Channel:  The Howard Hughes Medical Institute (HHMI)

1,923 Articles

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IL-25-induced memory ILC2s mediate long-term small intestinal adaptation
Cortez, V. S., Viragova, S., Koga, S., Liu, M., O'Leary, C., Ricardo-Gonzalez, R. R., Schroeder, A. W., Kochhar, N., Klein, O., Diamond, M., Liang, H.-E., Locksley, R. M.
10.1101/2025.03.25.645270 — Posted: 2025-03-29
Synaptic editing of frontostriatal circuitry prevents excessive grooming in SAPAP3-deficient mice
Walder-Christensen, K. K., Soliman, H. A., Calakos, N., Dzirasa, K.
10.1101/2025.03.27.645613 — Posted: 2025-03-29
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Agarwal, G., Antoszewski, M., Xie, X., Pershad, Y., Arora, U. P., Poon, C.-L., Lyu, P., Lee, A. J., Guo, C.-J., Ye, T., Norford, L. B., Neehus, A.-L., della Volpe, L., Wahlster, L., Ranasinghe, D., Ho, T.-C., Barlowe, T. S., Chow, A., Schurer, A., Taggart, J., Durham, B. H., Abdel-Wahab, O., McGraw, K. L., Allan, J. M., Soldatov, R., Bick, A. G., Kharas, M. G., Sankaran, V. G.
10.1101/2025.03.24.645017 — Posted: 2025-03-26
Long-term editing of brain circuits in mice using an engineered electrical synapse
Ransey, E., Thomas, G., Wisdom, E., Almoril-Porras, A., Bowman, R., Adamson, E., Walder-Christensen, K. K., White, J. A., Hughes, D. N., Schwennesen, H., Ferguson, C., Tye, K., Mague, S. D., Niu, L.-G., Wang, Z.-W., Colon-Ramos, D., Hultman, R., Bursac, N., Dzirasa, K.
10.1101/2025.03.25.645291 — Posted: 2025-03-26
Delphy: scalable, near-real-time Bayesian phylogenetics for outbreaks
Varilly, P., Schifferli, M., Yang, K., Burcham, T., Cronan, P., Glennon, O., Jacks, O., Laning, E., Marrs, L., Oba, K., Yeung, S., Parker, E., Omah, I., Pekar, J. E., Luebbert, L., Andersen, K. G., Park, D. J., Schaffner, S. F., MacInnis, B. L., Happi, C., Lemieux, J. E., Ozonoff, A., Mitzenmacher, M. D., Fry, B., Sabeti, P. C.
10.1101/2025.03.25.645253 — Posted: 2025-03-26
Addendum to Ancient DNA data from Mengzi Ren, a Late Pleistocene individual from Southeast Asia, cannot be reliably used in population genetic analysis
Tabin, D. R., Patterson, N. J., Mah, M., Reich, D. E.
10.1101/2025.03.24.645126 — Posted: 2025-03-26
Directed evolution expands CRISPR-Cas12a genome editing capacity
Ma, E., Chen, K., Shi, H., Wasko, K. M., Esain-Garcia, I., Trinidad, M. I., Zhou, K., Ye, J., Doudna, J. A.
10.1101/2025.03.26.645588 — Posted: 2025-03-26
Population and adaptation history of 739 Thlaspi arvense natural accessions
Wu, X., Epstein, R., Esfahanian, M., Gautam, B., Griffiths, M., Perez, J., Barry, K., Lipzen, A., Daum, C., Yoshinaga, Y., Abeyratne, C. R., Akhmetov, Z., Arana, S. T., Bayliss, R., Borphukan, B., Brusa, A., Chhetri, H., Combs-Giroir, R., Czech, L., Dyderski, M. K., Gjesvold, E. S., Grzejszczak, G., Hateley, S., Heller, N., Hoffmann, D., Jaikumar, N., Jarvis, B. A., Jawahir, V., Klisz, M., Kruse, P., Lane, M., Lima, A., Liu, A., Madrid, G., Marlino, M., McGinn, M., Pavicic, M., Perry, W., Shah, M., Thomas, J., Townsend, A., Wanigarathna, T. L., Wesley, T., Connolly, B., Lim, Y. P., Puchałka, R
10.1101/2025.03.21.644658 — Posted: 2025-03-25
Membrane-associated polymerases deliver most of the actin subunits to a lamellipodial network
Skruber, K., Sept, D., Mullins, D.
10.1101/2025.03.24.645090 — Posted: 2025-03-25
Long-term hunter-gatherer continuity in the Rhine-Meuse region was disrupted by local formation of expansive Bell Beaker groups
Olalde, I., Altena, E., Bourgeois, Q., Fokkens, H., Amkreutz, L., Deguilloux, M.-F., Fichera, A., Flas, D., Gandini, F., Kegler, J. F., Kootker, L. M., Leijnse, K., Kooijmans, L. L., Lauwerier, R., Miller, R., Molthof, H., Noiret, P., Raemaekers, D. C. M., Rivollat, M., Smits, L., Stewart, J. R., ten Anscher, T., Toussaint, M., Callan, K., Cheronet, O., Frost, T., Iliev, L., Mah, M., Micco, A., Oppenheimer, J., Patterson, I., Qiu, L., Soos, G., Workman, J. N., Edwards, C. J., Lazaridis, I., Mallick, S., Patterson, N., Rohland, N., Richards, M. B., Pinhasi, R., Haak, W., Pala, M., Reich, D.
10.1101/2025.03.24.644985 — Posted: 2025-03-25

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