Channel:  The Howard Hughes Medical Institute (HHMI)

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Medulloblastoma-Associated KBTBD4 Mutations Disrupt PP2A-A Orphan Quality Control
Baur, R., Schneider, L. A., Sathe, G., Lunardi, T., Schneider, J., Krebs, A.-S., Silva, J. C., Haakonsen, D. L., Waszak, S. M., Lingner, J., Ciulli, A., Rape, M., Thoma, N. H.
10.64898/2026.03.02.709011 — Posted: 2026-03-03
Tissue-specific clonal selection and differentiation of CD4+ T cells during infection
Parsa, R., Carvalho de Assis, H., B.R. de Castro, T., Lima dos Reis, G., Sushil, A., Hartweger, H., Bilate, A., Mucida, D.
10.1101/2025.08.25.672130 — Posted: 2026-03-03
Derlin-mediated ERAD of lipid regulator ORMDL3 safeguards mitochondrial function
Scott, N. A., Afolabi, J., Marshall, A. G., Schafer, J. C., Baskerville, V. R., Prasad, P., Kadam, A. A., Som de Cerff, C., Whisenant, T., Phillips, M. A., Tomar, D., McReynolds, M., Hinton, A., Neal, S. E.
10.64898/2026.02.27.708653 — Posted: 2026-03-03
Somatic mutation in human cerebellum illustrates neuron type-specific patterns of age-related mutation
Essuman, K., Yang, Y., Goodman, E., Cambridge, C., Cai, C., An, Z., Mao, S., Manam, M. D., Finander, B., Khoshkhoo, S., Sun, L., Huang, A. Y., Walsh, C. A.
10.64898/2026.02.27.708647 — Posted: 2026-03-02
Structural Basis for C8 methylation of 23S ribosomal RNA by Cfr
Esakova, O. A., Jung, J., Lee, H., Cho, S. H., Alumasa, J. N., Schwalm, E., Grove, T. L., Bauerle, M., Hafenstein, S., Yu, Z., Booker, S.
10.64898/2026.02.27.707579 — Posted: 2026-03-02
Cell body clustering drives gap junction-mediated synchronous activity in command neurons
Lee, K., Graciani, J., Rico Carvajal, N., Zhu, Z., Clark, M., Doe, C.
10.64898/2026.02.26.708359 — Posted: 2026-03-02
mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion
Gentile, C., Feng, W. W., Lenahan, S. M., Ying, A. W., Card, D. C., Wu, F. T. H., Pham, N.-A., Radulovich, N., Cao, P. M., Hueniken, K., Li, Q., Tsao, M.-S., Kulesza, J., Hinkley, M. M., Liao, L., Tsai, J. A. < A., Kohler, J., Facchinetti, F., Li, J., Weston, C., Locquet, M.-A., Ngo, K., Gokhale, P. C., Sacher, A. G., Janne, P. A., Kadoch, C.
10.64898/2026.02.27.708377 — Posted: 2026-03-01
Structural basis of RNA-guided transcription by a dCas12f-σE-RNAP complex
Xiao, R., Hoffmann, F. T., Xie, D., Wiegand, T., Palmieri, A. I., Sternberg, S. H., Chang, L.
10.1101/2025.06.10.658880 — Posted: 2026-02-28
Vampire bats target their social grooming to hard-to-reach body parts
Chen, C., Nguyen, T. I., Meyer, M., Hashem, E., Carter, G. G.
10.64898/2026.02.25.707567 — Posted: 2026-02-28
Exapted CRISPR-Cas12f homologs drive RNA-guided transcription
Hoffmann, F. T., Wiegand, T., Palmieri, A. I., Glass-Klaiber, J., Xiao, R., Tang, S., Le, H. C., Meers, C., Lampe, G. D., Chang, L., Sternberg, S. H.
10.1101/2025.06.10.658865 — Posted: 2026-02-28

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