Channel:  Aligning Science Across Parkinson's (ASAP)

463 Articles

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Myeloid PINK1 represses mtDNA release and immune signaling that impacts neuronal pathology in patient-derived idiopathic PD models
Recinto, S. J., MacDonald, A., Premachandran, S., Liu, L., Bayati, A., Rodriguez, L., Nguyen, M., Petit, F., Mukherjee, S., Larmanjat, J., Allot, A., Yaqubi, M., McPherson, P. S., Durcan, T. M., Gruenheid, S., Trudeau, L.-E., Drouin-Ouellet, J., McBride, H. M., Stratton, J. A.
10.64898/2026.01.07.694713 — Posted: 2026-01-08
System-wide profiling reveals metabolic alterations in a G2019S LRRK2 knockin mouse model of Parkinson's disease: systemic depletion of pyrimidine nucleosides
Ma, Y., Erb, M. L., Sipple, K., Offerman, A., Moore, D. J.
10.64898/2025.12.31.697225 — Posted: 2026-01-02
Postsynaptic adaptations in direct pathway muscarinic M4-receptor signaling follow the temporal and regional pattern of dopaminergic degeneration
Nielsen, B., Ford, C.
10.1101/2025.03.03.641233 — Posted: 2025-3-10
Cardiac-sympathetic state predicts action restraint, gated by demonstrated agency
Dundon, N. M., Rizor, E. J., Stasiak, J., Wang, J., Babenko, V., Lapate, R. C., Grafton, S. T.
10.64898/2025.12.29.696920 — Posted: 2025-12-31
Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation
Dundon, N. M., Rizor, E. J., Stasiak, J., Wang, J., Li, T., Sabugo, K., Villanueva, C., Barandon, P., Babenko, V., Beverly-Aylwin, R., Stump, A., Santander, T., Bostan, A. C., Lapate, R. C., Grafton, S. T.
10.64898/2025.12.21.695842 — Posted: 2025-12-23
Excitatory nicotinic signaling drives action potential bursting in dopaminergic axons
Kramer, P. F., Yanez, A., Clever, F., Zhang, R., Khaliq, Z. M.
10.64898/2025.12.19.695584 — Posted: 2025-12-21
ATG2A engages Rab1a and ARFGAP1 positive membranes during autophagosome biogenesis
Fuller, D. M., Wu, Y., Schueder, F., Rasool, B., Nag, S., Korfhage, J. L., Garcia-Milian, R., Melnyk, K. D., Bewersdorf, J., De Camilli, P., Melia, T.
10.1101/2025.03.24.645038 — Posted: 2025-12-17
Striatal ensembles specify and control granular forelimb actions
Rodrigues-Vaz, I., Athalye, V. R., Peterka, D. S., Costa, R. M.
10.64898/2025.12.03.692128 — Posted: 2025-12-08
Elucidating an anterior cingulate circuit for self-initiated actions and rescue of Parkinsonian akinesia
Ulloa Severino, F., Lu, B., Kim, J., Friedman, A., Roshchina, M., Johnson, S., Bakhurin, K., Eroglu, C., Yin, H.
10.64898/2025.12.01.691607 — Posted: 2025-12-03
Tau, amyloid-beta and alpha-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology
Webster, J. M., Yang, Y.-T., Miller, A. T., Zane, A., Scholz, K., Stone, W. J., Corbin-Stein, N. J., Mudium, N., Won, W.-J., Stoll, A. C., Greathouse, K. M., Cooper, N. H., Long, L. F., Manuel, P. N., Herskowitz, J. H., Yacoubian, T. A., Tyrrell, D. J., Sandoval, I. M., Manfredsson, F. P., Kordower, J. H., Harms, A. S.
10.1101/2024.10.13.618101 — Posted: 2025-11-24

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