Channel: RNA Therapeutics Institute at UMass Chan Med School

137 Articles

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Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching

Zhang, K., Grant, T., Grigorieff, N.

10.1101/2025.09.11.675606 — Posted: 2026-04-11

In extracto cryo-EM reveals eEF2 as a major hibernation factor on 60S and 80S particles

Seraj, Z., Zottig, X., Huang, C., Loveland, A. B., Diggs, S., Sholi, E., Grigorieff, N., Korostelev, A. A.

10.1101/2025.11.25.690450 — Posted: 2026-03-17

Divalent siRNA for prion disease

Gentile, J. E., Corridon, T. L., Serack, F. E., Echeverria, D., Kennedy, Z. E., Gallant-Behm, C. L., Hassler, M. R., Kinberger, G., Kamath, N. G., Lian, Y., Gross, K. Y., Miller, R., DeSouza-Lenz, K., Howard, M., Guzman, K., Chan, N., Laversenne, V., Curtis, D. T., Fettes, K., Lemaitre, M., Jackson, A. L., Yamada, K., Alterman, J. F., Coffey, A. A., Minikel, E. V., Khvorova, A., Vallabh, S. M.

10.1101/2024.12.05.627039 — Posted: 2026-03-05

Germline Blastomeres transcriptomics in the presence or absence of PIE-1 during C. elegans early embryogenesis

Ponsard, P., Stubbe, F.-X., Tricquet, P., Mello, C., Hermand, D.

10.64898/2026.02.14.705883 — Posted: 2026-02-14

Control of gene output by intron RNA structure

Schärfen, L., Bech, P., Podszywałow-Bartnicka, P., Neugebauer, K. M.

10.1101/2025.11.08.687378 — Posted: 2026-02-11

High-throughput quantification of huntingtin mRNA expression and aggregation in mouse brain using automated RNAscope imaging.

van Velde, P., Tran, B., Allen, S., Luu, E., Furgal, R., Summers, A., Belgrad, J., Knox, E., Khvorova, A., Grunwald, D.

10.64898/2026.02.09.704866 — Posted: 2026-02-11

Unbend: Correction of local beam-induced sample motion in cryo-EM images using a 3D spline model

Kong, L., Zottig, X., Elferich, J., Grigorieff, N.