Channel:  Aligning Science Across Parkinson's (ASAP)

403 Articles

Parkinson's Families Project: a UK-wide study of early onset and familial Parkinson's disease
Towns, C., Fang, Z.-H., Tan, M. M. X., Jasaityte, S., Schmaderer, T. M., Stafford, E. J., Pollard, M., Tilney, R., Hodgson, M., Wu, L., Labrum, R., Hehir, J., Polke, J., Lange, L. M., Schapira, A. H. V., Bhatia, K. P., Parkinsons Families Project (PFP) Study Group, , Global Parkinsons Genetics Program (GP2), , Singleton, A., Blauwendraat, C., Klein, C., Houlden, H., Wood, N. W., Jarman, P. R., Morris, H. R., Real, R.
10.1101/2023.12.05.23299397 — Posted: 2024-09-10
Presynapses are mitophagy pit stops that prevent axon degeneration
Lam, W. K., Lindblom, R. S. J., Milky, B., Mazzachi, P., Hadian-Jazi, M., Kung, C., Khuu, G., Uoselis, L., Nguyen, T. N., Skulsuppaisarn, M., Saunders, T. L., Schmidt, M. F., Dewson, G., Fogel, A. I., Bardy, C., Lazarou, M.
10.1101/2024.09.09.611943 — Posted: 2024-09-09
The mitochondrial unfolded protein response promotes senescence in human microglia by increasing S-adenosylmethionine availability for polyamine synthesis.
Perez Jimenez, M. J., Bertoli, F., Raji, H., Lam, A., Bosch, M., Weissleder, C., Nemazanyy, I., Kalb, S., Hirschberg, I., Brunetti, D., Heckenbach, I., Scheibye-Knudsen, M., Deleidi, M.
10.1101/2024.09.03.610925 — Posted: 2024-09-03
CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism
Liao, S.-C., Kano, K., Phanse, S., Nguyen, M., Margolis, E. B., Fu, Y., Meng, J., Moutaoufik, M. T., Chatterton, Z., Aoki, H., Simms, J., Hsieh, I., Suteja, F., Sei, Y., Huang, E. J., McAvoy, K., Manfredi, G., Halliday, G., Babu, M., Nakamura, K.
10.1101/2024.08.30.610586 — Posted: 2024-09-01
Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery
Adriaenssens, E., Schaar, S., Cooke, A. S. I., Stuke, J. F. M., Sawa-Makarska, J., Nguyen, T. N., Ren, X., Schuschnig, M., Romanov, J., Khuu, G., Lazarou, M., Hummer, G., Hurley, J. H., Martens, S.
10.1101/2024.08.28.609967 — Posted: 2024-08-28
Behavioral screening defines three molecular Parkinsonism subgroups in Drosophila
Kaempf, N., Valadas, J. D. S., Robberechts, P., Schoovaerts, N., Praschberger, R., Ortega, A., Kilic, A., Chabot, D., Pech, U., Kuenen, S., Vilain, S., Baz, E.-S., Singh, J., Davis, J., Liu, S., Verstreken, P.
10.1101/2024.08.27.609924 — Posted: 2024-08-27
Peripheral Blood Immune Cells from Individuals with Parkinson's Disease or Inflammatory Bowel Disease Share Deficits in Iron Storage and Transport that are Modulated by Non-Steroidal Anti-Inflammatory Drugs
Bolen, M. L., Gomes, B. N., Gill, B., Menees, K. B., Staley, H., Jernigan, J., Tansey, M. G.
10.1101/2024.08.19.608634 — Posted: 2024-08-19
Modelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits
Laguna, A., Penuelas, N., Gonzalez-Sepulveda, M., Nicolau, A., Arthaud, S., Guilliard-Sirieix, C., Lorente-Picon, M., Compte, J., Miquel-Rio, L., Xicoy, H., Liu, J., Parent, A., Cuadros, T., Romero-Gimenez, J., Pujol, G., Gimenez-Llort, L., Fort, P., Bortolozzi, A., Carballo-Carbajal, I., Vila, M.
10.1101/2023.08.08.552400 — Posted: 2024-08-14
Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation
Chen, L., Chehade, H. D., Chu, H.-Y.
10.1101/2024.07.24.604995 — Posted: 2024-08-14
Development of a Simplified Smell Test to Identify Patients with Typical Parkinson's as Informed by Multiple Cohorts, Machine Learning and External Validation
Li, J., Grimes, K., Saade, J., Tomlinson, J. J., Mestre, T., Schade, S., Weber, S., Dakna, M., Wicke, T., Lang, E., Trenkwalder, C., Salmaso, N., Frank, A., Ramsay, T., Manuel, D., Investigators, a.-P., Mollenhauer, B., Schlossmacher, M. G.
10.1101/2024.08.09.24311696 — Posted: 2024-08-09

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