Channel:  The Howard Hughes Medical Institute (HHMI)

2,398 Articles

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Nuclear envelope budding is a non-canonical mechanism to export large transcripts in muscle cells
Zaganelli, S., Meehl, J., Abrisch, R. G., Voeltz, G. K.
10.1101/2025.04.18.649598 — Posted: 2026-01-24
Engaging Unstabilized Alkyl Radicals with Pyridoxal Radical Biocatalysis: Enantiodivergent Synthesis of Aliphatic Non-Canonical Amino Acids
Cheng, L., Chen, J., Bo, Z., Zhang, X., Liu, P., Yang, Y.
10.64898/2026.01.21.700944 — Posted: 2026-01-23
New methods for epigenetic characterization and manipulation of rare fly brain neurons
Ojha, P., Berglund, G., Yu, A. D., Rosbash, M.
10.64898/2026.01.21.700891 — Posted: 2026-01-23
Inference of germinal center evolutionary dynamics via simulation-based deep learning
Ralph, D. K., Bakis, A. G., Galloway, J., Vora, A. A., Araki, T., Song, Y. S., DeWitt, W. S., Matsen, F. A.
10.1101/2025.08.12.669950 — Posted: 2026-01-22
Sciphy: A Bayesian phylogenetic framework using sequential genetic lineage tracing data.
Seidel, S., Zwaans, A., Regalado, S., Choi, J., Shendure, J., Stadler, T.
10.1101/2024.10.01.615771 — Posted: 2026-01-22
High-efficiency targeted integration of extrachromosomal arrays in C. elegans using PhiC31 integrase
Rich, M. S., Pellow, R., Hefel, A., Rog, O., Jorgensen, E. M.
10.1101/2025.11.11.687718 — Posted: 2026-01-21
Inefficient autophagosome formation limits the temporal dynamics of OPTN-mediated mitophagy in neurons
Green, J. R., Gooden, M. K., Ojo, A. E., Kalejaiye, T. D., Evans, C. S.
10.64898/2026.01.16.700014 — Posted: 2026-01-20
Establishing the molecular basis for MDA5 mutation-linked autoimmunity
Xu, L., Chung, K., Guo, R., Pan, A., Pyle, A.
10.64898/2026.01.20.700587 — Posted: 2026-01-20
Selective Immune Silencing by Targeted TGF-β Agonists
Sun, Q., Ogishi, M., Jiang, H., Barrett, A. K., Yan, H., Sola, E., Zhang, J., Xiao, P., Lyu, H., Salehi, A., Tang, Q., Lanz, T. V., Davis, M. M., Negrin, R. S., Garcia, K. C.
10.64898/2026.01.19.700410 — Posted: 2026-01-20
Cytoplasmic mRNA decay by the anti-viral nuclease RNase L promotes transcriptional repression
Mao, X., Tokamov, S., Pahmeier, F., Lari, A., Xu, J., Harris, E., Glaunsinger, B.
10.1101/2025.07.08.663778 — Posted: 2026-01-19

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