Channel:  Francis Crick Institute

1,213 Articles

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Peptide molecular glues select between BET paralogues by exploiting allosteric sites and conformational dynamics
Patel, K., Mohanty, B., Norman, A., Franck, C., Pachl, P., Yang, L., Jing, X., Reid, X. J., Walshe, J. L., Solomon, P., Tran, D. H., Ford, D., Low, J. K. K., Wilkinson-White, L., Passioura, T., Payne, R. J., Suga, H., Walport, L. J., Mackay, J. P.
10.1101/2025.09.24.678353 — Posted: 2025-09-24
Distinct ATRX functions cooperate with 9-1-1 and CST complexesto safeguard replication and telomere integrity
Segura-Bayona, S., Maric, M., Takaki, T., Manova, Z., Li, S., Stanage, T. H., Idilli, A. I., Hewitt, G., Ruis, P., Millar, R., Patel, H., Howell, S., Kotsantis, P., Howell, M., Boulton, S. J.
10.1101/2025.09.22.677761 — Posted: 2025-09-22
Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation
Olthof, A. M., Gonzalez, M. N., Poulsen, N. B., Moreno, N. N., Bautu, T., Cugusi, S., Svejstrup, J.
10.1101/2025.09.18.677100 — Posted: 2025-09-18
Characterisation of LAMP1- and LAMP2A-positive organelles in neurons
Abouward, R., Abdelhafid, A. M., Wilkins, O. G., Lee, S.-Y., Ibrahim, F., Skehel, M., Ting, A., Birsa, N., Ule, J., Schiavo, G.
10.1101/2025.09.17.676809 — Posted: 2025-09-17
Morphogen and juxtacrine signalling dynamically integrate to specify cell fates with single-cell resolution
Donoghue, A., Mosby, L., Lago-Baldaia, I., Hodgetts, T., Ursu, E., Erten, Z., Hadjivasiliou, Z., Fernandes, V. M.
10.1101/2025.09.15.676088 — Posted: 2025-09-17
Conserved Aberrant Developmental Trajectories of Human and Mouse SBMA Motor Neurons
Devine, H., Roberts, M. J., Ziff, O. J., Hanna, M. G., Greensmith, L., Patani, R., Malik, B.
10.1101/2025.09.17.674754 — Posted: 2025-09-17
Mechanisms for cross-neutralisation of diverse bat sarbecoviruses
Upadhyay, A., Seow, J., Alguel, Y., Newman, J., Thakur, N., Hay, A., Tam, J. C. H., Nans, A., Orton, R., Bailey, D., Cherepanov, P., Doores, K. J.
10.1101/2025.09.17.674891 — Posted: 2025-09-17
Cell migration sculpts evolutionary dynamics favouring therapy resistance in lung cancer
Bhargava, A., Fu, X., Bailey, S., Naito, Y., Mohammadi, H., Hynds, R. E., Hooper, S., Biswas, D., Le Marois, A., Kumar, S., Alexandrov, Y., French, P. M., McGinty, J., Bates, P. A., Swanton, C., Sahai, E.
10.1101/2025.09.15.675999 — Posted: 2025-09-16
Investigations into fission yeast chromosome size determinants
Wu, P.-S., Fallesen, T., Uhlmann, F.
10.1101/2025.09.15.676266 — Posted: 2025-09-15
Streptococcus pneumoniae accessory capsular genes modulate fitness, pathogenicity and immune evasion
Chan, J. M., Flynn, H. R., Kim, S., Demetriou, H., Ramos-Sevillano, E., Alsari, A., Roalfe, L., Ercoli, G., Kalizang'oma, A., Brown, C., Chaguza, C., French, N., Brown, J. S., Goldblatt, D., de Carvalho, L. P. S., Heyderman, R.
10.1101/2025.09.11.675585 — Posted: 2025-09-15

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