Channel:  The Howard Hughes Medical Institute (HHMI)

1,958 Articles

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ELAVL3 regulates splicing of RNAs encoding synaptic signaling proteins in D1 and D2 striatal medium spiny neurons.
Irmady, K., Scheckel, C., Singer, R. A., Carroll, T., Darnell, R. B.
10.1101/2024.11.18.622571 — Posted: 2024-11-19
Improved protein binder design using -pairing targeted RFdiffusion
Sappington, I., Toul, M., Lee, D. S., Robinson, S. A., Goreshnik, I., McCurdy, C., Chan, T. C., Buchholz, N., Huang, B., Vafeados, D., Roullier, N., Garcia-Sanchez, M., Glögl, M., Kim, C., Watson, J. L., Torres, S. V., Verschueren, K. H. G., Verstraete, K., Hinck, C. S., Bernard-Valle, M., Coventry, B., Sims, J. N., Ahn, G., Wang, X., Hinck, A. P., Jenkins, T. P., Ruohola-Baker, H., Banik, S., Savvides, S. N., Baker, D.
10.1101/2024.10.11.617496 — Posted: 2024-11-19
Sensory History Drives Adaptive Neural Geometry in LP/Pulvinar-Prefrontal Cortex Circuits
Leow, Y. N., Barlowe, A., Luo, C. T., Osako, Y., Jazayeri, M., Sur, M.
10.1101/2024.11.16.623977 — Posted: 2024-11-18
Accurate de novo design of high-affinity protein binding macrocycles using deep learning
Rettie, S., Juergens, D., Adebomi, V., Bueso, Y. F., Zhao, Q., Leveille, A., Liu, A., Bera, A., Wilms, J., Üffing, A., Kang, A., Brackenbrough, E., Lamb, M., Gerben, S., Murray, A., Levine, P., Schneider, M., Vasireddy, V., Ovchinnikov, S., Weiergräber, O., Willbold, D., Kritzer, J., Mougous, J., Baker, D., DiMaio, F., Bhardwaj, G.
10.1101/2024.11.18.622547 — Posted: 2024-11-18
Dynamic cytoplasmic fluidity during morphogenesis in a human fungal pathogen
Serrano, A., Puerner, C., Plumb, E., Chevalier, L., Elferich, J., Sinn, L. R., Grigorieff, N., Ralser, M., Delarue, M., Bassilana, M., Arkowitz, R. A.
10.1101/2024.11.16.623909 — Posted: 2024-11-17
Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice
Wang, Y., Zhang, W., Zhang, C., Van, H. T., Seino, T., Zhang, Y.
10.1101/2024.11.09.622774 — Posted: 2024-11-17
A novel rhodopsin-based voltage indicator for simultaneous two-photon optical recording with GCaMP in vivo
Villette, V., Yang, S., Valenti, R., Macklin, J. J., Bradley, J., Mathieu, B., Lombardini, A., Podgorski, K., Dieudonne, S., Schreiter, E. R., Abdelfattah, A. S.
10.1101/2024.11.15.623698 — Posted: 2024-11-17
Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors
McClune, C. J., Liu, J. C.-T., Wick, C., De La Pena, R., Lange, B. M., Fordyce, P. M., Sattely, E. S.
10.1101/2024.11.06.622305 — Posted: 2024-11-16
Design of facilitated dissociation enables control over cytokine signaling duration
Broerman, A. J., Pollmann, C., Lichtenstein, M. A., Jackson, M. D., Tessmer, M. H., Ryu, W. H., Abedi, M. H., Sahtoe, D. D., Allen, A., Kang, A., De La Cruz, J., Brackenbrough, E., Sankaran, B., Bera, A. K., Zuckerman, D. M., Stoll, S., Praetorius, F., Piehler, J., Baker, D.
10.1101/2024.11.15.623900 — Posted: 2024-11-16
Biochemical principles of miRNA targeting in flies
Vega-Badillo, J., Zamore, P., Jouravleva, K.
10.1101/2024.11.16.623948 — Posted: 2024-11-16

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