[
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production
]]>
https://biorxiv.org/cgi/content/short/2023.10.14.562276v1?rss=1"
Bennett, N. K.Lee, M.Orr, A. L.Nakamura, K.2023-10-18doi:10.1101/2023.10.14.562276Cold Spring Harbor Laboratory Press2023-10-18
<![CDATA[
Synapsin E-domain is essential for α-synuclein function
]]>
https://biorxiv.org/cgi/content/short/2023.06.24.546170v1?rss=1"
Stavsky, A.Parra-Rivas, L. A.Tal, S.Madhivanan, K.Roy, S.Gitler, D.2023-06-26doi:10.1101/2023.06.24.546170Cold Spring Harbor Laboratory Press2023-06-26
<![CDATA[
A Markov Random Field Model for Network-based Differential Expression Analysis of Single-cell RNA-seq Data
]]>
https://biorxiv.org/cgi/content/short/2020.11.11.378976v1?rss=1"
Li, H.Xu, Z.Adams, T.Kaminski, N.Zhao, H.2020-11-12doi:10.1101/2020.11.11.378976Cold Spring Harbor Laboratory Press2020-11-12
<![CDATA[
Splicing accuracy varies across human introns, tissues and age
]]>
https://biorxiv.org/cgi/content/short/2023.03.29.534370v1?rss=1"
Garcia-Ruiz, S.Zhang, D.Gustavsson, E. K.Rocamora-Perez, G.Grant-Peters, M.Fairbrother-Browne, A.Reynolds, R. H.Brenton, J. W.Gil-Martinez, A. L.Chen, Z.Rio, D. C.Botia, J. A.Guelfi, S.Collado-Torres, L.Ryten, M.2023-03-30doi:10.1101/2023.03.29.534370Cold Spring Harbor Laboratory Press2023-03-30
<![CDATA[
KAT8 compound inhibition inhibits PINK1/Parkin-dependent mitophagy and initiates mitochondrial delivery to lysosomes
]]>
https://biorxiv.org/cgi/content/short/2023.08.03.551835v1?rss=1"
de Talhouet, C.O'Callaghan, B.Esteras Gallego, N.Plun-Favreau, H.2023-08-05doi:10.1101/2023.08.03.551835Cold Spring Harbor Laboratory Press2023-08-05
<![CDATA[
The Hsc70 Disaggregation Machinery RemovesMonomer Units Directly from α-Synuclein FibrilEnds
]]>
https://biorxiv.org/cgi/content/short/2020.11.02.365825v1?rss=1"
Schneider, M. M.Gautam, S.Herling, T. W.Andrzejwska, E.Krainer, G.Miller, A. M.Peter, Q. A. E.Ruggeri, F. S.Vendruscolo, M.Bracher, A.Dobson, C. M.Hartl, F.-U.Knowles, T.2020-11-03doi:10.1101/2020.11.02.365825Cold Spring Harbor Laboratory Press2020-11-03
<![CDATA[
Progranulin deficiency results in reduced bis(monoacylglycero)phosphate (BMP) levels and gangliosidosis
]]>
https://biorxiv.org/cgi/content/short/2021.09.30.461806v1?rss=1"
Boland, S.Swarup, S.Ambaw, Y. A.Richards, R. C.Fischer, A. W.Singh, S.Aggarwal, G.Spina, S.Nana, A. L.Grinberg, L. T.Seeley, W. W.Surma, M. A.Klose, C.Paulo, J. A.Nguyen, A. D.Harper, J. W.Walther, T. C.Farese, R. V.2021-09-30doi:10.1101/2021.09.30.461806Cold Spring Harbor Laboratory Press2021-09-30
<![CDATA[
Combinatorial selective ER-phagy remodels the ER during neurogenesis
]]>
https://biorxiv.org/cgi/content/short/2023.06.26.546565v1?rss=1"
Hoyer, M. J.Smith, I. R.Paoli, J. C.Jiang, Y.Paulo, J. A.Harper, W.2023-06-26doi:10.1101/2023.06.26.546565Cold Spring Harbor Laboratory Press2023-06-26
<![CDATA[
Proteostasis and lysosomal quality control deficits in Alzheimer's disease neurons
]]>
https://biorxiv.org/cgi/content/short/2023.03.27.534444v1?rss=1"
Chou, C.-C.Vest, R.Prado, M. A.Wilson-Grady, J.Paulo, J. A.Shibuya, Y.Moran-Losada, P.Lee, T.-T.Luo, J.Gygi, S. P.Kelly, J. W.Finley, D.Wernig, M.Wyss-Coray, T.Frydman, J.2023-03-27doi:10.1101/2023.03.27.534444Cold Spring Harbor Laboratory Press2023-03-27
<![CDATA[
RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors
]]>
https://biorxiv.org/cgi/content/short/2023.07.25.550521v1?rss=1"
Dou, D.Aiken, J.Holzbaur, E. L. F.2023-07-25doi:10.1101/2023.07.25.550521Cold Spring Harbor Laboratory Press2023-07-25
<![CDATA[
Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD
]]>
https://biorxiv.org/cgi/content/short/2023.09.25.559255v1?rss=1"
Adriaenssens, E.Nguyen, T. N.Sawa-Makarska, J.Khuu, G.Schuschnig, M.Shoebridge, S.Watts, E. M.Csalyi, K. D.Padman, B. S.Lazarou, M.Martens, S.2023-09-25doi:10.1101/2023.09.25.559255Cold Spring Harbor Laboratory Press2023-09-25
<![CDATA[
A leaky gut dysregulates gene networks in the brain associated with immune activation, oxidative stress, and myelination in a mouse model of colitis
]]>
https://biorxiv.org/cgi/content/short/2023.08.10.552488v1?rss=1"
Boles, J. S.Krueger, M.Jernigan, J.Cole, C.Neighbarger, N.Huarte, O. U.Tansey, M. G.2023-08-13doi:10.1101/2023.08.10.552488Cold Spring Harbor Laboratory Press2023-08-13
<![CDATA[
Gut mucosal cells transfer α-synuclein to the vagus nerve
]]>
https://biorxiv.org/cgi/content/short/2023.08.14.553305v1?rss=1"
Chandra, R.Sokratian, A.Chavez, K. R.King, S.Swain, S. M.Snyder, J. C.West, A. B.Liddle, R. A.2023-08-14doi:10.1101/2023.08.14.553305Cold Spring Harbor Laboratory Press2023-08-14
<![CDATA[
Structure of LRRK1 and mechanisms of autoinhibition and activation
]]>
https://biorxiv.org/cgi/content/short/2022.11.22.517582v1?rss=1"
Reimer, J. M.Dickey, A. M.Lin, Y. X.Abrisch, R. G.Mathea, S.Chatterjee, D.Fay, E. J.Daugherty, M. D.Reck-Peterson, S. L.Leschziner, A. E.2022-11-23doi:10.1101/2022.11.22.517582Cold Spring Harbor Laboratory Press2022-11-23
<![CDATA[
A mono- and intralink filter (mi-filter) to improve false-discovery rates in cross-linking mass spectrometry data
]]>
https://biorxiv.org/cgi/content/short/2022.02.03.478943v1?rss=1"
Chen, X.Sailer, C.Kammer, K.-M.Fuersch, J.Eisele, M. R.Sakata, E.Stengel, F.2022-02-03doi:10.1101/2022.02.03.478943Cold Spring Harbor Laboratory Press2022-02-03
<![CDATA[
Inhibition of Parkinsons Disease-related LRRK2 by type-I and type-II kinase inhibitors: activity and structures
]]>
https://biorxiv.org/cgi/content/short/2023.09.07.556689v1?rss=1"
Leschziner, A. E.Sanz Murillo, M.Suarez, A. V.Dederer, V.Chatterjee, D.Louro, J. A.Knapp, S.Mathea, S.2023-09-09doi:10.1101/2023.09.07.556689Cold Spring Harbor Laboratory Press2023-09-09
<![CDATA[
Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation
]]>
https://biorxiv.org/cgi/content/short/2020.11.09.375048v1?rss=1"
Galvagnion, C.Cerri, S.Schapira, A. H. V.Blandini, F.Di Monte, D. A.2020-11-09doi:10.1101/2020.11.09.375048Cold Spring Harbor Laboratory Press2020-11-09
<![CDATA[
The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines.
]]>
https://biorxiv.org/cgi/content/short/2022.06.01.494130v1?rss=1"
Smith, L. J.Bolsinger, M. M.Chau, K.-Y.Gegg, M. E.Schapira, A. H. V.2022-06-01doi:10.1101/2022.06.01.494130Cold Spring Harbor Laboratory Press2022-06-01
<![CDATA[
Reduction of a-synuclein aggregates by PIKfyve inhibition via TFEB-mediated lysosomal biogenesis in a Parkinson disease model
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https://biorxiv.org/cgi/content/short/2023.10.23.563557v1?rss=1"
Lucas-Del-Pozo, S.Uras, G.Fierli, F.Lentini, V.Koletsi, S.Chau, K.-Y.Hughes, D.Schapira, A. H.2023-10-24doi:10.1101/2023.10.23.563557Cold Spring Harbor Laboratory Press2023-10-24
<![CDATA[
Chemically Induced Senescence in Human Stem Cell-Derived Neurons Promotes Phenotypic Presentation of Neurodegeneration
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https://biorxiv.org/cgi/content/short/2021.07.11.451956v1?rss=1"
Fathi, A.Mathivanan, S.Kong, L.Petersen, A. J.Harder, C. R. K.Block, J.Miller, J. M.Bhattacharyya, A.Wang, D.Zhang, S.-C.2021-07-12doi:10.1101/2021.07.11.451956Cold Spring Harbor Laboratory Press2021-07-12
<![CDATA[
Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease
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https://biorxiv.org/cgi/content/short/2023.04.01.535194v1?rss=1"
Dong, X.Bai, Y.Liao, Z.Gritsch, D.Liu, X.Wang, T.Borges-Monroy, R.Ehrlich, A.Serano, G. E.Feany, M. B.Beach, T. G.Scherzer, C. R.2023-04-03doi:10.1101/2023.04.01.535194Cold Spring Harbor Laboratory Press2023-04-03
<![CDATA[
α-synuclein promotes neuronal dysfunction and death by disrupting the binding of ankyrin to β-spectrin
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https://biorxiv.org/cgi/content/short/2023.06.02.543481v1?rss=1"
Maor, G.Dubreuil, R. R.Feany, M. B.2023-06-05doi:10.1101/2023.06.02.543481Cold Spring Harbor Laboratory Press2023-06-05
<![CDATA[
Detecting Full-Length EccDNA with FLED and long-reads sequencing
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https://biorxiv.org/cgi/content/short/2023.06.21.545840v1?rss=1"
Li, F.Ming, W.Lu, W.Wang, Y.Li, X.Dong, X.Bai, Y.2023-06-24doi:10.1101/2023.06.21.545840Cold Spring Harbor Laboratory Press2023-06-24
<![CDATA[
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor dysfunction and cortical atrophy, independent of protein aggregation.
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https://biorxiv.org/cgi/content/short/2021.10.13.464123v1?rss=1"
Geertsma, H. M.Suk, T. R.Ricke, K. M.Horsthuis, K.Parmasad, J.-L. A.Fisk, Z.Callaghan, S. M.Rousseaux, M. W. C.2021-10-14doi:10.1101/2021.10.13.464123Cold Spring Harbor Laboratory Press2021-10-14
<![CDATA[
Detecting rhythmic spiking through the power spectra of point process model residuals
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https://biorxiv.org/cgi/content/short/2023.09.08.556120v1?rss=1"
Cox, K. M.Kase, D.Znati, T.Turner, R. S.2023-09-08doi:10.1101/2023.09.08.556120Cold Spring Harbor Laboratory Press2023-09-08
<![CDATA[
The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons
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https://biorxiv.org/cgi/content/short/2023.07.19.549710v1?rss=1"
Russo, T.Kolisnyk, B.BS, A.Kim, T. W.Martin, J.Plessis-Belair, J.Ni, J.Pearson, J. A.Park, E. J.Sher, R. B.Studer, L.Riessland, M.2023-07-21doi:10.1101/2023.07.19.549710Cold Spring Harbor Laboratory Press2023-07-21
<![CDATA[
Interaction of an α-synuclein epitope with HLA-DRB1*15:01 initiates early enteric features of Parkinson's disease in humanized mice
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https://biorxiv.org/cgi/content/short/2022.02.03.479014v1?rss=1"
Garretti, F.Monahan, C.Sloan, N.Shariar, S.Kim, S. W.Sette, A.Cutforth, T.Kanter, E.Sulzer, D.Agalliu, D.2022-02-05doi:10.1101/2022.02.03.479014Cold Spring Harbor Laboratory Press2022-02-05
<![CDATA[
Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain
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https://biorxiv.org/cgi/content/short/2022.12.14.520294v1?rss=1"
Sulzer, D.Hobson, B.Stanley, A.De Los Santos, M.Culbertson, B.Mosharov, E.Sims, P.2022-12-15doi:10.1101/2022.12.14.520294Cold Spring Harbor Laboratory Press2022-12-15
<![CDATA[
Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson's Disease
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https://biorxiv.org/cgi/content/short/2023.11.09.566376v1?rss=1"
Summa, K. C.Jiang, P.Gonzalez-Rodriguez, P.Huang, X.Lin, X.Vitaterna, M. H.Dan, Y.Surmeier, D. J.Turek, F. W.2023-11-13doi:10.1101/2023.11.09.566376Cold Spring Harbor Laboratory Press2023-11-13
<![CDATA[
Disruption of lysosomal proteolysis in astrocytes facilitates midbrain proteostasis failure in an early-onset PD model.
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https://biorxiv.org/cgi/content/short/2022.08.26.505472v1?rss=1"
Morrone Parfitt, G.Coccia, E.Goldman, C.Whitney, K.Reyes, R.Sarrafha, L.Nam, K. H.Jones, D.crary, J. F.Ordureau, A.Blanchard, J.Ahfeldt, T. D.2022-08-27doi:10.1101/2022.08.26.505472Cold Spring Harbor Laboratory Press2022-08-27
<![CDATA[
Functional characterization of ATP13A2 variants associated with distinct neurodegenerative disorders
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https://biorxiv.org/cgi/content/short/2023.08.21.552829v1?rss=1"
Vrijsen, S.El Asrar, R. A.Houdou, M. C.Van den Haute, C.Baekelandt, V.Lyons, J. A.Eggermont, J.Vangheluwe, P.2023-08-21doi:10.1101/2023.08.21.552829Cold Spring Harbor Laboratory Press2023-08-21
<![CDATA[
Adult-specific Reelin expression alters striatal neuronal organization. Implications for neuropsychiatric disorders.
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https://biorxiv.org/cgi/content/short/2023.01.21.525025v1?rss=1"
Pardo, M.Gregorio, S.Montalban, E.Pujadas, L.Elias-Tersa, A.Masachs, N.Vilchez-Acosta, A.Parent, A.Auladell, C.Girault, J. A.Vila, M.Nairn, A. C.Manso, Y.Soriano, E.2023-01-22doi:10.1101/2023.01.21.525025Cold Spring Harbor Laboratory Press2023-01-22
<![CDATA[
Single-cell somatic copy number variants in brain using different amplification methods and reference genomes
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https://biorxiv.org/cgi/content/short/2023.08.07.552289v1?rss=1"
Kalef-Ezra, E.Turan, Z. G.Perez-Rodriguez, D.Bomann, I.Behera, S.Morley, C.Scholz, S. W.Jaunmuktane, Z.Demeulemeester, J.Sedlazeck, F.Proukakis, C.2023-08-08doi:10.1101/2023.08.07.552289Cold Spring Harbor Laboratory Press2023-08-08
<![CDATA[
Neuronal phase shifts differ for excitation vs. inhibition: a computer modeling study
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https://biorxiv.org/cgi/content/short/2023.03.20.533519v1?rss=1"
Kelley, C.Antic, S. D.Carnevale, N. T.Kubie, J. L.Lytton, W.2023-03-21doi:10.1101/2023.03.20.533519Cold Spring Harbor Laboratory Press2023-03-21
<![CDATA[
Integrated single cell and unsupervised spatial transcriptomic analysis defines molecular anatomy of the human dorsolateral prefrontal cortex
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https://biorxiv.org/cgi/content/short/2023.02.15.528722v1?rss=1"
Huuki-Myers, L. A.Spangler, A.Eagles, N. J.Montgomery, K. D.Kwon, S. H.Guo, B.Grant-Peters, M.Divecha, H. R.Tippani, M.Sriworarat, C.Nguyen, A. B.Ravichandran, P.Tran, M. N.Seyedian, A.PsychENCODE Consortium,Hyde, T. M.Kleinman, J. E.Battle, A.Page, S. C.Ryten, M.Hicks, S. C.Martinowich, K.Collado-Torres, L.Maynard, K. R.2023-02-15doi:10.1101/2023.02.15.528722Cold Spring Harbor Laboratory Press2023-02-15
<![CDATA[
Alpha-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinsons disease
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https://biorxiv.org/cgi/content/short/2023.12.11.571045v1?rss=1"
Geibl, F. F.Henrich, M. T.Xie, Z.Zampese, E.Tkatch, T.Wokosin, D. L.Nasiri, E.Grotmann, C. A.Dawson, V. L.Dawson, T. M.Chandel, N. S.Oertel, W. H.Surmeier, D. J.2023-12-11doi:10.1101/2023.12.11.571045Cold Spring Harbor Laboratory Press2023-12-11
<![CDATA[
FASlpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus
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https://biorxiv.org/cgi/content/short/2023.11.01.563607v1?rss=1"
Bohat, R.Liang, X.Chen, Y.Xu, C.Zheng, N.Guerrero, A.Jaffery, R.Egan, N. A.Robles, A.Hicks, M. J.Du, Y.Chen, X.Mohan, C.Peng, W.2023-11-02doi:10.1101/2023.11.01.563607Cold Spring Harbor Laboratory Press2023-11-02
<![CDATA[
Development And Characterization Of A Non-Human Primate Model Of Disseminated Synucleinopathy
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https://biorxiv.org/cgi/content/short/2023.12.15.571818v1?rss=1"
Rico, A. J.Corcho, A.Chocarro, J.Ariznabarreta, G.Roda, E.Honrubia, A.Arnaiz Esteban, P.Lanciego, J. L.2023-12-15doi:10.1101/2023.12.15.571818Cold Spring Harbor Laboratory Press2023-12-15
<![CDATA[
Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19
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https://biorxiv.org/cgi/content/short/2023.12.18.572180v1?rss=1"
Lengacher, N. A.Tomlinson, J. J.Jochum, A.-K.Franz, J.Hasan Ali, O.Flatz, L.Jochum, W.Penninger, J.aSCENT-PD Investigators,Stadelmann-Nessler, C.Woulfe, J. M.Schlossmacher, M. G.2023-12-19doi:10.1101/2023.12.18.572180Cold Spring Harbor Laboratory Press2023-12-19
<![CDATA[
Synchronous Measurements of Extracellular Action Potentials and Neurochemical Activity with Carbon Fiber Electrodes in Nonhuman Primates
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https://biorxiv.org/cgi/content/short/2023.12.23.573130v1?rss=1"
Amjad, U.Choi, J.Gibson, D. J.Murray, R.Graybiel, A. M.Schwerdt, H. N.2023-12-24doi:10.1101/2023.12.23.573130Cold Spring Harbor Laboratory Press2023-12-24
<![CDATA[
Mutations in GPNMB associated with Amyloid cutis dyschromica alter intracellular trafficking and processing of GPNMB
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https://biorxiv.org/cgi/content/short/2023.12.19.572409v1?rss=1"
Bogacki, E. C.Lewis, P. A.Herbst, S.2023-12-20doi:10.1101/2023.12.19.572409Cold Spring Harbor Laboratory Press2023-12-20
<![CDATA[
Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition
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https://biorxiv.org/cgi/content/short/2023.12.16.571979v1?rss=1"
Talaia, G.Bentley-DeSousa, A.Ferguson, S.2023-12-17doi:10.1101/2023.12.16.571979Cold Spring Harbor Laboratory Press2023-12-17
<![CDATA[
VPS13B is localized at the cis-trans Golgi complex interface and is a functional partner of FAM177A1
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https://biorxiv.org/cgi/content/short/2023.12.18.572081v1?rss=1"
Ugur, B.Schueder, F.Shin, J.Hanna, M. G.Wu, Y.Leonzino, M.Su, M.McAdow, A. R.Wilson, C. A.Postlethwait, J.Solnica-Krezel, L.Bewersdorf, J.De Camilli, P.2023-12-18doi:10.1101/2023.12.18.572081Cold Spring Harbor Laboratory Press2023-12-18
<![CDATA[
RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds
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https://biorxiv.org/cgi/content/short/2023.12.18.572148v1?rss=1"
Fu, B.Brock, E. E.Breiter, J. C.Tian, R.Andrews, R.Toomey, C. E.Lachica, J.Lashley, T.Ryten, M.Wood, N. W.Vendruscolo, M.Gandhi, S.Weiss, L. E.Beckwith, J. S.Lee, S. F.2023-12-18doi:10.1101/2023.12.18.572148Cold Spring Harbor Laboratory Press2023-12-18
<![CDATA[
Pathogenic LRRK2 R1441C mutation is associated with striatal alterations
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https://biorxiv.org/cgi/content/short/2020.03.11.986455v1?rss=1"
Xenias, H.Chen, C.Kang, S.Shanmugasundaram, B.Cherian, S.Situ, X.Scesa, G.Chan, C. S.Parisiadou, L.2020-03-12doi:10.1101/2020.03.11.986455Cold Spring Harbor Laboratory Press2020-03-12
<![CDATA[
Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons
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https://biorxiv.org/cgi/content/short/2021.10.28.466357v1?rss=1"
Hwang, F.-J.Roth, R. H.Wu, Y.-W.Sun, Y.Liu, Y.Ding, J. B.2021-10-28doi:10.1101/2021.10.28.466357Cold Spring Harbor Laboratory Press2021-10-28
<![CDATA[
In situ architecture of the lipid transport protein VPS13C at ER-lysosomes membrane contacts
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https://biorxiv.org/cgi/content/short/2022.03.08.482579v1?rss=1"
Cai, S.Wu, Y.Guillen-Samander, A.Hancock-Cerutti, W. F.Liu, J.De Camilli, P.2022-03-08doi:10.1101/2022.03.08.482579Cold Spring Harbor Laboratory Press2022-03-08
<![CDATA[
Dynamic refinement of behavioral structure mediates dopamine-dependent credit assignment
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https://biorxiv.org/cgi/content/short/2022.09.22.507905v1?rss=1"
Tang, J. C. Y.Paixao, V.Carvalho, F.Silva, A.Klaus, A.Alves da Silva, J.Costa, R. M.2022-09-22doi:10.1101/2022.09.22.507905Cold Spring Harbor Laboratory Press2022-09-22
<![CDATA[
POLCAM: Instant molecular orientation microscopy for the life sciences
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https://biorxiv.org/cgi/content/short/2023.02.07.527479v1?rss=1"
Bruggeman, E.Zhang, O.Needham, L.-M.Koerbel, M.Daly, S.Cheetham, M.Peters, R.Wu, T.Klymchenko, A. S.Davis, S. J.Paluch, E. K.Klenerman, D.Lew, M. D.O'Holleran, K.Lee, S. F.2023-02-08doi:10.1101/2023.02.07.527479Cold Spring Harbor Laboratory Press2023-02-08
<![CDATA[
Into the deep: The subthalamic and para-subthalamic nuclei in behavioral avoidance
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https://biorxiv.org/cgi/content/short/2023.07.18.549513v1?rss=1"
Serra, G. P.Guillaumin, A.Vlcek, B.Delagado-Zabalza, L.Ricci, A.Rubino, E.Dumas, S.Baufreton, J. M.Georges, F.Wallen-Mackenzie, A.2023-07-19doi:10.1101/2023.07.18.549513Cold Spring Harbor Laboratory Press2023-07-19
<![CDATA[
The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner
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https://biorxiv.org/cgi/content/short/2023.10.12.562063v1?rss=1"
Wallings, R.McFarland, K.Staley, H.Neighbarger, N.Schaake, S.Brueggemann, N.Zittel, S.Usnich, T.Klein, C.Sammler, E.Tansey, M. G.2023-10-17doi:10.1101/2023.10.12.562063Cold Spring Harbor Laboratory Press2023-10-17
<![CDATA[
A STING-CASM-GABARAP Pathway Activates LRRK2 at Lysosomes
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https://biorxiv.org/cgi/content/short/2023.10.31.564602v1?rss=1"
Bentley-DeSousa, A.Ferguson, S.2023-11-01doi:10.1101/2023.10.31.564602Cold Spring Harbor Laboratory Press2023-11-01
<![CDATA[
Movement-related increases in subthalamic activity optimize locomotion
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https://biorxiv.org/cgi/content/short/2023.12.07.570617v1?rss=1"
Callahan, J. W.Morales, J. C.Atherton, J. F.Wang, D.Kostic, S.Bevan, M. D.2023-12-08doi:10.1101/2023.12.07.570617Cold Spring Harbor Laboratory Press2023-12-08
<![CDATA[
Mechanism of human PINK1 activation at the TOM complex in a reconstituted system
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https://biorxiv.org/cgi/content/short/2023.12.23.573181v1?rss=1"
Raimi, O.Ojha, H.Ehses, K.Dederer, V.Lange, S.Rivera, C. P.Deegan, T.Chen, Y.Wightman, M.Toth, R.Labib, K.Mathea, S.Ranson, N.Fernandez-Busnadiego, R. F.Muqit, M.2023-12-23doi:10.1101/2023.12.23.573181Cold Spring Harbor Laboratory Press2023-12-23
<![CDATA[
Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency
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https://biorxiv.org/cgi/content/short/2024.01.08.574634v1?rss=1"
Nithianadam, V.Sarkar, S.Feany, M. B.2024-01-08doi:10.1101/2024.01.08.574634Cold Spring Harbor Laboratory Press2024-01-08
<![CDATA[
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinsons disease
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https://biorxiv.org/cgi/content/short/2024.01.15.575737v1?rss=1"
Khan, S. S.Jaimon, E.Lin, Y.-E.Nikoloff, J.Tonelli, F.Alessi, D. R.Pfeffer, S. R.2024-01-16doi:10.1101/2024.01.15.575737Cold Spring Harbor Laboratory Press2024-01-16
<![CDATA[
3D Bioprinting of Human Neural Tissues with Functional Connectivity
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https://biorxiv.org/cgi/content/short/2024.01.18.576289v1?rss=1"
Yan, Y.Li, X.Gao, Y.Mathivanan, S.Kong, L.Tao, Y.Dong, Y.Li, X.Bhattacharyya, A.Zhao, X.Zhang, S.-C.2024-01-23doi:10.1101/2024.01.18.576289Cold Spring Harbor Laboratory Press2024-01-23
<![CDATA[
Biochemical fractionation of human α-Synuclein in a Drosophila model of synucleinopathies
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https://biorxiv.org/cgi/content/short/2024.02.05.579034v1?rss=1"
Imomnazarov, K.Lopez-Scarim, J.Bagheri, I.Joers, V.Tansey, M. G.Martin-Pena, A.2024-02-07doi:10.1101/2024.02.05.579034Cold Spring Harbor Laboratory Press2024-02-07
<![CDATA[
PINK1 is a target of T cell responses in Parkinson's disease
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https://biorxiv.org/cgi/content/short/2024.02.09.579465v1?rss=1"
Williams, G. P.Michaelis, T.Rodrigues Lima-Junior, J.Frazier, A.Tran, N. K.Phillips, E. J.Mallal, S. A.Litvan, I.Goldman, J. G.Alcalay, R. N.Sidney, J.Sulzer, D.Sette, A.Lindestam Arlehamn, C. S.2024-02-12doi:10.1101/2024.02.09.579465Cold Spring Harbor Laboratory Press2024-02-12
<![CDATA[
Alpha-synuclein overexpression can drive microbiome dysbiosis in mice
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https://biorxiv.org/cgi/content/short/2024.02.01.578464v1?rss=1"
Sampson, T. R.Wallen, Z. D.Won, W.-J.Standaert, D. G.Payami, H.Harms, A. S.2024-02-01doi:10.1101/2024.02.01.578464Cold Spring Harbor Laboratory Press2024-02-01
<![CDATA[
Transcriptional programs mediating neuronal toxicity and altered glial-neuronal signaling in a Drosophila knock-in tauopathy model
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https://biorxiv.org/cgi/content/short/2024.02.02.578624v1?rss=1"
Bukhari, H.Nithianandam, V.Battaglia, R.Cicalo, A.Sarkar, S.Comjean, A.Hu, Y.Leventhal, M.Dong, X.Feany, M.2024-02-04doi:10.1101/2024.02.02.578624Cold Spring Harbor Laboratory Press2024-02-04
<![CDATA[
Visualizing chaperone-mediated multistep assembly of the human 20S proteasome
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https://biorxiv.org/cgi/content/short/2024.01.27.577538v1?rss=1"
Adolf, F.Du, J.Goodall, E. A.Walsh, R. M.rawson, S.von Gronaua, S.Harper, J. W.Hanna, J.Schulman, B. A.2024-01-28doi:10.1101/2024.01.27.577538Cold Spring Harbor Laboratory Press2024-01-28
<![CDATA[
The landscape of glial pathology and T-call response in Parkinson's substantia nigra
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https://biorxiv.org/cgi/content/short/2024.01.08.574736v1?rss=1"
Jakubiak, K.Paryani, F.Kannan, A.Lee, J.Madden, N.Li, J.Chen, D.Mahajan, A.Xia, S.Flowers, X.Menon, V.Sulzer, D.Goldman, J. E.Sims, P. A.Al-Dalahmah, O.2024-01-09doi:10.1101/2024.01.08.574736Cold Spring Harbor Laboratory Press2024-01-09
<![CDATA[
Systemic inflammation triggers long-lasting neuroinflammation and accelerates neurodegeneration in a rat model of Parkinson's disease overexpressing human alpha-synuclein
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https://biorxiv.org/cgi/content/short/2024.01.30.577912v1?rss=1"
Massaro Cenere, M.Tiberi, M.Paldino, E.D'Addario, S. L.Federici, M.Giacomet, C.Cutuli, D.Matteocci, A.Cossa, F.Zarrilli, B.Ledonne, A.Petrosini, L.Berretta, N.Fusco, F. R.Chiurchiu, V.Mercuri, N. B.2024-01-30doi:10.1101/2024.01.30.577912Cold Spring Harbor Laboratory Press2024-01-30
<![CDATA[
Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitis
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https://biorxiv.org/cgi/content/short/2024.02.12.580010v1?rss=1"
Boles, J. S.Holt, J.Cole, C. L.Neighbarger, N. K.Urs, N. M.Uriarte Huarte, O.Tansey, M. G.2024-02-13doi:10.1101/2024.02.12.580010Cold Spring Harbor Laboratory Press2024-02-13
<![CDATA[
AlphaFold Prediction of Structural Ensembles of Disordered Proteins
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https://biorxiv.org/cgi/content/short/2023.01.19.524720v1?rss=1"
Brotzakis, Z. F.Zhang, S.Vendruscolo, M.2023-01-19doi:10.1101/2023.01.19.524720Cold Spring Harbor Laboratory Press2023-01-19
<![CDATA[
Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior
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https://biorxiv.org/cgi/content/short/2023.11.17.567425v1?rss=1"
Vu, M.-A. T.Brown, E. H.Wen, M. J.Noggle, C. A.Zhang, Z.Monk, K. J.Bouabid, S.Mroz, L.Graham, B. M.Zhuo, Y.Li, Y.Otchy, T. M.Tian, L.Davison, I. G.Boas, D. A.Howe, M. W.2023-11-17doi:10.1101/2023.11.17.567425Cold Spring Harbor Laboratory Press2023-11-17
<![CDATA[
Polyglucosan body density in the aged mouse hippocampus is controlled by a novel modifier locus on chromosome 1
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https://biorxiv.org/cgi/content/short/2023.11.22.567373v1?rss=1"
Gomez-Pascual, A.Glikman, D. M.Ng, H. X.Tomkins, J. E.Lu, L.Xu, Y.Ashbrook, D. G.Kaczorowski, C.Kempermann, G.Killmar, J.Mozhui, K.Aebersold, R.Williams, E. G.Williams, R. W.Overall, R. W.Jucker, M.de Bakker, D. E. M.2023-11-22doi:10.1101/2023.11.22.567373Cold Spring Harbor Laboratory Press2023-11-22
<![CDATA[
Open-Source Platform for Kinematic Analysis of Mouse Forelimb Movement
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https://biorxiv.org/cgi/content/short/2024.01.31.578239v1?rss=1"
Berezhnoi, D.Chehade, H. D.Chu, H.-y.2024-02-02doi:10.1101/2024.01.31.578239Cold Spring Harbor Laboratory Press2024-02-02
<![CDATA[
A proteome-wide quantitative guide for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs
]]>
https://biorxiv.org/cgi/content/short/2024.02.10.579775v1?rss=1"
Brown, C.Ghosh, S.McAllister, R.Kumar, M.Walker, G.Sun, E.Aman, T.Panda, A.Kumar, S.Li, W. V.Coleman, J.Liu, Y.Rothman, J. E.Bhattacharyya, M.Gupta, K.2024-02-12doi:10.1101/2024.02.10.579775Cold Spring Harbor Laboratory Press2024-02-12
<![CDATA[
iSCORE-PD: an isogenic stem cell collection to research Parkinson Disease
]]>
https://biorxiv.org/cgi/content/short/2024.02.12.579917v1?rss=1"
G/FS, SYNJ1 R258Q/FS, VPS13C A444P/FS, VPS13C W395C/FS, GBA1 IVS2+1/FS). All mutations were introduced into a fully characterized and sequenced female human embryonic stem cell (hESC) line (WIBR3; NIH approval number NIHhESC-10-0079) using different genome editing techniques. To ensure the genetic integrity of these cell lines, we implemented rigorous quality controls, including whole-genome sequencing of each line. Our analysis of the genetic variation in this cell line collection revealed that while genome editing, particularly using CRISPR/Cas9, can introduce rare off-target mutations, the predominant source of genetic variants arises from routine cell culture and are fixed in cell lines during clonal isolation. The observed genetic variation was minimal compared to that typically found in patient-derived iPSC experiments and predominantly affected non-coding regions of the genome. Importantly, our analysis outlines strategies for effectively managing genetic variation through stringent quality control measures and careful experimental design. This systematic approach ensures the high quality of our stem cell collection, highlights advantages of prime editing over conventional CRISPR/Cas9 methods and provides a roadmap for the generation of gene-edited hPSC collections at scale in an academic setting. Our iSCORE-PD collection represents an easily accessible and valuable platform to study PD, which can be used by investigators to understand the molecular pathophysiology of PD in a human cellular setting.
]]>Busquets, O.Li, H.Syed, K. M.Jerez, P. A.Dunnack, J.Bu, R. L.Verma, Y.Pangilinan, G. R.Martin, A.Straub, J.Du, Y.Simon, V. M.Poser, S.Bush, Z.Diaz, J.Sahagun, A.Gao, J.Hernandez, D.Levine, K. S.Booth, E. O.Bateup, H.Rio, D.Hockemeyer, D.Blauwendraat, C.Soldner, F.2024-02-13doi:10.1101/2024.02.12.579917Cold Spring Harbor Laboratory Press2024-02-13
<![CDATA[
Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue
]]>
https://biorxiv.org/cgi/content/short/2024.02.17.580698v1?rss=1"
Andrews, R.Fu, B.Toomey, C. E.Breiter, J. C.Lachica, J.Tian, R.Beckwith, J. S.Needham, L.-M.Chant, G. J.Loiseau, C.Deconfin, A.Baspin, K.Magill, P. J.Jaunmuktane, Z.Freeman, O. J.Taylor, B. J. M.Hardy, J.Lashley, T.Ryten, M.Vendruscolo, M.Wood, N. W.Weiss, L. E.Gandhi, S.Lee, S. F.2024-02-19doi:10.1101/2024.02.17.580698Cold Spring Harbor Laboratory Press2024-02-19
<![CDATA[
An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys
]]>
https://biorxiv.org/cgi/content/short/2024.02.17.580767v1?rss=1"
Liang, L.Zimmermann Rollin, I.Alikaya, A.Ho, J. C.Santini, T.Bostan, A. C.Schwerdt, H. N.Stauffer, W. R.Ibrahim, T. S.Pirondini, E.Schaeffer, D.2024-02-20doi:10.1101/2024.02.17.580767Cold Spring Harbor Laboratory Press2024-02-20
<![CDATA[
An axonal brake on striatal dopamine output by cholinergic interneurons
]]>
https://biorxiv.org/cgi/content/short/2024.02.17.580796v1?rss=1"
Zhang, Y.-F.Luan, P.Qiao, Q.He, Y.Zatka-Haas, P.Zhang, G.Lin, M.Lak, A.Jing, M.Mann, E. O.Cragg, S.2024-02-21doi:10.1101/2024.02.17.580796Cold Spring Harbor Laboratory Press2024-02-21
<![CDATA[
Nova-ST: Nano-Patterned Ultra-Dense platform for spatial transcriptomics
]]>
https://biorxiv.org/cgi/content/short/2024.02.22.581576v1?rss=1"
Poovathingal, S.Davie, K.Vandepoel, R.Poulvellarie, N.Verfaillie, A.Corthout, N.Aerts, S.2024-02-24doi:10.1101/2024.02.22.581576Cold Spring Harbor Laboratory Press2024-02-24
<![CDATA[
Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/- mice induces CD8 T cell-dependent motor and cognitive dysfunction.
]]>
https://biorxiv.org/cgi/content/short/2024.02.25.580545v1?rss=1"
Kazanova, A.Sung, J.Oliveira, N. L.Gavino, C.Bessaiah, H.Pei, J.Burns, L.Miller, W.Brouillard-Galipeau, M.Zhu, L.Guerra, L. M.Elemeery, M. N.Recinto, S. J.MacDonald, A.Lanoix, J.Thibault, P.McBride, H. M.Desjardins, M.Stratton, J. A.Labrecque, N.Gruenheid, S.2024-02-26doi:10.1101/2024.02.25.580545Cold Spring Harbor Laboratory Press2024-02-26
<![CDATA[
Comparative study of enriched dopaminergic neurons from siblings with Gaucher disease discordant for parkinsonism
]]>
https://biorxiv.org/cgi/content/short/2024.02.25.581985v1?rss=1"
Hertz, E.Perez, G.Hao, Y.Rytel, K.Ma, C.Kirby, M.Anderson, S.Wincovitch, S.Andersh, K.Ahfeldt, T.Blanchard, J.Qi, Y. A.Lopez, G.Tayebi, N.Sidransky, E.Chen, Y.2024-02-28doi:10.1101/2024.02.25.581985Cold Spring Harbor Laboratory Press2024-02-28
<![CDATA[
Alpha-synuclein aggregates trigger anti-viral immune pathways and RNA editing in human astrocytes
]]>
https://biorxiv.org/cgi/content/short/2024.02.26.582055v1?rss=1"
D'Sa, K.Choi, M. L.Wagen, A. Z.Seto-Salvia, N.Kopach, O.Evans, J. R.Rodrigues, M.Lopez-Garcia, P.Ghareeb, A.Bayne, J.Grant-Peters, M.Garcia-Ruiz, S.Chen, Z.Rodriques, S.Athauda, D.Gustavsson, E.Gagliano Taliun, S. A.Reynolds, R. H.Young, G.Strohbuecker, S.Warner, T.Rusakov, D. A.Patani, R.Bryant, C.Klenerman, D. A.Gandhi, S.Ryten, M.2024-02-28doi:10.1101/2024.02.26.582055Cold Spring Harbor Laboratory Press2024-02-28
<![CDATA[
Adoptive transfer of mitochondrial antigen-specific CD8+ T-cells in mice causes parkinsonism and compromises the dopamine system
]]>
https://biorxiv.org/cgi/content/short/2024.02.26.582098v1?rss=1"
Elemeery, M. N.Tchung, A.Boulet, S.Mukherjee, S.Giguere, N.Daudelin, J.-F.Hetu-Arbour, R.Matheoud, D.STRATTON, J. A.Labrecque, N.Trudeau, L.-E.2024-02-28doi:10.1101/2024.02.26.582098Cold Spring Harbor Laboratory Press2024-02-28
<![CDATA[
Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta
]]>
https://biorxiv.org/cgi/content/short/2024.02.28.582356v1?rss=1"
Conrad, W. S.Oriol, L.Faget, L.Hnasko, T. S.2024-02-28doi:10.1101/2024.02.28.582356Cold Spring Harbor Laboratory Press2024-02-28
<![CDATA[
Comparison of Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson's Disease Mutations
]]>
https://biorxiv.org/cgi/content/short/2024.02.28.582420v1?rss=1"
Lee, Y. J.Syed, K.Busquets, O.Li, H.Dunnack, J.Sahagun, A.Bateup, H.Soldner, F.Hockemeyer, D.Rio, D.2024-03-03doi:10.1101/2024.02.28.582420Cold Spring Harbor Laboratory Press2024-03-03
<![CDATA[
GLP-1 receptor agonism ameliorates Parkinsons disease through modulation of neuronal insulin signalling and glial suppression
]]>
https://biorxiv.org/cgi/content/short/2024.02.28.582460v1?rss=1"
Athauda, D.Evans, J. R.Sanchez, L.Virdi, G.Lopez Garcia, P.Wernick, A.Wagen, A.D'Sa, K.Lachica, J.Strohbuecker, S.Vecchi, G.Leighton, C.Saleeb, R. S.OShaughnessy, J.Toomey, C.Vijiaratnam, N.Girges, C.Li, Y.Mustapic, M.Ismail, K.Davies, M.Kapogiannis, D.Choi, M. L.Ryten, M.Horrocks, M. H.Greig, N. H.Foltynie, T.Gandhi, S.2024-02-28doi:10.1101/2024.02.28.582460Cold Spring Harbor Laboratory Press2024-02-28
<![CDATA[
LRRK2 G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3
]]>
https://biorxiv.org/cgi/content/short/2024.02.28.582561v1?rss=1"
Zheng, N.Jaffery, R.Guerrero, A.Hou, J.Pan, Y.Zhou, F.Chen, S.Xu, C.Egan, N. A.Bohat, R.Chen, K.Schwarzschild, M. A.Chen, X.Peng, W.2024-03-03doi:10.1101/2024.02.28.582561Cold Spring Harbor Laboratory Press2024-03-03
<![CDATA[
Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies
]]>
https://biorxiv.org/cgi/content/short/2024.03.03.583145v1?rss=1"
Nazeen, S.Wang, X.Zielinski, D.Lam, I.Xu, P.Ethier, E.Strom, R.Zanella, C. A.Nithianandam, V.Ritter, D.Henderson, A.Saurat, N.Nutter-Upham, A.Benyamini, H.Copty, J.Ravishankar, S.Morrow, A.Mitchel, J.Neavin, D.Gupta, R.Farbehi, N.Grundman, J.Myers, R. H.Scherzer, C. R.Trojanowski, J. Q.Van Deerlin, V. M.Cooper, A. A.Lee, E. B.Erlich, Y.Lindquist, S.Peng, J.Geschwind, D. H.Powell, J.Studer, L.Feany, M. B.Sunyaev, S. R.Khurana, V.2024-03-05doi:10.1101/2024.03.03.583145Cold Spring Harbor Laboratory Press2024-03-05
<![CDATA[
Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons
]]>
https://biorxiv.org/cgi/content/short/2023.10.12.562142v1?rss=1"
Mohd Rafiq, N.Fujise, K.Rosenfeld, M.Xu, P.Wu, Y.De Camilli, P.2023-10-13doi:10.1101/2023.10.12.562142Cold Spring Harbor Laboratory Press2023-10-13
<![CDATA[
Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape for insights into Neurodegenerative Disorders
]]>
https://biorxiv.org/cgi/content/short/2023.12.13.571527v1?rss=1"
Kumar, M.Knapp, J.Gupta, K.Ryan, T. A.2023-12-14doi:10.1101/2023.12.13.571527Cold Spring Harbor Laboratory Press2023-12-14
<![CDATA[
Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson's Disease
]]>
https://biorxiv.org/cgi/content/short/2024.02.19.581062v1?rss=1"
Zhuang, X.Lemak, J.Sridhar, S.Nelson, A. B.2024-02-22doi:10.1101/2024.02.19.581062Cold Spring Harbor Laboratory Press2024-02-22
<![CDATA[
Lysosomal storage disease proteo/lipidomic profiling using nMOST links ferritinophagy with mitochondrial iron deficiencies in cells lacking NPC2
]]>
https://biorxiv.org/cgi/content/short/2024.03.26.586828v1?rss=1"
Harper, J. W.Kraus, F.He, Y.Swarup, S.Overmyer, K. A.Brenner, J.Capitanio, C.Bieber, A.Jen, A.Nightingale, N. M.Anderson, B. J.Lee, C.Paulo, J. A.Smith, I. R.Plitzko, J. M.Schulman, B. A.Wilfling, F.Coon, J. J.2024-03-27doi:10.1101/2024.03.26.586828Cold Spring Harbor Laboratory Press2024-03-27
<![CDATA[
Tonic dendritic GABA release by substantia nigra dopaminergic neurons
]]>
https://biorxiv.org/cgi/content/short/2024.03.27.586699v1?rss=1"
Simmons, D. V.Ding, J.Khakh, B.Awatramani, R. V.Surmeier, D. J.2024-03-30doi:10.1101/2024.03.27.586699Cold Spring Harbor Laboratory Press2024-03-30
<![CDATA[
Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
]]>
https://biorxiv.org/cgi/content/short/2024.04.05.588321v1?rss=1"
Rademacher, K. L.Doric, Z.Haddad, D.Mamaligas, A.Liao, S.-C.Creed, R.Kano, K.Chatterton, Z.Fu, Y.Garcia, J. H.Vance, V.Sei, Y.Kreitzer, A.Halliday, G.Nelson, A.Margolis, E.Nakamura, K. L.2024-04-10doi:10.1101/2024.04.05.588321Cold Spring Harbor Laboratory Press2024-04-10
<![CDATA[
Transient dopamine neuron activity precedes and encodes the vigor of contralateral movements
]]>
https://biorxiv.org/cgi/content/short/2021.04.20.440527v1?rss=1"
Mendonca, M. D.Alves da Silva, J.Hernandez, L. F.Castela, I.Obeso, J.Costa, R. M.2021-04-20doi:10.1101/2021.04.20.440527Cold Spring Harbor Laboratory Press2021-04-20
<![CDATA[
escheR: Unified multi-dimensional visualizations with Gestalt principles
]]>
https://biorxiv.org/cgi/content/short/2023.03.18.533302v1?rss=1"
Guo, B.Hicks, S. C.2023-03-23doi:10.1101/2023.03.18.533302Cold Spring Harbor Laboratory Press2023-03-23
<![CDATA[
SynBot: An open-source image analysis software for automated quantification of synapses
]]>
https://biorxiv.org/cgi/content/short/2023.06.26.546578v1?rss=1"
Savage, J. T.Ramirez, J.Risher, W. C.Irala, D.Eroglu, C.2023-06-28doi:10.1101/2023.06.26.546578Cold Spring Harbor Laboratory Press2023-06-28
<![CDATA[
Linking Gba1 E326K mutation to microglia activation and mild age-dependent dopaminergic Neurodegeneration
]]>
https://biorxiv.org/cgi/content/short/2023.09.14.557673v1?rss=1"
Kweon, S. H.Ryu, H. G.Park, H.Lee, S.Kim, N.Kwon, S.-H.Ma, S.Kim, S.Ko, H. S.2023-09-14doi:10.1101/2023.09.14.557673Cold Spring Harbor Laboratory Press2023-09-14
<![CDATA[
LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis
]]>
https://biorxiv.org/cgi/content/short/2023.11.02.565364v1?rss=1"
Holmes, G.Ferguson, S. R.Lewis, P. A.Echeverri, K.2023-11-04doi:10.1101/2023.11.02.565364Cold Spring Harbor Laboratory Press2023-11-04
<![CDATA[
Development of LRRK2 designed ankyrin-repeat proteins
]]>
https://biorxiv.org/cgi/content/short/2023.11.14.567123v1?rss=1"
Dederer, V.Sanz Murillo, M.Karasmanis, E. P.Hatch, K. S.Chatterjee, D.Preuss, F.Abdul Azeez, K. R.Nguyen, L. V.Galicia, C.Dreier, B.Pluckthun, A.Versees, W.Mathea, S.Leschziner, A. E.Reck-Peterson, S. L.Knapp, S.2023-11-15doi:10.1101/2023.11.14.567123Cold Spring Harbor Laboratory Press2023-11-15
<![CDATA[
Adult-Onset Deletion of ATP13A2 in Mice Induces Progressive Nigrostriatal Pathway Dopaminergic Degeneration and Lysosomal Abnormalities
]]>
https://biorxiv.org/cgi/content/short/2024.01.25.577280v1?rss=1"
Erb, M. L.Sipple, K.Levine, N.Chen, X.Moore, D. J.2024-01-26doi:10.1101/2024.01.25.577280Cold Spring Harbor Laboratory Press2024-01-26
<![CDATA[
SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides
]]>
https://biorxiv.org/cgi/content/short/2024.04.02.587827v1?rss=1"
Loreto, A.Cramb, K. M. L.McDermott, L. A.Antoniou, C.Cirilli, I.Caiazza, M. C.Merlini, E.Arthur-Farra, P.Mock, E. D.Zhao, H. T.Bennett, D. L.Orsomando, G.Coleman, M. P.Wade-Martins, R.2024-04-03doi:10.1101/2024.04.02.587827Cold Spring Harbor Laboratory Press2024-04-03
<![CDATA[
Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder
]]>
https://biorxiv.org/cgi/content/short/2024.04.22.590542v1?rss=1"
Dautan, D.Paslawski, W.Montejo, S.Doyon, D.Marangiu, R.Kaplitt, M. G.Chen, R.Dawson, V. L.Zhang, X.Dawson, T. M.Svenningsson, P.2024-04-26doi:10.1101/2024.04.22.590542Cold Spring Harbor Laboratory Press2024-04-26
<![CDATA[
Reward perseveration is shaped by GABAA-mediated dopamine pauses
]]>
https://biorxiv.org/cgi/content/short/2024.05.09.593320v1?rss=1"
Burwell, S. C. V.Yan, H.Lim, S. S. X.Shields, B. C.TADROSS, M. R.2024-05-09doi:10.1101/2024.05.09.593320Cold Spring Harbor Laboratory Press2024-05-09
<![CDATA[
A comparative analysis of Parkinson's disease and inflammatory bowel disease gut microbiomes highlights shared depletions in key butyrate-producing bacteria
]]>
https://biorxiv.org/cgi/content/short/2024.04.26.591350v1?rss=1"
Krueger, M. E.Boles, J. S.Simon, Z. D.Alvarez, S. D.McFarland, N. R.Okun, M. S.Zimmermann, E. M.Forsmark, C. E.Tansey, M. G.2024-04-29doi:10.1101/2024.04.26.591350Cold Spring Harbor Laboratory Press2024-04-29
<![CDATA[
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
]]>
https://biorxiv.org/cgi/content/short/2024.05.09.593334v1?rss=1"
Sokratian, A.Zhou, Y.Tatli, M.Burbidge, K. J.Xu, E.Viverette, E.Duda, A. M.Yuan, Y.Li, H.Strader, S.Patel, N.Shiell, L.Malankhanova, T.Chen, O.Mazzulli, J. R.Perera, L.Stahlberg, H.Borgnia, M. J.Bartesaghi, A.Lashuel, H.West, A.2024-05-09doi:10.1101/2024.05.09.593334Cold Spring Harbor Laboratory Press2024-05-09
<![CDATA[
Genetic screening and metabolomics identify glial adenosine metabolism as a therapeutic target in Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2024.05.15.594309v1?rss=1"
Sodders, M. J.Avila-Pacheco, J.Okorie, E. C.Shen, M.Kumari, N.Marathi, A.Lakhani, M.Bullock, K.Pierce, K.Dennis, C.Jeanfavre, S.Sarkar, S.Scherzer, C. R.Clish, C.Olsen, A. L.2024-05-15doi:10.1101/2024.05.15.594309Cold Spring Harbor Laboratory Press2024-05-15
<![CDATA[
Tagless LysoIP method for molecular profiling of lysosomal content in clinical samples
]]>
https://biorxiv.org/cgi/content/short/2024.05.17.594681v1?rss=1"
Saarela, D.Lis, P.Gomes, S.Nirujogi, R. S.Dong, W.Rawat, E.Glendinning, S.Zeneviciute, K.Bagnoli, E.Fasimoye, R.Lin, C.Nyame, K.Boros, F. A.Zunke, F.Lamoliatte, F.Elshani, S.Jaconnelli, M.Jans, J. J. M.Huisman, M. A.Posern, C.Westermann, L. M.Schulz, A.van Hasselt, P. M.Alessi, D. R.Abu-Remaileh, M.Sammler, E.2024-05-19doi:10.1101/2024.05.17.594681Cold Spring Harbor Laboratory Press2024-05-19
<![CDATA[
Cell type directed design of synthetic enhancers
]]>
https://biorxiv.org/cgi/content/short/2022.07.26.501466v1?rss=1"
Taskiran, I. I.Spanier, K. I.Christiaens, V.Mauduit, D.Aerts, S.2022-07-27doi:10.1101/2022.07.26.501466Cold Spring Harbor Laboratory Press2022-07-27
<![CDATA[
Neither alpha-synuclein-preformed fibrils derived from patients with GBA1 mutations nor the host murine genotype significantly influence seeding efficacy in the mouse olfactory bulb.
]]>
https://biorxiv.org/cgi/content/short/2023.08.24.554646v1?rss=1"
Killinger, B.Kordower, J. H.Walton, S.Fenyi, A.Tittle, T.Choi, S.Sidransky, E.Paul, G.Melki, R.2023-08-25doi:10.1101/2023.08.24.554646Cold Spring Harbor Laboratory Press2023-08-25
<![CDATA[
Aggregation inhibits alpha-synuclein dephosphorylation resulting in the observation of pathological enrichment
]]>
https://biorxiv.org/cgi/content/short/2023.11.20.567854v1?rss=1"
Choi, S. G.Prada, D. A. G.Tittle, T.Kordower, J. H.Melki, R.Killinger, B. A.2023-11-21doi:10.1101/2023.11.20.567854Cold Spring Harbor Laboratory Press2023-11-21
<![CDATA[
Impaired Cortico-Amygdala Functional Connectivity Can Drive Social Behavior Deficits in Synucleinopathies
]]>
https://biorxiv.org/cgi/content/short/2024.05.20.594995v1?rss=1"
Zhou, W.Daniels, S.Singh, V.Menard, M.Galvis, M. E.Chu, H.-Y.2024-05-20doi:10.1101/2024.05.20.594995Cold Spring Harbor Laboratory Press2024-05-20
<![CDATA[
Decreased cellular excitability of pyramidal tract neurons in primary motor cortex leads to paradoxically increased network activity in simulated parkinsonian motor cortex
]]>
https://biorxiv.org/cgi/content/short/2024.05.23.595566v1?rss=1"
Doherty, D. W.Chen, L.Smith, Y.Wichmann, T.Chu, H.-y.Lytton, W. W.2024-05-23doi:10.1101/2024.05.23.595566Cold Spring Harbor Laboratory Press2024-05-23
<![CDATA[
Functional efficacy of the MAO-B inhibitor safinamide in murine substantia nigra pars compacta dopaminergic neurons in vitro: a comparative study with tranylcypromine
]]>
https://biorxiv.org/cgi/content/short/2024.05.28.596142v1?rss=1"
Zarrilli, B.Giacomet, C.Cossa, F.Federici, M.Berretta, N.Mercuri, N. B.2024-06-01doi:10.1101/2024.05.28.596142Cold Spring Harbor Laboratory Press2024-06-01
<![CDATA[
The diversity of SNCA transcripts in neurons, and its impact on antisense oligonucleotide therapeutics
]]>
https://biorxiv.org/cgi/content/short/2024.05.30.596437v1?rss=1"
Evans, J. R.Gustavsson, E. K.Doykov, I.Murphy, D.Virdi, G.Lachica, J.Rontgen, A.Murtada, M. H.Pang, C. W.Macpherson, H.Wernick, A. I.Toomey, C. E.Athauda, D.Choi, M.Hardy, J.Wood, N. W.Vendruscolo, M.Mills, K.Heywood, W.Ryten, M.Gandhi, S.2024-05-31doi:10.1101/2024.05.30.596437Cold Spring Harbor Laboratory Press2024-05-31
<![CDATA[
Refinement of efficient encodings of movement in the dorsolateral striatum throughout learning
]]>
https://biorxiv.org/cgi/content/short/2024.06.06.596654v1?rss=1"
Jaidar, O.Albarran, E.Albarran, E.Wu, Y.-W.Ding, J. B.2024-06-06doi:10.1101/2024.06.06.596654Cold Spring Harbor Laboratory Press2024-06-06
<![CDATA[
α-Synuclein Overexpression and the Microbiome Shape the Gut and Brain Metabolome in Mice
]]>
https://biorxiv.org/cgi/content/short/2024.06.07.597975v1?rss=1"
Morais, L. H.Boktor, J. C.MahmoudianDehkordi, S.Kaddurah-Daouk, R.Mazmanian, S. K.2024-06-10doi:10.1101/2024.06.07.597975Cold Spring Harbor Laboratory Press2024-06-10
<![CDATA[
Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C
]]>
https://biorxiv.org/cgi/content/short/2024.06.08.598070v1?rss=1"
Wang, X.Xu, P.Bentley-DeSousa, A.Hancock-Cerutti, W.Cai, S.Johnson, B. T.Tonelli, F.Talaia, G.Alessi, D. R.Ferguson, S. M.De Camilli, P.2024-06-08doi:10.1101/2024.06.08.598070Cold Spring Harbor Laboratory Press2024-06-08
<![CDATA[
Activity-Dependent Remodeling of Corticostriatal Axonal Boutons During Motor Learning
]]>
https://biorxiv.org/cgi/content/short/2024.06.10.598366v1?rss=1"
Sheng, M.Lu, D.Sheng, K.Ding, J.2024-06-10doi:10.1101/2024.06.10.598366Cold Spring Harbor Laboratory Press2024-06-10
<![CDATA[
Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
]]>
https://biorxiv.org/cgi/content/short/2024.06.11.598416v1?rss=1"
Bagnoli, E.Lin, Y.-E.Burel, S.Jaimon, E.Antico, O.Themistokleous, C.Nikoloff, J.Morella, I.Watzlawik, J.Fiesel, F.Springer, W.Tonelli, F.Brooks, S.Dunnett, S.Brambilla, R.Alessi, D. R.Pfeffer, S. R.Muqit, M.2024-06-11doi:10.1101/2024.06.11.598416Cold Spring Harbor Laboratory Press2024-06-11
<![CDATA[
Mitochondrial damage triggers concerted degradation of negative regulators of neuronal autophagy
]]>
https://biorxiv.org/cgi/content/short/2024.06.12.598718v1?rss=1"
Basak, B.Holzbaur, E. L. F.2024-06-13doi:10.1101/2024.06.12.598718Cold Spring Harbor Laboratory Press2024-06-13
<![CDATA[
Mitochondrial oxidant stress promotes alpha-synuclein aggregation and spreading in mice with mutated glucocerebrosidase
]]>
https://biorxiv.org/cgi/content/short/2024.06.13.598820v1?rss=1"
La Vitola, P.Szego, E. M.Pinto-Costa, R.Rollar, A.Harbachova, E.Schapira, A. H. V.Ulusoy, A.Di Monte, D. A.2024-06-13doi:10.1101/2024.06.13.598820Cold Spring Harbor Laboratory Press2024-06-13
<![CDATA[
Network nature of ligand-receptor interactions underlies disease comorbidity in the brain
]]>
https://biorxiv.org/cgi/content/short/2024.06.15.599140v1?rss=1"
Grant-Peters, M.Fairbrother-Browne, A.Hicks, A.Guo, B.Reynolds, R. H.Huuki-Myers, L. A.Eagles, N.Brenton, J.Garcia-Ruiz, S.Wood, N.Gandhi, S.Martinowich, K.Maynard, K.Collado-Torres, L.Ryten, M.2024-06-16doi:10.1101/2024.06.15.599140Cold Spring Harbor Laboratory Press2024-06-16
<![CDATA[
Pathogenic LRRK2 mutations cause loss of primary cilia and neuroprotective Neurturin in striatal Parvalbumin interneurons
]]>
https://biorxiv.org/cgi/content/short/2024.06.17.599289v1?rss=1"
Lin, Y.-E.Jaimon, E.Tonelli, F.Alessi, D. R.Pfeffer, S. R.2024-06-17doi:10.1101/2024.06.17.599289Cold Spring Harbor Laboratory Press2024-06-17
<![CDATA[
Transcriptional pathobiology and multi-omics predictors for Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2024.06.18.599639v1?rss=1"
Hu, R.Wang, R.Yuan, J.Lin, Z.Hutchins, E.Landin, B.Liao, Z.Liu, G.Scherzer, C. R.Dong, X.2024-06-21doi:10.1101/2024.06.18.599639Cold Spring Harbor Laboratory Press2024-06-21
<![CDATA[
MICROENDOSCOPIC CALCIUM IMAGING IN SUPPLEMENTARY MOTOR AREA AND PRIMARY MOTOR CORTEX OF RHESUS MACAQUES AT REST AND DURING ARM MOVEMENT
]]>
https://biorxiv.org/cgi/content/short/2024.06.20.599918v1?rss=1"
Martel, A.-C.Pittard, D.Devergnas, A.Risk, B.Nassi, J.Yu, W.Downer, J.Wichmann, T.Galvan, A.2024-06-25doi:10.1101/2024.06.20.599918Cold Spring Harbor Laboratory Press2024-06-25
<![CDATA[
Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits
]]>
https://biorxiv.org/cgi/content/short/2024.07.09.602700v1?rss=1"
Sanchiz-Calvo, M.Coccia, E.Cawthorne, C.Parfitt, G.Van Laere, K.Torre-Muruzabal, T.Cabezudo, D.Tsafaras, G.Cascalho, A.Van Den Haute, C.Vangheluwe, P.Blanchard, J.Bentea, E.Baekelandt, V.2024-07-13doi:10.1101/2024.07.09.602700Cold Spring Harbor Laboratory Press2024-07-13
<![CDATA[
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4
]]>
https://biorxiv.org/cgi/content/short/2024.07.01.601474v1?rss=1"
Feringa, F. M.Koppes-den Hertog, S. J.Wang, L.Derks, R. J. E.Kruijff, I.Erlebach, L.Heijneman, J.Miramontes, R.Pömpner, N.Blomberg, N.Olivier-Jimenez, D.Johanson, L. E.Cammack, A. J.Giblin, A.Toomey, C. E.Rose, I. V. L.Yuan, H.Ward, M. E.Isaacs, A.Kampmann, M.Kronenberg-Versteeg, D.Lashley, T.Thompson, L. M.Ori, A.Mohammed, Y.Giera, M.van der Kant, R. H. N.2024-07-03doi:10.1101/2024.07.01.601474Cold Spring Harbor Laboratory Press2024-07-03
<![CDATA[
Presynaptic GABAA receptors control integration of nicotinic input onto dopaminergic axons in the striatum
]]>
https://biorxiv.org/cgi/content/short/2024.06.25.600616v1?rss=1"
Brill-Weil, S. G.Kramer, P. F.Yanez, A.Clever, F. H.Zhang, R.Khaliq, Z. M.2024-06-25doi:10.1101/2024.06.25.600616Cold Spring Harbor Laboratory Press2024-06-25
<![CDATA[
A rewiring of the earliest immune events leading to T-cell mediated disease following intestinal infection in a PINK1KO mouse model of Parkinsons disease
]]>
https://biorxiv.org/cgi/content/short/2024.06.18.598931v1?rss=1"
Recinto, S.Kazanova, A.MacDonald, A.Afanasiev, E.Premachandran, S.Allot, A.Bessaiah, H.Cordeiro, B.Mukherjee, S.Pei, J.McBride, H. M.Trudeau, L.-E.Gruenheid, S.Stratton, J. A.2024-06-22doi:10.1101/2024.06.18.598931Cold Spring Harbor Laboratory Press2024-06-22
<![CDATA[
Excessive Firing of Dyskinesia-Associated Striatal Direct Pathway Neurons is Gated By Dopamine and Excitatory Synaptic Input
]]>
https://biorxiv.org/cgi/content/short/2022.10.31.514594v1?rss=1"
Ryan, M. B.Girasole, A. E.McGregor, M. M.Brakaj, R.Paletzki, R. F.Gerfen, C. R.Nelson, A. B.2022-11-01doi:10.1101/2022.10.31.514594Cold Spring Harbor Laboratory Press2022-11-01
<![CDATA[
GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes
]]>
https://biorxiv.org/cgi/content/short/2023.01.17.524433v1?rss=1"
Sivadasan Bindu, D.Tan, C. X.Savage, J. T.Eroglu, C.2023-01-19doi:10.1101/2023.01.17.524433Cold Spring Harbor Laboratory Press2023-01-19
<![CDATA[
Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes
]]>
https://biorxiv.org/cgi/content/short/2024.05.15.594341v1?rss=1"
Stedehouder, J.Roberts, B. M.Raina, S.Bossi, S.Liu, A. K. L.Doig, N. M.McGerty, K.Magill, P. J.Parkkinen, L.Cragg, S. J.2024-05-15doi:10.1101/2024.05.15.594341Cold Spring Harbor Laboratory Press2024-05-15
<![CDATA[
Cortico-amygdala synaptic structural abnormalities produced by templated aggregation of α-synuclein
]]>
https://biorxiv.org/cgi/content/short/2024.05.15.594419v1?rss=1"
Gcwensa, N. Z.Russell, D. L.Long, K. Y.Brzozowski, C. F.Liu, X.Gamble, K. L.Cowell, R. M.Volpicelli-Daley, L.2024-05-15doi:10.1101/2024.05.15.594419Cold Spring Harbor Laboratory Press2024-05-15
<![CDATA[
Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal widespread lysosomal and mitochondrial dysfunction in human PRKN knockout astrocytes and neurons
]]>
https://biorxiv.org/cgi/content/short/2024.05.21.594886v1?rss=1"
Goldman, C.Kareva, T.Sarrafha, L.Saharsrabudhe, A.Schuldt, B. R.Ahfeldt, T.Blanchard, J. W.2024-05-21doi:10.1101/2024.05.21.594886Cold Spring Harbor Laboratory Press2024-05-21
<![CDATA[
Internalized α-synuclein fibrils become truncated and resist degradation in neurons while glial cells rapidly degrade α-synuclein fibrils.
]]>
https://biorxiv.org/cgi/content/short/2024.06.05.597615v1?rss=1"
Karim, M. R.GAsparini, E.Tiegs, E.Schlichte, R.Vermilyea, S. C.Lee, M. K.2024-06-08doi:10.1101/2024.06.05.597615Cold Spring Harbor Laboratory Press2024-06-08
<![CDATA[
LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons
]]>
https://biorxiv.org/cgi/content/short/2024.06.06.597594v1?rss=1"
Chen, C.Masotti, M.Shepard, N.Promes, V.Tombesi, G.Arango, D.Manzoni, C.Greggio, E.Hilfiker, S.Kozorovitskiy, Y.Parisiadou, L.2024-06-08doi:10.1101/2024.06.06.597594Cold Spring Harbor Laboratory Press2024-06-08
<![CDATA[
Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2024.06.06.597807v1?rss=1"
Gaertner, Z.Oram, C.Schneeweis, A.Schonfeld, E.Bolduc, C.Chen, C.Dombeck, D. A.Parisiadou, L.Poulin, J. F.Awatramani, R.2024-06-08doi:10.1101/2024.06.06.597807Cold Spring Harbor Laboratory Press2024-06-08
<![CDATA[
Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2
]]>
https://biorxiv.org/cgi/content/short/2024.06.18.599606v1?rss=1"
Chen, S.Basiashvili, T.Hutchings, J.Murillo, M. S.Suarez, A. V.Louro, J. A.Leschziner, A. E.Villa, E.2024-06-20doi:10.1101/2024.06.18.599606Cold Spring Harbor Laboratory Press2024-06-20
<![CDATA[
Dissociation of novel open loop from ventral putamen to motor areas from classic closed loop in humans II: task-based function
]]>
https://biorxiv.org/cgi/content/short/2024.06.18.599622v1?rss=1"
Dundon, N. M.Rizor, E.Stasiak, J.Wang, J.Sabugo, K.Villaneuva, C.Barandon, P.Bostan, A. C.Lapate, R. C.Grafton, S. T.2024-06-22doi:10.1101/2024.06.18.599622Cold Spring Harbor Laboratory Press2024-06-22
<![CDATA[
Spatially organized striatum-wide acetylcholine dynamics for the learning and extinction of Pavlovian cues and actions
]]>
https://biorxiv.org/cgi/content/short/2024.07.10.602947v1?rss=1"
Bouabid, S.Zhang, L.Vu, M.-A. T.Tang, K.Graham, B. M.Noggle, C. A.Howe, M. W.2024-07-16doi:10.1101/2024.07.10.602947Cold Spring Harbor Laboratory Press2024-07-16
<![CDATA[
Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation
]]>
https://biorxiv.org/cgi/content/short/2024.07.24.604995v1?rss=1"
Chen, L.Chehade, H. D.Chu, H.-Y.2024-07-24doi:10.1101/2024.07.24.604995Cold Spring Harbor Laboratory Press2024-07-24
<![CDATA[
Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinsons linked-LRRK2 mutant mice
]]>
https://biorxiv.org/cgi/content/short/2024.07.31.606089v1?rss=1"
Jaimon, E.Lin, Y.-E.Tonelli, F.Antico, O.Alessi, D. R.Pfeffer, S. R.2024-08-03doi:10.1101/2024.07.31.606089Cold Spring Harbor Laboratory Press2024-08-03
<![CDATA[
Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data
]]>
https://biorxiv.org/cgi/content/short/2024.08.13.607784v1?rss=1"
Simmons, S. K.Adiconis, X.Haywood, N.Parker, J.Lin, Z.Liao, Z.Tuncali, I.Al'Khafaji, A.Shin, A.Jagadeesh, K.Gosik, K.Gatzen, M.Smith, J. T.El Kodsi, D. N.Kuras, Y.Baecher-Allan, C.Serrano, G. E.Beach, T. G.Garimella, K.Rozenblatt-Rosen, O.Regev, A.Dong, X.Scherzer, C.Levin, J. Z.2024-08-16doi:10.1101/2024.08.13.607784Cold Spring Harbor Laboratory Press2024-08-16
<![CDATA[
Peripheral Blood Immune Cells from Individuals with Parkinson's Disease or Inflammatory Bowel Disease Share Deficits in Iron Storage and Transport that are Modulated by Non-Steroidal Anti-Inflammatory Drugs
]]>
https://biorxiv.org/cgi/content/short/2024.08.19.608634v1?rss=1"
Bolen, M. L.Gomes, B. N.Gill, B.Menees, K. B.Staley, H.Jernigan, J.Tansey, M. G.2024-08-19doi:10.1101/2024.08.19.608634Cold Spring Harbor Laboratory Press2024-08-19
<![CDATA[
Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery
]]>
https://biorxiv.org/cgi/content/short/2024.08.28.609967v1?rss=1"
Adriaenssens, E.Schaar, S.Cooke, A. S. I.Stuke, J. F. M.Sawa-Makarska, J.Nguyen, T. N.Ren, X.Schuschnig, M.Romanov, J.Khuu, G.Lazarou, M.Hummer, G.Hurley, J. H.Martens, S.2024-08-28doi:10.1101/2024.08.28.609967Cold Spring Harbor Laboratory Press2024-08-28
<![CDATA[
Dissociation of putative open loop circuit from ventral putamen to motor cortical areas in humans I: high-resolution connectomics
]]>
https://biorxiv.org/cgi/content/short/2024.08.28.610129v1?rss=1"
0.1). Collectively, these results suggest that PUTv is functionally connected to motor cortical areas and may be integrated into a separable motor OLC with subcortical limbic inputs.
]]>Rizor, E. J.Dundon, N. M.Wang, J.Stasiak, J.Li, T.Bostan, A.Lapate, R. C.Grafton, S. T.2024-08-29doi:10.1101/2024.08.28.610129Cold Spring Harbor Laboratory Press2024-08-29
<![CDATA[
Movement-related activity in the internal globus pallidus of the parkinsonian macaque
]]>
https://biorxiv.org/cgi/content/short/2024.08.29.610310v1?rss=1"
Kase, D.Zimnik, A. J.Han, Y.Harsch, D. R.Bacha, S.Cox, K. M.Bostan, A. C.Richardson, R. M.Turner, R. S.2024-08-30doi:10.1101/2024.08.29.610310Cold Spring Harbor Laboratory Press2024-08-30
<![CDATA[
Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways
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https://biorxiv.org/cgi/content/short/2024.08.30.610524v1?rss=1"
Hickey, K. L.Panov, A.Whelan, E. M.Schaefer, T.Mizrak, A.Kopito, R. R.Baumeister, W.Fernandez-Busnadiego, R.Harper, W.2024-09-01doi:10.1101/2024.08.30.610524Cold Spring Harbor Laboratory Press2024-09-01
<![CDATA[
CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism
]]>
https://biorxiv.org/cgi/content/short/2024.08.30.610586v1?rss=1"
Liao, S.-C.Kano, K.Phanse, S.Nguyen, M.Margolis, E. B.Fu, Y.Meng, J.Moutaoufik, M. T.Chatterton, Z.Aoki, H.Simms, J.Hsieh, I.Suteja, F.Sei, Y.Huang, E. J.McAvoy, K.Manfredi, G.Halliday, G.Babu, M.Nakamura, K.2024-09-01doi:10.1101/2024.08.30.610586Cold Spring Harbor Laboratory Press2024-09-01
<![CDATA[
Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2024.06.20.599774v1?rss=1"
Sah, S.Sauerbeck, A. D.Gupta, J.Perez-Acuna, D.Reiber, J. E.Russell, D.Goralski, T.Henderson, M.Volpicelli-Daley, L. A.Higley, M. J.Kummer, T. T.Biederer, T.2024-06-21doi:10.1101/2024.06.20.599774Cold Spring Harbor Laboratory Press2024-06-21
<![CDATA[
Behavioral screening defines three molecular Parkinsonism subgroups in Drosophila
]]>
https://biorxiv.org/cgi/content/short/2024.08.27.609924v1?rss=1"
Kaempf, N.Valadas, J. D. S.Robberechts, P.Schoovaerts, N.Praschberger, R.Ortega, A.Kilic, A.Chabot, D.Pech, U.Kuenen, S.Vilain, S.Baz, E.-S.Singh, J.Davis, J.Liu, S.Verstreken, P.2024-08-27doi:10.1101/2024.08.27.609924Cold Spring Harbor Laboratory Press2024-08-27
<![CDATA[
The mitochondrial unfolded protein response promotes senescence in human microglia by increasing S-adenosylmethionine availability for polyamine synthesis.
]]>
https://biorxiv.org/cgi/content/short/2024.09.03.610925v1?rss=1"
Perez Jimenez, M. J.Bertoli, F.Raji, H.Lam, A.Bosch, M.Weissleder, C.Nemazanyy, I.Kalb, S.Hirschberg, I.Brunetti, D.Heckenbach, I.Scheibye-Knudsen, M.Deleidi, M.2024-09-03doi:10.1101/2024.09.03.610925Cold Spring Harbor Laboratory Press2024-09-03
<![CDATA[
Presynapses are mitophagy pit stops that prevent axon degeneration
]]>
https://biorxiv.org/cgi/content/short/2024.09.09.611943v1?rss=1"
Lam, W. K.Lindblom, R. S. J.Milky, B.Mazzachi, P.Hadian-Jazi, M.Kung, C.Khuu, G.Uoselis, L.Nguyen, T. N.Skulsuppaisarn, M.Saunders, T. L.Schmidt, M. F.Dewson, G.Fogel, A. I.Bardy, C.Lazarou, M.2024-09-09doi:10.1101/2024.09.09.611943Cold Spring Harbor Laboratory Press2024-09-09
<![CDATA[
Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2
]]>
https://biorxiv.org/cgi/content/short/2024.09.17.613365v1?rss=1"
Raig, N. D.Surridge, K. J.Sanz-Murillo, M.Dederer, V.Kramer, A.Schwalm, M. P.Elson, L.Chatterjee, D.Mathea, S.Hanke, T.Leschziner, A. E.Reck-Peterson, S. L.Knapp, S.2024-09-18doi:10.1101/2024.09.17.613365Cold Spring Harbor Laboratory Press2024-09-18
<![CDATA[
Comparative Analysis of AAV Serotypes for Transduction of Olfactory Sensory Neurons
]]>
https://biorxiv.org/cgi/content/short/2024.09.26.615247v1?rss=1"
Belfort, B. D.Jia, J. D.Garza, A. R.Insalaco, A. M.McGinnis, J. P.Pekarek, B. T.Ortiz, J.Tepe, B.Chen, H.Liu, Z.Arenkiel, B. R.2024-09-28doi:10.1101/2024.09.26.615247Cold Spring Harbor Laboratory Press2024-09-28
<![CDATA[
Bridge-like lipid transfer protein 3A (BLTP3A) is associated with membranes of the late endocytic pathway and is an effector of CASM
]]>
https://biorxiv.org/cgi/content/short/2024.09.28.615015v1?rss=1"
Hanna, M. G.Rodriguez Cruz, H. O.Fujise, K.Zhuoning, L.Monetti, M.De Camilli, P.2024-09-28doi:10.1101/2024.09.28.615015Cold Spring Harbor Laboratory Press2024-09-28
<![CDATA[
DIO-SPOTlight Transgenic Mouse to Functionally Monitor Protein Synthesis Regulated by the Integrated Stress Response
]]>
https://biorxiv.org/cgi/content/short/2024.10.14.618312v1?rss=1"
Oliver, M. L.Caffall, Z. F.Eatman, C. B.Faw, T. D.Calakos, N.2024-10-15doi:10.1101/2024.10.14.618312Cold Spring Harbor Laboratory Press2024-10-15
<![CDATA[
Cell-Type Resolved Protein Atlas of Brain Lysosomes Identifies SLC45A1-Associated Disease as a Lysosomal Disorder
]]>
https://biorxiv.org/cgi/content/short/2024.10.14.618295v1?rss=1"
Ghoochani, A.Heiby, J. C.Rawat, E. S.Medoh, U. N.Di Fraia, D.Dong, W.Gastou, M.Nyame, K.Laqtom, N. N.Gomez-Ospina, N.Ori, A.Abu-Remaileh, M.2024-10-15doi:10.1101/2024.10.14.618295Cold Spring Harbor Laboratory Press2024-10-15
<![CDATA[
Striatal lateral inhibition regulates action selection in a mouse model of levodopa-induced dyskinesia
]]>
https://biorxiv.org/cgi/content/short/2024.10.11.617939v1?rss=1"
Twedell, E. L.Bair-Marshall, C. J.Girasole, A. E.Scaria, L. K.Sridhar, S.Nelson, A. B.2024-10-12doi:10.1101/2024.10.11.617939Cold Spring Harbor Laboratory Press2024-10-12
<![CDATA[
Dopamine and cortical iPSC-derived neurons with different Parkinsonian mutations show variation in lysosomal and mitochondrial dysfunction: implications for protein deposition versus selective cell loss
]]>
https://biorxiv.org/cgi/content/short/2024.10.07.617117v1?rss=1"
Chedid, J.Li, Y.Labrador-Garrido, A.Abu-Bonsrah, D.Pavan, C.Fraser, T.Zhong, M.Johnston, J. A.Thompson, L. H.Kirik, D.Parish, C.Halliday, G.Sue, C.Wali, G.Dzamko, N.2024-10-11doi:10.1101/2024.10.07.617117Cold Spring Harbor Laboratory Press2024-10-11
<![CDATA[
LRRK2-mutant microglia trigger dopaminergic neurodegeneration when activated by neuromelanin
]]>
https://biorxiv.org/cgi/content/short/2024.10.07.616997v1?rss=1"
Blasco-Agell, L.Espinal, M. P.Testa, V.Roch, G.Montero-Mu, J.Fern, I.Baruffi, V.Gonzalez-Sepulveda, M.Richaud-Patin, Y.Jim, S.Cuadros, T.Cladera-Sastre, J. M.Compte, J.Otero, M. J.Tolosa, E.Raya, A.Vila, M.Consiglio, A.2024-10-07doi:10.1101/2024.10.07.616997Cold Spring Harbor Laboratory Press2024-10-07
<![CDATA[
Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex
]]>
https://biorxiv.org/cgi/content/short/2024.10.22.619706v1?rss=1"
Salazar, M. P. R.Kolanukuduru, S.Ramirez, V.Lyu, B.Sejourne, G.Sesaki, H.Yu, G.Eroglu, C.2024-10-23doi:10.1101/2024.10.22.619706Cold Spring Harbor Laboratory Press2024-10-23
<![CDATA[
Assembloid model to study loop circuits of the human nervous system
]]>
https://biorxiv.org/cgi/content/short/2024.10.13.617729v1?rss=1"
Miura, Y.Kim, J.-i.Jurjut, O.Kelley, K. W.Yang, X.Chen, X.Thete, M. V.Revah, O.Cui, B.Pachitariu, M.Pasca, S. P.2024-10-14doi:10.1101/2024.10.13.617729Cold Spring Harbor Laboratory Press2024-10-14
<![CDATA[
Endo-IP and Lyso-IP Toolkit for Endolysosomal Profiling of Human Induced Neurons
]]>
https://biorxiv.org/cgi/content/short/2024.09.24.614704v1?rss=1"
Hundley, F. V.Gonzalez-Lozano, M.Gottschalk, L. M.Cook, A. N. K.Zhang, J.Paulo, J. A.Harper, J. W.2024-09-26doi:10.1101/2024.09.24.614704Cold Spring Harbor Laboratory Press2024-09-26
<![CDATA[
Abnormal hyperactivity of specific striatal ensembles encodes distinct dyskinetic behaviors revealed by high-resolution clustering
]]>
https://biorxiv.org/cgi/content/short/2024.09.06.611664v1?rss=1"
Alcacer, C.Klaus, A.Mendonca, M.Abalde, S.Cenci, M. A.Costa, R. M.2024-09-08doi:10.1101/2024.09.06.611664Cold Spring Harbor Laboratory Press2024-09-08
<![CDATA[
Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses
]]>
https://biorxiv.org/cgi/content/short/2024.08.28.610136v1?rss=1"
Mendelsohn, A.Nikoobakht, L.Bikoff, J.Costa, R.2024-08-29doi:10.1101/2024.08.28.610136Cold Spring Harbor Laboratory Press2024-08-29
<![CDATA[
A Protocol for Neuralized Murine Olfactory Organoids
]]>
https://biorxiv.org/cgi/content/short/2024.10.29.620938v1?rss=1"
Ozgun, A.Suman, P.Coulombe, J.aSCENT-PD Investigators,Brown, E. G.Tomlinson, J. J.Woulfe, J. M.Schlossmacher, M. G.2024-10-31doi:10.1101/2024.10.29.620938Cold Spring Harbor Laboratory Press2024-10-31
<![CDATA[
Hydrophobic tails enable diverse functions of the extracellular chaperone clusterin
]]>
https://biorxiv.org/cgi/content/short/2024.10.30.620894v1?rss=1"
Yuste-Checa, P.Carvajal, A. I.Chenchen, M.Paatz, S.Hartl, F.-U.Bracher, A.2024-10-31doi:10.1101/2024.10.30.620894Cold Spring Harbor Laboratory Press2024-10-31
<![CDATA[
Network analysis of α-synuclein pathology progression reveals p21-activated kinases as regulators of vulnerability
]]>
https://biorxiv.org/cgi/content/short/2024.10.22.619411v1?rss=1"
View larger version (60K):
org.highwire.dtl.DTLVardef@10ac986org.highwire.dtl.DTLVardef@134b55eorg.highwire.dtl.DTLVardef@16f4581org.highwire.dtl.DTLVardef@3c491a_HPS_FORMAT_FIGEXP M_FIG C_FIG HIGHLIGHTSO_LILongitudinal -synuclein pathology assessment in 1046 brain regions over 9 months
C_LIO_LILinear diffusion modeling derivation of network vulnerability to -synuclein pathology
C_LIO_LIPANGEA: assessment of over 19,000 genes in 302 brain regions
C_LIO_LIGroup II PAK inhibitor prevents -synuclein pathology and neuron death
C_LI
]]>Vatsa, N.Brynildsen, J. K.Goralski, T. M.Kurgat, K.Meyerdirk, L.Breton, L.DeWeerd, D.Brasseur, L.Turner, L.Becker, K.Gallik, K. L.Bassett, D. S.Henderson, M. X.2024-10-22doi:10.1101/2024.10.22.619411Cold Spring Harbor Laboratory Press2024-10-22
<![CDATA[
RGS10 Attenuates Systemic Immune Dysregulation Induced by Chronic Inflammatory Stress
]]>
https://biorxiv.org/cgi/content/short/2024.10.24.620078v1?rss=1"
Jernigan, J. E.Staley, H. A.Baty, Z.Bolen, M. L.Gomes, B. N.Holt, J.Cole, C. L.Neighbarger, N. K.Dheeravath, K.Merchak, A. R.Menees, K. B.Coombes, S. A.Tansey, M. G.2024-10-29doi:10.1101/2024.10.24.620078Cold Spring Harbor Laboratory Press2024-10-29
<![CDATA[
RNApysoforms: Fast rendering interactive visualization of RNA isoform structure and expression in Python
]]>
https://biorxiv.org/cgi/content/short/2024.11.06.622357v1?rss=1"
Heberle, B. A.Page, M. L.Gustavsson, E. K.Ryten, M.Ebbert, M. T. W.2024-11-08doi:10.1101/2024.11.06.622357Cold Spring Harbor Laboratory Press2024-11-08
<![CDATA[
Autophagic stress activates distinct compensatory secretory pathways in neurons
]]>
https://biorxiv.org/cgi/content/short/2024.11.07.621551v1?rss=1"
Palumbos, S. D.Popolow, J.Goldsmith, J.Holzbaur, E.2024-11-07doi:10.1101/2024.11.07.621551Cold Spring Harbor Laboratory Press2024-11-07
<![CDATA[
Amyloid-beta, alpha-synuclein and tau aggregated co-pathologies enhance neuropathology and neuroinflammation
]]>
https://biorxiv.org/cgi/content/short/2024.10.13.618101v1?rss=1"
Webster, J. M.Stone, W. J.Yang, Y.-T.Miller, A. T.Childers, G. M.Corbin-Stein, N. J.Mudium, N.Molina, J.Won, W.-J.Sandoval, I. M.Tyrrell, D. J.Manfredsson, F. P.Kordower, J. H.Harms, A. S.2024-10-13doi:10.1101/2024.10.13.618101Cold Spring Harbor Laboratory Press2024-10-13
<![CDATA[
Thalamic integration of basal ganglia and cerebellar circuits during motor learning
]]>
https://biorxiv.org/cgi/content/short/2024.10.31.621388v1?rss=1"
Roth, R. H.Muniak, M. A.Huang, C. J.Hwang, F.-J.Sun, Y.Min, C.Mao, T.Ding, J. B.2024-11-01doi:10.1101/2024.10.31.621388Cold Spring Harbor Laboratory Press2024-11-01
<![CDATA[
Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories
]]>
https://biorxiv.org/cgi/content/short/2024.11.04.621665v1?rss=1"
Sansalone, L.Evans, R. C.Twedell, E.Zhang, R.Khaliq, Z. M.2024-11-05doi:10.1101/2024.11.04.621665Cold Spring Harbor Laboratory Press2024-11-05
<![CDATA[
Ancestry-specific gene expression in peripheral monocytes mediates risk of neurodegenerative disease
]]>
https://biorxiv.org/cgi/content/short/2024.11.20.624489v1?rss=1"
Wagen, A. Z.Reynolds, R. H.Nee Foo, J.Fairbrother-Browne, A.Gustavsson, E. K.Gagliano-Turin, S. A.Wood, N. W.Blauwendraat, C. K.Gandhi, S.Ryten, M.2024-11-22doi:10.1101/2024.11.20.624489Cold Spring Harbor Laboratory Press2024-11-22
<![CDATA[
CNV-Finder: Streamlining Copy Number Variation Discovery
]]>
https://biorxiv.org/cgi/content/short/2024.11.22.624040v1?rss=1"
Kuznetsov, N.Daida, K.Makarious, M. B.Al-Mubarak, B.Atterling Brolin, K.Malik, L.Kouam, C.Baker, B.Ostrozovicova, M.Andersh, K. M.Kung, P.-J.Mecheri, Y.Tay, Y.-W.Soundous Malek, B.Al Tassan, N.Teresa Perinan, M.Hong, S.Koretsky, M.Sargeant, L.Levine, K.Blauwendraat, C.Billingsley, K. J.Bandres-Ciga, S.Leonard, H. L.Morris, H. R.Singleton, A. B.Nalls, M. A.Vitale, D.The Global Parkinson's Genetics Program,2024-11-23doi:10.1101/2024.11.22.624040Cold Spring Harbor Laboratory Press2024-11-23
<![CDATA[
LRRK2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis
]]>
https://biorxiv.org/cgi/content/short/2024.11.26.625468v1?rss=1"
Pei, J.Oliveira, N. L.Recinto, S. J.Kazanova, A.Queiroz-Junior, C. M.Li, Z.Couto, K.Westfall, S.King, I. L.Ribeiro, C. T.Milnerwood, A.Desjardins, M.Thanabalasuriar, A.STRATTON, J. A.Gruenheid, S.2024-12-02doi:10.1101/2024.11.26.625468Cold Spring Harbor Laboratory Press2024-12-02
<![CDATA[
The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract
]]>
https://biorxiv.org/cgi/content/short/2024.12.14.628386v1?rss=1"
White, A. C.Krout, I. N.Mouhi, S.Chang, J.Kelly, S. D.Caudle, W. M.Sampson, T.2024-12-17doi:10.1101/2024.12.14.628386Cold Spring Harbor Laboratory Press2024-12-17
<![CDATA[
Exploring the relationship between GBA1 host genotype and gut microbiome in the GBA1L444P/WT mouse model: Implications for Parkinson disease pathogenesis
]]>
https://biorxiv.org/cgi/content/short/2024.12.15.627490v1?rss=1"
Menozzi, E.Geiger, M.Meslier, V.Fierli, F.Gilles, M.Chau, K.-Y.David, A.Shahar Golan, R.Famechon, A.Koletsi, S.Morabito, C.Quinquis, B.Pons, N.Ehrlich, S. D.Macnaughtan, J.Almeida, M.Schapira, A. H.2024-12-15doi:10.1101/2024.12.15.627490Cold Spring Harbor Laboratory Press2024-12-15
<![CDATA[
The gut microbiome promotes mitochondrial respiration in the brain of a Parkinson's disease mouse model
]]>
https://biorxiv.org/cgi/content/short/2024.12.18.629251v1?rss=1"
Morais, L. H.Stiles, L.Freeman, M.Oguienko, A. D.Hoang, J. D.Jones, J.Quan, B.Devine, J.Bois, J. S.Chou, T.-F.Trinh, J.Picard, M.Gradinaru, V.Mazmanian, S. K.2024-12-21doi:10.1101/2024.12.18.629251Cold Spring Harbor Laboratory Press2024-12-21
<![CDATA[
A Vulnerable Subtype of Dopaminergic Neurons Drives Early Motor Deficits in Parkinson's Disease
]]>
https://biorxiv.org/cgi/content/short/2024.12.20.629776v1?rss=1"
Fushiki, A.Ng, D.Lewis, Z. R.Yadav, A.Saraiva, T.Hammand, L. A.Wirblich, C.Tasic, B.Menon, V.Silva, J. A. d.Costa, R. M.2024-12-21doi:10.1101/2024.12.20.629776Cold Spring Harbor Laboratory Press2024-12-21
<![CDATA[
Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment
]]>
https://biorxiv.org/cgi/content/short/2024.12.22.629963v1?rss=1"
Mantas, I.Contestabile, A.Skara, V.Loiseau, C.Santos, I.Cramb, K.Filograna, R.Wade-Martins, R.Magill, P.Meletis, K.2024-12-22doi:10.1101/2024.12.22.629963Cold Spring Harbor Laboratory Press2024-12-22
<![CDATA[
Sub-second characterization of locomotor activities of mouse models of Parkinsonism
]]>
https://biorxiv.org/cgi/content/short/2024.12.26.630411v1?rss=1"
Berezhnoi, D.Chehade, H. D.Simms, G.Chen, L.Chu, H.-Y.2024-12-26doi:10.1101/2024.12.26.630411Cold Spring Harbor Laboratory Press2024-12-26
<![CDATA[
GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis
]]>
https://biorxiv.org/cgi/content/short/2025.01.01.630988v1?rss=1"
Bogacki, E. C.Longmore, G.Lewis, P. A.Herbst, S.2025-01-01doi:10.1101/2025.01.01.630988Cold Spring Harbor Laboratory Press2025-01-01
<![CDATA[
State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2025.01.02.631090v1?rss=1"
Zhai, S.Cui, Q.Wokosin, D.Sun, L.Tkatch, T.Crittenden, J. R.Graybiel, A. M.Surmeier, D. J.2025-01-02doi:10.1101/2025.01.02.631090Cold Spring Harbor Laboratory Press2025-01-02
<![CDATA[
Transgenic A53T mice have astrocytic α-synuclein aggregates in dopamine and striatal regions
]]>
https://biorxiv.org/cgi/content/short/2025.01.09.632283v1?rss=1"
Peat, C.Prasad, A.Finkelstein, D. I.Sue, C.Johnston, J.Parish, C.Thompson, L.Kirik, D.Halliday, G.2025-01-12doi:10.1101/2025.01.09.632283Cold Spring Harbor Laboratory Press2025-01-12
<![CDATA[
Alpha-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
]]>
https://biorxiv.org/cgi/content/short/2025.01.13.632710v1?rss=1"
Sitron, C. S.Trinkaus, V. A.Galesic, A. G.Garhammer, M.Yuste Checa, P.Dransfeld, U.Feigenbutz, D.Zhang, J.Dudanova, I.Harper, J. W.Hartl, F. U.2025-01-13doi:10.1101/2025.01.13.632710Cold Spring Harbor Laboratory Press2025-01-13
<![CDATA[
LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development
]]>
https://biorxiv.org/cgi/content/short/2025.01.17.633315v1?rss=1"
Adami, A.Garza, R.Gerdes, P.Johansson, P. A.Dorazehi, F.Koutounidou, S.Castilla-Vallmanya, L.Atacho, D. A. M.Sharma, Y.Johansson, J. G.Tam, O.Kirkeby, A.Barker, R. A.Gale Hammell, M.Douse, C. H.Jakobsson, J.2025-01-17doi:10.1101/2025.01.17.633315Cold Spring Harbor Laboratory Press2025-01-17
<![CDATA[
Lysosomal Glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway to Parkinsons disease
]]>
https://biorxiv.org/cgi/content/short/2025.01.20.633968v1?rss=1"
Nair, S. V.Jaimon, E.Adhikari, A.Nikoloff, J.Pfeffer, S. R.2025-01-21doi:10.1101/2025.01.20.633968Cold Spring Harbor Laboratory Press2025-01-21
<![CDATA[
Standardised TruAI automated quantification of intracellular neuromelanin granules in human brain tissue sections
]]>
https://biorxiv.org/cgi/content/short/2025.01.20.633975v1?rss=1"
Filimontseva, A.Cuadros, T.Chatterton, Z.Compte, J.Fu, Y.Vila, M.Halliday, G.2025-01-23doi:10.1101/2025.01.20.633975Cold Spring Harbor Laboratory Press2025-01-23
<![CDATA[
Micro-invasive probes for monitoring electrical and chemical neural activity in nonhuman primates
]]>
https://biorxiv.org/cgi/content/short/2025.01.30.635139v1?rss=1"
100 mm), and provides compatibility with standard intracranial insertion protocols (e.g., guide tubes and chamber setups) that require a sufficiently rigid and long shaft for deep brain insertion in monkeys. The s-{micro}IP was further expanded to provide dual-channel chemical and electrical neural activity recording with micrometer spatial resolution. Measurements of reward- and movement-related dopamine, spikes, and local field potentials were made from single and dual-channel s-{micro}IPs implanted in task-performing monkeys. Recordings from chronically implanted s-{micro}IPs display the capability of functional multi-modal (chemical and electrical) neural activity measurements over 1-year post-implantation from micro-invasive devices.
]]>Amjad, U.Mahajan, S.Choi, J.Shrivastav, R.Murray, R.Somich, A.Coyne, O.Schwerdt, H. N.2025-02-05doi:10.1101/2025.01.30.635139Cold Spring Harbor Laboratory Press2025-02-05
<![CDATA[
EndoMAPV1, a Structural Protein Complex Landscape of Human Endosomes
]]>
https://biorxiv.org/cgi/content/short/2025.02.07.636106v1?rss=1"
Gonzalez-Lozano, M.Schmid, E. W.Whelan, E. M.Jiang, Y.Paulo, J. A.Walter, J.Harper, J. W.2025-02-09doi:10.1101/2025.02.07.636106Cold Spring Harbor Laboratory Press2025-02-09
<![CDATA[
Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue
]]>
https://biorxiv.org/cgi/content/short/2025.02.09.637107v1?rss=1"
Mesentier-Louro, L. A.Goldman, C.Ndayisaba, A.Buonfiglioli, A.Rooklin, R. B.Schuldt, B. R.Uchitelev, A.Khurana, V.Blanchard, J. W.2025-02-09doi:10.1101/2025.02.09.637107Cold Spring Harbor Laboratory Press2025-02-09
<![CDATA[
Aseptic, semi-sealed cranial chamber implants for chronic multi-channel neurochemical and electrophysiological neural recording in nonhuman primates
]]>
https://biorxiv.org/cgi/content/short/2025.02.10.636943v1?rss=1"
Choi, J.Amjad, U.Murray, R.Shrivastav, R.Teichert, T.Goodell, B.Schaeffer, D. J.Oluoch, J. K.Schwerdt, H. N.2025-02-11doi:10.1101/2025.02.10.636943Cold Spring Harbor Laboratory Press2025-02-11
<![CDATA[
Molecularly-guided spatial proteomics captures single-cell identity and heterogeneity of the nervous system
]]>
https://biorxiv.org/cgi/content/short/2025.02.10.637505v1?rss=1"
Dutta, S.Pang, M.Coughlin, G. M.Gudavalli, S.Roukes, M. L.Chou, T.-F.Gradinaru, V.2025-02-11doi:10.1101/2025.02.10.637505Cold Spring Harbor Laboratory Press2025-02-11
<![CDATA[
Specific cell states underlie complex tissue regeneration in spiny mice
]]>
https://biorxiv.org/cgi/content/short/2025.02.10.637521v1?rss=1"
Rivadeneira, E. O.Allen, R. S.Adam, M.Seifert, A. W.2025-02-11doi:10.1101/2025.02.10.637521Cold Spring Harbor Laboratory Press2025-02-11
<![CDATA[
Postsynaptic adaptations in direct pathway muscarinic M4-receptor signaling follow the temporal and regional pattern of dopaminergic degeneration
]]>
https://biorxiv.org/cgi/content/short/2025.03.03.641233v1?rss=1"
Nielsen, B.Ford, C.2025-3-10doi:10.1101/2025.03.03.641233Cold Spring Harbor Laboratory Press2025-3-10
<![CDATA[
PPM1M, a LRRK2-counteracting, phosphoRab12-preferring phosphatase with potential link to Parkinsons disease
]]>
https://biorxiv.org/cgi/content/short/2025.03.19.644182v1?rss=1"
Chiang, C. Y.Pratuseviciute, N.Lin, Y.-E.Adhikari, A.Yeshaw, W. M.Flitton, C.Sherpa, P. L.Tonelli, F.Rektorova, I.Lynch, T.Siuda, J.Rudzinska-Bar, M.Pulyk, O.Bauer, P.Beetz, C.Dickson, D. W.Ross, O. A.Wszolek, Z.Klein, C.Zimprich, A.Alessi, D. R.Sammler, E. M.Pfeffer, S. R.2025-03-19doi:10.1101/2025.03.19.644182Cold Spring Harbor Laboratory Press2025-03-19
<![CDATA[
In situ cryo-ET visualization of mitochondrial depolarization and mitophagic engulfment
]]>
https://biorxiv.org/cgi/content/short/2025.03.24.645001v1?rss=1"
Rose, K.Herrmann, E.Kakudji, E. V.Lizarrondo, J.Celebi, A. Y.Wilfling, F.Lewis, S. C.Hurley, J. H.2025-03-25doi:10.1101/2025.03.24.645001Cold Spring Harbor Laboratory Press2025-03-25
<![CDATA[
ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis
]]>
https://biorxiv.org/cgi/content/short/2025.03.24.645038v1?rss=1"
Fuller, D. M.Wu, Y.Schueder, F.Rasool, B.Nag, S.Korfhage, J. L.Garcia-Milian, R.Melnyk, K. D.Bewersdorf, J.De Camilli, P.Melia, T.2025-03-25doi:10.1101/2025.03.24.645038Cold Spring Harbor Laboratory Press2025-03-25
<![CDATA[
AI-directed voxel extraction and volume EM identify intrusions as sites of mitochondrial contact
]]>
https://biorxiv.org/cgi/content/short/2024.11.20.624606v1?rss=1"
Padman, B. S.Lindblom, R. S. J.Lazarou, M.2024-11-21doi:10.1101/2024.11.20.624606Cold Spring Harbor Laboratory Press2024-11-21
<![CDATA[
A single Citrobacter rodentium infection in Pink1 knockout and wild type mice leads to regional blood-brain-barrier perturbation and glial activation without dopamine neuron axon terminal loss
]]>
https://biorxiv.org/cgi/content/short/2024.12.24.630165v1?rss=1"
Mukherjee, S.Grouza, V.Tchung, A.Even, A.Yaqubi, M.Tuznik, M.Cannon, T.Recinto, S. J.Gavino, C.Bourque, M.-J.McBride, H. M.Desjardins, M.Gruenheid, S.Stratton, J. A.Rudko, D. A.Trudeau, L.-E.2024-12-24doi:10.1101/2024.12.24.630165Cold Spring Harbor Laboratory Press2024-12-24
<![CDATA[
Soluble Immune Factor Profiles in Blood and CSF Associated with LRRK2 Mutations and Parkinson's Disease
]]>
https://biorxiv.org/cgi/content/short/2025.03.20.644460v1?rss=1"
Jaffery, R.Zhao, Y.Ahmed, S.Schumacher, J. G.Ahn, J.Shi, L.Wang, Y.Tan, Y.Chen, K.Tawbi, H.Wang, J.Schwarzschild, M. A.Peng, W.Chen, X.2025-03-24doi:10.1101/2025.03.20.644460Cold Spring Harbor Laboratory Press2025-03-24
<![CDATA[
iNeurons are sweet, maybe too sweet? Exploring the impact of media composition on PINK1-dependent mitophagy
]]>
https://biorxiv.org/cgi/content/short/2025.04.01.646648v1?rss=1"
O'Callaghan, B.Melandri, D.Soltic, D.Cosker, K.Soutar, M. P. M.Plun-Favreau, H.2025-04-03doi:10.1101/2025.04.01.646648Cold Spring Harbor Laboratory Press2025-04-03
<![CDATA[
HyDrop v2: Scalable atlas construction for training sequence-to-function models
]]>
https://biorxiv.org/cgi/content/short/2025.04.02.646792v1?rss=1"
Dickmanken, H.Wojno, M.Theunis, K.Eksi, E. C.Mahieu, L.Christiaens, V.Kempynck, N.De Rop, F. V.Roels, N.Spanier, K. I.Vandepoel, R.Hulselmans, G. J.Poovathingal, S.Aerts, S.2025-04-04doi:10.1101/2025.04.02.646792Cold Spring Harbor Laboratory Press2025-04-04
<![CDATA[
CREsted: modeling genomic and synthetic cell type-specific enhancers across tissues and species
]]>
https://biorxiv.org/cgi/content/short/2025.04.02.646812v1?rss=1"
Kempynck, N.De Winter, S.Blaauw, C. H.Konstantakos, V.Dieltiens, S.Eksi, E. C.Bercier, V.Taskiran, I. I.Hulselmans, G.Spanier, K.Christiaens, V.Van Den Bosch, L.Mahieu, L.Aerts, S.2025-04-03doi:10.1101/2025.04.02.646812Cold Spring Harbor Laboratory Press2025-04-03
<![CDATA[
Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2025.04.18.649338v1?rss=1"
D'Addario, S. L.Massaro Cenere, M.Cossa, F.Scaricamazza, S.Nesci, V.D'Ottavio, G.Caprioli, D.Ferri, A.Vila, M.Ledonne, A.Mercuri, N. B.2025-04-23doi:10.1101/2025.04.18.649338Cold Spring Harbor Laboratory Press2025-04-23
<![CDATA[
Differential memory enrichment of cytotoxic CD4 T cells in Parkinson's disease patients reactive to α-synuclein
]]>
https://biorxiv.org/cgi/content/short/2025.04.21.649867v1?rss=1"
Freuchet, A.Johansson, E.Frazier, A.Litvan, I.Goldman, J. G.Alcalay, R. N.Sulzer, D.Lindestam Arlehamn, C. S.Sette, A.2025-04-24doi:10.1101/2025.04.21.649867Cold Spring Harbor Laboratory Press2025-04-24
<![CDATA[
T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2025.04.21.649871v1?rss=1"
Johansson, E.Freuchet, A.Williams, G. P.Michealis, T.Frazier, A.Litvan, I.Goldman, J. G.Alcalay, R. N.Standaert, D. G.Amara, A. W.Stover, N.Fon, E. A.Postuma, R. B.Sidney, J.Sulzer, D.Lindestam Arlehamn, C. S.Sette, A.2025-04-24doi:10.1101/2025.04.21.649871Cold Spring Harbor Laboratory Press2025-04-24
<![CDATA[
Spatial genomics of AAVs reveals mechanism of transcriptional crosstalk that enables targeted delivery of large genetic cargo
]]>
https://biorxiv.org/cgi/content/short/2023.12.23.573214v1?rss=1"
Coughlin, G. M.Borsos, M.Appling, N.Barcelona, B. H.Mayfield, A. M. H.Mackey, E. D.Eser, R. A.Chen, X.Kumar, S. R.Gradinaru, V.2023-12-24doi:10.1101/2023.12.23.573214Cold Spring Harbor Laboratory Press2023-12-24
<![CDATA[
Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice
]]>
https://biorxiv.org/cgi/content/short/2025.05.09.653147v1?rss=1"
Xu, P.Mancuso, R. I.Leonzino, M.Zeiss, C. J.Krause, D. S.De Camilli, P.2025-05-13doi:10.1101/2025.05.09.653147Cold Spring Harbor Laboratory Press2025-05-13
<![CDATA[
Introducing PIGMO, a novel PIGmented MOuse model of Parkinson's disease (V1)
]]>
https://biorxiv.org/cgi/content/short/2025.05.09.653000v1?rss=1"
Chocarro, J.Marana, S.Espelosin, M.Rico, A. J.Ariznabarreta, G.Lorenzo-Ramos, E.Illarduya, M. M.Hernandez-Alcoceba, R.Chillon, M.Vila, M.Kordower, J.Schapira, A. H. V.Garcia-Osta, A.Cuadrado-Tejedor, M.Lanciego, J. L.2025-05-14doi:10.1101/2025.05.09.653000Cold Spring Harbor Laboratory Press2025-05-14
<![CDATA[
End-product inhibition of the LRRK2-counteracting PPM1H phosphatase
]]>
https://biorxiv.org/cgi/content/short/2025.05.16.654599v1?rss=1"
Adhikari, A.Tripathi, A.Chiang, C. Y.Sherpa, P. L.Pfeffer, S. R.2025-05-17doi:10.1101/2025.05.16.654599Cold Spring Harbor Laboratory Press2025-05-17
<![CDATA[
Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson's Disease
]]>
https://biorxiv.org/cgi/content/short/2025.05.16.654530v1?rss=1"
Zhang, L.Yasumizu, Y.Deerhake, M. E.Moon, J.Buitrago-Pocasangre, N.Russo, A.Wang, H.Zhu, B.Seibyl, J. P.Reddy, V.Wang, Q.Spillantini, M. G.Posner, D. A.Clatworthy, M.Sumida, T. S.Longbrake, E. E.Cedarbaum, J. M.Hafler, D. A.2025-05-21doi:10.1101/2025.05.16.654530Cold Spring Harbor Laboratory Press2025-05-21
<![CDATA[
Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice
]]>
https://biorxiv.org/cgi/content/short/2025.05.16.654598v1?rss=1"
Paz, R. M.Ryan, M. B.Marcott, P. F.Girasole, A. E.Faryean, J.Duong, V.Sridhar, S.Nelson, A. B.2025-05-21doi:10.1101/2025.05.16.654598Cold Spring Harbor Laboratory Press2025-05-21
<![CDATA[
Spatio-molecular analysis of primate subthalamus defines anatomical domains relevant to Parkinson disease and neuropsychiatry
]]>
https://biorxiv.org/cgi/content/short/2025.05.21.655268v1?rss=1"
Dumas, S.Francois, C.Karachi, C.Mackenzie, A.2025-05-21doi:10.1101/2025.05.21.655268Cold Spring Harbor Laboratory Press2025-05-21
<![CDATA[
17q21.31 locus regulates Parkinson's disease relevant pathways through KANSL1 activity
]]>
https://biorxiv.org/cgi/content/short/2025.03.17.641409v1?rss=1"
Hicks, A. R.O'Callaghan, B.Brenton, J. W.Grant-Peters, M.Fairbrother-Browne, A.Rocamora Perez, G.Loh, C. A.Reynolds, R. H.Gustavsson, E. K.Montgomery, K.Tsalenchuk, M.Real, R.Morris, H.Lunnon, K.Marzi, S. J.Jaunmuktane, Z.Hardy, J.Plun-Favreau, H.Ryten, M.2025-03-17doi:10.1101/2025.03.17.641409Cold Spring Harbor Laboratory Press2025-03-17
<![CDATA[
Single-cell multiomics identifies both shared and unique features of immune dysfunction in the colon, plasma and stool from individuals diagnosed with Parkinson's disease or inflammatory bowel disease
]]>
https://biorxiv.org/cgi/content/short/2025.04.29.651228v1?rss=1"
Bolen, M. L.buendia, m.Shi, J.Staley, H.Kachergus, J. M.Efron, P. A.Park, G.Nagpal, R.Xue, Q.-S.McFarland, N. R.Zimmermann, E. M.Forsmark, C. E.Menees, K. B.Salas, A.Thompson, E. A.Tansey, M. G.2025-05-02doi:10.1101/2025.04.29.651228Cold Spring Harbor Laboratory Press2025-05-02
<![CDATA[
Molecular and cellular signatures differentiate Parkinson's disease from Parkinson's disease with dementia
]]>
https://biorxiv.org/cgi/content/short/2025.03.04.641379v1?rss=1"
Fairbrother-Browne, A.Grant-Peters, M.Brenton, J. W.Nelvagal, H.Reynolds, R. H.Lim, Y. M.Gustavsson, E. K.Macpherson, H.Montgomery, K.Evans, J. R.Hicks, A. R.Chiraki, N.Curless, T.Real, R.Xenakis, T.Houlden, H.Morris, H. R.Gandhi, S.Wood, N. W.Hardy, J.Jaunmuktane, Z.Ryten, M.2025-03-04doi:10.1101/2025.03.04.641379Cold Spring Harbor Laboratory Press2025-03-04
<![CDATA[
LRP10 promotes trafficking of progranulin and prosaposin to lysosomes
]]>
https://biorxiv.org/cgi/content/short/2025.05.02.651888v1?rss=1"
Filippini, F.Devireddy, S.Ferguson, S.2025-05-03doi:10.1101/2025.05.02.651888Cold Spring Harbor Laboratory Press2025-05-03
<![CDATA[
Matters arising: Forced Symmetry Artifacts in a Prohibitin Complex Structure
]]>
https://biorxiv.org/cgi/content/short/2025.05.16.653159v1?rss=1"
Herrmann, E.Rose, K. M.Hurley, J. H.2025-05-20doi:10.1101/2025.05.16.653159Cold Spring Harbor Laboratory Press2025-05-20
<![CDATA[
Parkinson's disease-vulnerable and -resilient dopamine neurons display opposite responses to excitatory input
]]>
https://biorxiv.org/cgi/content/short/2025.06.03.657460v1?rss=1"
Hadjas, L. C.Kollman, G. J.Linderhof, L.Xia, M.Mansur, S.Saint-Pierre, M.Lim, B.Lee, E. B.Cicchetti, F.Awatramani, R.Hollon, N. G.Hnasko, T. S.2025-06-07doi:10.1101/2025.06.03.657460Cold Spring Harbor Laboratory Press2025-06-07
<![CDATA[
JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux
]]>
https://biorxiv.org/cgi/content/short/2025.06.06.657909v1?rss=1"
Nassar, L. M.Shi, x.Roczniak-Ferguson, A.Shen, H.Ferguson, S. M.2025-06-09doi:10.1101/2025.06.06.657909Cold Spring Harbor Laboratory Press2025-06-09
<![CDATA[
Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neurons
]]>
https://biorxiv.org/cgi/content/short/2025.06.15.659794v1?rss=1"
Albarran, E.Fushiki, A.Nelson, A.Ng, D.Chaimowitz, C.Nikoobakht, L.Sippy, T.Peterka, D. S.Costa, R. M.2025-06-15doi:10.1101/2025.06.15.659794Cold Spring Harbor Laboratory Press2025-06-15
<![CDATA[
Bidirectional regulation of glycoprotein nonmetastatic melanoma protein B by β-glucocerebrosidase deficiency in GBA1 isogenic dopaminergic neurons from a patient with Gaucher disease and parkinsonism
]]>
https://biorxiv.org/cgi/content/short/2025.06.23.661126v1?rss=1"
Chen, C.Ma, C.Sam, R.Lichtenberg, J.Chen, T.Hao, Y.Li, Z.Kowal, I.Andersh, K.Qi, Y. A.Perez, G.Hertz, E.Li, Y.Williams, D.Henderson, M. J.Park, M.Jiang, X.Jerez, P. A.Blauwendraat, C.Sidransky, E.Chen, Y.2025-06-25doi:10.1101/2025.06.23.661126Cold Spring Harbor Laboratory Press2025-06-25
<![CDATA[
EVscope: A Comprehensive Bioinformatics Pipeline for Accurate and Robust Analysis of Total RNA Sequencing from Extracellular Vesicles
]]>
https://biorxiv.org/cgi/content/short/2025.06.24.660984v1?rss=1"
Zhao, Y.Chintalapudi, H.Xu, Z.Liu, W.Hu, Y.Grassin, E.Song, M.Hong, S.Lee, L. P.Dong, X.2025-06-27doi:10.1101/2025.06.24.660984Cold Spring Harbor Laboratory Press2025-06-27
<![CDATA[
TX2P: A Proteogenomic Tool for Comprehensive Transcript Analysis
]]>
https://biorxiv.org/cgi/content/short/2025.06.24.661260v1?rss=1"
Murphy, D.Wood, N. W.Ryten, M.Gustavsson, E. K.2025-06-27doi:10.1101/2025.06.24.661260Cold Spring Harbor Laboratory Press2025-06-27
<![CDATA[
AutoMorphoTrack: An Automated Python Package for Organelle Morphology, Motility, and Colocalization Analysis in Live-Cell Imaging
]]>
https://biorxiv.org/cgi/content/short/2025.07.19.665650v1?rss=1"
View larger version (32K):
org.highwire.dtl.DTLVardef@103ecb0org.highwire.dtl.DTLVardef@a81b6forg.highwire.dtl.DTLVardef@a145fcorg.highwire.dtl.DTLVardef@1f9c27c_HPS_FORMAT_FIGEXP M_FIG C_FIG
]]>Bayati, A.Schumacher, J. G.Chen, X.2025-07-23doi:10.1101/2025.07.19.665650Cold Spring Harbor Laboratory Press2025-07-23
<![CDATA[
Elevated brain α-synuclein, phosphorylated-tau, and oxidative stress in mice that survived influenza A pneumonitis
]]>
https://biorxiv.org/cgi/content/short/2025.07.31.667659v1?rss=1"
Lunn, M. O.Lengacher, N. A.Hake-Volling, Q.Tomlinson, J. J.aSCENT-PD Investigators,Brown, E. G.Schlossmacher, M. G.2025-08-01doi:10.1101/2025.07.31.667659Cold Spring Harbor Laboratory Press2025-08-01
<![CDATA[
Neuron subtype-specific effector gene expression in the Motor Ganglion of Ciona
]]>
https://biorxiv.org/cgi/content/short/641233v1?rss=1"
Gibboney, S.Kim, K.Johnson, C. J.Orvis, J.Martinez-Feduchi, P.Lowe, E. K.Sharma, S.Stolfi, A.2019-05-17doi:10.1101/641233Cold Spring Harbor Laboratory Press2019-05-17
<![CDATA[
Genetic modulation of immune gene co-expression in the aged mouse hippocampus by the Apbb1ip locus
]]>
https://biorxiv.org/cgi/content/short/2025.06.04.657838v1?rss=1"
70 genes, between young and aged mice. These results provide novel insights into transcriptional dynamics of hippocampal ageing and identified the immune gene Apbb1ip as a potential modulator of immune response and microglial gene upregulation with implications for neurodegenerative disease pathogenesis.
HighlightsO_LIComplementary gene expression analyses indicated an upregulation of immune responses in the ageing hippocampus of a genetically diverse mouse cohort, likely driven by microglia subtypes.
C_LIO_LIA systems genetics approach revealed the Apbb1ip locus as a modulator of immune gene co-expression, highlighting a novel candidate regulator of age-associated neuroimmune dynamics.
C_LIO_LISignalling chaperone Ywhab gene expression was highly differentially correlated with other transcripts during ageing which may underlie widespread age-associated molecular perturbations in the hippocampus.
C_LI
]]>Tomkins, J. E.Methi, A.Bouland, G.Doludda, B.Murphy, K.Miller, J. A.Overall, R. W.Mozhui, K.2025-06-08doi:10.1101/2025.06.04.657838Cold Spring Harbor Laboratory Press2025-06-08
<![CDATA[
Patch deconvolution for Fourier light-field microscopy
]]>
https://biorxiv.org/cgi/content/short/2025.06.13.659385v1?rss=1"
Fu, B.Jones, C. L.Heraghty, D.Yang, S.O'Brien-Ball, C.Junghans, V.Yang, H.Knowles, T.Weiss, L. E.Fernandes, R. A.Lee, S.2025-06-17doi:10.1101/2025.06.13.659385Cold Spring Harbor Laboratory Press2025-06-17
<![CDATA[
Development of a protocol utilizing single-cell analysis for the differentiation of human iPSCs into SOX6+ midbrain dopaminergic neurons.
]]>
https://biorxiv.org/cgi/content/short/2025.06.18.660098v1?rss=1"
Lyu, G.Garcia Swinburn, R.Kreutzmann, J. C.Xiong, A.Kojima, R.Abaurre, C.Tremolanti, C.Gellhaar, S.Uhlen, P.Svenningsson, P.Castelo Branco, G.Dagliyan, O.Salto, C.Arenas, E.2025-06-22doi:10.1101/2025.06.18.660098Cold Spring Harbor Laboratory Press2025-06-22
<![CDATA[
A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation
]]>
https://biorxiv.org/cgi/content/short/2025.08.16.670665v1?rss=1"
Holzer, E.Sawa-Makarska, J.Bernklau, D.Romanov, J.Schuschnig, M.Martens, S.2025-08-18doi:10.1101/2025.08.16.670665Cold Spring Harbor Laboratory Press2025-08-18
<![CDATA[
Neuromodulator control of energy reserves in dopaminergic neurons
]]>
https://biorxiv.org/cgi/content/short/2025.08.19.671144v1?rss=1"
Pulido, C.Gentry, M. S.Ryan, T. A.2025-08-19doi:10.1101/2025.08.19.671144Cold Spring Harbor Laboratory Press2025-08-19
<![CDATA[
α-Synuclein driven cell susceptibility in Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2025.08.19.670819v1?rss=1"
Breiter, J. C.Beckwith, J. S.Brock, E. E.Lachica, J.Toomey, C. E.Fu, B.Ryten, M.Weiss, L. E.Wood, N. W.Gandhi, S.Vendruscolo, M.Lee, S. F.2025-08-23doi:10.1101/2025.08.19.670819Cold Spring Harbor Laboratory Press2025-08-23
<![CDATA[
Integrated Representations of Threat and Controllability in the Lateral Frontal Pole
]]>
https://biorxiv.org/cgi/content/short/2025.08.24.671754v1?rss=1"
Stasiak, J. E.Wang, J.Dundon, N. M.Rizor, E. J.Villanueva, C. M.Barandon, P. L.Grafton, S. T.Lapate, R. C.2025-08-24doi:10.1101/2025.08.24.671754Cold Spring Harbor Laboratory Press2025-08-24
<![CDATA[
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2025.08.25.671921v1?rss=1"
Evans, J. R.Grant-Peters, M.Beckwith, J. S.Toomey, C. E.Popovic, R.Breiter, J. C.Brenton, J. W.Fairbrother-Browne, A.Strohbuecker, S.Lachica, J.Rodriguez-Lopez, M.Brock, E. E.Fu, B.Nahidiazar, L.Lopez-Garcia, P.Ferguson, R.Saleeb, R. S.Lucas-Clarke, H.Penverne, A.D'Sa, K.Pang, C. W.Horrocks, M. H.Vendruscolo, M.Wood, N.Lee, S. F.Ryten, M.Gandhi, S.2025-08-28doi:10.1101/2025.08.25.671921Cold Spring Harbor Laboratory Press2025-08-28
<![CDATA[
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons
]]>
https://biorxiv.org/cgi/content/short/2025.08.28.672006v1?rss=1"
Chen, C.He, Q.Tombesi, G.Napier, E.Jaconelli, M.Moreno-Ramos, O.Serio, H.Naaldijk, Y.Promes, V.Schneeweis, A.Quinn, K.Nasios, C.Greggio, E.Kozorovitskiy, Y.Arango, D.Khan, A. R.Alessi, D. R.Dombeck, D. A.Hilfiker, S.Awatramani, R.Parisiadou, L.2025-08-28doi:10.1101/2025.08.28.672006Cold Spring Harbor Laboratory Press2025-08-28
<![CDATA[
TDP-43 loss of function drives aberrant splicing in Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2025.09.04.673943v1?rss=1"
500 post-mortem human brain samples from individuals with and without PD to show that splicing alterations are frequently detected. Differentially spliced genes were significantly more enriched for those causally-implicated in both PD and ALS than genes that were differentially expressed. Furthermore, we observed a strong association between these splicing alterations and dysfunction of the RNA-binding protein (RBP), TAR DNA-binding protein 43 (TDP-43). Strikingly, genes and exon junctions affected by TDP-43 knockdown overlapped significantly with those dysregulated across brain regions in PD. In brains from individuals with the LRRK2 c.6055G>A (p.G2019S) mutation, the most common genetic cause of PD, we also observed significant enrichment of TDP-43-dependent splicing changes. This finding was corroborated in human pluripotent stem cell-derived midbrain dopaminergic neurons and a LRRK2 p.G2019S knock-in mouse model, where reduced nuclear TDP-43 levels evidenced the well-recognised loss-of-function mechanism contributing to splicing dysregulation. By leveraging our RNA-based analyses we predicted TDP-43-dependent novel peptide sequences and validated their existence within human LRRK2 mutation mDNs, while also demonstrating an overall loss of protein and mRNA expression in mis-spliced genes. Collectively, our findings reveal that PD is marked by extensive splicing dysregulation dependent on TDP-43, making TDP-43 a promising new therapeutic target in PD.
]]>Brenton, J. W.Follett, J.Nirujogi, R.Toomey, C. E.Lopez-Garcia, P.Evans, J. R.Lee, Y. J.Syed, K. M.Rocamora Perez, G.Fairbrother-Browne, A.D'Sa, K.Grant-Peters, M.Lachica, J.Hicks, A. R.Wagen, A. Z.O'Callaghan, B.Macpherson, H.Montgomery, K.-a.Busquets, O.Reynolds, R. H.Garcia Ruiz, S.Cao, T.Chen, Z.Plun-Favreau, H.Wong, P. C.Farrer, M.Lashley, T.Soldner, F.Hockemeyer, D.Alessi, D.Wood, N. W.Hardy, J.Rio, D. C.Jaunmuktane, Z.Gustavsson, E. K.Gandhi, S.Ryten, M.2025-09-09doi:10.1101/2025.09.04.673943Cold Spring Harbor Laboratory Press2025-09-09
<![CDATA[
Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice
]]>
https://biorxiv.org/cgi/content/short/2025.09.18.677192v1?rss=1"
Moiseyenko, A.Antonello, G.Schonhoff, A. M.Boktor, J. C.Long, K.Dirks, B.Oguienko, A. D.Winnett, A. V.Simpson, P.Daeizadeh, D.Ismagilov, R. F.Krajmalnik-Brown, R.Segata, N.Waldron, L. D.Mazmanian, S. K.2025-09-21doi:10.1101/2025.09.18.677192Cold Spring Harbor Laboratory Press2025-09-21
<![CDATA[
Alternate Splicing Directs PMCA2 to Lysosomes and is Linked to Neurodegeneration
]]>
https://biorxiv.org/cgi/content/short/2025.10.01.679724v1?rss=1"
Fernandez-Suarez, M. E.Bush, R.Brenton, J. W.Pereira, G.Grant-Peters, M.Reynolds, R. H.te Vruchte, D.Shepherd, D.Weng, Y.Artaza-Fernandez, E.Lis, P.Sanchez-Pulido, L.Morgan, A.Davis, L.Gomez-Coronado, D.Eden, E. R.Alessi, D. R.Ponting, C.Galione, A.Newstead, S.Hardy, J.Patel, S.Ryten, M.Platt, F. M.2025-10-02doi:10.1101/2025.10.01.679724Cold Spring Harbor Laboratory Press2025-10-02
<![CDATA[
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
]]>
https://biorxiv.org/cgi/content/short/2025.10.06.680693v1?rss=1"
Ehses, K. L.Lopez-Alonso, J. P.Antico, O.Azem, A.Muqit, M.Ubarretxena-Belandia, I.Fernandez-Busnadiego, R.2025-10-06doi:10.1101/2025.10.06.680693Cold Spring Harbor Laboratory Press2025-10-06
<![CDATA[
Proteome Landscapes Decode Organelle Vulnerabilities in cortical and dopaminergic-like induced neurons Across Lysosomal Storage Disorders
]]>
https://biorxiv.org/cgi/content/short/2025.10.08.681047v1?rss=1"
Kraus, F.He, Y.Jiang, Y.Li, D.Ambaw, Y. A.Gasparoli, F. M.Paulo, J. A.Walther, T. C.Farese, R.Gygi, S. P.Wilfling, F.Harper, J. W.2025-10-08doi:10.1101/2025.10.08.681047Cold Spring Harbor Laboratory Press2025-10-08
<![CDATA[
Robust analytical methods for bis(monoacylglycero)phosphate profiling in health and disease
]]>
https://biorxiv.org/cgi/content/short/2025.02.13.638174v1?rss=1"
Dong, W.Nyame, K.Rawat, E. S.Medoh, U. N.Xiong, J.Bonin, C. C.Alsohybe, H. N.Liu, H. Y.Gomes, S.Hsieh, T.Arnold, M.Hsieh, F.Sammler, E.Abu-Remaileh, M.2025-02-17doi:10.1101/2025.02.13.638174Cold Spring Harbor Laboratory Press2025-02-17
<![CDATA[
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved TBM motif
]]>
https://biorxiv.org/cgi/content/short/2025.08.19.670962v1?rss=1"
Waschbuesch, D.Pal, P.Nirujogi, R. S.Cavin, M.Singh, J.Alessi, D. R.Khan, A. R.2025-08-24doi:10.1101/2025.08.19.670962Cold Spring Harbor Laboratory Press2025-08-24
<![CDATA[
LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload
]]>
https://biorxiv.org/cgi/content/short/2025.08.25.672135v1?rss=1"
Goldman, A.Nguyen, M.Lanoix, J.Fahmy, A.Zhong Xu, Y.Schurr, E.Thibault, P.Desjardins, M.McBride, H.2025-08-25doi:10.1101/2025.08.25.672135Cold Spring Harbor Laboratory Press2025-08-25
<![CDATA[
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
]]>
https://biorxiv.org/cgi/content/short/2025.09.03.673956v1?rss=1"
Garza, R.Adami, A.Thiruvalluvan, A.Wijesinghe, S.Curle, A. J.Tam, O.Forcier, T.Lagka, D. A.Kazakou, N. L.Atacho, D. A. M.Sharma, Y.Jonsson, M. E.Horvath, V.Bermudez, S.Johansson, J. G.Rainbow, D. B.Castilla-Vallmanya, L.Jones, J. L.Quaegebeur, A.Gale Hammell, M.Kirkeby, A.Barker, R. A.Jakobsson, J.2025-09-07doi:10.1101/2025.09.03.673956Cold Spring Harbor Laboratory Press2025-09-07
<![CDATA[
Proteome-wide impact of LRRK1 and 2 inhibitors on protein interactions and phosphorylation
]]>
https://biorxiv.org/cgi/content/short/2025.09.03.674114v1?rss=1"
Jansen, J.Wendel, M.Raig, N. D.Kraus, T. V.Surridge, K. J.Mahesula, S.Richter-Muller, N.Mathea, S.Reck-Peterson, S. L.Knapp, S.Stengel, F.2025-09-07doi:10.1101/2025.09.03.674114Cold Spring Harbor Laboratory Press2025-09-07
<![CDATA[
A molecular atlas of cell-type specific signatures in the parkinsonian striatum.
]]>
https://biorxiv.org/cgi/content/short/2025.09.09.675138v1?rss=1"
Graziano, M.Mantas, I.Masarapu, Y.Frapard, S.Garza, R.Adami, A.Fazal, S.Quaegebeur, A.Barker, R.Jakobsson, J.Giacomello, S.Meletis, K.2025-09-10doi:10.1101/2025.09.09.675138Cold Spring Harbor Laboratory Press2025-09-10
<![CDATA[
The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis
]]>
https://biorxiv.org/cgi/content/short/2025.10.13.682089v1?rss=1"
Mahoney-Sanchez, L.Clarke-Lucas, H.Penverne, A.Evans, J. R.D'Sa, K.Strohbuecker, S.Lopex Garcia, P.Cosker, K.Soltic, D.O'Callaghan, B. J.Griffiths, A.Pintchovski, S. A.Plun-Favreau, H.Hallqvist, J.Mills, K.Gandhi, S.2025-10-14doi:10.1101/2025.10.13.682089Cold Spring Harbor Laboratory Press2025-10-14
<![CDATA[
A framework for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
]]>
https://biorxiv.org/cgi/content/short/2025.10.24.684366v1?rss=1"
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]]>Adami, A.Garza, R.Dorazehi, F.Douse, C. H.Jakobsson, J.2025-10-28doi:10.1101/2025.10.24.684366Cold Spring Harbor Laboratory Press2025-10-28
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Extracellular space diffusion modelling identifies distinct functional advantages of archetypical glutamatergic and GABAergic synapse geometries
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Reconstitution of multistep recruitment of ULK1 to membranes in autophagy
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https://biorxiv.org/cgi/content/short/2025.11.07.687251v1?rss=1"
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Insights into the regulation of VPS13 family bridge-like lipid transfer proteins from the structure of VPS13C.
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Pathway and gates for ATG2A-mediated lipid transport in autophagy
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Cabezudo, A. C.Holzer, E.Martens, S.Hummer, G.2025-11-16doi:10.1101/2025.11.16.688672Cold Spring Harbor Laboratory Press2025-11-16
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A Multimodal Atlas Reveals the Anatomical Distribution of Medium Spiny Neuron Subtypes and a Novel RGS6+ Population in the Primate Striatum
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LRRK2 integrates Rab and GABARAP interactions to sense and respond to distinct lysosomal stresses
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Clegg, D.Bentley-DeSousa, A.Roczniak-Ferguson, A.Ferguson, S. M.2025-11-19doi:10.1101/2025.11.19.689251Cold Spring Harbor Laboratory Press2025-11-19
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Elucidating an anterior cingulate circuit for self-initiated actions and rescue of Parkinsonian akinesia
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Striatal ensembles specify and control granular forelimb actions
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Rodrigues-Vaz, I.Athalye, V. R.Peterka, D. S.Costa, R. M.2025-12-08doi:10.64898/2025.12.03.692128Cold Spring Harbor Laboratory Press2025-12-08
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Excitatory nicotinic signaling drives action potential bursting in dopaminergic axons
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Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
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Dundon, N. M.Rizor, E. J.Stasiak, J.Wang, J.Li, T.Sabugo, K.Villanueva, C.Barandon, P.Babenko, V.Beverly-Aylwin, R.Stump, A.Santander, T.Bostan, A. C.Lapate, R. C.Grafton, S. T.2025-12-23doi:10.64898/2025.12.21.695842Cold Spring Harbor Laboratory Press2025-12-23
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Cardiac-sympathetic state predicts action restraint, gated by demonstrated agency
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https://biorxiv.org/cgi/content/short/2025.12.29.696920v1?rss=1"
Dundon, N. M.Rizor, E. J.Stasiak, J.Wang, J.Babenko, V.Lapate, R. C.Grafton, S. T.2025-12-31doi:10.64898/2025.12.29.696920Cold Spring Harbor Laboratory Press2025-12-31
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System-wide profiling reveals metabolic alterations in a G2019S LRRK2 knockin mouse model of Parkinson's disease: systemic depletion of pyrimidine nucleosides
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https://biorxiv.org/cgi/content/short/2025.12.31.697225v1?rss=1"
Ma, Y.Erb, M. L.Sipple, K.Offerman, A.Moore, D. J.2026-01-02doi:10.64898/2025.12.31.697225Cold Spring Harbor Laboratory Press2026-01-02
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Myeloid PINK1 represses mtDNA release and immune signaling that impacts neuronal pathology in patient-derived idiopathic PD models
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https://biorxiv.org/cgi/content/short/2026.01.07.694713v1?rss=1"
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]]>Recinto, S. J.MacDonald, A.Premachandran, S.Liu, L.Bayati, A.Rodriguez, L.Nguyen, M.Petit, F.Mukherjee, S.Larmanjat, J.Allot, A.Yaqubi, M.McPherson, P. S.Durcan, T. M.Gruenheid, S.Trudeau, L.-E.Drouin-Ouellet, J.McBride, H. M.Stratton, J. A.2026-01-08doi:10.64898/2026.01.07.694713Cold Spring Harbor Laboratory Press2026-01-08
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Location and mapping of the human rostromedial tegmental nucleus and associated midbrain inhibitory nuclei regulating dopamine neurons
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https://biorxiv.org/cgi/content/short/2026.01.12.699117v1?rss=1"
Filimontseva, A.Fu, Y.Halliday, G.2026-01-12doi:10.64898/2026.01.12.699117Cold Spring Harbor Laboratory Press2026-01-12
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In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of a-synuclein Toxicity in Dopamine Neurons.
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https://biorxiv.org/cgi/content/short/2026.01.16.699530v1?rss=1"
Shonai, D.Kent, J.Okafor, A.Gao, Y.Parameswaran, P.Bustamante, E.Ramani, B.Diao, Y.Kampmann, M.Soderblom, E. J.Soderling, S. H.2026-01-17doi:10.64898/2026.01.16.699530Cold Spring Harbor Laboratory Press2026-01-17
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Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes
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https://biorxiv.org/cgi/content/short/2026.01.17.700056v1?rss=1"
Li, D.Zhang, W.Medina, M.Stuke, J. F. M.Schwarz, A.Brill, J.Brenner, J.Kraus, F.Ohlerich, S.Lizarrondo, J.Pflaum, J.Grass, J. H.Soltow, L.-M.Hammerschmid, D.Weber, N.Welsch, S.Langer, J.Windbergs, M.Harper, W. J.Schuman, E.Hummer, G.Grotjahn, D. A.Wilfling, F.2026-01-19doi:10.64898/2026.01.17.700056Cold Spring Harbor Laboratory Press2026-01-19
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An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement
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https://biorxiv.org/cgi/content/short/2026.01.20.700614v1?rss=1"
Bouabid, S.Vu, M.-A. T.Noggle, C.Vietti-Michelina, S.Brimblecombe, K.Platt, N.Zhang, L.Joshi, A.Cragg, S.Howe, M. W.2026-01-21doi:10.64898/2026.01.20.700614Cold Spring Harbor Laboratory Press2026-01-21
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Parkinsons disease modeling in regenerative spiny mice (Acomys dimidiatus) captures key disease-relevant behavioral, histological, and molecular signatures
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https://biorxiv.org/cgi/content/short/2025.11.06.687049v1?rss=1"
Dutta, S.Pang, M.Donahue, R. R.Chou, T.-F.Seifert, A. W.Gradinaru, V.2025-11-08doi:10.1101/2025.11.06.687049Cold Spring Harbor Laboratory Press2025-11-08
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Machine learning-based image analysis of Parkinson's disease iPS-derived neurons predicts genotype and reveals mitochondria-lysosome abnormalities
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https://biorxiv.org/cgi/content/short/2026.01.28.702423v1?rss=1"
Li, Y.Powell, M.Chedid, J.Sutharsan, R.Garrido, A. L.Abu-Bonsrah, D.Pavan, C.Fraser, T.Ovchinnikov, D.Zhong, M.Davis, R.Strbenac, D.Johnston, J. A.Thompson, L. H.Kirik, D.Parish, C. L.Halliday, G. M.Sue, C. M.Dzamko, N.Wali, G.2026-01-29doi:10.64898/2026.01.28.702423Cold Spring Harbor Laboratory Press2026-01-29
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Distinct amygdalar pathways to frontopolar cortex and medial temporal lobe support temporal memory for emotional events
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Wang, J.Stasiak, J. S.Dundon, N. M.Rizor, E.Barandon, P. L.Villanueva, C. M.Grafton, S. T.Lapate, R. C.2026-02-20doi:10.64898/2026.02.19.706842Cold Spring Harbor Laboratory Press2026-02-20
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Selective loss of Primary Cilia and Neurotrophic Signaling in G51D alpha-Synuclein Mice Highlights a Common Pathway to Parkinsons Disease
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Lin, Y.-E.Jaimon, E.Kim, Y.Loftman, A.Vijayakumaran, A.Belfort, B. D.Chiang, C. Y.Arenkiel, B. R.Zoghbi, H. Y. Y.Pfeffer, S. R.2026-02-25doi:10.64898/2026.02.25.708014Cold Spring Harbor Laboratory Press2026-02-25
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Neural Control of Autonomic Arousal During Threat Anticipation Revealed by High-Resolution Cardiac Contractility
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https://biorxiv.org/cgi/content/short/2026.02.23.707545v1?rss=1"
Stasiak, J. E.Wang, J.Dundon, N. M.Rizor, E. J.Barandon, P. L.Villanueva, C. M.Babenko, V.Li, T. L.Sabugo, K. M.Grafton, S. T.Lapate, R. C.2026-02-26doi:10.64898/2026.02.23.707545Cold Spring Harbor Laboratory Press2026-02-26