Channel:  The Howard Hughes Medical Institute (HHMI)

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Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas
St. Laurent, J. D., Xu, G. D., Ying, A. W., Gokbayrak, B., Patil, A., Paulo, J. A., Cervantes, K. S., Chen, S., Feng, W. W., Sankar, A., Same Guerra, D. D., Qi, J., Neel, D. S., Hornick, J. L., Kolin, D. L., Gygi, S., Huntsman, D. G., Wang, Y., Kadoch, C.
10.1101/2025.10.13.681937 — Posted: 2025-10-15
A reference brain for the clonal raider ant
Frank, D. D., Lopes, L. E., Mohanta, R., Seckler, I., Lacroix, I., Kronauer, D. J. C.
10.1101/2025.10.13.679875 — Posted: 2025-10-14
Mapping cellular targets of covalent cancer drugs in the entire mammalian body
Pang, Z., Leung, V. H., Wang, C. C., Attarpour, A., Rinaldi, A., Shen, H., Moya-Garzon, M. D., Sigua, L. H., Rammel, C., Selke, A., Glynn, C., Yender, M., Xu, S., Moslehi, J. J., Wu, P., Long, J. Z., Goubran, M., Cravatt, B. F., Ye, L.
10.1101/2025.03.28.645991 — Posted: 2025-10-14
The complete genome of a songbird
Formenti, G., Jain, N., Medico, J. A., Sollitto, M., Antipov, D., Balacco, J., Barcellos, S., Biegler, M. T., Borges, I., Chang, J. K., Chen, Y., Cheng, H., Conceicao, H. B., Davenport, M., De Oliveira, L. C., Duarte, E., Durham, G. P., Fenn, J., Forde, N., Kim, J., Komissarov, A., Koo, B., Koren, S., Galante, P. A. F., Gerhardt, K., Giani, A. M., Giunta, S., Larkin, D., Lee, C., Li, H., Makova, K., Masterson, P., Murphy, T., McCaffrey, K., Mercuri, R. L. V., Na, Y., O Connell, M. J., Ou, S., Phillippy, A. M., Popova, M., Rhie, A., Ruiz-Ruano, F. J., Secomandi, S., Smeds, L., Suh, A., Tilley
10.1101/2025.10.14.682431 — Posted: 2025-10-14
Ecological cues orchestrate concerted courtship in a Drosophila host specialist
Brand, P., Keller, K., Coleman, R. T., Eghbali, N. B., Zylka, S., Prieto-Godino, L. L., Ruta, V.
10.1101/2025.10.13.681913 — Posted: 2025-10-14
Rapid development and field evaluation of a portable CRISPR-based assay for Mpox during the 2025 Sierra Leone outbreak
Gopal, N., Abay, T., Payne, C., Gomez, M., Fofanah, I. U., Rogers, M. M., Kallon, T. P., Kamara, M. S., Suk, H.-J., Sandi, J. D., Brock-Fisher, T., Stachler, E., Allan-Blitz, L.-T., Roach, D. J., Paye, M. F., Wilkason, C., Grant, D. S., Ozonoff, A., Sabeti, P. C.
10.1101/2025.10.08.25337506 — Posted: 2025-10-13
High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists
Abedi, M., Exposit, M., Coventry, B., Mathew, D., Jain, S., Krishnakumar, A., Goreshnik, I., Gray-Gaillard, S., Lunn-Halbert, M., Yu, T.-Y., Glögl, M., Mitchell, U., Keshri, R., Chun, J. H., Ruohola-Baker, H., Wherry, E. J., Baker, D.
10.1101/2025.10.12.681920 — Posted: 2025-10-13
Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity
Keshri, R., Exposit, M., Abedi, M., R Hicks, D., Foreman, Z., Phal, A., Lim, Y. C., Barrett, P., Sniezek, C., Lin, J., Schlichthaerle, T., J Robinson, A., Detraux, D., Ching, T. C., Wu, K., Coventry, B., Chang, L., S.T. Smith, A., L Mack, D., K Schweppe, D., Martin, B. E., Hristova, K., Mathieu, J., Baker, D., Ruohola-Baker, H.
10.1101/2025.10.12.681903 — Posted: 2025-10-13
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Rehfeld, F., Lundstrom, C., Zhang, H., Mendell, J. T.
10.1101/2025.10.13.682107 — Posted: 2025-10-13
Single-sequence deep learning delivers crystal-quality models of covalent K-Ras G12 hotspot complexes
Jung, S., Zheng, Q., Shokat, K.
10.1101/2025.09.16.676163 — Posted: 2025-10-13

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