Channel:  RNA Therapeutics Institute at UMass Chan Med School

137 Articles

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The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA mediated inherited silencing
Ding, Y.-H., Ochoa, H., Ishidate, T., Mello, C.
10.1101/2022.10.04.510877 — Posted: 2022-10-05
Drosophila Males Use 5'-to-3' Phased Biogenesis to Make Stellate-silencing piRNAs that Lack Homology to Maternally Deposited piRNA Guides
Venkei, Z. G., Gainetdinov, I., Starostik, M., Choi, C., Chen, P., Balsara, C., Whitfield, T., Bell, G. W., Feng, S., Jacobsen, S. E., Aravin, A., Kim, J. K., Zamore, P., Yamashita, Y. M.
10.1101/2022.09.12.507655 — Posted: 2022-09-13
Di-valent siRNA Mediated Silencing of MSH3 Blocks Somatic Repeat Expansion in Mouse Models of Huntington's Disease
O'Reilly, D., Belgrad, J., Ferguson, C., Summers, A., Sapp, E., McHugh, C., Mathews, E., Buchwald, J., Ly, S., Echeverria Moreno, D., Kennedy, Z., Hariharan, V., Monopoli, K., Yang, X., Carroll, J., Difiglia, M., Aronin, N., Khvorova, A.
10.1101/2022.09.06.506795 — Posted: 2022-09-06
Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state
Maiti, A., Hedger, A., Myint, W., Balachandran, V., Watts, J., Schiffer, C. A., Matsuo, H.
10.1101/2022.08.15.504001 — Posted: 2022-08-15
Relaxed targeting rules allow PIWI-clade Argonaute proteins to silence ever-mutating transposons
Gainetdinov, I., Cecchini, K., Vega-Badillo, J., Bagci, A., Colpan, C., Arif, A., Wu, P.-H., Zamore, P. D.
10.1101/2022.08.04.502788 — Posted: 2022-08-05
Asymmetric trichotomous data partitioning enables development of predictive machine learning models using limited siRNA efficacy datasets
Monopoli, K. R., Korkin, D., Khvorova, A.
10.1101/2022.07.08.499317 — Posted: 2022-07-10
Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in vivo in CNS
Conroy, F., Miller, R., Alterman, J. F., Hassler, M. R., Echeverria, D., Godinho, B. M. D. C., Knox, E. G., Sapp, E., Sousa, J., Yamada, K., Mahmood, F., Boudi, A., Kegel-Gleason, K., DiFiglia, M., Aronin, N., Khvorova, A., Pfister, E. L.
10.1101/2022.06.29.498088 — Posted: 2022-07-05
Silencing of ApoE with Divalent siRNAs Drives Activation of Immune Clearance Pathways and Improves Amyloid Pathology in Mouse Models of Alzheimer's Disease
Ferguson, C., Hildebrand, S., Godinho, B. M. D. C., Buchwald, J., Echeverria, D., Coles, A., Grigorenko, A., Vanjielli, L., Sousa, J., McHugh, N., Hassler, M., Santarelli, F., Heneka, M. T., Rogaev, E., Khvorova, A.
10.1101/2022.06.28.498012 — Posted: 2022-07-02
Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for Label-Free Detection of Molecules across Entire Cell Sections
Elferich, J., Schiroli, G., Scadden, D., Grigorieff, N.
10.1101/2022.06.13.495969 — Posted: 2022-06-14
Structural Basis of MicroRNA Biogenesis by Dicer-1 and Its Partner Protein Loqs-PB
Jourevleva, K., Golovenko, D., Demo, G., Dutcher, R. C., Hall, T. M., Zamore, P. D., Korostelev, A. A.
10.1101/2022.04.19.488762 — Posted: 2022-04-20

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