Channel:  RNA Therapeutics Institute at UMass Chan Med School

137 Articles

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A programmable dual-targeting di-valent siRNA scaffold supports potent multi-gene modulation in the central nervous system
Belgrad, J., Tang, Q., Hildebrand, S., Summers, A., Sapp, E., Echeverria, D., O'Reilly, D., Luu, E., Bramato, B., Allen, S., Cooper, D., Alterman, J., Yamada, K., Aronin, N., DiFiglia, M., Khvorova, A.
10.1101/2023.12.19.572404 — Posted: 2023-12-19
Structural mechanism of angiogenin activation by the ribosome
Loveland, A. B., Koh, C. S., Ganesan, R., Jacobson, A., Korostelev, A. A.
10.1101/2023.12.11.570495 — Posted: 2023-12-11
Addressing the dNTP bottleneck restricting prime editing activity
Ponnienselvan, K., Liu, P., Nyalile, T., Oikemus, S., Joynt, A. T., Kelly, K., Guo, D., Chen, Z., Lee, J. M., Schiffer, C. A., Emerson, C. P., Lawson, N. D., Watts, J. K., Sontheimer, E. J., Luban, J., Wolfe, S. A.
10.1101/2023.10.21.563443 — Posted: 2023-10-29
Modular vector assembly enables rapid assessment of emerging CRISPR technologies
McGee, A. V., Liu, Y. V., Griffith, A. L., Szegletes, Z. M., Wen, B., Kraus, C., Miller, N. W., Steger, R. J., Escude Velasco, B., Bosch, J. A., Zirin, J. D., Viswanatha, R., Sontheimer, E. J., Goodale, A., Greene, M. A., Green, T. M., Doench, J. G.
10.1101/2023.10.25.564061 — Posted: 2023-10-27
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis
Min, K., Yenilmez, B., Kelly, M., Echeverria, D., Elleby, M., Lifshitz, L. M., Raymond, N., Tsagkaraki, E., Harney, S. M., DiMarzio, C., Wang, H., McHugh, N., Bramato, B., Morrison, B., Rothstein, J. D., Khvorova, A., Czech, M. P.
10.1101/2023.05.03.539244 — Posted: 2023-10-19
Glucose stress causes mRNA retention in nuclear Nab2 condensates
Heinrich, S., Hondele, M., Marchand, D., Derrer, C. P., Zedan, M., Oswald, A., Malinovska, L., Uliana, F., Khawaja, S., Mancini, R., Grunwald, D., Weis, K.
10.1101/2022.01.30.478372 — Posted: 2023-10-12
Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias
Lucas, B. A., Himes, B. A., Grigorieff, N.
10.1101/2023.07.03.547552 — Posted: 2023-10-06
Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in rodent and swine photoreceptors
Cheng, S.-Y., Caiazzi, J., Biscans, A., Alterman, J. F., Echeverria, D., McHugh, N., Hassler, M., Jolly, S., Giguere, D., Cipi, J., Khvorova, A., Punzo, C.
10.1101/2023.09.20.558641 — Posted: 2023-09-22
Casein kinase II promotes piRNA production through direct phosphorylation of USTC component TOFU-4
Mello, C., ZHANG, G., Zheng, C., ding, y.-h.
10.1101/2023.08.09.552615 — Posted: 2023-08-10
Challenges in identifying mRNA transcript starts and ends from long-read sequencing data
Calvo-Roitberg, E., Daniels, R. F., Pai, A. A.
10.1101/2023.07.26.550536 — Posted: 2023-07-27

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