Channel:  Francis Crick Institute

1,203 Articles

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SLFN11 restricts escape from telomere crisis to prevent alternative lengthening of telomeres
Segura-Bayona, S., Borel, V., Stanage, T. H., Maric, M., Walter, M., Oliveira, R. A., Li, S., Idilli, A. I., Peritore, M., Hewitt, G., Hekkelman, M., Snell, D. M., Jones, S. T., Cheshire, C., Elezi, A., Chakravarty, P., Mitter, R., Mikolajczak, A., Gee, H. E., Nye, E., O'Sullivan, R. J., Singhi, A. D., Brummelkamp, T. R., Cesare, A. J., Boulton, S. J.
10.1101/2025.09.10.675313 — Posted: 2025-09-10
Critical point drying of brain tissue for X-ray phase contrast imaging
Khan, S., Albers, J., Vorobyev, A., Zhang, Y., Reichmann, J., Svetlove, A., de Marco, F., Denisova, K., Yang, Y., Seichepine, F., Douglas, J. O., Duke, E., Cloetens, P., Pacureanu, A., Schaefer, A., Bosch, C.
10.1101/2025.09.02.673701 — Posted: 2025-09-09
TDP-43 loss of function drives aberrant splicing in Parkinson's disease
Brenton, J. W., Follett, J., Nirujogi, R., Toomey, C. E., Lopez-Garcia, P., Evans, J. R., Lee, Y. J., Syed, K. M., Rocamora Perez, G., Fairbrother-Browne, A., D'Sa, K., Grant-Peters, M., Lachica, J., Hicks, A. R., Wagen, A. Z., O'Callaghan, B., Macpherson, H., Montgomery, K.-a., Busquets, O., Reynolds, R. H., Garcia Ruiz, S., Cao, T., Chen, Z., Plun-Favreau, H., Wong, P. C., Farrer, M., Lashley, T., Soldner, F., Hockemeyer, D., Alessi, D., Wood, N. W., Hardy, J., Rio, D. C., Jaunmuktane, Z., Gustavsson, E. K., Gandhi, S., Ryten, M.
10.1101/2025.09.04.673943 — Posted: 2025-09-09
Pregranulosa cells engage a distinct transcriptional programme prior to cell-cycle dependent primordial follicle activation
Taylor, G., Frost, E. R., Crow, B. N., Radley, A., Boeing, S., Galichet, C., Bucinskaite, B., Baker, M. A., Sutherland, J. M., Lovell-Badge, R.
10.1101/2022.10.24.513438 — Posted: 2025-09-05
Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis
Calado, D. P., Boulat, V., Alberts, E., Driscoll, P. C., Hung, M. S., Cunha, A., Quist, J., Liu, F., Brundin, C. A., Bhalla, A., Avalle, L., Rosekilly, J., Ryan, L., Gillett, C., Strom, M., Poli, V., MacRae, J. I., Grigoriadis, A.
10.1101/2025.08.30.673054 — Posted: 2025-09-04
Brain-derived neurotrophic factor amplifies neuron-intrinsic programs to enhance axonal regeneration in human motor neurons
Vargas, J. N. S., Brown, A.-L., Sun, K., Hagemann, C., Geary, B., Villarroel-Campos, D., Bryce-Smith, S., Zanovello, M., Lombardo, M., Majewski, S., Tosolini, A., Secrier, M., Keuss, M. J., Serio, A., Sleigh, J. N., Fratta, P., Schiavo, G.
10.1101/2023.11.06.565775 — Posted: 2025-09-04
The actomyosin cortex controls t-tubule remodeling in muscle
Pereira, A. R., Soares, A. d. R., Francescantonio, S. D., Liu, T., Carvalho, F. A., Ferreira, J. L., Leal, G., Faleiro, I., Kogata, N., Santos, N. C., Way, M., Moores, C., Gomes, E. R.
10.1101/2024.08.13.607563 — Posted: 2025-09-02
Balanced contractility and adhesion drive polarization in a minimal elastic actomyosin network
Messi, Z., Raynaud, F., Goehring, N. W., Verkhovsky, A. B.
10.1101/2025.08.26.672435 — Posted: 2025-08-29
Disease-attenuated pneumococcal biosynthesis gene mutants invade the mucosal epithelium and induce innate immunity
Weight, C. M., Pollara, G. M., Betts, M., Ragazzini, R., Connor, M., Ramos-Sevillano, E., Reine, J., Whelan, M., Guerra-Assuncao, J. A., Bonfanti, P., Jolly, C., Noursadeghi, M., Ferreira, D., Brown, J., Heyderman, R. S.
10.1101/2023.06.15.545009 — Posted: 2025-08-29
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson's disease
Evans, J. R., Grant-Peters, M., Beckwith, J. S., Toomey, C. E., Popovic, R., Breiter, J. C., Brenton, J. W., Fairbrother-Browne, A., Strohbuecker, S., Lachica, J., Rodriguez-Lopez, M., Brock, E. E., Fu, B., Nahidiazar, L., Lopez-Garcia, P., Ferguson, R., Saleeb, R. S., Lucas-Clarke, H., Penverne, A., D'Sa, K., Pang, C. W., Horrocks, M. H., Vendruscolo, M., Wood, N., Lee, S. F., Ryten, M., Gandhi, S.
10.1101/2025.08.25.671921 — Posted: 2025-08-28

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