Channel:  The Howard Hughes Medical Institute (HHMI)

2,708 Articles

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Human acrocentric chromosome short arm de novo mutation and recombination
Lin, J., Mastrorosa, F. K., Noyes, M. D., Yoo, D., Rhie, A., Porubsky, D., Hoekzema, K., Munson, K. M., Koundinya, N., Watkins, W. S., Jorde, L. B., Quinlan, A. R., Neklason, D. W., Phillippy, A. M., Eichler, E. E.
10.64898/2025.12.16.694519 — Posted: 2025-12-17
The Drosophila maternal-effect gene abnormal oocyte (ao) does not repress histone gene expression
Takenaka, R., Albanese, E. H., Simmerman, S. M., Verghese, S., Maddox, M. A. E., de la Cruz, A., Young, J. M., Schmidt, C. A., Rieder, L. E., Malik, H. S.
10.1101/2024.09.17.613536 — Posted: 2025-12-16
A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects
Hart, S. F. M., Alcala, N., Feder, A. F., Harris, K.
10.1101/2025.05.15.654154 — Posted: 2025-12-16
Conserved phenotype and function of human brain border-associated macrophages in iPSC-derived models
Barr, H. J., Depp, C., Hingerl, M., Nguyen, T., Reimertz, J. M., Connolly, E., Patel, J., Doman, J. L., Marsh, S. E., Stevens, B.
10.64898/2025.12.11.693582 — Posted: 2025-12-14
Phosphatase SHP2 pathogenic mutations enhance activity by altering conformational sampling
Glaser, A., Padua, R., Ojoawo, A., Sullivan, C., Kern, D.
10.64898/2025.12.12.694068 — Posted: 2025-12-14
Tolerance toward foreigners in ants requires chronic exposure for establishment but only sporadic exposure for maintenance
Bailly, T. P. M., Rossi, M., Valdes-Rodriguez, S., Schmitt, T., Frank, E. T., Kronauer, D.
10.64898/2025.12.10.693507 — Posted: 2025-12-13
Cell Type-Specific Hormonal Signaling Configures Hypothalamic Circuits for Parenting
Logeman, B. L., Horvath, P. M., Talay, M., Kapoor, V., Kaplan, H. S., Dulac, C.
10.64898/2025.12.11.693766 — Posted: 2025-12-12
Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology
Drexler, R., Yalcin, B., Mancusi, R., Rogers, A., Shamardani, K., Woo, P. J., Ravel, A., Wu, S., Yabo, Y., Oliveira de Biagi-Junior, C. A., Lo Cascio, C., Malenka, R. C., Heifets, B. D., Filbin, M. G., Heiland, D. H., Deisseroth, K., Monje, M.
10.64898/2025.12.10.693579 — Posted: 2025-12-12
Engineering immunotoxin-equipped effector cells and evaluation in primary human immune cells
Pearlman, A. H., Mog, B. J., Hwang, M. S., Rincon-Torroella, J., DiNapoli, S. R., Paul, S., Douglass, J., Hsiue, E. H.-C., Glavaris, S. A., Pardoll, D. M., Papadopoulos, N., Kinzler, K. W., Bettegowda, C., Zhou, S., Vogelstein, B., Konig, M. F.
10.64898/2025.12.09.691975 — Posted: 2025-12-11
A shared DNA-repeat toxicity threshold, reached somatically at cell-type-specific rates, unites cortical and striatal neurodegeneration in Huntingtons disease
Kashin, S., Lee, W.-S., McDonald, T. M., Morris, K., Handsaker, R. E., Mello, C., Spina, L., Reed, N. M., de Rivera, H., Jana, S. H., Hogan, M., Berretta, S., McCarroll, S. A.
10.64898/2025.12.09.688862 — Posted: 2025-12-11

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