Channel:  The Howard Hughes Medical Institute (HHMI)

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Computational Design of Metallohydrolases
Kim, D., Woodbury, S. M., Ahern, W., Tischer, D., Hanikel, N., Salike, S., Yim, J., Pellock, S. J., Lauko, A., Kalvet, I., Hilvert, D., Baker, D.
10.1101/2024.11.13.623507 — Posted: 2025-04-11
Atom level enzyme active site scaffolding using RFdiffusion2
Ahern, W., Yim, J., Tischer, D., Salike, S., Woodbury, S., Kim, D., Kalvet, I., Kipnis, Y., Coventry, B., Altae-Tran, H., Bauer, M., Barzilay, R., Jaakkola, T., Krishna, R., Baker, D. A.
10.1101/2025.04.09.648075 — Posted: 2025-04-10
OmniSplice: a framework-free splicing event reporter
Lannes, R., Fingerhut, J. M., Yamashita, Y. M. M.
10.1101/2025.04.06.647416 — Posted: 2025-04-08
Small-molecule modulation of Beta-arrestins
Kahsai, A. W., Pakharukova, N., Kwon, H. Y., Shah, K. S., Liang-Lin, J. G., del Real, C. T., Shim, P. J., Lee, M. A., Ngo, V. A., Shreiber, B. N., Liu, S., Schwalb, A. M., Espinoza, E. F., Thomas, B. N., Kunzle, C. A., Smith, J. S., Wang, J., Kim, J., Zhang, X., Rockman, H. A., Thomsen, A. R. B., Rein, L. A. M., Shi, L., Ahn, S., Masoudi, A., Lefkowitz, R. J.
10.1101/2024.12.27.630464 — Posted: 2025-04-08
Biosynthesis of Macrocyclic Peptides by Formation and Crosslinking of ortho-Tyrosines
Padhi, C., Zhu, L., Chen, J. Y., Moreira, R., van der Donk, W. A.
10.1101/2025.04.04.647296 — Posted: 2025-04-08
Transitions in dynamical regime and neural mode underlie perceptual decision-making
Luo, T. Z., Kim, T. D., Gupta, D., Bondy, A. G., Kopec, C. D., Elliott, V. A., DePasquale, B., Brody, C.
10.1101/2023.10.15.562427 — Posted: 2025-04-07
Superinfection with intact HIV-1 results in conditional replication of defective proviruses and nonsuppressible viremia in people living with HIV-1
Hariharan, V., White, J. A., Dragoni, F., Fray, E. J., Pathoulas, N., Moskovljevic, M., Zhang, H., Singhal, A., Lai, J., Beg, S. A., Scully, E. P., Gilliams, E. A., Block, D. S., Keruly, J., Moore, R. D., Siliciano, J. D., Simonetti, F. R., Siliciano, R. F.
10.1101/2025.04.04.647291 — Posted: 2025-04-04
BLTP3A is associated with membranes of the late endocytic pathway and is an effector of CASM
Hanna, M. G., Rodriguez Cruz, H. O., Fujise, K., Wu, Y., Xu, C. S., Pang, S., Zhuoning, L., Monetti, M., De Camilli, P.
10.1101/2024.09.28.615015 — Posted: 2025-04-03
The aPBP-type cell wall synthase PBP1b plays a specialized role in fortifying the Escherichia coli division site against osmotic rupture
Navarro, P. P., Vettiger, A., Hajdu, R., Ananda, V. Y., Lopez-Tavares, A., Schmid, E., Walter, J., Loose, M., Chao, L. H., Bernhardt, T. G.
10.1101/2025.04.02.646830 — Posted: 2025-04-02
A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathway
Doherty, E. E., Adler, B. A., Yoon, P. H., Hsieh, K., Loi, K., Armbruster, E. G., Lahiri, A., Bolling, C. S., Wilcox, X. E., Akkati, A., Iavarone, A. T., Pogliano, J., Doudna, J. A.
10.1101/2025.03.28.646030 — Posted: 2025-04-01

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