Channel:  The Howard Hughes Medical Institute (HHMI)

2,206 Articles

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Efficient transgene-free multiplexed genome editing via viral delivery of an engineered TnpB.
Weiss, T., Kamalu, M., Shi, H., Wirnowski, G., Ingelsson, A., Amerasekera, J., Vohra, K., Trinidad, M. I., Li, Z., Freitas, E., Steinmetz, N., Ambrose, C., Chen, K., Doudna, J. A., Jacobsen, S. E.
10.64898/2026.01.23.700382 — Posted: 2026-02-25
A 5-hydroxymethylcytosine DNA glycosylase provides defense against T-even bacteriophages
Mejia-Pitta, A., Zhang, Z., Hossain, A., Bartosik, K., Baca, C., Peralta, C., Molina, H., Teplova, M., Brady, S. F., Micura, R., Patel, D. J., Marraffini, L. A.
10.64898/2026.02.25.707755 — Posted: 2026-02-25
Metabolic stress reveals widespread accumulation of cap-unmethylated RNAs
Xing, Z., Freitas, A. V., Sutter, B. M., Dang, N. K., Ingolia, N. T., Tu, B. P.
10.64898/2026.02.23.707474 — Posted: 2026-02-24
Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785
Zhang, S., Stix, R., Orabi, E. A., Bernhardt, N., Faraldo-Gomez, J. D.
10.1101/2024.07.25.605170 — Posted: 2026-02-24
Automated localization of calling birds with small passive acoustic arrays in complex soundscapes
Eisen, M. B., Brown, P. O., Sanz-Matias, A.
10.64898/2026.02.23.707497 — Posted: 2026-02-24
Viral SSB-bound ssDNA activates the bacterial anti-phage defense system DARNA
Puteikiene, R., Vassallo, C., Silanskas, A., Juozapaitis, J., Songailiene, I., Laub, M. T., Sasnauskas, G.
10.64898/2026.02.22.705581 — Posted: 2026-02-23
Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potential
Raz, A. A., Hassan, H., Yamashita, Y. M.
10.1101/2025.04.10.648217 — Posted: 2026-02-23
Reprogramming CAR T-Cells with designed bioPROTACs
Peche, V. S., Kenny, S., Kang, T. G., Coventry, B., Mi, T., Goreshnik, I., Garcia Sanchez, M., Martin, R., Smith, M., Vafeados, D., Kathayat, R., Kaiwen, Y., Yuan, Z.-F., Wu, L., High, A., Nemecek, A., Wickmann, E., Adeshakin, A., Ferrara, F., Throm, R., Chen, T., Youngblood, B., Baker, D., Gottschalk, S.
10.64898/2026.02.21.706835 — Posted: 2026-02-22
Husbandry and Maintenance of Carausius morosus Laboratory Populations
Ingersoll, M., Kovacikova, P., Hashmi, Y., Extavour, C. G.
10.64898/2026.02.19.706905 — Posted: 2026-02-20
The promoter-poised Rpd3 HDAC complex orchestrates global chromatin reprogramming upon nutrient transition
Bhattacharya, S., Sutter, B. M., Tu, B.
10.64898/2026.02.19.706824 — Posted: 2026-02-20

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