Channel:  Aligning Science Across Parkinson's (ASAP)

506 Articles

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LRRK2 integrates Rab and GABARAP interactions to sense and respond to distinct lysosomal stresses
Clegg, D., Bentley-DeSousa, A., Roczniak-Ferguson, A., Ferguson, S. M.
10.1101/2025.11.19.689251 — Posted: 2025-11-19
Pathway and gates for ATG2A-mediated lipid transport in autophagy
Cabezudo, A. C., Holzer, E., Martens, S., Hummer, G.
10.1101/2025.11.16.688672 — Posted: 2025-11-16
Insights into the regulation of VPS13 family bridge-like lipid transfer proteins from the structure of VPS13C.
Li, D., Wang, X., Hu, B., Hao, H., Hamill, S., Li, Y., Chen, G., De Camilli, P., Reinisch, K.
10.1101/2025.11.10.687702 — Posted: 2025-11-11
Parkinsons disease modeling in regenerative spiny mice (Acomys dimidiatus) captures key disease-relevant behavioral, histological, and molecular signatures
Dutta, S., Pang, M., Donahue, R. R., Chou, T.-F., Seifert, A. W., Gradinaru, V.
10.1101/2025.11.06.687049 — Posted: 2025-11-08
Introducing PIGMO, a novel PIGmented MOuse model of Parkinson's disease
Chocarro, J., Marana, S., Espelosin, M., Rico, A. J., Ariznabarreta, G., Lorenzo-Ramos, E., Ilarduya, M. M., Hernandez-Alcoceba, R., Chillon, M., Vila, M., Kordower, J., Schapira, A. H. V., Garcia-Osta, A., Cuadrado-Tejedor, M., Lanciego, J. L.
10.1101/2025.05.09.653000 — Posted: 2025-11-05
Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility.
Weglage, M., Aehrlund Richter, S., Contestabile, A., Skara, V., Fuzik, J., Santos, I., Lazaridis, I., Meletis, K.
10.1101/2022.03.16.484460 — Posted: 2025-10-30
Extracellular space diffusion modelling identifies distinct functional advantages of archetypical glutamatergic and GABAergic synapse geometries
Gimenez, P., Shakya, R. T., Santamaria, F., Tonnesen, J.
10.1101/2025.10.29.685288 — Posted: 2025-10-29
The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis
Mahoney-Sanchez, L., Clarke-Lucas, H., Penverne, A., Evans, J. R., D'Sa, K., Strohbuecker, S., Lopex Garcia, P., Cosker, K., Soltic, D., O'Callaghan, B. J., Griffiths, A., Pintchovski, S. A., Plun-Favreau, H., Hallqvist, J., Mills, K., Gandhi, S.
10.1101/2025.10.13.682089 — Posted: 2025-10-14
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
Ehses, K. L., Lopez-Alonso, J. P., Antico, O., Azem, A., Muqit, M., Ubarretxena-Belandia, I., Fernandez-Busnadiego, R.
10.1101/2025.10.06.680693 — Posted: 2025-10-06
Programmable self-assembling system to model intracellular protein aggregation and decode neurodegenerative diseases
Fan, Y., Hoang, J., Steele, C., Benchetrit, Y., Dutta, S., Coughlin, G., Appling, N., Ding, X., Lin, C., Qu, Z., Mackey, E. D., Gradinaru, V.
10.1101/2025.03.06.641009 — Posted: 2025-10-06

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