Channel:  Francis Crick Institute

1,153 Articles

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Advanced human iPSC-based modelling of LMNA-related congenital muscular dystrophy enables development of targeted genetic therapies for muscle laminopathies
Moore, D. P., Steele-Stallard, H. B., Pinton, L., Lionello, V. M., Rossi, L., Aghaeipour, A., Jalal, S., Wong, C. T. Y., Clara-Hwang, A., Bonne, G., Zammit, P. S., Tedesco, F. S.
10.1101/2025.06.22.660928 — Posted: 2025-06-23
Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell
Jones, D., Belda, H., Broncel, M., Fuchs, G., Anaguano, D., Nofal, S. D., Treeck, M.
10.1101/2025.05.14.653932 — Posted: 2025-06-21
The evolution of gene regulatory programs controlling gonadal development in primates
Trost, N., Fallahshahroudi, A., Sarropoulos, I., Schneider, C., Schmidt, J., Mbengue, N., Wolff, E., Drummer, C., Frömel, R., Lisgo, S., Murat, F., Sepp, M., Cardoso-Moreira, M., Behr, R., Kaessmann, H.
10.1101/2025.06.17.659946 — Posted: 2025-06-19
Anti-activin treatment increases T cell infiltration in breast and pancreatic tumours and promotes survival in a SMAD4-null mouse pancreatic cancer model
McCluney, S., Park, D., Miller, D. S., Mehic, M., Bloxham, R. D., De Vries, E., Wang, X., Boeing, S., D'Antonio, L., Wieteska, L., Pyeatt, G., Strohbuecker, S., Chakravarty, P., Maia De Oliveira, T., Wilcockson, R., Hyvonen, M., Hunt, J., Hill, C. S.
10.1101/2025.06.13.659133 — Posted: 2025-06-17
Overnight circuit remodelling drives juvenile alloparental care
Jamieson, B. B., Chen, M. X., Liang, S., El Rasheed, L. S. H., Chattey, G. M. K., Kohl, J.
10.1101/2025.06.13.659524 — Posted: 2025-06-15
SARS-CoV-2 envelope protein induces LC3 lipidation via the V-ATPase-ATG16L1 axis
Figueras-Novoa, C., Timimi, L. J., Marcassa, E., Taveira-Marques, R., Adams, L., Jiang, M., Wu, M. Y., Montaner, B., Ng, K., De Lorenzo, G., Furnon, W., Cowton, V. M., Upfold, N., Kassiotis, G., Harvey, R., Patel, A. H., Howell, M., Ulferts, R., Beale, R.
10.1101/2025.06.12.659257 — Posted: 2025-06-13
The gene regulatory landscape driving mouse gonadal supporting cell differentiation
Stevant, I., Abberbock, E., Ridnik, M., Weiss, R., Swisa, L., Futtner, C., Maatouk, D., Lovell-Badge, R., Malysheva, V., Gonen, N.
10.1101/2024.12.09.627451 — Posted: 2025-06-12
Cross-species comparative connectomics reveals the evolution of an olfactory circuit
Roberts, R., Giez, C., Dhawan, S., Pang, S., Randel, N., Zhiyuan, L., Gong, H., Dekens, L., DiFrisco, J., Xu, C. S., Hess, H., Zlatic, M., Cardona, A., Prieto-Godino, L. L.
10.1101/2025.06.11.659158 — Posted: 2025-06-11
Single-cell transcriptional dynamics in a living vertebrate
Eck, E., Moretti, B., Schlomann, B. H., Bragantini, J., Lange, M., Zhao, X., VijayKumar, S., Valentin, G., Loureiro, C., Franco, P. P., Jollivet, C., Motomochi, B., Royer, L. A., Oates, A. C., Garcia, H. G.
10.1101/2024.01.03.574108 — Posted: 2025-06-11
Subclonal mutation load predicts survival and response to immunotherapy in cancers with low to moderate tumor mutation burden
Jiang, Y., Montierth, M. D., Yu, K., Ji, S., Tran, Q., Liu, X., Shen, J. P., Guo, S., Wu, A., Dai, Y., Shin, S. J., Li, R., Cao, S., Tang, Y., Lesluyes, T., Kopetz, S., Msaouel, P., Sood, A. K., Devonshire, G., Jones, C. M., Ajani, J., Subudhi, S. K., Aparicio, A., Sharma, P., Shen, J. P., Kimmel, M., Wang, J. R., Tarabichi, M., Fitzgerald, R. C., Zhu, H., Loo, P. V., Wang, W.
10.1101/2024.07.03.601939 — Posted: 2025-06-10

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