Channel:  The Howard Hughes Medical Institute (HHMI)

2,194 Articles

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Computational design of pH-sensitive binders
Ahn, G., Coventry, B., Sadre, S., Haefner, E., Hu, J., Van, M., Huang, B., Sappington, I. W., Broerman, A. J., Lichtenstein, M., Glögl, M., Goreshnik, I., Vafeados, D., Baker, D.
10.1101/2025.09.29.678932 — Posted: 2025-09-29
Cell-cycle-dependent repression of histone gene transcription by histone H4
Ahmad, K., Wooten, M., Takushi, B. N., Vidaurre, V., Chen, X., Henikoff, S.
10.1101/2024.12.23.630206 — Posted: 2025-09-29
Determination of Aedes mosquito mating success by a rapidly-evolving female-controlled lock-and-key mechanism
Houri-Zeevi, L., Walker, M. M., Razzauti, J., Sharma, A., Pasolli, H. A., Vosshall, L. B.
10.1101/2025.04.11.648401 — Posted: 2025-09-28
Modeling protein-small molecule conformational ensembles with PLACER
Anishchenko, I., Kipnis, Y., Kalvet, I., Zhou, G., Krishna, R., Pellock, S. J., Lauko, A., Lee, G. R., An, L., Dauparas, J., DiMaio, F., Baker, D.
10.1101/2024.09.25.614868 — Posted: 2025-09-27
Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy
Pakharukova, N., Thomas, B. N., Bansia, H., Li, L., Bassford, D. K., Abzalimov, R. R., Kim, J., Kahsai, A. W., Pani, B., Xiao, K., Ochakovski, R., Liu, S., Zhang, X., Ahn, S., des Georges, A., Lefkowitz, R. J.
10.1101/2024.07.31.605623 — Posted: 2025-09-27
Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning
Liu, Z., Qiu, C., Kubo, C. A., Xu, S., Daza, R. M., Nichols, E., Yang, W., Vo, A., O'Neill, M. B., Lee, C., Shendure, J., Hamazaki, N.
10.1101/2025.09.25.678678 — Posted: 2025-09-26
Atlas of Lysosomal Aging Reveals a Molecular Clock of Storage Disorder-Associated Metabolites
Puszynska, A. M., Nguyen, T. P., Cangelosi, A. L., Armani, A., Roberts, J. M., Singh, K. A., Cameron, J. C., Tseyang, T., Liu, G. Y., Lai, S., Sprenger, H.-G., Yang, J., Colgan, W. N., Kedir, J. F., Kajderowicz, K. M., Esantsi, T. K., Lu, Y. R., Waite, M., Kunchok, T., Lewis, C. A., Schulte, F., Bell, G. W., Sabatini, D. M., Weissman, J. S.
10.1101/2025.09.25.678303 — Posted: 2025-09-26
EPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity
Granat, J., Liu, S., Popoca, L., Oksuz, O., Reinberg, D.
10.1101/2025.09.25.678634 — Posted: 2025-09-25
Simulated climate change magnifies genetic vulnerabilities from mutation load and maladaptation
Leventhal, L., Ruffley, M. R., Carnegie Field Consortium, , Exposito-Alonso, M.
10.1101/2025.09.25.677362 — Posted: 2025-09-25
Regulation of Glypican 6-mediated Wnt activation maintains TDP-43 nuclear localization in neurons
Zhang, N., Sockanathan, S.
10.1101/2025.09.24.678385 — Posted: 2025-09-25

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