Channel:  Aligning Science Across Parkinson's (ASAP)

465 Articles

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Parkinson's disease-vulnerable and -resilient dopamine neurons display opposite responses to excitatory input
Hadjas, L. C., Kollman, G. J., Linderhof, L., Xia, M., Mansur, S., Saint-Pierre, M., Lim, B., Lee, E. B., Cicchetti, F., Awatramani, R., Hollon, N. G., Hnasko, T. S.
10.1101/2025.06.03.657460 — Posted: 2025-06-07
Bridging Pleiotropic Mechanisms in Leprosy Type-1 Reactions and Neurodegenerative diseases
Fava, V. M., Perico, J., Orlova, M., Dallmann-Sauer, M., Xu, Y. Z., Van Thuc, N., Thai, V. H., Belone, A. F., Latini, A. C. P., Schurr, E.
10.1101/2025.06.05.25329059 — Posted: 2025-06-06
RAB32-linked Parkinson's disease: Deep phenotyping, MDSGene literature review, and application of SynNeurGe criteria
Kleinz, T., Cavallieri, F., Borsche, M., Toschi, G., Valzania, F., Fioravanti, V., Valente, E. M., Mitrotti, P., Avenali, M., Zittel, S., Born, R., Matarazzo, M., Di Fonzo, A., Monfrini, E., Radefeldt, M., Santinelli, L., Griebner, N., Shambetova, C., Brand, M., Gabbert, C., Blauwendraat, C., Trinh, J., Beetz, C., Bauer, P., Brueggemann, N., Global Parkinson's Genetics Program (GP2), , Klein, C.
10.1101/2025.06.03.25328628 — Posted: 2025-06-03
Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockout
Goldman, C., Kareva, T., Sarrafha, L., Sahasrabudhe, A., Schuldt, B. R., Ahfeldt, T., Blanchard, J. W.
10.1101/2024.05.21.594886 — Posted: 2025-06-02
Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson's disease
Sah, S., Sauerbeck, A. D., Gupta, J., Perez-Acuna, D., Reiber, J. E., Russell, D., Goralski, T., Henderson, M., Volpicelli-Daley, L. A., Higley, M. J., Kummer, T. T., Biederer, T.
10.1101/2024.06.20.599774 — Posted: 2025-05-31
Movement-related activity in the internal globus pallidus of the parkinsonian macaque
Kase, D., Zimnik, A. J., Han, Y., Harsch, D. R., Bacha, S., Cox, K. M., Bostan, A. C., Richardson, R. M., Turner, R. S.
10.1101/2024.08.29.610310 — Posted: 2025-05-30
Sex-dimorphic effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson's disease
D'Addario, S. L., Massaro Cenere, M., Cossa, F., Scaricamazza, S., Nesci, V., D'Ottavio, G., Caprioli, D., Ferri, A., Vila, M., Ledonne, A., Mercuri, N. B.
10.1101/2025.04.18.649338 — Posted: 2025-05-27
Genome-wide assessment identifies novel runs of homozygosity linked to Parkinson's disease etiology across diverse ancestral populations
Step, K., Hernandez, C. F., Eltaraifee, E., Hernandez-Medrano, A. J., Kung, P.-J., Ostrozovicova, M., Zirra, A., Perez-Palma, E., Mencacci, N. E., Keller Sarmiento, I. J., Morris, H., Mata, I., Global Parkinson's Genetics Program, , Acosta-Uribe, J., Fang, Z.-H., Bandres Ciga, S.
10.1101/2025.05.21.25328076 — Posted: 2025-05-22
Repetitive Levodopa Treatment Drives Cell Type-Specific Striatal Adaptations Associated With Progressive Dyskinesia in Parkinsonian Mice
Paz, R. M., Ryan, M. B., Marcott, P. F., Girasole, A. E., Faryean, J., Duong, V., Sridhar, S., Nelson, A. B.
10.1101/2025.05.16.654598 — Posted: 2025-05-21
Drug Repurposing for Parkinson's Disease: A Large-Scale Multi-Cohort Study
Hu, Y., Liu, W., Waits, M., Zhao, Y., Olivero-Acosta, M. I., Zhang, L., Scherzer, C. R., Dong, X.
10.1101/2025.05.20.25327943 — Posted: 2025-05-21

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