Channel:  Aligning Science Across Parkinson's (ASAP)

537 Articles

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A framework for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
Adami, A., Garza, R., Dorazehi, F., Douse, C. H., Jakobsson, J.
10.1101/2025.10.24.684366 — Posted: 2026-01-22
An anatomical hotspot for striatal dopamine-acetylcholine interactions during reward and movement
Bouabid, S., Vu, M.-A. T., Noggle, C., Vietti-Michelina, S., Brimblecombe, K., Platt, N., Zhang, L., Joshi, A., Cragg, S., Howe, M. W.
10.64898/2026.01.20.700614 — Posted: 2026-01-21
Multi-omics reveal critical differentiation target for Parkinsons' Disease-vulnerable midbrain dopaminergic neurons
Garcia Swinburn, R., Lyu, G., Kreutzmann, J. C., Xiong, A., Kojima, R., Abaurre, C., Tremolanti, C., Gellhaar, S., Uhlen, P., Svenningsson, P., Castelo Branco, G., Dagliyan, O., Salto, C., Arenas, E.
10.1101/2025.06.18.660098 — Posted: 2026-01-20
Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes
Li, D., Zhang, W., Medina, M., Stuke, J. F. M., Schwarz, A., Brill, J., Brenner, J., Kraus, F., Ohlerich, S., Lizarrondo, J., Pflaum, J., Grass, J. H., Soltow, L.-M., Hammerschmid, D., Weber, N., Welsch, S., Langer, J., Windbergs, M., Harper, W. J., Schuman, E., Hummer, G., Grotjahn, D. A., Wilfling, F.
10.64898/2026.01.17.700056 — Posted: 2026-01-19
In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of a-synuclein Toxicity in Dopamine Neurons.
Shonai, D., Kent, J., Okafor, A., Gao, Y., Parameswaran, P., Bustamante, E., Ramani, B., Diao, Y., Kampmann, M., Soderblom, E. J., Soderling, S. H.
10.64898/2026.01.16.699530 — Posted: 2026-01-17
Genome-Wide Association and Population-Tailored Polygenic Risk for Parkinson's Disease in Taiwan
Chu, Y.-T., Su, Y.-A., Lin, C.-H., Tai, C.-H., Wu, Y.-R., Hong, C.-T., Chen, Y.-W., Tsai, M.-H., Hardy, J., Wu, R.-M. R., Mok, K.-Y., East Asian Parkinson Disease Genomics Consortium, , Global Parkinson's Genetics Program
10.64898/2026.01.14.26344088 — Posted: 2026-01-16
The Global Landscape of Genetic Variation in Parkinson's disease: Multi-Ancestry Insights into Established Disease Genes and their Translational Relevance
Lange, L. M., Fang, Z.-H., Makarious, M. B., Kuznetsov, N., Atterling Brolin, K., Ballard, S., Bardien, S., Doquenia, M. L., Heutink, P., Houlden, H., Iwaki, H., Jasaityte, S., Jones, L., Junker, J., Kaiyrzhanov, R., Koretsky, M., Kumar, K. R., the Latin American Research Consortium on the Genetics of Parkinson's Disease (LARGE-PD), , Leonard, H., Levine, K., Lim, S.-Y., Mencacci, N. E., Mohamed, W. M. Y., Nalls, M. A., Noyce, A., Ojha, R., Okubadejo, N. U., Rehman, S. u., Screven, L., Shashkin, C., Sopromadze, S., Stafford, E. J., Tan, A. H., Tan, M., Tavadyan, Z., Trinh, J., Tserensodnom, B
10.1101/2025.07.08.25330815 — Posted: 2026-01-14
Myeloid PINK1 represses mtDNA release and immune signaling that impacts neuronal pathology in patient-derived idiopathic PD models
Recinto, S. J., MacDonald, A., Premachandran, S., Liu, L., Bayati, A., Rodriguez, L., Nguyen, M., Petit, F., Mukherjee, S., Larmanjat, J., Allot, A., Yaqubi, M., McPherson, P. S., Durcan, T. M., Gruenheid, S., Trudeau, L.-E., Drouin-Ouellet, J., McBride, H. M., Stratton, J. A.
10.64898/2026.01.07.694713 — Posted: 2026-01-08
Shared and Sex-Specific Genetic Risk for Parkinson's Disease Risk Across European Populations
The Global Parkinson's Genetics Program (GP2), , Leonard, H. L.
10.64898/2025.12.29.25343160 — Posted: 2026-01-02
Cardiac-sympathetic state predicts action restraint, gated by demonstrated agency
Dundon, N. M., Rizor, E. J., Stasiak, J., Wang, J., Babenko, V., Lapate, R. C., Grafton, S. T.
10.64898/2025.12.29.696920 — Posted: 2025-12-31

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