Channel:  The Howard Hughes Medical Institute (HHMI)

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Designed NGF mimetics with reduced nociceptive signatures in neurons
Schlichthaerle, T., Yang, A., Detraux, D., Johnson, D. E., Peach, C. J., Edman, N. I., Sniezek, C., Williams, C. A., Arora, S., Katiyar, N., Chen, I., Etemadi, A., Favor, A., Lee, D., Kubo, C., Coventry, B., Huang, B., Gerben, S., Ennist, N. M., Milles, L., Sankaran, B., Kang, A., Nguyen, H., Bera, A. K., Negahdari, B., Hamazaki, N., Schweppe, D. K., Stewart, L., Young, J. E., Bunnett, N. W., Ruohola-Baker, H., Mathieu, J., Pattwell, S., Garcia, K. C., Baker, D.
10.1101/2025.04.14.648806 — Posted: 2025-04-14
Modular regulation of the stem cell transcriptome defines self-renewal, differentiation, and dedifferentiation
Raz, A. A., Hassan, H., Yamashita, Y. M.
10.1101/2025.04.10.648217 — Posted: 2025-04-14
De novo design and structure of a peptide-centric TCR mimic binding module
Householder, K. D., Xiang, X., Jude, K. M., Deng, A., Obenaus, M., Wilson, S. C., Chen, X., Wang, N., Garcia, K. C.
10.1101/2024.12.16.628822 — Posted: 2025-04-14
Computational Design of Metallohydrolases
Kim, D., Woodbury, S. M., Ahern, W., Tischer, D., Hanikel, N., Salike, S., Yim, J., Pellock, S. J., Lauko, A., Kalvet, I., Hilvert, D., Baker, D.
10.1101/2024.11.13.623507 — Posted: 2025-04-11
Atom level enzyme active site scaffolding using RFdiffusion2
Ahern, W., Yim, J., Tischer, D., Salike, S., Woodbury, S., Kim, D., Kalvet, I., Kipnis, Y., Coventry, B., Altae-Tran, H., Bauer, M., Barzilay, R., Jaakkola, T., Krishna, R., Baker, D. A.
10.1101/2025.04.09.648075 — Posted: 2025-04-10
Biosynthesis of Macrocyclic Peptides by Formation and Crosslinking of ortho-Tyrosines
Padhi, C., Zhu, L., Chen, J. Y., Moreira, R., van der Donk, W. A.
10.1101/2025.04.04.647296 — Posted: 2025-04-08
Transcription factor hubs exhibit gene-specific properties that tune expression
Fallacaro, S., Mukherjee, A., Turner, M. A., Garcia, H. G., Mir, M.
10.1101/2025.04.07.647578 — Posted: 2025-04-08
OmniSplice: a framework-free splicing event reporter
Lannes, R., Fingerhut, J. M., Yamashita, Y. M. M.
10.1101/2025.04.06.647416 — Posted: 2025-04-08
Small-molecule modulation of Beta-arrestins
Kahsai, A. W., Pakharukova, N., Kwon, H. Y., Shah, K. S., Liang-Lin, J. G., del Real, C. T., Shim, P. J., Lee, M. A., Ngo, V. A., Shreiber, B. N., Liu, S., Schwalb, A. M., Espinoza, E. F., Thomas, B. N., Kunzle, C. A., Smith, J. S., Wang, J., Kim, J., Zhang, X., Rockman, H. A., Thomsen, A. R. B., Rein, L. A. M., Shi, L., Ahn, S., Masoudi, A., Lefkowitz, R. J.
10.1101/2024.12.27.630464 — Posted: 2025-04-08
Transitions in dynamical regime and neural mode underlie perceptual decision-making
Luo, T. Z., Kim, T. D., Gupta, D., Bondy, A. G., Kopec, C. D., Elliott, V. A., DePasquale, B., Brody, C.
10.1101/2023.10.15.562427 — Posted: 2025-04-07

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