Channel:  The Howard Hughes Medical Institute (HHMI)

2,313 Articles

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A genome-scale drug discovery pipeline uncovers new therapeutic targets and a unique p97 allosteric binding site in Schistosoma mansoni
Stephens, D. R., Fung, H. Y. J., Han, Y., Liang, J., Chen, Z., Ready, J., Collins, J.
10.1101/2025.03.14.643303 — Posted: 2025-03-15
Nonequilibrium polysome dynamics promote chromosome segregation and its coupling to cell growth in Escherichia coli
Papagiannakis, A., Yu, Q., Govers, S. K., Lin, W.-H., Wingreen, N. S., Jacobs-Wagner, C.
10.1101/2024.10.08.617237 — Posted: 2025-03-15
HortaCloud: An Open and Collaborative Platform for Whole Brain Neuronal Reconstructions
Rokicki, K., Schauder, D., Olbris, D. J., Goina, C., Clements, J., Edson, P., Kawase, T., Svirskas, R., Arshadi, C., Feng, D., Chandrashekar, J., Ferreira, T. A., MouseLight Project Team
10.1101/2025.03.13.642887 — Posted: 2025-03-14
Design of solubly expressed miniaturized SMART MHCs
White, W. L., Bai, H., Kim, C. J., Jude, K. M., Sun, R., Guerrero, L., Han, X., Chen, X. T., Chaudhuri, A., Bonzanini, J. E., Sun, Y., Onwuka, A. E., Wang, N., Wang, C., Li, X., Goreshnik, I., Allen, A., Levine, P. M., Kueh, H. Y., Jewett, M. C., Sgourakis, N., Achour, A., Garcia, K. C., Baker, D.
10.1101/2025.03.14.643101 — Posted: 2025-03-14
Engineering Multiplexed Synthetic Breath Biomarkers as Diagnostic Probes
Wang, S.-T., Anahtar, M., Kim, D. M., Samad, T. S., Zhang, C. M., Patel, S., Ko, H., Ngambenjawong, C., Wang, C. S., Kirkpatrick, J. D., Kumar, V., Fleming, H. E., Bhatia, S. N.
10.1101/2024.12.30.630769 — Posted: 2025-03-13
Structural mechanisms of PIP2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1
Xue, J., Zeng, W., John, S., Attiq, N., Ottolia, M., Jiang, Y.
10.1101/2024.12.05.627058 — Posted: 2025-03-13
Canonical Wnt Signaling Suppresses Brain Endothelial Cell Transcytosis to Maintain Blood-Brain Barrier Integrity
du Maine, X., Gu, C.
10.1101/2025.03.10.642437 — Posted: 2025-03-13
Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis
Lee, Y., Biasini, A., Tipping, C., Hong, S. H., Zamore, P.
10.1101/2025.03.05.641556 — Posted: 2025-03-11
Functional microRNA targeting without seed pairing
Hall, M. H., Wang, P. Y., Pham, T. M., Bartel, D. P.
10.1101/2025.03.03.641270 — Posted: 2025-03-11
Targeted suppression of type 1 interferon signaling during RNA delivery enhances vaccine-elicited immunity
Kim, B. J., Hosn, R. R., Remba, T. K., Dye, J., Mak, H. H., Jeong, J. Y., Cornwall-Brady, M., Abraham, W., Maiorino, L., Melo, M. B., Li, B., Zhang, Y., Dong, Y., Irvine, D. J.
10.1101/2025.03.09.642244 — Posted: 2025-03-10

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