Channel:  Aligning Science Across Parkinson's (ASAP)

503 Articles

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Bidirectional regulation of glycoprotein nonmetastatic melanoma protein B by β-glucocerebrosidase deficiency in GBA1 isogenic dopaminergic neurons from a patient with Gaucher disease and parkinsonism
Chen, C., Ma, C., Sam, R., Lichtenberg, J., Chen, T., Hao, Y., Li, Z., Kowal, I., Andersh, K., Qi, Y. A., Perez, G., Hertz, E., Li, Y., Williams, D., Henderson, M. J., Park, M., Jiang, X., Jerez, P. A., Blauwendraat, C., Sidransky, E., Chen, Y.
10.1101/2025.06.23.661126 — Posted: 2025-06-25
Characterizing Parkinson's Disease Clinical and Biomarker Interactions in REM Sleep Behavior Disorder
Reddy, V. L., Esposito, S., Renkl, E., Benyakoub, A., Mead, K., Chrysostoum, C., Patel, S., Seibyl, J. P., Huang, Y., Koo, B. B., Cedarbaum, J. M.
10.1101/2025.05.16.25327469 — Posted: 2025-06-23
Sub-second analysis of locomotor activity in Parkinsonian mice
Berezhnoi, D., Chehade, H. D., Simms, G., Chen, L., SIVANVAYAL NARASIMHAN, K. K., Dravid, S., Chu, H.-Y.
10.1101/2024.12.26.630411 — Posted: 2025-06-18
Generation of knock-in Cre and FlpO mouse lines for precise targeting of striatal projection neurons and dopaminergic neurons
Albarran, E., Fushiki, A., Nelson, A., Ng, D., Chaimowitz, C., Nikoobakht, L., Sippy, T., Peterka, D. S., Costa, R. M.
10.1101/2025.06.15.659794 — Posted: 2025-06-15
Internalized α-synuclein fibrils become truncated and resist degradation in neurons while glial cells rapidly degrade α-synuclein fibrils.
Karim, M. R., Tiegs, E., Gasparini, E., Schlichte, R., Vermilyea, S. C., Lee, M. K.
10.1101/2024.06.05.597615 — Posted: 2025-06-11
Single-cell multiomics identifies both shared and unique features of immune dysfunction in Parkinson's disease and inflammatory bowel disease colon, plasma and stool
Bolen, M. L., Buendia, M., Shi, J., Staley, H., Kachergus, J. M., Efron, P. A., Park, G., Nagpal, R., Alvarez, S. D., Xue, Q.-S., McFarland, N. R., Zimmermann, E. M., Forsmark, C. E., Menees, K. B., Salas, A., Thompson, E. A., Tansey, M. G.
10.1101/2025.04.29.651228 — Posted: 2025-06-11
JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux
Nassar, L. M., Shi, x., Roczniak-Ferguson, A., Shen, H., Ferguson, S. M.
10.1101/2025.06.06.657909 — Posted: 2025-06-09
The age at onset of LRRK2 p.Gly2019Ser Parkinson's disease across ancestries and countries of origin
Lüth, T., Laabs, B.-H., Sendel, S., König, I. R., Caliebe, A., Noyce, A. J., Screven, L. A., Bardien, S., Farrer, M., Hentati, F., Klein, C., Ben Sassi, S., Trinh, J., Global Parkinson's Genetics Program (GP2)
10.1101/2025.06.04.25327685 — Posted: 2025-06-09
Genetic modulation of immune gene co-expression in the aged mouse hippocampus by the Apbb1ip locus
Tomkins, J. E., Methi, A., Bouland, G., Doludda, B., Murphy, K., Miller, J. A., Overall, R. W., Mozhui, K.
10.1101/2025.06.04.657838 — Posted: 2025-06-08
Parkinson's disease-vulnerable and -resilient dopamine neurons display opposite responses to excitatory input
Hadjas, L. C., Kollman, G. J., Linderhof, L., Xia, M., Mansur, S., Saint-Pierre, M., Lim, B., Lee, E. B., Cicchetti, F., Awatramani, R., Hollon, N. G., Hnasko, T. S.
10.1101/2025.06.03.657460 — Posted: 2025-06-07

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