Channel:  The Howard Hughes Medical Institute (HHMI)

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Large-scale discovery of neural enhancers for cis-regulation therapies
McDiarmid, T. A., Page, N. F., Chardon, F. M., Daza, R. M., Chen, G. T., Kosicki, M., James, L. M., Nourie, H. C., Laboy-Cintron, D., Lee, A. S., Vij, P., Calderon, D., Lalanne, J.-B., Martin, B. K., Fink, K., Talkowski, M. E., Muotri, A. R., Philpot, B. D., Pennacchio, L. A., Geschwind, D. H., Sanders, S. J., Ahituv, N., Shendure, J.
10.1101/2025.11.04.686611 — Posted: 2025-11-05
Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation
Carroll, S. L., Ly, A., Liu, A. K., Canesso, M. C. C., Victora, G. D., Mucida, D., Barton, G. M.
10.1101/2025.11.04.686414 — Posted: 2025-11-05
Chromosome-scale genome assembly and annotation of the two-spotted cricket Gryllus bimaculatus (Orthoptera: Gryllidae)
Kataoka, K., Sanno, R., Gaczorek, T., Bhattarai, U. R., Ito, Y., Inoue, S., Yura, K., Asahi, T., Ylla, G., Mito, T., Extavour, C. G.
10.1101/2025.10.31.685973 — Posted: 2025-11-03
A membrane-bound nuclease directly cleaves phage DNA during genome injection
Saxton, D. S., Deweirdt, P. C., Doering, C. R., Roney, I. J., Laub, M. T.
10.1101/2025.11.03.685801 — Posted: 2025-11-03
Blind Prediction of Complex Water and Ion Ensembles Around RNA in CASP16
Kretsch, R. C., Posani, E., Baulin, E. F., Bujnicki, J. M., Bussi, G., Cheatham, T. E., Chen, S.-J., Elofsson, A., Farsani, M. A., Fisher, O. N., Gromiha, M. M., Gupta, A., Hamada, M., Harini, K., Hu, G., Huang, D., Iwakiri, J., Jain, A., Kagaya, Y., Kihara, D., Kmiecik, S., Krishnan, S. R., Kurisaki, I., Languin-Cattoen, O., Li, J., Li, S., Malekzadeh, K., Nakamura, T., Ni, W., Nithin, C., Palo, M. Z., Park, J. H., Pilla, S. P., Poblete, S., Pucci, F., Punuru, P., Saha, A., Sato, K., Srivastava, A., Terashi, G., Tugolukova, E., Verburgt, J., Wuyun, Q., Zerze, G. H., Zhang, K., Zhang, S., Zhen
10.1101/2025.11.03.685595 — Posted: 2025-11-03
B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes
Zhou, P., Hartweger, H., MacLean, A. J., Ramos, V., Yao, K.-h., Hernandez, B., Wang, Z., Gazumyan, A., Nussenzweig, M. C.
10.1101/2025.10.30.685663 — Posted: 2025-11-01
Co-opting the bacterial lipoprotein pathway in the biosynthesis of a lipidated macrocyclic peptide
Chen, J. Y., Zhu, L., Zhang, K. Y., Berthold, D. A., van der Donk, W. A.
10.1101/2025.10.31.685832 — Posted: 2025-11-01
Adapting CRISPR-associated transposons for rapid and high-throughput reverse genetics
Basta, D. W., Zingl, F. G., Yang, Y., Nguyen, K. T., Liu, Y.-Y., Waldor, M. K.
10.1101/2025.10.31.685825 — Posted: 2025-11-01
De novo design of metal-oxide templating proteins
Saragovi, A., Pyles, H., Huddy, T. F., Li, X., Borst, A. J., Hanikel, N., Courbet, A., Kwon, P., Davila-Hernandez, F. A., Kibler, R. D., Vafeados, D. K., Allen, A., Carr, K. D., Bera, A., Kang, A., Brackenbrough, E., Schmid, S., Bae, Y., Stewart, L., Zhang, S., De Yoreo, J., Baker, D.
10.1101/2024.06.24.600095 — Posted: 2025-11-01
Specialized parallel pathways for adaptive control of visual object pursuit
Collie, M. F., Jin, C., Rockwell, V., Kellogg, E., Vanerbeck, Q. X., Hartman, A. K., Holtz, S. L., Wilson, R. I.
10.1101/2025.04.23.650240 — Posted: 2025-11-01

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