Channel:  The Howard Hughes Medical Institute (HHMI)

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Rapid and repeated evolution of myosin copy number in threespine stickleback
Yoxsimer, A. M., Daugherty, R. R., Hare, E. E., Chan, Y. F., Jones, F. C., Roberts Kingman, G. A., Offenberg, E. G., Howes, T. R., Zhang, H., Pollen, A. A., Brady, S. D., Xie, K. T., Chen, H. I., Lowe, C. B., Au, E. H., Grimwood, J., Schmutz, J., Myers, R. M., Schluter, D., Heins, D. C., Reyes, M. L., Baker, J. A., Jonsson, B., Reimchen, T. E., Bell, M. A., Kingsley, D. M.
10.64898/2025.12.22.696110 — Posted: 2026-03-17
Biophysical trade-offs in antibody evolution are resolved by conformation-mediated epistasis
Tharp, C. R., Catalano, C., Khalifeh, A., Ghaffari-Kashani, S., Huang, R., Kang, G., Scapin, G., Phillips, A. M.
10.64898/2026.03.12.711465 — Posted: 2026-03-17
In vivo multiomic Perturb-seq with enhanced nuclear gRNA capture
Zheng, X., Li, J., Kim, K., Simmons, S. K., Zhao, Z., Tastemel, M., Huynh, N., Qiu, H., Ye, J., Whte, C. M., Levin, J. Z., Jin, X.
10.64898/2026.03.15.711739 — Posted: 2026-03-17
Statistical BURST imaging for high-fidelity biomolecular ultrasound
Lee, S., Shivaei, S., Shapiro, M. G.
10.64898/2026.03.13.711726 — Posted: 2026-03-17
In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles
Seraj, Z., Zottig, X., Huang, C., Loveland, A. B., Diggs, S., Sholi, E., Grigorieff, N., Korostelev, A. A.
10.1101/2025.11.25.690450 — Posted: 2026-03-17
Specialization of independently acquired flagellar FliC proteins in plant-associated Sphingomonas balances swimming and immunogenicity
Russ, D., Saha, C., Paul, K., Zheng, Z., Law, T. F., Anguita-Maeso, M., Lundberg, D. S., Fitzpatrick, C. R., Dangl, J. L.
10.64898/2026.02.23.707200 — Posted: 2026-03-16
A stress-function tradeoff organizes epithelial heterogeneity across spatial scales in the human thyroid
Korem Kohanim, Y., Barkai, T., Novoselsky, R., Shir, S., Bahar Halpern, K., Reich-Zeliger, S., Elkahal, J., Tessler, I., Shivatzki, S., Schwartz, I., Remer, E., Avior, G., Hoefllin, R., Kedmi, M., Keren-Shaul, H., Goliand, I., Addadi, Y., Golani, O., Alon, E., Itzkovitz, S., Medzhitov, R.
10.64898/2026.03.12.711294 — Posted: 2026-03-16
A potential role for acyl-phosphate in the coordination of phospholipid and lipopolysaccharide synthesis in Escherichia coli
DeHart, T. G., Fivenson, E. M., de Bakker, V., Sakenova, N., Bernhardt, T. G.
10.64898/2026.03.13.711678 — Posted: 2026-03-14
GAP mimetic activity of pan-Ras TCI daraxonrasib synergizes with K-Ras Switch-II pocket inhibition
Pfaff, P., Shokat, K.
10.64898/2026.03.11.711097 — Posted: 2026-03-13
Genomic surveillance reveals age-structured SARS-CoV-2 transmission across demographics and settings
Moreno, G. K., Brock-Fisher, T., Krasilnikova, L. A., Schaffner, S., Burns, M., Casiello, C. E., Messer, K. S., Petros, B. A., Specht, I., DeRuff, K. C., Siddle, K. J., Loreth, C., Fitzgerald, N. A., Rooke, H. M., Gabriel, S. B., Smole, S., Wohl, S., Park, D. J., Madoff, L. C., Brown, C. M., MacInnis, B. L., Sabeti, P. C.
10.1101/2025.04.04.25324273 — Posted: 2026-03-13

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