Channel:  The Howard Hughes Medical Institute (HHMI)

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Glutamate indicators with increased sensitivity and tailored deactivation rates
Aggarwal, A., Negrean, A., Chen, Y., Iyer, R., Reep, D., Liu, A., Palutla, A., Xie, M. E., MacLennan, B., Hagihara, K. M., Kinsey, L. W., Sun, J. L., Yao, P., Zheng, J., Tsang, A., Tsegaye, G., Zhang, Y., Patel, R. H., Arthur, B. J., Hiblot, J., Leippe, P., Tarnawski, M., Marvin, J. S., Vevea, J. D., Turaga, S. C., Tebo, A. G., Carandini, M., Rossi, L. F., Kleinfeld, D., Konnerth, A., Svoboda, K., Turner, G. C., Hasseman, J., Podgorski, K.
10.1101/2025.03.20.643984 — Posted: 2025-03-31
Human-chimpanzee tetraploid system defines mechanisms of species-specific neural gene regulation
Song, J. H., Carter, A. C., Bushinsky, E. M., Beck, S. G., Petrocelli, J. E., Koreman, G. T., Babu, J., Kingsley, D. M., Greenberg, M. E., Walsh, C. A.
10.1101/2025.03.31.646367 — Posted: 2025-03-31
Interleukin-1 receptor antagonist is a conserved early factor for exacerbating tuberculosis susceptibility
Lee, O. V., Ji, D. X., Rosa, B. A., Jaye, D. L., Suliman, S., Mitreva, M., Gabay, C., Vance, R. E., Kotov, D. I.
10.1101/2023.10.27.564420 — Posted: 2025-03-29
Synaptic editing of frontostriatal circuitry prevents excessive grooming in SAPAP3-deficient mice
Walder-Christensen, K. K., Soliman, H. A., Calakos, N., Dzirasa, K.
10.1101/2025.03.27.645613 — Posted: 2025-03-29
IL-25-induced memory ILC2s mediate long-term small intestinal adaptation
Cortez, V. S., Viragova, S., Koga, S., Liu, M., O'Leary, C., Ricardo-Gonzalez, R. R., Schroeder, A. W., Kochhar, N., Klein, O., Diamond, M., Liang, H.-E., Locksley, R. M.
10.1101/2025.03.25.645270 — Posted: 2025-03-29
Addendum to Ancient DNA data from Mengzi Ren, a Late Pleistocene individual from Southeast Asia, cannot be reliably used in population genetic analysis
Tabin, D. R., Patterson, N. J., Mah, M., Reich, D. E.
10.1101/2025.03.24.645126 — Posted: 2025-03-26
Directed evolution expands CRISPR-Cas12a genome editing capacity
Ma, E., Chen, K., Shi, H., Wasko, K. M., Esain-Garcia, I., Trinidad, M. I., Zhou, K., Ye, J., Doudna, J. A.
10.1101/2025.03.26.645588 — Posted: 2025-03-26
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Agarwal, G., Antoszewski, M., Xie, X., Pershad, Y., Arora, U. P., Poon, C.-L., Lyu, P., Lee, A. J., Guo, C.-J., Ye, T., Norford, L. B., Neehus, A.-L., della Volpe, L., Wahlster, L., Ranasinghe, D., Ho, T.-C., Barlowe, T. S., Chow, A., Schurer, A., Taggart, J., Durham, B. H., Abdel-Wahab, O., McGraw, K. L., Allan, J. M., Soldatov, R., Bick, A. G., Kharas, M. G., Sankaran, V. G.
10.1101/2025.03.24.645017 — Posted: 2025-03-26
Long-term editing of brain circuits in mice using an engineered electrical synapse
Ransey, E., Thomas, G., Wisdom, E., Almoril-Porras, A., Bowman, R., Adamson, E., Walder-Christensen, K. K., White, J. A., Hughes, D. N., Schwennesen, H., Ferguson, C., Tye, K., Mague, S. D., Niu, L.-G., Wang, Z.-W., Colon-Ramos, D., Hultman, R., Bursac, N., Dzirasa, K.
10.1101/2025.03.25.645291 — Posted: 2025-03-26
Delphy: scalable, near-real-time Bayesian phylogenetics for outbreaks
Varilly, P., Schifferli, M., Yang, K., Burcham, T., Cronan, P., Glennon, O., Jacks, O., Laning, E., Marrs, L., Oba, K., Yeung, S., Parker, E., Omah, I., Pekar, J. E., Luebbert, L., Andersen, K. G., Park, D. J., Schaffner, S. F., MacInnis, B. L., Happi, C., Lemieux, J. E., Ozonoff, A., Mitzenmacher, M. D., Fry, B., Sabeti, P. C.
10.1101/2025.03.25.645253 — Posted: 2025-03-26

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