Channel:  RNA Therapeutics Institute at UMass Chan Med School

137 Articles

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In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles
Seraj, Z., Zottig, X., Huang, C., Loveland, A. B., Diggs, S., Sholi, E., Grigorieff, N., Korostelev, A. A.
10.1101/2025.11.25.690450 — Posted: 2026-03-17
Divalent siRNA for prion disease
Gentile, J. E., Corridon, T. L., Serack, F. E., Echeverria, D., Kennedy, Z. E., Gallant-Behm, C. L., Hassler, M. R., Kinberger, G., Kamath, N. G., Lian, Y., Gross, K. Y., Miller, R., DeSouza-Lenz, K., Howard, M., Guzman, K., Chan, N., Laversenne, V., Curtis, D. T., Fettes, K., Lemaitre, M., Jackson, A. L., Yamada, K., Alterman, J. F., Coffey, A. A., Minikel, E. V., Khvorova, A., Vallabh, S. M.
10.1101/2024.12.05.627039 — Posted: 2026-03-05
Germline Blastomeres transcriptomics in the presence or absence of PIE-1 during C. elegans early embryogenesis
Ponsard, P., Stubbe, F.-X., Tricquet, P., Mello, C., Hermand, D.
10.64898/2026.02.14.705883 — Posted: 2026-02-14
Control of gene output by intron RNA structure
Schärfen, L., Bech, P., Podszywałow-Bartnicka, P., Neugebauer, K. M.
10.1101/2025.11.08.687378 — Posted: 2026-02-11
High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imaging.
van Velde, P., Tran, B., Allen, S., Luu, E., Furgal, R., Summers, A., Belgrad, J., Knox, E., Khvorova, A., Grunwald, D.
10.64898/2026.02.09.704866 — Posted: 2026-02-11
Unbend: Correction of local beam-induced sample motion in cryo-EM images using a 3D spline model
Kong, L., Zottig, X., Elferich, J., Grigorieff, N.
10.1101/2025.09.05.674398 — Posted: 2026-02-07
Systematic Identification of Germ Granule Proteins Reveals Specialized Roles in RNAi and Small RNA Inheritance
Chen, S., Prescott, L. H., Mello, C. C., Phillips, C. M.
10.64898/2026.01.26.701902 — Posted: 2026-01-28
Structural basis for non-AUG translation regulation by 5MPs
Zottig, X., Huang, C.-Y., Seraj, Z., Grigorieff, N., Korostelev, A. A.
10.64898/2025.12.28.696766 — Posted: 2025-12-29
Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system
Fakih, H., Ohara, M., Summers, A., Sarli, S., Kelly, K., Maru, B., Bramato, B., Khvorova, A., Watts, J.
10.64898/2025.12.16.694641 — Posted: 2025-12-18
SPARK: in silico simulations for benchmarking nascent RNA sequencing experiments
Calvo-Roitberg, E., Lehman, J. W., Tam, E., Elhajjajy, S., Engelhardt, B. E., Pai, A. A.
10.1101/2025.11.06.687082 — Posted: 2025-11-08

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