Channel:  The Howard Hughes Medical Institute (HHMI)

1,788 Articles

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De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
Muratspahic, E., Feldman, D., Kim, D. E., Qu, X., Bratovianu, A.-M., Rivera-Sanchez, P., Dimitri, F., Cao, J., Cary, B. P., Belousoff, M. J., Keov, P., Chen, Q., Ren, Y., Fine, J., Sappington, I., Schlichthaerle, T., Zhang, J. Z., Pillai, A., Mihaljevic, L., Bauer, M., Torres, S. V., Motmaen, A., Lee, G. R., Tran, L., Wang, X., Goreshnik, I., Vafeados, D. K., Svendsen, J. E., Hosseinzadeh, P., Lindegaard, N., Brandt, M., Waltenspühl, Y., Deibler, K., Oostdyk, L., Cao, W., Anantharaman, L., Stewart, L., Halloran, L., Spangler, J. B., Sexton, P. M., Roth, B. L., Krumm, B. E., Wootten, D., Tate
10.1101/2025.03.23.644666 — Posted: 2025-06-05
Replaying germinal center evolution on a quantified affinity landscape
DeWitt, W. S. S., Vora, A. A., Araki, T., Galloway, J. G., Alkutkar, T., Bortolatto, J., Castro, T. B., Dumm, W., Jennings-Schaffer, C., Jia, T., Mesin, L., Ozorowski, G., Pae, J., Ralph, D. K., Bloom, J. D., Nourmohammad, A., Song, Y. S., Ward, A., Starr, T. N., Matsen, F. A., Victora, G. D.
10.1101/2025.06.02.656870 — Posted: 2025-06-05
Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques
Pratap, P. P., Cottrell, C. A., Quinn, J., Carnathan, D. G., Bader, D. L. V., Tran, A. S., Enemuo, C. A., Ngo, J. T., Richey, S. T., Gao, H., Shen, X., Greene, K. M., Hurtado, J., Michaels, K. K., Ben-Akiva, E., Lemnios, A., Melo, M. B., Allen, J. D., Ozorowski, G., Crispin, M., Briney, B., Montefiori, D., Silvestri, G., Irvine, D. J., Crotty, S., Ward, A. B.
10.1101/2024.11.27.625755 — Posted: 2025-06-05
A covalent recognition strategy enables conspecific mate identification
Jang, S. S., Mandala, S., Jiang, H., Zhang, X., Cole, P. A., del Marmol, J. I.
10.1101/2025.05.30.657074 — Posted: 2025-06-03
Transforming descending input into motor output: An analysis of the Drosophila Male Adult Nerve Cord connectome
Cheong, H. S. J., Eichler, K., Stuerner, T., Asinof, S. K., Champion, A. S., Marin, E. C., Oram, T. B., Sumathipala, M., Venkatasubramanian, L., Namiki, S., Siwanowicz, I., Costa, M., Berg, S., Janelia FlyEM Project Team, , Jefferis, G. S. X. E., Card, G. M.
10.1101/2023.06.07.543976 — Posted: 2025-06-03
Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum
Chan, J. C., Di Salvo, G., Cunningham, A. M., Dutta, S., Brindley, E. A., Weekley, B. H., Wan, E., Zhang, C., Mechawar, N., Turecki, G., Maze, I.
10.1101/2025.02.20.639313 — Posted: 2025-06-02
Cell-type-specific patterns and consequences of somatic mutation in development and aging brain
Kriz, A. J., Mao, S., Shao, D. D., Snellings, D. A., Andersen, R., Dong, G., Ma, C. C., Cline, H. E., Huang, A. Y., Lee, E. A., Walsh, C. A.
10.1101/2025.05.30.656844 — Posted: 2025-06-01
A primate model organism for cardiac arrhythmias identifies a magnesium transporter in pacemaker function
Chang, S., Karanewsky, C. J., Pendleton, J. L., Ren, L., Anzeraey, A., Froelicher, V., Liang, D., Razafindrakoto, A., Ravelonjanahary, H. N., Albertelli, M. A., Quertermous, T., Wright, P. C., Perret, M., Terrien, J., Aujard, F., Wu, J. C., Krasnow, M. A.
10.1101/2025.05.28.655959 — Posted: 2025-06-01
Bacterial and host enzymes modulate the inflammatory response produced by the peptidoglycan of the Lyme disease agent
McCausland, J. W., Kloos, Z. A., Irnov, I., Sonnert, N. D., Zhou, J., Putnick, R., Mueller, E. A., Steere, A. C., Palm, N. W., Grimes, C. L., Jacobs-Wagner, C.
10.1101/2025.01.08.631998 — Posted: 2025-05-31
Epigenetic and evolutionary features of ape subterminal heterochromatin
Yoo, D., Munson, K. M., Eichler, E. E.
10.1101/2025.05.29.656835 — Posted: 2025-05-30

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