Channel:  The Howard Hughes Medical Institute (HHMI)

2,124 Articles

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Mechanistic insights into direct DNA and RNA strand transfer and dynamic protein exchange of SSB and RPA
Paul, T., Lee, I.-R., Pangeni, S., Rashid, F., Yang, O., Antony, E., Berger, J. M., Myong, S., Ha, T.
10.1101/2025.04.01.643995 — Posted: 2025-04-01
Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulation
Song, J. H., Carter, A. C., Bushinsky, E. M., Beck, S. G., Petrocelli, J. E., Koreman, G. T., Babu, J., Kingsley, D. M., Greenberg, M. E., Walsh, C. A.
10.1101/2025.03.31.646367 — Posted: 2025-03-31
In-Situ High-Resolution Cryo-EM Reconstructions from CEMOVIS
Elferich, J., Kaminek, M., Kong, L., Odriozola, A., Kukulski, W., Zuber, B., Grigorieff, N.
10.1101/2025.03.29.646093 — Posted: 2025-03-31
Glutamate indicators with increased sensitivity and tailored deactivation rates
Aggarwal, A., Negrean, A., Chen, Y., Iyer, R., Reep, D., Liu, A., Palutla, A., Xie, M. E., MacLennan, B., Hagihara, K. M., Kinsey, L. W., Sun, J. L., Yao, P., Zheng, J., Tsang, A., Tsegaye, G., Zhang, Y., Patel, R. H., Arthur, B. J., Hiblot, J., Leippe, P., Tarnawski, M., Marvin, J. S., Vevea, J. D., Turaga, S. C., Tebo, A. G., Carandini, M., Rossi, L. F., Kleinfeld, D., Konnerth, A., Svoboda, K., Turner, G. C., Hasseman, J., Podgorski, K.
10.1101/2025.03.20.643984 — Posted: 2025-03-31
IL-25-induced memory ILC2s mediate long-term small intestinal adaptation
Cortez, V. S., Viragova, S., Koga, S., Liu, M., O'Leary, C., Ricardo-Gonzalez, R. R., Schroeder, A. W., Kochhar, N., Klein, O., Diamond, M., Liang, H.-E., Locksley, R. M.
10.1101/2025.03.25.645270 — Posted: 2025-03-29
Interleukin-1 receptor antagonist is a conserved early factor for exacerbating tuberculosis susceptibility
Lee, O. V., Ji, D. X., Rosa, B. A., Jaye, D. L., Suliman, S., Mitreva, M., Gabay, C., Vance, R. E., Kotov, D. I.
10.1101/2023.10.27.564420 — Posted: 2025-03-29
Synaptic editing of frontostriatal circuitry prevents excessive grooming in SAPAP3-deficient mice
Walder-Christensen, K. K., Soliman, H. A., Calakos, N., Dzirasa, K.
10.1101/2025.03.27.645613 — Posted: 2025-03-29
Addendum to Ancient DNA data from Mengzi Ren, a Late Pleistocene individual from Southeast Asia, cannot be reliably used in population genetic analysis
Tabin, D. R., Patterson, N. J., Mah, M., Reich, D. E.
10.1101/2025.03.24.645126 — Posted: 2025-03-26
Directed evolution expands CRISPR-Cas12a genome editing capacity
Ma, E., Chen, K., Shi, H., Wasko, K. M., Esain-Garcia, I., Trinidad, M. I., Zhou, K., Ye, J., Doudna, J. A.
10.1101/2025.03.26.645588 — Posted: 2025-03-26
Delphy: scalable, near-real-time Bayesian phylogenetics for outbreaks
Varilly, P., Schifferli, M., Yang, K., Burcham, T., Cronan, P., Glennon, O., Jacks, O., Laning, E., Marrs, L., Oba, K., Yeung, S., Parker, E., Omah, I., Pekar, J. E., Luebbert, L., Andersen, K. G., Park, D. J., Schaffner, S. F., MacInnis, B. L., Happi, C., Lemieux, J. E., Ozonoff, A., Mitzenmacher, M. D., Fry, B., Sabeti, P. C.
10.1101/2025.03.25.645253 — Posted: 2025-03-26

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