Channel:  The Howard Hughes Medical Institute (HHMI)

2,006 Articles

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De novo design and structure of a peptide-centric TCR mimic binding module
Householder, K. D., Xiang, X., Jude, K. M., Deng, A., Obenaus, M., Wilson, S. C., Chen, X., Wang, N., Garcia, K. C.
10.1101/2024.12.16.628822 — Posted: 2025-04-14
Designed NGF mimetics with reduced nociceptive signatures in neurons
Schlichthaerle, T., Yang, A., Detraux, D., Johnson, D. E., Peach, C. J., Edman, N. I., Sniezek, C., Williams, C. A., Arora, S., Katiyar, N., Chen, I., Etemadi, A., Favor, A., Lee, D., Kubo, C., Coventry, B., Huang, B., Gerben, S., Ennist, N. M., Milles, L., Sankaran, B., Kang, A., Nguyen, H., Bera, A. K., Negahdari, B., Hamazaki, N., Schweppe, D. K., Stewart, L., Young, J. E., Bunnett, N. W., Ruohola-Baker, H., Mathieu, J., Pattwell, S., Garcia, K. C., Baker, D.
10.1101/2025.04.14.648806 — Posted: 2025-04-14
Computational Design of Metallohydrolases
Kim, D., Woodbury, S. M., Ahern, W., Tischer, D., Hanikel, N., Salike, S., Yim, J., Pellock, S. J., Lauko, A., Kalvet, I., Hilvert, D., Baker, D.
10.1101/2024.11.13.623507 — Posted: 2025-04-11
Atom level enzyme active site scaffolding using RFdiffusion2
Ahern, W., Yim, J., Tischer, D., Salike, S., Woodbury, S., Kim, D., Kalvet, I., Kipnis, Y., Coventry, B., Altae-Tran, H., Bauer, M., Barzilay, R., Jaakkola, T., Krishna, R., Baker, D. A.
10.1101/2025.04.09.648075 — Posted: 2025-04-10
OmniSplice: a framework-free splicing event reporter
Lannes, R., Fingerhut, J. M., Yamashita, Y. M. M.
10.1101/2025.04.06.647416 — Posted: 2025-04-08
Small-molecule modulation of Beta-arrestins
Kahsai, A. W., Pakharukova, N., Kwon, H. Y., Shah, K. S., Liang-Lin, J. G., del Real, C. T., Shim, P. J., Lee, M. A., Ngo, V. A., Shreiber, B. N., Liu, S., Schwalb, A. M., Espinoza, E. F., Thomas, B. N., Kunzle, C. A., Smith, J. S., Wang, J., Kim, J., Zhang, X., Rockman, H. A., Thomsen, A. R. B., Rein, L. A. M., Shi, L., Ahn, S., Masoudi, A., Lefkowitz, R. J.
10.1101/2024.12.27.630464 — Posted: 2025-04-08
Biosynthesis of Macrocyclic Peptides by Formation and Crosslinking of ortho-Tyrosines
Padhi, C., Zhu, L., Chen, J. Y., Moreira, R., van der Donk, W. A.
10.1101/2025.04.04.647296 — Posted: 2025-04-08
Transitions in dynamical regime and neural mode underlie perceptual decision-making
Luo, T. Z., Kim, T. D., Gupta, D., Bondy, A. G., Kopec, C. D., Elliott, V. A., DePasquale, B., Brody, C.
10.1101/2023.10.15.562427 — Posted: 2025-04-07
Superinfection with intact HIV-1 results in conditional replication of defective proviruses and nonsuppressible viremia in people living with HIV-1
Hariharan, V., White, J. A., Dragoni, F., Fray, E. J., Pathoulas, N., Moskovljevic, M., Zhang, H., Singhal, A., Lai, J., Beg, S. A., Scully, E. P., Gilliams, E. A., Block, D. S., Keruly, J., Moore, R. D., Siliciano, J. D., Simonetti, F. R., Siliciano, R. F.
10.1101/2025.04.04.647291 — Posted: 2025-04-04
Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral Cortex
Shao, D. D., Zhao, Y., Brew, J., Ghosh, U., Luquette, L. J., Zhao, S., Kriz, A. J., Qian, X., Viswanadham, V. V., Taketomi, T., Tsuruta, F., Park, P. J., Walsh, C. A.
10.1101/2024.10.08.617159 — Posted: 2025-04-03

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