Channel:  The Howard Hughes Medical Institute (HHMI)

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Derlin-mediated ERAD of lipid regulator ORMDL3 safeguards mitochondrial function
Scott, N. A., Afolabi, J., Marshall, A. G., Schafer, J. C., Baskerville, V. R., Prasad, P., Kadam, A. A., Som de Cerff, C., Whisenant, T., Phillips, M. A., Tomar, D., McReynolds, M., Hinton, A., Neal, S. E.
10.64898/2026.02.27.708653 — Posted: 2026-03-03
Somatic mutation in human cerebellum illustrates neuron type-specific patterns of age-related mutation
Essuman, K., Yang, Y., Goodman, E., Cambridge, C., Cai, C., An, Z., Mao, S., Manam, M. D., Finander, B., Khoshkhoo, S., Sun, L., Huang, A. Y., Walsh, C. A.
10.64898/2026.02.27.708647 — Posted: 2026-03-02
Structural Basis for C8 methylation of 23S ribosomal RNA by Cfr
Esakova, O. A., Jung, J., Lee, H., Cho, S. H., Alumasa, J. N., Schwalm, E., Grove, T. L., Bauerle, M., Hafenstein, S., Yu, Z., Booker, S.
10.64898/2026.02.27.707579 — Posted: 2026-03-02
Cell body clustering drives gap junction-mediated synchronous activity in command neurons
Lee, K., Graciani, J., Rico Carvajal, N., Zhu, Z., Clark, M., Doe, C.
10.64898/2026.02.26.708359 — Posted: 2026-03-02
mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion
Gentile, C., Feng, W. W., Lenahan, S. M., Ying, A. W., Card, D. C., Wu, F. T. H., Pham, N.-A., Radulovich, N., Cao, P. M., Hueniken, K., Li, Q., Tsao, M.-S., Kulesza, J., Hinkley, M. M., Liao, L., Tsai, J. A. < A., Kohler, J., Facchinetti, F., Li, J., Weston, C., Locquet, M.-A., Ngo, K., Gokhale, P. C., Sacher, A. G., Janne, P. A., Kadoch, C.
10.64898/2026.02.27.708377 — Posted: 2026-03-01
Structural basis of RNA-guided transcription by a dCas12f-σE-RNAP complex
Xiao, R., Hoffmann, F. T., Xie, D., Wiegand, T., Palmieri, A. I., Sternberg, S. H., Chang, L.
10.1101/2025.06.10.658880 — Posted: 2026-02-28
Exapted CRISPR-Cas12f homologs drive RNA-guided transcription
Hoffmann, F. T., Wiegand, T., Palmieri, A. I., Glass-Klaiber, J., Xiao, R., Tang, S., Le, H. C., Meers, C., Lampe, G. D., Chang, L., Sternberg, S. H.
10.1101/2025.06.10.658865 — Posted: 2026-02-28
The deubiquitinating enzyme Otu1 releases substrates from the conserved initiation complex of the Cdc48/p97 ATPase for proteasomal degradation
Li, H., Guan, H., Rapoport, T.
10.1101/2025.11.08.687396 — Posted: 2026-02-28
Superabundant microRNAs are transcribed from human rDNA spacer promoters insulated by CTCF
Henikoff, S., Henikoff, J. G.
10.1101/2025.11.10.687711 — Posted: 2026-02-26
Aspartate aminotransferase is required for Salmonella expansion in the inflamed gut via TCA anaplerosis
Shealy, N. G., Baltagulov, M., Avalos, H. F., Olivas, J., Jones, K. M., Byndloss, M. X.
10.64898/2026.02.24.707732 — Posted: 2026-02-26

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