Channel:  The Howard Hughes Medical Institute (HHMI)

2,398 Articles

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5-azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia
Gao, B., Li, Y., Zhao, L., Zou, Z., Ma, X., Hong, J., Xiang, J., Dou, X., Yang, F.-C., Xu, M., He, C.
10.1101/2025.06.24.661348 — Posted: 2025-06-27
Prioritizing replay when future goals are unknown
Sagiv, Y., Akam, T., Witten, I., Daw, N. D.
10.1101/2024.02.29.582822 — Posted: 2025-06-27
Histone diversity in the archaeal domain of life
Laursen, S. p., Luger, K.
10.1101/2025.06.26.661778 — Posted: 2025-06-27
Direct observation of interdependent and hierarchical kinetochore assembly on individual centromeres
Hu, C., Popchock, A. R., Latino, A. A., Asbury, C. L., Biggins, S.
10.1101/2025.06.25.661565 — Posted: 2025-06-26
Early transcriptional signatures of MeCP2 positive and negative cells in Rett syndrome
Li, Y., Anderson, A. G., Qi, G., Wu, S.-R., Revelli, J.-P., Liu, Z., Zoghbi, H. Y.
10.1101/2025.06.26.661761 — Posted: 2025-06-26
A trove of antiviral TRIM family E3 ligases in reptiles
Boys, I. N., Quinlan, M. R., Elde, N. C.
10.1101/2025.06.23.661133 — Posted: 2025-06-25
Global Neuron Shape Reasoning with Point Affinity Transformers
Troidl, J., Knittel, J., Li, W., Zhan, F., Pfister, H., Turaga, S. C.
10.1101/2024.11.24.625067 — Posted: 2025-06-25
Magnesium depletion unleashes two unusual modes of colistin resistancewith different fitness costs
Hsieh, Y.-Y. P., O'Keefe, I. P., Sun, W., Wang, Z., Yang, H., Vu, L. M., Ernst, R. K., Dandekar, A. A., Malik, H. S.
10.1101/2024.10.15.618514 — Posted: 2025-06-25
Polo-Like Kinase 1 phosphorylation tunes the functional viscoelastic properties of the centrosome scaffold
Amato, M., Hwang, J. H., Rios, M. U., Familiari, N. E., Rosen, M. K., Woodruff, J. B.
10.1101/2024.08.29.610374 — Posted: 2025-06-24
L-2-hydroxyglutarate impairs neuronal differentiation through epigenetic activation of MYC expression
Gu, W., Wang, X., Solmonson, A., Cai, L., Xiao, Y., Tasdogan, A., Franklin, J., Zhang, Y., Zhang, H., Westfall, A. K., Rowe, A., Trivedi, H., Faubert, B., Wu, Z., Sudderth, J., Zacharias, L. G., Afroze, B., Bezprozvanny, I., Sudarshan, S., Cai, F., McBrayer, S. K., Mathews, T. P., DeBerardinis, R. J.
10.1101/2025.04.16.649033 — Posted: 2025-06-24

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