Channel:  RNA Therapeutics Institute at UMass Chan Med School

137 Articles

Most recent first Previous |  Page 2: Articles 11-20  | Next

The Inaugural Flatiron Institute Cryo-EM Conformational Heterogeneity Challenge
Astore, M. A., Woollard, G., Silva-Sanchez, D., Zhou, W., Kopylov, M., Dao Duc, K., Lederman, R. R., Li, Y., Zhou, Y., Yuan, J., Ye, F., Gu, Q., Vuillemot, R., Jonic, S., Dang, L., Ludtke, S. J., Bridges, H., Liu, S., McLean, M., Peretroukhin, V., Schwab, J., Cruz-Chu, E. R., Schwander, P., Gilles, M. A., Singer, A., Herreros, D., Carazo, J. M., Sorzano, C. O. S., Feathers, J. R., Zhong, E. D., Grigorieff, N., Cossio, P., Hanson, S. M.
10.1101/2025.07.18.665582 — Posted: 2025-11-06
Structural mechanism of mRNA decoding by mammalian GTPase GTPBP1
Susorov, D., Miscicka, A., Golovenko, D., Loveland, A. B., Zinoviev, A., Pestova, T. V., Korostelev, A. A.
10.1101/2025.09.26.678779 — Posted: 2025-09-26
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching
Zhang, K., Grant, T., Grigorieff, N.
10.1101/2025.09.11.675606 — Posted: 2025-09-16
Therapeutic delivery of albumin-binding siRNA targeting IRS2 to diverse cell types reduces mammary tumor growth
Tocheny, C. M., Buchwald, J. E., Dahlke, C. D., Fakih, H. H., Morgan, J. S., Summers, A., Wisniewski, C. A., Jackson, S. O., Lee, J.-S., Card, M.-A., Echeverria, D., Peterson, C., Mercurio, A. M., Khvorova, A., Shaw, L. M.
10.1101/2025.07.29.667434 — Posted: 2025-08-01
Pervasive noise in human splice site selection
Khokhar, E. S., Brokaw, K., Kartje, Z. J., Sanabria, V., Javeed, N., Kumar, A., Watts, J. K., Pai, A. A.
10.1101/2025.07.16.665169 — Posted: 2025-07-20
Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntingtons disease pathogenesis in mice
Belgrad, J., Summers, A., Landles, C., Greene, J. R., Hildebrand, S., Knox, E., Sapp, E., Yamada, N., Furgal, R., Miller, R., Osborne, G. F., Chase, K., Luu, E., Freedman, J., Bramato, B., McHugh, N., Benoit, V., OReilly, D., Greer, P., Bates, G. P., Vogt, T. F., Lee, R., Howland, D., DiFiglia, M., Aronin, N., Khvorova, A.
10.1101/2025.06.24.661398 — Posted: 2025-06-25
A single amino acid variant in the variable region I of AAV capsid confers liver detargeting
Xing, R., Xu, M., Reil, D., Destefano, A., Cui, M., Liu, N., Liang, J., Xu, G., Luo, L., Xu, M., Zhang, F., Tai, P. W., Wei, Y., Gruntman, A. M., Flotte, T. R., Gao, G., Wang, D.
10.1101/2025.03.04.641478 — Posted: 2025-06-14
Lowering the HTT1a transcript as an effective therapy for Huntingtons disease
Papadopoulou, A. S., Alterman, J., Landles, C., Smith, E. J., Conroy, F., Phillips, J., Canibano-Pico, M., Nita, I. M., Osborne, G. F., Iqbal, A., Aldous, S. G., Bondulich, M. K., Gomez-Paredes, C., Sathasivam, K., O'Reilly, D., Echeverria, D., Bobkov, K., Greene, J. R., Aronin, N., Khvorova, A., Bates, G. P.
10.1101/2025.06.10.658804 — Posted: 2025-06-11
Mutant Huntingtin exon1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MSH3 silencing, and aggregation
Sapp, E., Boudi, A., Iwanowicz, A., Belgrad, J., Miller, R., Robertson, R., O'Reilly, D., Yamada, K., Deng, Y., Joni, M., Li, X., Kegel-Gleason, K., Khvorova, A., Reiner, A., Aronin, N., DiFiglia, M.
10.1101/2024.12.31.630891 — Posted: 2025-06-05
A Compact Base Editor Rescues AATD-associated Liver and Lung Disease in Mouse Models
Gao, J., Bamidele, N., Pires-Ferreira, D., Destefano, A., Tang, Q., Cao, Y., Xie, J., Gao, G., Gruntman, A., Sontheimer, E., Flotte, T., Xue, W. J.
10.1101/2025.05.07.652636 — Posted: 2025-05-09

RSS  Channel RSS