Channel:  Francis Crick Institute

1,314 Articles

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Glycogen-Dependent Metabolic Reprogramming Regulates Microglial Activation and Dysfunction in Neurodegenerative Disease
McAlister, H., Merchant, H., Mitchener, V., Gatto, N., Thackray, M., Blackburn, E., Shackleton, L., Gentry, M. S., Arancibia Carcamo, L., Lloyd, A. F.
10.64898/2026.07.13.738226 — Posted: 2026-07-16
MEN1 deficiency establishes a selenite-dependent binary switch in ferroptosis
Low, R. R. J., Parnandi, N., Idilli, A. I., Gjelaj, E., Subtil, F. T., Segura-Bayona, S., MacRae, J. I., Boulton, S. J.
10.64898/2026.07.16.738891 — Posted: 2026-07-16
RAS-PI3K signaling promotes myofibroblastic CAF identity and restrains an immunomodulatory stromal program
Cuesta, C., Alcon-Perez, M., Cota, R. R., Coadour, S., Zheng, J., Procel, N., Fennema, D., Rosell, A., Meson, D. L., Martinez-Castedo, B., Arafat, Y., Sanz-Fraile, H., Rajeeve, V., Alonso, D., Hynds, R. E., Swanton, C., Alcaraz, J., Cutillas, P., Reyes-Aldasoro, C. C., Wang, H., Castellano, E.
10.1101/2025.01.20.633776 — Posted: 2026-07-14
Gene Regulatory Networks Mediate Pattern Scaling in Growing Tissues
Bowen, A. E., Hadjivasiliou, Z.
10.64898/2026.07.08.737218 — Posted: 2026-07-12
Mitochondrial Optic Atrophy (OPA)1 expression regulates the injury response to neonatal hypoxia-ischaemia.
Curel, C., Jones, A., Crawford, A. H., Goikolea Vives, A., Chabrier, G., Gil, G., Oregioni, A., Southworth, R., Eykyn, T. R., Stolp, H. B., Nobeli, I., Thornton, C.
10.64898/2026.05.21.726935 — Posted: 2026-07-10
Low-abundance αSyn-112 promotes αSyn-140 aggregation in vitro and forms immunoreactive deposits in Parkinson's disease brain tissue
Röntgen, A., Fusco, G., Breiter, J., Beckwith, J. S., Lachica, J., Toomey, C. E., Singh, J., Klementieva, O., Gandhi, S., Lee, S., De Simone, A., Toprakcioglu, Z., Vendruscolo, M.
10.64898/2026.07.05.736591 — Posted: 2026-07-09
Dynamic interaction between tentacle-tethered microdomains in Integrator and NELF regulates the promoter-proximal pause checkpoint
Blears, D., Bech, P., Martinez, D. L., Dai, P., Shah, R. A., Fong, N., Han, Z., Mitter, R., Sheridan, R., Johansen, J. V., Dirac-Svejstrup, A. B., Bentley, D., Svejstrup, J. Q.
10.64898/2026.06.30.735463 — Posted: 2026-07-09
PKN2 regulates cell-junctions to limit colitis
Henry, J. C., Campbell, A., Huddar, P., Sewell, J., Menezes, S., Passman, A., Smith, K., McGauran, S., Quetier, I., Lin, M.-L., Jansen, M., McDonald, N., Graham, T. A., McDonald, S., Cameron, A. J.
10.64898/2025.12.15.694339 — Posted: 2026-07-09
Fitness and immune-escape within germinal centers shape premalignant evolution toward lymphoma
Zhang, L., Hung, M. S., Atkins, O., Artemov, P., Sochon, A., Boulat, V., Kashkar, H., Reinhardt, H. C., Fitzgibbon, J., Okosun, J., Calado, D. P.
10.64898/2026.06.25.734549 — Posted: 2026-07-09
Solid-like PAR protein assemblies encode long-term spatial memory of cell polarity during suspended animation
Borrego-Pinto, J., Cornwall Scoones, J., Hirani, N., Ng, K., Baum, B., Banerjee, S., Goehring, N. W.
10.64898/2026.06.30.733387 — Posted: 2026-07-09

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