Channel:  Francis Crick Institute

1,153 Articles

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Chromosome-Specific Aneuploidy Engineering via dCas9-Induced Centromeric Chromatin Relaxation
FENG, H., Deng, D., Dahiya, R., Wang, L., Zeng, J., Tan, B. J. Y., Byrne, F., Shepherd, S. T. C., Wang, J., Johnson, S. C., Harrod, A., Lane, K. A., Fendler, A., Cattin, A.-L., Tippu, Z., Nie, M., Zhao, Y., Wang, R., Ai, W., Bouricha, O., Barber, T., Dovga, Y., Xu, Y., Xu, Y., Devito, L. G., Healy, L., Sun, Z., Shen, W., Wang, H., Lim, E. S., OToole, S. M., Akker, S., Drake, W. M., Jin, H., Downs, J. A., McClelland, S. E., Diffley, J. F. C., Ly, P., Turajlic, S.
10.1101/2025.04.25.650684 — Posted: 2025-04-27
Structure-Function Mapping of Olfactory Bulb Circuits with Synchrotron X-ray Nanotomography
Zhang, Y., Bosch, C., Ackels, T., Laugros, A., Bonnin, A., Livingstone, J., Waltenberg, C., Berning, M., Tootoonian, S., Kollo, M., Nathansen, A., Rzepka, N., Cloetens, P., Pacureanu, A., Schaefer, A.
10.1101/2025.04.24.650439 — Posted: 2025-04-27
Volatile anaesthetics modulate voltage-gated sodium channel function at a site critical for gating
Hollingworth, D., Herold, K. F., Kelly, G., Mykhaylyk, V. B., Zhang, D., Wallace, B. A., Hemmings, H. C.
10.1101/2024.11.04.621342 — Posted: 2025-04-25
3D spatial transcriptomics reveals the molecular structure of input and output pathways in the mouse olfactory bulb
Klimpert, N., Kollo, M., Brann, D. H., Tan, C., Barry, D., Ma, Y., Schaefer, A. T., Fleischmann, A.
10.1101/2025.02.19.639192 — Posted: 2025-04-23
Chronobot: Deep learning guided time-resolved cryo-EM captures molecular choreography of RecA in homology search
Mäeots, M.-E., Tupin, S., Esfahani, N. M. M., Molina, J. B. R., Clapperton, J. A., Amin, A., Imbert, A., Enchev, R. I.
10.1101/2025.04.21.649820 — Posted: 2025-04-22
An intrinsically disordered region mediates RNA-binding selectivity and pro-oncogenic activities of LARP6
Capraro, F., Abis, G., Incocciati, A., Karimzadeh, M., Masino, L., Barley, A., Bui, T. T. T., Kelly, G., Goodarzi, H., Conte, M. R., Mardakheh, F. K.
10.1101/2024.09.20.614075 — Posted: 2025-04-15
VP-CLEM-Kit: An accessible pipeline for visual proteomics using super resolution volume correlative light and electron microscopy (SR-vCLEM)
Lumkwana, D., Lightley, J., Vesga, A. G., de Folter, J., Domart, M.-C., Maclachlan, C., Kumar, S., Evans, J. R., Peddie, C., Burrell, A., Yoshimura, A., Mangali, A., Vahrjmeijer, N., Bhaga, M., Smit, C., Titze, B., Horrocks, M. H., Cobra Straker, L., Garcia, E., Jones, M. L., Mclean, A., Roufosse, C., Loos, B., Gandhi, S., Strange, A., Henriques, R., French, P. M., Collinson, L.
10.1101/2025.04.08.647770 — Posted: 2025-04-10
Measuring the functional complexity of nanoscale connectomes: polarity matters
Wang, Q., Randel, N., Yin, Y., Shand, C., Strange, A., Winding, M., Cardona, A., Zlatic, M., Vogelstein, J., Priebe, C.
10.1101/2024.09.24.614724 — Posted: 2025-04-07
An intercellular metabolic relay for brain sparingin Drosophila
Franchet, A., Jin, Y., Newell, C. L., Girard, V., Maniere, G., Grosjean, Y., Barrington, C., MacRae, J. I., Gilmore, I. S., Gould, A. P.
10.1101/2025.04.02.645514 — Posted: 2025-04-03
The ubiquitin E3 ligase Huwe1 facilitates viral and self RNA sensing by RIG-I-like receptors
Oosenbrug, T., Gravekamp, D., Pinto-Fernandez, A., Crotta, S., Finsterbusch, K., van der Kooij, S. B., ter Haar, L. R., Asschert, Y., Kleian, G. F. E., Kessler, B. M., Wack, A., van der Veen, A. G.
10.1101/2025.03.27.645708 — Posted: 2025-04-01

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