Channel:  Aligning Science Across Parkinson's (ASAP)

476 Articles

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A molecular atlas of cell-type specific signatures in the parkinsonian striatum.
Graziano, M., Mantas, I., Masarapu, Y., Frapard, S., Garza, R., Adami, A., Fazal, S., Quaegebeur, A., Barker, R., Jakobsson, J., Giacomello, S., Meletis, K.
10.1101/2025.09.09.675138 — Posted: 2025-09-10
TDP-43 loss of function drives aberrant splicing in Parkinson's disease
Brenton, J. W., Follett, J., Nirujogi, R., Toomey, C. E., Lopez-Garcia, P., Evans, J. R., Lee, Y. J., Syed, K. M., Rocamora Perez, G., Fairbrother-Browne, A., D'Sa, K., Grant-Peters, M., Lachica, J., Hicks, A. R., Wagen, A. Z., O'Callaghan, B., Macpherson, H., Montgomery, K.-a., Busquets, O., Reynolds, R. H., Garcia Ruiz, S., Cao, T., Chen, Z., Plun-Favreau, H., Wong, P. C., Farrer, M., Lashley, T., Soldner, F., Hockemeyer, D., Alessi, D., Wood, N. W., Hardy, J., Rio, D. C., Jaunmuktane, Z., Gustavsson, E. K., Gandhi, S., Ryten, M.
10.1101/2025.09.04.673943 — Posted: 2025-09-09
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Garza, R., Adami, A., Thiruvalluvan, A., Wijesinghe, S., Curle, A. J., Tam, O., Forcier, T., Lagka, D. A., Kazakou, N. L., Atacho, D. A. M., Sharma, Y., Jonsson, M. E., Horvath, V., Bermudez, S., Johansson, J. G., Rainbow, D. B., Castilla-Vallmanya, L., Jones, J. L., Quaegebeur, A., Gale Hammell, M., Kirkeby, A., Barker, R. A., Jakobsson, J.
10.1101/2025.09.03.673956 — Posted: 2025-09-07
Proteome-wide impact of LRRK1 and 2 inhibitors on protein interactions and phosphorylation
Jansen, J., Wendel, M., Raig, N. D., Kraus, T. V., Surridge, K. J., Mahesula, S., Richter-Muller, N., Mathea, S., Reck-Peterson, S. L., Knapp, S., Stengel, F.
10.1101/2025.09.03.674114 — Posted: 2025-09-07
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons
Chen, C., He, Q., Tombesi, G., Napier, E., Jaconelli, M., Moreno-Ramos, O., Serio, H., Naaldijk, Y., Promes, V., Schneeweis, A., Quinn, K., Nasios, C., Greggio, E., Kozorovitskiy, Y., Arango, D., Khan, A. R., Alessi, D. R., Dombeck, D. A., Hilfiker, S., Awatramani, R., Parisiadou, L.
10.1101/2025.08.28.672006 — Posted: 2025-09-03
The LRRK2 p.A419V variant associates with risk of Parkinson disease in the East Asian population and an evaluation on age of onset
Lim, K. S., Perinan, M. T., Chew, E. G. Y., Lee, P. S., Akcimen, F., Lim, J. L., Koretsky, M. J., Funayama, M., Yoshino, H., Hattori, N., Kaiyrzhanov, R., Houlden, H., Isayan, M., Tay, Y. W., Toh, T. S., Lit, L.-C., Khairul Anuar, A. N., Ding, H. X., Screven, L., Mohamed Ibrahim, N., Lin, C.-H., Kim, H.-J., Lee, J.-Y., Chung, S. J., Foo, J. N., Tan, E.-K., Lim, S.-Y., Tan, A. H., Bandres Ciga, S., Ahmad-Annuar, A., Global Parkinson's Genetics Program (GP2)
10.1101/2025.08.28.25333987 — Posted: 2025-09-02
Increased serum Neurofilament light chain levels in Parkinson's Disease patients carrying the p.A53T SNCA mutation: Data from the PPMI study
Papagiannakis, N., Simitsi, A. M., Koros, C., Stefanis, L., The Parkinson's Progression Markers Initiative
10.1101/2025.08.28.25334674 — Posted: 2025-08-29
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Evans, J. R., Grant-Peters, M., Beckwith, J. S., Toomey, C. E., Popovic, R., Breiter, J. C., Brenton, J. W., Fairbrother-Browne, A., Strohbuecker, S., Lachica, J., Rodriguez-Lopez, M., Brock, E. E., Fu, B., Nahidiazar, L., Lopez-Garcia, P., Ferguson, R., Saleeb, R. S., Lucas-Clarke, H., Penverne, A., D'Sa, K., Pang, C. W., Horrocks, M. H., Vendruscolo, M., Wood, N., Lee, S. F., Ryten, M., Gandhi, S.
10.1101/2025.08.25.671921 — Posted: 2025-08-28
TMEM175, SCARB2 and CTSB associations with Parkinson's disease risk across populations.
Sun, W., Schulte, C., Gasser, T., Tan, M., The Global Parkinson's Genetics Program (GP2)
10.1101/2025.08.17.25333823 — Posted: 2025-08-25
LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload
Goldman, A., Nguyen, M., Lanoix, J., Fahmy, A., Zhong Xu, Y., Schurr, E., Thibault, P., Desjardins, M., McBride, H.
10.1101/2025.08.25.672135 — Posted: 2025-08-25

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