Channel:  Aligning Science Across Parkinson's (ASAP)

537 Articles

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An isogenic single-cell atlas of familial Parkinson's disease mutations reveals convergent changes in dopamine neurons
Syed, K. M., Dunnack, J., Paatz, S., Ajjarapu, K., Sahagun, A., Rio, D., Soldner, F., Bateup, H., Hockemeyer, D.
10.64898/2026.05.04.722458 — Posted: 2026-05-10
A human lysosomal storage disorder toolkit for decoding proteome landscapes in cortical and dopaminergic-like induced neurons
Kraus, F., He, Y., Jiang, Y., Li, D., Ambaw, Y. A., Gasparoli, F. M., Paulo, J. A., Walther, T. C., Farese, R., Gygi, S. P., Wilfling, F., Harper, J. W.
10.1101/2025.10.08.681047 — Posted: 2026-05-10
Cortical synaptic vulnerabilities revealed in a α-synuclein aggregation model of Parkinson's disease
Sah, S., Sauerbeck, A. D., Gupta, J., Perez-Acuna, D., Reiber, J. E., Russell, D., Goralski, T., Henderson, M., Volpicelli-Daley, L. A., Higley, M. J., Kummer, T. T., Biederer, T.
10.1101/2024.06.20.599774 — Posted: 2026-05-08
Utilizing Intraindividual Cognitive Variability to Predict Stage 2 Neuronal Synuclein Disease Progression
Combs, H. L., Kurth, R., Nair, A., York, M. K., Weintraub, D., Lafontant, D.-E., Caspell-Garcia, C., and the Parkinson's Progression Markers Initiative
10.1101/2025.10.21.25338482 — Posted: 2026-05-01
A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and Intervention
Marciano, S., Velazquez, L. G., Rodriguez Lopez, C., De Silva, N., Sommer, G., Tower, W., Torrres, E. R. S., Kaplitt, M. G., Milner, T. A., Marongiu, R.
10.64898/2026.03.20.712963 — Posted: 2026-04-30
Single cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease
Lin, Z., Parker, J., Nithianandam, V., Mathivanan, S., Wang, T., Liao, Z., Simmons, S. K., Tuncali, I., Adiconis, X., Haywood, N., Weykopf, B., Teng, X., Sharma, M., Yuan, J., Baecher-Allan, C., Dong, X., Beach, T. G., Serrano, G. E., Levin, J. Z., Zhang, S., Feany, M. B., Scherzer, C. R.
10.64898/2026.04.24.720642 — Posted: 2026-04-29
LRRK2 mutations block NCOA4 trafficking upon iron overload leading to ferroptotic death
Goldman, A., Nguyen, M., Lanoix, J., Li, C., Fahmy, A., Zhong Xu, Y., Schurr, E., Thibault, P., Desjardins, M., McBride, H.
10.1101/2025.08.25.672135 — Posted: 2026-04-17
Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra
Simmons, D. V., Moreno-Ramos, O. A., Raj, D. D. A., Kaganovsky, K., Pamukcu, A., Vrieler, N., Tkatch, T., Xie, Z., Zampese, E., De Sousa, A. I. S., Ding, J., Awatramani, R. V., Wilson, C., Surmeier, D. J.
10.1101/2024.03.27.586699 — Posted: 2026-04-17
Modeling cis-regulatory variation in human brain enhancers across a large Parkinson's Disease cohort
Sigalova, O. M., Pancikova, A., De Man, J., Theunis, K., Hulselmans, G. J., Konstantakos, V., Stuyven, B., De Brabandere, A., Geurts, J., Mikorska, A., Mukherjee, S., Abouelasrar Salama, S., Vandereyken, K., Davie, K., Mahieu, L., Adler, C. H., Beach, T. G., Serrano, G. E., Voet, T., Demeulemeester, J., Aerts, S.
10.64898/2026.03.15.711881 — Posted: 2026-04-16
Myeloid-Driven Inflammation in Prodromal Parkinson's Disease
Yasumizu, Y., Deerhake, M. E., Moon, J., Buitrago-Pocasangre, N., Russo, A., Wang, H., Zhu, B., Seibyl, J. P., Reddy, V., Wang, Q., Neish, K. J., Spillantini, M. G., Posner, D. A., Clatworthy, M., Sumida, T. S., Longbrake, E. E., Cedarbaum, J. M., Zhang, L., Hafler, D. A.
10.1101/2025.05.16.654530 — Posted: 2026-04-14

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