Channel:  Aligning Science Across Parkinson's (ASAP)

403 Articles

Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration
Rademacher, K. L., Doric, Z., Haddad, D., Mamaligas, A., Liao, S.-C., Creed, R., Kano, K., Chatterton, Z., Fu, Y., Garcia, J. H., Vance, V., Sei, Y., Kreitzer, A., Halliday, G., Nelson, A., Margolis, E., Nakamura, K. L.
10.1101/2024.04.05.588321 — Posted: 2025-03-04
MICROENDOSCOPIC CALCIUM IMAGING IN SUPPLEMENTARY MOTOR AREA AND PRIMARY MOTOR CORTEX OF RHESUS MACAQUES AT REST AND DURING ARM MOVEMENT
Martel, A.-C., Pittard, D., Devergnas, A., Risk, B., Nassi, J., Yu, W., Downer, J., Wichmann, T., Galvan, A.
10.1101/2024.06.20.599918 — Posted: 2025-03-04
Astrocytic RNA editing regulates the host immune response to alpha-synuclein
D'Sa, K., Choi, M. L., Wagen, A. Z., Seto-Salvia, N., Kopach, O., Evans, J. R., Rodrigues, M., Lopez-Garcia, P., Lachica, J., Singh, J., Ghareeb, A., Bayne, J., Grant-Peters, M., Garcia-Ruiz, S., Chen, Z., Rodriques, S., Athauda, D., Gustavsson, E. K., Gagliano Taliun, S. A., Toomey, C., Reynolds, R. H., Young, G., Strohbuecker, S., Warner, T., Rusakov, D. A., Patani, R., Bryant, C., Klenerman, D. A., Gandhi, S., Ryten, M.
10.1101/2024.02.26.582055 — Posted: 2025-03-03
Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C
Wang, X., Xu, P., Bentley-DeSousa, A., Hancock-Cerutti, W., Cai, S., Johnson, B. T., Tonelli, F., Shao, L., Talaia, G., Alessi, D. R., Ferguson, S. M., De Camilli, P.
10.1101/2024.06.08.598070 — Posted: 2025-02-26
Deciphering the Genetic Architecture of Parkinsons Disease in India
Kishore, A., Ashok Kumar Sreelatha, A., Tenghe, A. M. M., Borgohain, R., Puthanveedu, D. K., Rajan, R., Urulangodi, M., Gonzalez-Ricardo, L.-G., Pal, P. K., Kandadai, R. M., Khodaee, S., Yadav, R., Mehta, S., Kumar, H., Kumar, N., Kukkle, P. L., Desai, S. D., Shetty, K., Wadia, P., Aggarwal, A., Agarwal, P., Abbas, M. M., Wali, G. M., Krishnan, S., Radhakrishnan, D. M., Kamble, N., Srivastava, A. K., Lal, V., Ferreira, T. M. C., Chacko, M., Raghavan, C. T., Sarma, G., Solle, J., Fiske, B., Thalakkatttu, A., Garg, D., Kruger, J., Lichntner, P., Vitale, D., Nalls, M. A., Blauwendraat, C., Single
10.1101/2025.02.17.25322132 — Posted: 2025-02-21
Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue
Mesentier-Louro, L. A., Goldman, C., Ndayisaba, A., Buonfiglioli, A., Rooklin, R. B., Schuldt, B. R., Uchitelev, A., Khurana, V., Blanchard, J. W.
10.1101/2025.02.09.637107 — Posted: 2025-02-14
A novel alpha-synuclein K58N missense variant in a patient with Parkinson's disease
Al-Azzani, M., Weber, S., Ramalingam, N., Ramon, M., Shvachiy, L., Mestre, G., Zech, M., Sicking, K., Ibanez de Opakua, A., Jayanthi, V., Amaral, L., Agarwal, A., Chandran, A., Chaves, S. R., Winkelmann, J., Trenkwalder, C., Schwager, M., Pauli, S., Dettmer, U., Fernandez, C. O., Lautenschläger, J., Zweckstetter, M., Busnadiego, R. F., Mollenhauer, B., Outeiro, T. F.
10.1101/2025.02.07.25321793 — Posted: 2025-02-14
Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2
Raig, N. D., Surridge, K. J., Sanz-Murillo, M., Dederer, V., Kramer, A., Schwalm, M. P., Elson, L., Chatterjee, D., Mathea, S., Hanke, T., Leschziner, A. E., Reck-Peterson, S. L., Knapp, S.
10.1101/2024.09.17.613365 — Posted: 2025-02-13
Molecularly-guided spatial proteomics captures single-cell identity and heterogeneity of the nervous system
Dutta, S., Pang, M., Coughlin, G. M., Gudavalli, S., Roukes, M. L., Chou, T.-F., Gradinaru, V.
10.1101/2025.02.10.637505 — Posted: 2025-02-11
Specific cell states underlie complex tissue regeneration in spiny mice
Rivadeneira, E. O., Allen, R. S., Adam, M., Seifert, A. W.
10.1101/2025.02.10.637521 — Posted: 2025-02-11

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