Channel: The Howard Hughes Medical Institute (HHMI)

1,994 Articles

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Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells

Grzywa, T., Mehta, N., Cossette, B., Romanov, A., Paruzzo, L., Ramasubramanian, R., Cozzone, A., Morgan, D., Sukaj, I., Bergaggio, E., Tannir, R., Kadauke, S., Myers, R., Yousefpour, P., Ghilardi, G., Schuster, S., Neeser, A., Frey, N., Goncalves, B., Zhang, L., Abraham, W., Suh, H., Ruella, M., Grupp, S., Chiarle, R., Wittrup, K. D., Ma, L., Irvine, D. J.

10.1101/2024.04.16.589780 — Posted: 2024-10-01

An aneuploidy epistasis map reveals metabolic vulnerabilities associated with supernumerary chromosomes in cancer

Magesh, R. Y., Kaur, A. N., Keller, F. N., Frederick, A., Tseyang, T., Haley, J. A., Rivera Nieves, A. M., Liang, A. C., Guertin, D., Spinelli, J., Elledge, S. J., Watson, E. V.

10.1101/2024.09.30.615609 — Posted: 2024-10-01

Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording

McDiarmid, T. A., Taylor, M. L., Chen, W., Chardon, F. M., Choi, J., Liao, H., Li, X., Kim, H., Lalanne, J.-B., Li, T., Nathans, J. F., Martin, B. K., Knuth, J., Coradini, A. L. V., Gray, J. M., Pinglay, S., Shendure, J.

10.1101/2024.09.30.615957 — Posted: 2024-10-01

Latent-TGF-β has a domain swapped architecture

Jin, M., Seed, R., Shing, T., Cheng, Y., Nishimura, S.

10.1101/2024.09.27.615443 — Posted: 2024-09-30

Mapping and engineering RNA-controlled architecture of the multiphase nucleolus

Quinodoz, S. A., Jiang, L., Abu-Alfa, A. A., Comi, T. J., Zhao, H., Yu, Q., Wiesner, L. W., Botello, J. F., Donlic, A., Soehalim, E., Zorbas, C., Wacheul, L., Kosmrlj, A., Lafontaine, D. L., Klinge, S., Brangwynne, C. P.

10.1101/2024.09.28.615444 — Posted: 2024-09-29

Functional protein mining with conformal guarantees

Boger, R. S., Chithrananda, S., Angelopoulos, A. N., Yoon, P. H., Jordan, M. I., Doudna, J. A.

10.1101/2024.06.27.601042 — Posted: 2024-09-28

DNA polymerase Zeta is a robust reverse transcriptase

Mayle, R., Holloman, W. K., O'Donnell, M. E.

10.1101/2024.09.27.615452 — Posted: 2024-09-28

Dysregulation of the fluid homeostasis system by aging

Jang, H., Behne Sharma, A., Dan, U., Wong, J. H., Knight, Z. A., Garrison, J. L.

10.1101/2024.09.26.615271 — Posted: 2024-09-27

Tunable Elliptical Cylinders for Rotational Mechanical Studies of Single DNA Molecules

Hong, Y., Ye, F., Gao, X., Inman, J. T., Wang, M. D.