Channel:  Aligning Science Across Parkinson's (ASAP)

477 Articles

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Multi-omics reveal critical differentiation target for Parkinsons' Disease-vulnerable midbrain dopaminergic neurons
Garcia Swinburn, R., Lyu, G., Kreutzmann, J. C., Xiong, A., Kojima, R., Abaurre, C., Tremolanti, C., Gellhaar, S., Uhlen, P., Svenningsson, P., Castelo Branco, G., Dagliyan, O., Salto, C., Arenas, E.
10.1101/2025.06.18.660098 — Posted: 2026-01-20
Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes
Li, D., Zhang, W., Medina, M., Stuke, J. F. M., Schwarz, A., Brill, J., Brenner, J., Kraus, F., Ohlerich, S., Lizarrondo, J., Pflaum, J., Grass, J. H., Soltow, L.-M., Hammerschmid, D., Weber, N., Welsch, S., Langer, J., Windbergs, M., Harper, W. J., Schuman, E., Hummer, G., Grotjahn, D. A., Wilfling, F.
10.64898/2026.01.17.700056 — Posted: 2026-01-19
In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of a-synuclein Toxicity in Dopamine Neurons.
Shonai, D., Kent, J., Okafor, A., Gao, Y., Parameswaran, P., Bustamante, E., Ramani, B., Diao, Y., Kampmann, M., Soderblom, E. J., Soderling, S. H.
10.64898/2026.01.16.699530 — Posted: 2026-01-17
The Global Landscape of Genetic Variation in Parkinson's disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance
Lange, L. M., Fang, Z.-H., Makarious, M. B., Kuznetsov, N., Atterling Brolin, K., Ballard, S., Bardien, S., Doquenia, M. L., Heutink, P., Houlden, H., Iwaki, H., Jasaityte, S., Jones, L., Junker, J., Kaiyrzhanov, R., Koretsky, M., Kumar, K. R., the Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD), , Leonard, H., Levine, K., Lim, S.-Y., Mencacci, N. E., Mohamed, W. M. Y., Nalls, M. A., Noyce, A., Ojha, R., Okubadejo, N. U., Rehman, S. u., Screven, L., Shashkin, C., Sopromadze, S., Stafford, E. J., Tan, A. H., Tan, M., Tavadyan, Z., Trinh, J., Tserensodnom, B
10.1101/2025.07.08.25330815 — Posted: 2026-01-14
Location and mapping of the human rostromedial tegmental nucleus and associated midbrain inhibitory nuclei regulating dopamine neurons
Filimontseva, A., Fu, Y., Halliday, G.
10.64898/2026.01.12.699117 — Posted: 2026-01-12
Myeloid PINK1 represses mtDNA release and immune signaling that impacts neuronal pathology in patient-derived idiopathic PD models
Recinto, S. J., MacDonald, A., Premachandran, S., Liu, L., Bayati, A., Rodriguez, L., Nguyen, M., Petit, F., Mukherjee, S., Larmanjat, J., Allot, A., Yaqubi, M., McPherson, P. S., Durcan, T. M., Gruenheid, S., Trudeau, L.-E., Drouin-Ouellet, J., McBride, H. M., Stratton, J. A.
10.64898/2026.01.07.694713 — Posted: 2026-01-08
System-wide profiling reveals metabolic alterations in a G2019S LRRK2 knockin mouse model of Parkinson's disease: systemic depletion of pyrimidine nucleosides
Ma, Y., Erb, M. L., Sipple, K., Offerman, A., Moore, D. J.
10.64898/2025.12.31.697225 — Posted: 2026-01-02
Postsynaptic adaptations in direct pathway muscarinic M4-receptor signaling follow the temporal and regional pattern of dopaminergic degeneration
Nielsen, B., Ford, C.
10.1101/2025.03.03.641233 — Posted: 2025-3-10
Cardiac-sympathetic state predicts action restraint, gated by demonstrated agency
Dundon, N. M., Rizor, E. J., Stasiak, J., Wang, J., Babenko, V., Lapate, R. C., Grafton, S. T.
10.64898/2025.12.29.696920 — Posted: 2025-12-31
Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
Dundon, N. M., Rizor, E. J., Stasiak, J., Wang, J., Li, T., Sabugo, K., Villanueva, C., Barandon, P., Babenko, V., Beverly-Aylwin, R., Stump, A., Santander, T., Bostan, A. C., Lapate, R. C., Grafton, S. T.
10.64898/2025.12.21.695842 — Posted: 2025-12-23

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