Channel:  Aligning Science Across Parkinson's (ASAP)

499 Articles

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ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity
Coccia, E., Morrone Parfitt, G., Ijaz, S., Sati, A., Gesner, J., Perez Arevalo, A., Strong, J., Bright, A., Sohail, S., Meimoun, T., Ahfeldt, T., Vangheluwe, P., Blanchard, J.
10.64898/2026.04.02.716164 — Posted: 2026-04-06
Neural cell state modulation by PARK2 and dopaminergic neuroprotection by small molecule Parkin agonism
Gong, Y., Bayati, A., Alban, T. J., Parthasarathy, P., Zhou, F., Makarov, V., Zhao, Y., Su, C., Schumacher, J. G., Singh, V., Volpicelli-Daley, L. A., Luo, W., Durcan, T. M., Dutta, S., Schwarzschild, M. A., Johnston, J. A., Chan, T. A., Chen, X.
10.64898/2026.04.01.715918 — Posted: 2026-04-04
Utilizing Intraindividual Cognitive Variability to Predict Early Neuronal Synuclein Disease Progression
Combs, H. L., Kurth, R., Nair, A., York, M. K., Weintraub, D., Lafontant, D.-E., Caspell-Garcia, C., and the Parkinson's Progression Markers Initiative
10.1101/2025.10.21.25338482 — Posted: 2026-03-31
Genetic Identification of Dopamine Neurons Required for Circadian Food Anticipatory Activity in Mice
Villa, A., Trzeciak, J., Wolfe, D., Ehichioya, D., Falkenstein, J., Wong, J. T., Dimalanta, L., Kaiban, W., Dhanoa, J., Stevens, G., Garcia, F., Scarpa, L., Chalfoun, C., Zweifel, L., Awatramani, R., Palmiter, R., Darvas, M., Yamazaki, S., Steele, A.
10.64898/2026.03.27.714759 — Posted: 2026-03-31
Rise-and-fall dynamics reveal a molecular and cellular vulnerability axis in prion-like α-synuclein propagation
Alexandersen, C. G., Brynildsen, J. K., Prigent, A., Tamborrino, M., Mantziou, A., Kurgat, K., Henderson, M. X., Bassett, D. S.
10.64898/2026.03.27.714785 — Posted: 2026-03-31
Molecularly-guided spatial proteomics captures single-cell identity of the healthy and diseased nervous system
Dutta, S., Pang, M., Coughlin, G. M., Gudavalli, S., Roukes, M. L., Chou, T.-F., Gradinaru, V.
10.1101/2025.02.10.637505 — Posted: 2026-03-30
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson's disease vulnerable dopamine axons
Chen, C., He, Q., Tombesi, G., Napier, E., Jaconelli, M., Moreno-Ramos, O., Serio, H., Naaldijk, Y., Promes, V., Schneeweis, A., Quinn, K., Nasios, C., Greggio, E., Kozorovitskiy, Y., Arango, D., Khan, A. R., Alessi, D. R., Dombeck, D. A., Hilfiker, S., Awatramani, R., Parisiadou, L.
10.1101/2025.08.28.672006 — Posted: 2026-03-28
A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and Intervention
Marciano, S., Velazquez, L. G., Rodriguez Lopez, C., De Silva, N., Sommer, G., Tower, W., Torrres, E. R. S., Kaplitt, M. G., Milner, T. A., Marongiu, R.
10.64898/2026.03.20.712963 — Posted: 2026-03-24
Integrating Long-Read Structural Variant Analysis with single-nucleus RNA-seq to Elucidate Gene Expression Effects in Disease
Kim, K., Lin, Z., Simmons, S. K., Parker, J., Kearney, M., Liao, Z., Haywood, N., Zhang, J., Cline, M. P., Tuncali, I., Sharma, M., Serrano, G. E., Beach, T. G., Dong, X., Popic, V., Scherzer, C. R., Levin, J. Z.
10.64898/2026.03.20.713192 — Posted: 2026-03-23
A human lysosomal storage disorder toolkit for decoding proteome landscapes in cortical and dopaminergic-like induced neurons
Kraus, F., He, Y., Jiang, Y., Li, D., Ambaw, Y. A., Gasparoli, F. M., Paulo, J. A., Walther, T. C., Farese, R., Gygi, S. P., Wilfling, F., Harper, J. W.
10.1101/2025.10.08.681047 — Posted: 2026-03-23

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