Channel:  Aligning Science Across Parkinson's (ASAP)

bioRxiv posts many COVID19-related papers. A reminder: they have not been formally peer-reviewed and should not guide health-related behavior or be reported in the press as conclusive.

246 Articles

The annotation and function of the Parkinson's and Gaucher disease-linked gene GBA1 has been concealed by its protein-coding pseudogene GBAP1
Gustavsson, E. K., Sethi, S., Gao, Y., Brenton, J., Garcia Ruiz, S., Zhang, D., Garza, R., Reynolds, R. H., Evans, J. R., Chen, Z., Grant-Peters, M., MacPherson, H., Montgomery, K., Dore, R., Wernick, A. I., Arber, C., Wray, S., Gandhi, S., Esselborn, J., Blauwendraat, C., Douse, C. H., Adami, A., Atacho, D. A. M., Kouli, A., Quaegebeur, A., Barker, R. A., Englund, E., Platt, F. M., Jakobsson, J., Wood, N. W., Houlden, H., Saini, H., Bento, C. F., Hardy, J., Ryten, M.
10.1101/2022.10.21.513169 — Posted: 2023-03-21
Proteomics analysis of autophagy cargos reveals distinct adaptations in PINK1 and LRRK2 models of Parkinson disease
Goldsmith, J., Ordureau, A., Boecker, C. A., Arany, M., Harper, J. W., Holzbaur, E. L.
10.1101/2022.10.03.510717 — Posted: 2023-12-13
PARK15/FBXO7 is dispensable for PINK1/Parkin-dependent mitophagy in iNeuron and HeLa cell systems
Kraus, F., Goodall, E. A., Smith, I. R., Jiang, Y., Paoli, J. C., Adolf, F., Zhang, J., Paulo, J. A., Schulman, B. A., Harper, J. W.
10.1101/2022.11.02.514817 — Posted: 2023-04-15
Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons
Virdi, G. S., Choi, M. L., Evans, J. R., Yao, Z., Athauda, D., Strohbuecker, S., Wernick, A. I., Alrashidi, H., Melandri, D., Perez-lloret, J., Stroh, P. R., Sylantyev, S., Eaton, S., Heales, S., Kunath, T., Horrocks, M. H., Abramov, A. Y., Patani, R., Gandhi, S.
10.1101/2022.10.28.514238 — Posted: 2022-10-28
Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease
Schonhoff, A. M., Figge, D. A., Jurkuvenaite, A. J., Gallups, N. J., Childers, G. M., Webster, J. A., Standaert, D. G., Goldman, J. E., Harms, A. S.
10.1101/2022.10.12.511960 — Posted: 2022-10-16
Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
Dou, D., Smith, E. M., Evans, C. S., Boecker, C. A., Holzbaur, E. L. F.
10.1101/2022.11.14.516471 — Posted: 2022-11-14
Golgi-IP, a novel tool for multimodal analysis of Golgi molecular content
Fasimoye, R., Dong, W., Nirujogi, R. S., Rawat, E. S., Iguchi, M., Nyame, K., Phung, T. K., Bagnoli, E., Prescott, A. R., Alessi, D. R., Abu-remaileh, M.
10.1101/2022.11.22.517583 — Posted: 2022-11-23
Temporal landscape of mitochondrial proteostasis governed by the UPRmt
Uoselis, L., Lindblom, R., Skulsuppaisarn, M., Khuu, G., Nguyen, T. N., Rudler, D. L., Filipovska, A., Schittenhelm, R. B., Lazarou, M.
10.1101/2022.11.30.518286 — Posted: 2022-11-30
Sex-specific microglial responses to glucocerebrosidase inhibition: relevance to GBA1-linked Parkinson disease
Ciana, P., Brunialti, E., Villa, A., Toffoli, M., Lucas Del Pozo, S., Rizzi, N., Meda, C., Maggi, A. C., Schapira, A. H. V.
10.1101/2022.12.05.519143 — Posted: 2022-12-05
Rapid iPSC inclusionopathy models shed light on formation, consequence and molecular subtype of alpha-synuclein inclusions
Lam, I., Ndayisaba, A., Lewis, A. J., Fu, Y., Sagredo, G. T., Zaccagnini, L., Sandoe, J., Sanz, R. L., Vahdatshoar, A., Martin, T. D., Morshed, N., Ichihashi, T., Tripathi, A., Ramalingam, N., Oettgen-Suazo, C., Bartels, T., Schabinger, M., Hallacli, E., Jiang, X., Verma, A., Tea, C., Wang, Z., Hakozaki, H., Yu, X., Hyles, K., Park, C., Theunissen, T. W., Wang, H., Jaenisch, R., Lindquist, S., Stevens, B., Stefanova, N., Wenning, G., Luk, K. C., Sanchez Pernaute, R., Gomez-Esteban, J. C., Felsky, D., Kiyota, Y., Sahni, N., Yi, S. S., Chung, C.-Y., Stahlberg, H., Ferrer, I., Schoneberg, J., Ell
10.1101/2022.11.08.515615 — Posted: 2022-12-02

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