Channel:  The Howard Hughes Medical Institute (HHMI)

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Accelerating protein design by scaling experimental characterization
Qian, J., Milles, L. F., Wicky, B. I. M., Ragotte, R. J., Motmaen, A., Borst, A. J., Skotheim, R., Ols, S., Coventry, B., Li, X., Kibler, R. D., Goreshnik, I., Exposit, M., Lore, K., Stewart, L., Baker, D.
10.1101/2025.08.05.668824 — Posted: 2025-10-16
Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas
St. Laurent, J. D., Xu, G. D., Ying, A. W., Gokbayrak, B., Patil, A., Paulo, J. A., Cervantes, K. S., Chen, S., Feng, W. W., Sankar, A., Same Guerra, D. D., Qi, J., Neel, D. S., Hornick, J. L., Kolin, D. L., Gygi, S., Huntsman, D. G., Wang, Y., Kadoch, C.
10.1101/2025.10.13.681937 — Posted: 2025-10-15
An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics
Picard, C. L., Ichino, L., Buckley, T. J., Boone, B. A., Abuhanna, K. D., Zhang, Y., Behrendt, N. J., May Lei Soe, S., Luo, C., Jacobsen, S. E.
10.1101/2025.10.13.682236 — Posted: 2025-10-15
The complete genome of a songbird
Formenti, G., Jain, N., Medico, J. A., Sollitto, M., Antipov, D., Balacco, J., Barcellos, S., Biegler, M. T., Borges, I., Chang, J. K., Chen, Y., Cheng, H., Conceicao, H. B., Davenport, M., De Oliveira, L. C., Duarte, E., Durham, G. P., Fenn, J., Forde, N., Kim, J., Komissarov, A., Koo, B., Koren, S., Galante, P. A. F., Gerhardt, K., Giani, A. M., Giunta, S., Larkin, D., Lee, C., Li, H., Makova, K., Masterson, P., Murphy, T., McCaffrey, K., Mercuri, R. L. V., Na, Y., O Connell, M. J., Ou, S., Phillippy, A. M., Popova, M., Rhie, A., Ruiz-Ruano, F. J., Secomandi, S., Smeds, L., Suh, A., Tilley
10.1101/2025.10.14.682431 — Posted: 2025-10-14
Ecological cues orchestrate concerted courtship in a Drosophila host specialist
Brand, P., Keller, K., Coleman, R. T., Eghbali, N. B., Zylka, S., Prieto-Godino, L. L., Ruta, V.
10.1101/2025.10.13.681913 — Posted: 2025-10-14
A reference brain for the clonal raider ant
Frank, D. D., Lopes, L. E., Mohanta, R., Seckler, I., Lacroix, I., Kronauer, D. J. C.
10.1101/2025.10.13.679875 — Posted: 2025-10-14
Mapping cellular targets of covalent cancer drugs in the entire mammalian body
Pang, Z., Leung, V. H., Wang, C. C., Attarpour, A., Rinaldi, A., Shen, H., Moya-Garzon, M. D., Sigua, L. H., Rammel, C., Selke, A., Glynn, C., Yender, M., Xu, S., Moslehi, J. J., Wu, P., Long, J. Z., Goubran, M., Cravatt, B. F., Ye, L.
10.1101/2025.03.28.645991 — Posted: 2025-10-14
Single-sequence deep learning delivers crystal-quality models of covalent K-Ras G12 hotspot complexes
Jung, S., Zheng, Q., Shokat, K.
10.1101/2025.09.16.676163 — Posted: 2025-10-13
Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling
Exposit, M., Abedi, M., Krishnakumar, A., Jain, S., Yu, T.-Y., Hercus, T. R., Mathew, D., Gray-Gaillard, S., Chen, Z., Grubbe, W. S., Favor, A., Kan, W. L., Schlichthaerle, T., Chen, W., Parker, M. W., Mendoza, J. L., Lopez, A. F., Wherry, E. J., Baker, D.
10.1101/2025.10.12.681819 — Posted: 2025-10-13
Multiplex design and discovery of proximity handles for programmable proteome editing
Suiter, C. C., Ahn, G., Chiu, M., Fu, Y., Sadre, S., Simon, J. J., Lee, D. S., Fowler, D. M., Maly, D. J., Baker, D., Shendure, J.
10.1101/2025.10.13.681693 — Posted: 2025-10-13

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