Channel:  Francis Crick Institute

1,327 Articles

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Cellular context restricts a promiscuous m6A reader IDR to a single functional effector interface for mRNA decay
Chan, W. Y., Jin, E., Cross, H., Masino, L., Ibrahim, F., Albihlal, W. S., Berger, D., Boot, J., Michrowska, A., Mouilleron, S., Skehel, M., Kranc, K. R., van Werven, F. J.
10.64898/2026.08.04.742832 — Posted: 2026-08-05
DNA entry into the cohesin ring through the kleisin N-gate
Gmurczyk, K., Higashi, T. L., Whitton, G., Uhlmann, F.
10.64898/2026.08.04.742744 — Posted: 2026-08-04
Multi-scale modeling of human tissues from spatial transcriptomics with TERRA
Birk, S., Sanian, M. V., Vahidi, A., Ogden, S., Jafree, D. J., Miraki Feriz, A., Leonardi, C., Merchant, A., He, Z., Steele, L., Boxall, A., Sallese, M. R., Maaskola, J., Ramirez-Suastegui, C., Ogut, S., Rademaker, K., Vijayabaskar, M., Cakir, B., Marco Salas, S., Lorenzi, V., Bryant, J. M., Kyany'a, C., Jones, J. O., Rahbari, R., Raghubar, A. M., Stewart, G. D., Rumney, B., Tudor, C., Patel, M., Halliwell, J., Chan, H. M., Li, T., Stanley, H., Foster, A. R., Memi, F., Roberts, K., Trinh, A. L., Tuck, E., Gracia, T., Rai, S., Adams, D. J., Webb, S., Prete, M., Vento-Tormo, R., Nilsson, M., Lic
10.64898/2026.07.29.741565 — Posted: 2026-08-04
An RPEL-based FRET sensor for G-actin
Fedoryshchak, R. O., FONS, J. M., RENSHAW, M. J., Treisman, R.
10.64898/2026.07.31.741674 — Posted: 2026-08-03
Deep Mechanistic Models reveal pathway-extrinsic drivers of mammary MAPK signalling heterogeneity
Fabrini, G., Froehlich, F.
10.64898/2026.07.30.741759 — Posted: 2026-07-31
A Single Lipid Nanoparticle Formulation Enables Delivery of Diverse RNA Therapeutics to Human Muscle Models of Duchenne Muscular Dystrophy
Galbiati, P., Leclerc, D., Mombled, M., Khan, R., Ralu, M., Bimbi, G., Scalisi, G., Mamchaoui, K., Tedesco, F. S., Albini, S., Amendola, M.
10.64898/2026.07.29.741396 — Posted: 2026-07-29
Mutations in severe human H5N1 cases facilitate evasion from human mucus and antivirals
Sukhova, K., Yang, J., Di Maio, A., Yu, J., Oliveira, M. R., Hens, H., Sadeyen, J.-R., Bagri, S., Jones, S., Hassard, J. A., Mettier, J., Zhou, J., Srivastava, A. D., Mathur, N., Schumann, B., Haslam, S. M., Iqbal, M., Liu, Y., Peacock, T. P., Barclay, W. S., Klim, H.
10.64898/2026.07.28.740943 — Posted: 2026-07-28
TRPML1 loss drives lysosomal calcium failure and astrocyte dysfunction across Alzheimer's Disease progression
Shah, D., Desai, P., Chertavian, C., Thackray, M., Demoulin, M., Mitchener, V., Strom, M., De Strooper, B., Arancibia Carcamo, L.
10.64898/2026.07.23.740052 — Posted: 2026-07-27
Glycogen-Dependent Metabolic Reprogramming Regulates Microglial Activation and Dysfunction in Neurodegenerative Disease
McAlister, H., Merchant, H., Mitchener, V., Gatto, N., Thackray, M., Blackburn, E., Shackleton, L., Gentry, M. S., Arancibia Carcamo, L., Lloyd, A. F.
10.64898/2026.07.13.738226 — Posted: 2026-07-16
RAS-PI3K signaling promotes myofibroblastic CAF identity and restrains an immunomodulatory stromal program
Cuesta, C., Alcon-Perez, M., Cota, R. R., Coadour, S., Zheng, J., Procel, N., Fennema, D., Rosell, A., Meson, D. L., Martinez-Castedo, B., Arafat, Y., Sanz-Fraile, H., Rajeeve, V., Alonso, D., Hynds, R. E., Swanton, C., Alcaraz, J., Cutillas, P., Reyes-Aldasoro, C. C., Wang, H., Castellano, E.
10.1101/2025.01.20.633776 — Posted: 2026-07-14

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