Channel:  Aligning Science Across Parkinson's (ASAP)

449 Articles

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Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Garza, R., Adami, A., Thiruvalluvan, A., Wijesinghe, S., Curle, A. J., Tam, O., Forcier, T., Lagka, D. A., Kazakou, N. L., Atacho, D. A. M., Sharma, Y., Jonsson, M. E., Horvath, V., Bermudez, S., Johansson, J. G., Rainbow, D. B., Castilla-Vallmanya, L., Jones, J. L., Quaegebeur, A., Gale Hammell, M., Kirkeby, A., Barker, R. A., Jakobsson, J.
10.1101/2025.09.03.673956 — Posted: 2025-09-07
Tau, amyloid-beta and alpha-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology
Webster, J. M., Yang, Y.-T., Miller, A. T., Zane, A., Scholz, K., Stone, W. J., Corbin-Stein, N. J., Mudium, N., Won, W.-J., Stoll, A. C., Greathouse, K. M., Cooper, N. H., Long, L. F., Manuel, P. N., Herskowitz, J. H., Yacoubian, T. A., Tyrrell, D. J., Sandoval, I. M., Manfredsson, F. P., Kordower, J. H., Harms, A. S.
10.1101/2024.10.13.618101 — Posted: 2025-09-04
Comparison of Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson's Disease Mutations
Lee, Y. J., Syed, K., Busquets, O., Li, H., Dunnack, J., Bateup, H., Soldner, F., Hockemeyer, D., Rio, D.
10.1101/2024.02.28.582420 — Posted: 2025-09-04
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons
Chen, C., He, Q., Tombesi, G., Napier, E., Jaconelli, M., Moreno-Ramos, O., Serio, H., Naaldijk, Y., Promes, V., Schneeweis, A., Quinn, K., Nasios, C., Greggio, E., Kozorovitskiy, Y., Arango, D., Khan, A. R., Alessi, D. R., Dombeck, D. A., Hilfiker, S., Awatramani, R., Parisiadou, L.
10.1101/2025.08.28.672006 — Posted: 2025-09-03
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Evans, J. R., Grant-Peters, M., Beckwith, J. S., Toomey, C. E., Popovic, R., Breiter, J. C., Brenton, J. W., Fairbrother-Browne, A., Strohbuecker, S., Lachica, J., Rodriguez-Lopez, M., Brock, E. E., Fu, B., Nahidiazar, L., Lopez-Garcia, P., Ferguson, R., Saleeb, R. S., Lucas-Clarke, H., Penverne, A., D'Sa, K., Pang, C. W., Horrocks, M. H., Vendruscolo, M., Wood, N., Lee, S. F., Ryten, M., Gandhi, S.
10.1101/2025.08.25.671921 — Posted: 2025-08-28
TMEM175, SCARB2 and CTSB associations with Parkinson's disease risk across populations.
Sun, W., Schulte, C., Gasser, T., Tan, M., The Global Parkinson's Genetics Program (GP2)
10.1101/2025.08.17.25333823 — Posted: 2025-08-25
LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload
Goldman, A., Nguyen, M., Lanoix, J., Fahmy, A., Zhong Xu, Y., Schurr, E., Thibault, P., Desjardins, M., McBride, H.
10.1101/2025.08.25.672135 — Posted: 2025-08-25
Integrated Representations of Threat and Controllability in the Lateral Frontal Pole
Stasiak, J. E., Wang, J., Dundon, N. M., Rizor, E. J., Villanueva, C. M., Barandon, P. L., Grafton, S. T., Lapate, R. C.
10.1101/2025.08.24.671754 — Posted: 2025-08-24
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved TBM motif
Waschbuesch, D., Pal, P., Nirujogi, R. S., Cavin, M., Singh, J., Alessi, D. R., Khan, A. R.
10.1101/2025.08.19.670962 — Posted: 2025-08-24
α-Synuclein driven cell susceptibility in Parkinson's disease
Breiter, J. C., Beckwith, J. S., Brock, E. E., Lachica, J., Toomey, C. E., Fu, B., Ryten, M., Weiss, L. E., Wood, N. W., Gandhi, S., Vendruscolo, M., Lee, S. F.
10.1101/2025.08.19.670819 — Posted: 2025-08-23

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